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Rapid and short-term onset of drug tolerance
Nicotine may also show tachyphylaxis over the course of a day, although the mechanism of this action is unclear. Acute tachyphylaxis which does not carry
Tachyphylaxis
When antidepressants become ineffective
Antidepressant treatment tachyphylaxis (ADT tachyphylaxis), also known as Prozac poop-out, is a medical condition in which progressive or acute tolerance
Antidepressant treatment tachyphylaxis
Antidepressant_treatment_tachyphylaxis
Reduced reaction to a drug following repeated use
which overt adverse effects of a drug can be tolerated by a patient. Tachyphylaxis is a subcategory of drug tolerance referring to cases of sudden, short-term
Drug_tolerance
Psychoactive drug, often called ecstasy
effects tend to remain elevated. This is important, as the marked acute tachyphylaxis to subjective effects may drive repeated use within intervals of 4 hours
MDMA
Psychedelic drug
Activation of β-arrestin2 is linked to receptor downregulation and tachyphylaxis. Similarly to DMT, 5-MeO-DMT is a biased agonist of the serotonin 5-HT2A
Dimethyltryptamine
Psychedelic drug
flashbacks, even months after stopping LSD use. LSD shows significant tachyphylaxis, with tolerance developing 24 hours after administration. The progression
LSD
Psychedelic drug
Activation of β-arrestin2 is linked to receptor downregulation and tachyphylaxis. 5-MeO-DMT is not orally active and must be administered parenterally
5-MeO-DMT
Topical decongestant
Khan F, Lipworth B (2010). "Fluticasone reverses oxymetazoline-induced tachyphylaxis of response and rebound congestion". American Journal of Respiratory
Oxymetazoline
Benzodiazepine used for anesthesia and procedural sedation
anticonvulsant therapeutic effects. With prolonged use, tolerance and tachyphylaxis can occur and the elimination half-life may increase, up to days. Buccal
Midazolam
Pharmaceutical drug
levels produced by rhGH injections. As a result, sermorelin avoids tachyphylaxis by promoting a more physiological pattern of hGH release. Additionally
Sermorelin
Central nervous system stimulant
Walker H, Parlatini V, Cortese S (2 February 2026). "Tolerance and Tachyphylaxis to Medications for Attention-Deficit/Hyperactivity Disorder (ADHD):
Amphetamine
Antihypertensive drug
Meller J, Gorlin R, Herman MV (March 1979). "Hemodynamic and clinical tachyphylaxis to prazosin-mediated afterload reduction in severe chronic congestive
Prazosin
Chemical compound found in some species of mushrooms
pharmacokinetics rather than by pharmacodynamics. Conversely, tolerance and tachyphylaxis rapidly develop to psilocybin's psychedelic effects with repeated administration
Psilocybin
Medication used to treat ADHD
in combination with pyridostigmine. While acutely effective however, tachyphylaxis has been found to occur with continuous administration of atomoxetine
Atomoxetine
Chemical compound
including strong analgesia, sedation, euphoria, constipation, itching, tachyphylaxis and respiratory depression, which could be harmful or fatal. Due to
Ro4-1539
Drug mixture used mainly to treat ADHD and narcolepsy
Walker H, Parlatini V, Cortese S (2 February 2026). "Tolerance and Tachyphylaxis to Medications for Attention-Deficit/Hyperactivity Disorder (ADHD):
Adderall
Half maximal inhibitory concentration
list of essential medicines Tolerance and resistance Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple drug resistance Antimicrobial
IC50
Medication for skin
adverse effects. Tachyphylaxis: The acute development of tolerance to the action of a drug after repeated doses. Significant tachyphylaxis can occur by day
Topical_steroid
Synthetic decongestant
occurred at rates of less than 4% and were not different from placebo. Tachyphylaxis is known to develop with prolonged use of pseudoephedrine, especially
Pseudoephedrine
CNS stimulant and isomer of amphetamine
Walker H, Parlatini V, Cortese S (2 February 2026). "Tolerance and Tachyphylaxis to Medications for Attention-Deficit/Hyperactivity Disorder (ADHD):
Dextroamphetamine
Drug to relieve nasal congestion
nervousness. Topical nasal or ophthalmic decongestants quickly develop tachyphylaxis (a rapid decrease in the response to a drug after repeated doses over
Decongestant
Chemical compound
potent of fentanyl analogues and so would most likely cause pronounced tachyphylaxis following repeated dosing. 14-Cinnamoyloxycodeinone 7-PET N-Phenethylnormorphine
14-Phenylpropoxymetopon
When a receptor decreases its response to an agonist at high concentration
concentrations. Homologous desensitization serves as a mechanism for tachyphylaxis and helps organisms to maintain homeostasis. The process of homologous
Homologous_desensitization
Chemical compound
neurotransmitters into the synaptic cleft through their reuptake transporters. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class. Benzphetamine
Benzphetamine
Hallucinogenic class of psychoactive drug
acute and self-limited. A very rapid and strong tolerance, known as tachyphylaxis, develops to the effects of psychedelics with repeated administration
Psychedelic_drug
Medication, stimulant and decongestant
Redosing usually requires increased doses to offset the development of tachyphylaxis, which is attributed to the depletion of catecholamine stores. Ephedrine
Ephedrine
Measure of organism response to stimulus
list of essential medicines Tolerance and resistance Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple drug resistance Antimicrobial
Dose–response_relationship
Medical condition
of the stomach. Its prolonged use is limited by the development of tachyphylaxis; therapeutic effects may wane after a few weeks of consistent use. Clarithromycin
Gastroparesis
Industry involved with discovery, development, production and marketing of drugs
hydralazine monotherapy was that it lost its effectiveness over time (tachyphylaxis). In the mid-1950s Karl H. Beyer, James M. Sprague, John E. Baer, and
Pharmaceutical_industry
Medical condition
drawbacks that may limit its usefulness. In addition, tolerance or tachyphylaxis may occur with continuous therapy. Other potential options for oxytocin
Oxytocin_deficiency
Chemical compound
potency and long duration of action causes D1 receptor downregulation and tachyphylaxis, and unlike other D1 full agonists such as SKF-82,958, it does not produce
A-77636
Integral of drug concentration in blood plasma over time
list of essential medicines Tolerance and resistance Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple drug resistance Antimicrobial
Area under the curve (pharmacokinetics)
Area_under_the_curve_(pharmacokinetics)
Medication
effectiveness of nitroglycerin is limited by development of tolerance/tachyphylaxis within 2–3 weeks of sustained use. Continuous administration and absorption
Nitroglycerin_(medication)
Theoretical drug measure in pharmacology
list of essential medicines Tolerance and resistance Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple drug resistance Antimicrobial
Volume_of_distribution
Spray that delivers medications locally in the nasal cavities or systemically
Lipworth B (July 2010). "Fluticasone reverses oxymetazoline-induced tachyphylaxis of response and rebound congestion". American Journal of Respiratory
Nasal_spray
Class of medication used to treat depression and other conditions
Targum SD (March 2014). "Identification and treatment of antidepressant tachyphylaxis". Innovations in Clinical Neuroscience. 11 (3–4): 24–28. PMC 4008298
Antidepressant
Head movement in rodents upon 5-HT2A receptor activation
behavioral disruption limits the expression of the HTR. Tolerance and tachyphylaxis to the HTR and/or other effects of serotonergic psychedelics may be
Head-twitch_response
Drop in blood pressure when standing up or sitting down
the treatment of orthostatic hypotension. While acutely effective, tachyphylaxis has been found to occur with continuous administration. The reasons
Orthostatic_hypotension
Class of opioid receptors found in humans
mechanisms, which are upregulated with chronic use, leading to rapid tachyphylaxis. The most important regulatory proteins for the MOR are the β-arrestins
Mu-opioid_receptor
Biochemical analysis procedure
list of essential medicines Tolerance and resistance Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple drug resistance Antimicrobial
Ligand_binding_assay
Chemical compound
daily use at up to 300 mg/day. Moreover, there was no evidence of the tachyphylaxis typical of neuroactive agents like caffeine and other stimulants. In
Theacrine
Group of psychiatric and neurological conditions
effects tend to remain elevated. This is important, as the marked acute tachyphylaxis to subjective effects may drive repeated use within intervals of 4 hours
Disorders of diminished motivation
Disorders_of_diminished_motivation
Field of study
list of essential medicines Tolerance and resistance Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple drug resistance Antimicrobial
Pharmacoepigenetics
list of essential medicines Tolerance and resistance Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple drug resistance Antimicrobial
Pharmacomicrobiomics
Drug that causes vasodilation by releasing nitric oxide
hypotension. Nitrates exhibit development of tolerance, or more specifically tachyphylaxis, meaning that repeated application results in a fast decrease of effect
Nitrovasodilator
Drug increasing motivation in humans
effects tend to remain elevated. This is important, as the marked acute tachyphylaxis to subjective effects may drive repeated use within intervals of 4 hours
Motivation-enhancing_drug
Drug discovery by phenotypic screening
list of essential medicines Tolerance and resistance Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple drug resistance Antimicrobial
Classical_pharmacology
dosing is recommended during therapy with estradiol pellet implants. Tachyphylaxis of relief of vasomotor symptoms, or hot flashes returning even with
Pharmacokinetics_of_estradiol
Drug experimentation technique
powerful hallucinogenic effects and cultural associations. Tolerance and tachyphylaxis are known to rapidly develop to the hallucinogenic effects and to other
Psychedelic_microdosing
Pharmaceutical drug
caused by the T cell activation. Repeated application can result in tachyphylaxis (reduced effectiveness) due to the formation of anti-mouse antibodies
Muromonab-CD3
Decrease in a behavioral response to a repeated stimulus
History of Human Knowledge: on habituation Preference tests (animals) Tachyphylaxis, the effect of continued exogenous entries (habituation of) into the
Habituation
Biological cell regulation mechanisms
receptor protein is decreased in order to protect the cell (see also tachyphylaxis). Gene Regulation can be summarized by the response of the respective
Regulation_of_gene_expression
Psychedelic drug
induction. In addition, as with many other psychedelics, tolerance and tachyphylaxis develop to the HTR induced by 25CN-NBOH. A study of 25CN-NBOH concluded
25CN-NBOH
Behavioral measure in animals
PMID 32298690. Buchborn T, Lyons T, Knöpfel T (2018). "Tolerance and Tachyphylaxis to Head Twitches Induced by the 5-HT2A Agonist 25CN-NBOH in Mice". Front
Locomotor_activity
Medical condition
lose their efficacy as a side effect when taken regularly over time (tachyphylaxis) compared to H2 receptor antagonists. It is recommended that individuals
Mallory–Weiss_syndrome
Drug discovery by identifying protein targets
list of essential medicines Tolerance and resistance Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple drug resistance Antimicrobial
Reverse_pharmacology
Medical condition
depletion of associated neurotransmitters, and receptor down-regulation (tachyphylaxis), the cocaine user may experience dysphoria, or a "crash" after the
Cocaine_intoxication
Chemical compound
the compound, did not show any significant systemic side-effects and tachyphylaxis phenomena whereas the oral dosage is higher than 400 mg per day. A fast
Ibopamine
Class of compounds
greater risks than SRIs, for instance higher risk of serotonin syndrome. Tachyphylaxis to their beneficial therapeutic effects might also occur. A few SRAs
Serotonin_releasing_agent
Pharmaceutical compound
Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis". The Journal of Pharmacology and Experimental Therapeutics. 360 (1):
DETQ
Planned period of time when taking a medication is paused
drug holiday for HIV. Downregulation and upregulation Rebound effect Tachyphylaxis Feig, Christy (2000-01-21). "AIDS virus stays in check during drug holiday
Drug_holiday
Protein-coding gene in humans
Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis". The Journal of Pharmacology and Experimental Therapeutics. 360 (1):
Dopamine_receptor_D1
Medical condition
treatment for HI, but its effectiveness is limited by the development of tachyphylaxis. It is important to note that in countries where diazoxide is not available
Congenital_hyperinsulinism
Biochemical analysis procedure
list of essential medicines Tolerance and resistance Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple drug resistance Antimicrobial
Structural Dynamics Response Assay
Structural_Dynamics_Response_Assay
Enzyme
increased beta adrenergic receptor numbers in lung and heart, diminished tachyphylaxis to β2-adrenergic receptor agonists, hyporesponsiveness to methacholine
Formaldehyde_dehydrogenase
I, Lue TF, Padma-Nathan H, Rosen RC, Steers, William D., Wicker PA. Tachyphylaxis and phosphodiesterase type 5 inhibitors. Author Steers, William D. Viability
William_D._Steers
resistance MeSH G12.392.617 – insulin resistance MeSH G12.454.910 – tachyphylaxis MeSH G12.869.500 – quantitative structure-activity relationship The
List_of_MeSH_codes_(G12)
Chemical compound
capsaicin and other stimuli. It was shown that desensitization and tachyphylaxis of TRPV1 channels contribute to capsaicin-induced pain relief. Desensitization
Zucapsaicin
deletion MeSH G04.610.484.800 – self tolerance MeSH G04.610.484.910 – tachyphylaxis MeSH G04.610.484.955 – transplantation tolerance MeSH G04.610.555.070
List_of_MeSH_codes_(G04)
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