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Chemical compound
SERBA-2, short for selective estrogen receptor beta agonist-2, is a synthetic, nonsteroidal estrogen which acts as a selective ERβ agonist. For the ERα
SERBA-2
Municipality in Thuringia, Germany
Serba is a municipality in the district Saale-Holzland, in Thuringia, Germany. Gewählte Bürgermeister - aktuelle Landesübersicht, Freistaat Thüringen
Serba
Primary female sex hormone
3β-androstanediol. Some estrogen metabolites, such as the catechol estrogens 2-hydroxyestradiol, 2-hydroxyestrone, 4-hydroxyestradiol, and 4-hydroxyestrone, as well
Estrogen
Dietary supplement and medication
epidermal permeability barrier in vivo. The application of 2% topical nicotinamide for 2 and 4 weeks is effective in lowering the sebum excretion rate
Nicotinamide
Primary male sex hormone
(2): 127–31. doi:10.3109/13813459209035274. PMID 1379488. Dakin CL, Wilson CA, Kalló I, Coen CW, Davies DC (May 2008). "Neonatal stimulation of 5-HT(2)
Testosterone
Herbicide
are of Pseudomonas sp. strain ADP. Dealkylation of the amino groups gives 2-chloro-4-hydroxy-6-amino-1,3,5-triazine, the degradation of which is unknown
Atrazine
Plant-derived xenoestrogen
feeding". Journal of Pediatric Endocrinology & Metabolism. 17 (2): 191–6. doi:10.1515/JPEM.2004.17.2.191. PMID 15055353. S2CID 43304969. Merritt RJ, Jenks BH
Phytoestrogen
Human hormone
5α-reductase type 2 deficiency, an intersex condition caused by a loss-of-function mutation in the gene encoding 5α-reductase type 2, the major enzyme
Dihydrotestosterone
Chemical compound
EnCyzix), was under development for the treatment of male hypogonadism and type 2 diabetes. By December 2016, it was in preregistration and was under review
Enclomifene
Androgen and anabolic steroid
Oxymetholone, also known as 2-hydroxymethylene-17α-methyl-4,5α-dihydrotestosterone (2-hydroxymethylene-17α-methyl-DHT) or as 2-hydroxymethylene-17α-meth
Oxymetholone
Polycyclic organic compound having sterane as a core structure
1039/9781849733069. ISBN 978-0-85404-182-4. p. 1112: oxy* –O– P-15.3.1.2.1.1; P-63.2.2.1.1 Barrientos EJ, Lapuerta M, Boehman AL (August 2013). "Group additivity
Steroid
Organochloride known as an insecticide
Darstellung von 1,1,4,4-p,p′,p",p‴-Tetraphenetyl-butin-2 und von 1,1,4,4-p,p′,p",p‴-Tetra(chlorphenyl)-butin-2. 11. Mitteilung. Über die Reduktion organischer
DDT
Steroidal antiandrogen and antimineralocorticoid
hospitalization due to hyperkalemia from 0.2 to 11% and in the rate of death due to hyperkalemia from 0.3 to 2.0 per 1,000 between early 1994 and late 2001
Spironolactone
Chemical compound
2-Methoxyestradiol (2-ME2, 2-MeO-E2) is a natural metabolite of estradiol and 2-hydroxyestradiol (2-OHE2). It is specifically the 2-methyl ether of 2-hydroxyestradiol
2-Methoxyestradiol
Androgen and anabolic steroid
given at a dosage of 5 to 10 mg/day in men and 2.5 mg/day in women. Metandienone was provided in the form of 2.5, 5 and 10 mg oral tablets. Metandienone is
Metandienone
Chemical compound
Metabolism. Lippincott Williams & Wilkins. pp. 1185, 1187. ISBN 978-0-7817-1750-2. Archived from the original on 2024-04-07. Retrieved 2018-01-03. Ayd FJ (2000)
Testosterone_cypionate
Chemical compound
glucuronoconjugates), suggesting extensive first-pass metabolism and a half-life of 2.43 hours. Mediterranean diets, characterized by regular intake of olive oil
Hydroxytyrosol
Chemical compound
Metabolism. Lippincott Williams & Wilkins. pp. 1185, 1187. ISBN 978-0-7817-1750-2. Archived from the original on 2024-04-07. Retrieved 2018-01-03. Kicman AT
Testosterone_enanthate
Chemical compound
LY-500307; also known as selective estrogen receptor beta agonist-1 or SERBA-1) is a synthetic, nonsteroidal estrogen which acts as a selective ERβ agonist
Erteberel
Chemical used in plastics, xenoestrogen
Toxicology. 217 (2–3): 81–90. Bibcode:2006Toxgy.217...81K. doi:10.1016/j.tox.2005.10.001. PMID 16288945. Zhang C, Li Y, Wang C, et al. (2 January 2016).
Bisphenol_A
Chemical compound
two-compartment model (initial half-life of 8.8 minutes, terminal half-life of 2.4 hours). Because it undergoes rapid and extensive metabolism, the biological
Quercetin
Mineralocorticoid steroid hormone
activity acutely. Aldosterone is responsible for the reabsorption of about 2% of filtered sodium in the kidneys, which is nearly equal to the entire sodium
Aldosterone
Catechin (polyphenol) in tea
safe if consumed as a tea beverage. 100 mL of green tea contains about 70.2 mg of EGCG (about 165 mg per cup). Over 2008 to 2017, the US Food and Drug
Epigallocatechin_gallate
Polyphenol with a stilbene skeleton
effect on systolic or diastolic blood pressure; a sub-analysis revealed a 2 mmHg decrease in systolic pressure only from resveratrol doses of 300 mg per
Resveratrol
Type of steroid hormone
→ Dihydrotestosterone → Androstanediol Estrogens 2-Hydroxyestrone ← Estrone → 16α-Hydroxyestrone 2-Hydroxyestradiol ← Estradiol → Estriol → Estetrol
Sex_hormone
Anabolic steroid
50 mg once every 6 to 12 weeks (working out to an average exposure of about 2 to 8 mg per week) by intramuscular injection is considered to be appropriate
Nandrolone_decanoate
Drugs acting on the estrogen receptor
hydrophobicity. The differential positioning of the activating function 2 (AF-2) helix 12 in the ligand-binding domain by the bound ligand determines whether
Selective estrogen receptor modulator
Selective_estrogen_receptor_modulator
Chemical compound
beneficial effects on the skin. In addition, a study has found that topical 2% progesterone cream significantly increases skin elasticity and firmness and
Estradiol
Infertility treatment for women
[non-primary source needed] It has been found to increase testosterone levels by 2–2.5 times in hypogonadal men at such dosages. Despite the use of questionnaires
Clomifene
Anti-seizure medication
and unfair" prices. The CMA imposed a record £84.2 million fine on the manufacturer Pfizer, and a £5.2 million fine on the distributor Flynn Pharma and
Phenytoin
Chemical compound
Control, 2. Individual Insecticides". Ullmann's Encyclopedia of Industrial Chemistry. pp. 1–94. doi:10.1002/14356007.s14_s01. ISBN 978-3-527-30673-2. Rytwinski
Rotenone
Androgenic Anabolic steroid
Research / Progrès des recherches pharmaceutiques. Vol. 2. pp. 71–134. doi:10.1007/978-3-0348-7038-2_2. ISBN 978-3-0348-7040-5. PMID 14448579. {{cite book}}:
Nandrolone
Selective estrogen receptor modulator
mineral density was increased in the spine (by 2.1% at 60 mg, 2.4% at 120 mg) and femoral neck (2.6% at 60 mg, 2.7% at 120 mg). It has been found to possess
Raloxifene
Selective estrogen receptor modulator
system releasing levonorgestrel might increase vaginal bleeding after 1 to 2 years, but reduces somewhat endometrial polyps and hyperplasia, but not necessarily
Tamoxifen
Chemical compound
2. PMID 2467866. Waddell, W. J. (2002). "Thresholds of carcinogenicity of flavors". Toxicological Sciences. 68 (2): 275–279. doi:10.1093/toxsci/68.2.275
Anethole
Chemical compound
Zearalenone (ZEN), also known as RAL and F-2 mycotoxin, is a potent estrogenic metabolite produced by some Fusarium and Gibberella species. Specifically
Zearalenone
Chemical compound
in the treatment of prostate cancer. The medication is taken by mouth 1 to 2 times a day or by injection into muscle or fat once every 4 to 7 days. Side
Estradiol_valerate
Antimicrobial agent
Triclosan was developed in 1966. A 2006 study recommended showering with 2% triclosan as a regimen in surgical units to rid patients' skin of methicillin-resistant
Triclosan
Chemical compound
forms stigmasterol tosylate 2 from stigmasterol 1 (95% purity) using p-TsCl, DMAP, and pyridine (90% yield). The tosylate 2 then undergoes solvolysis as
Β-Sitosterol
Chemical compound
Europea (olive) leaf extract and antioxidant activities". Molecules. 20 (2): 2903–2921. doi:10.3390/molecules20022903. ISSN 1420-3049. PMC 6272143. PMID 25679050
Oleuropein
Chemicals that can interfere with endocrine or hormonal systems
of Occupational Medicine and Environmental Health. 24 (2): 115–41. doi:10.2478/s13382-011-0022-2. PMID 21594692. Bornehag CG, Engdahl E, Unenge Hallerbäck
Endocrine_disruptor
Class of drugs
and ERβ include activation function 1 (AF1) domain and activation function 2 (AF2) domain in which SERMS act as antagonists for the AF2 domain, while "pure"
Antiestrogen
Proteins activated by the hormone estrogen
genes, ESR1 and ESR2 on the sixth and fourteenth chromosome (6q25.1 and 14q23.2), respectively. There are two different forms of the estrogen receptor, usually
Estrogen_receptor
Hormonal antineoplastic drug
therapy of breast cancer". Expert Rev Anticancer Ther. 2 (2): 151–60. doi:10.1586/14737140.2.2.151. PMID 12113237. S2CID 20294814. Ganesh AN, Donders
Fulvestrant
Chemical compound
been found to be estriol 16α-glucuronide (65.8%), estriol 3-glucuronide (14.2%), estriol 3-sulfate (13.4%), and estriol 3-sulfate 16α-glucuronide (5.1%)
Estriol
Androgenic and anabolic steroid medication
been found to be 2.5- to 10-fold more potent than testosterone. Upon intramuscular injection in rats, androstanolone is about 1.5- to 2.5-fold the potency
Androstanolone
Anabolic steroid
Metabolism. Lippincott Williams & Wilkins. pp. 1185–. ISBN 978-0-7817-1750-2. William Llewellyn (2011). Anabolics. Molecular Nutrition Llc. pp. 460–467
Nandrolone_phenylpropionate
Chemical compound
metabolized in part by CYP3A4; metabolites include digitoxigenin, digoxin (>2%), and conjugate esters. In healthy people, 60% are eliminated via the kidneys
Digitoxin
Chemical compound
injection once every 1 or 2 weeks for hormone therapy in transgender women. The doses used to induce puberty in girls are 0.2 to 2.5 mg per month, gradually
Estradiol_cypionate
Chemical compound
Feminizing hormone therapy for transgender women DES was used at a dosage of 0.2 to 0.5 mg/day in menopausal hormone therapy. Interest in the use of DES to
Diethylstilbestrol
Selective estrogen receptor modulator
ospemifene 30 mg. Safety was also evaluated in these phase 3 trials. There was a 5.2% increase in the incidence of hot flushes, 1.6% increase in urinary tract
Ospemifene
Chemical compound
(MENT): the optimal androgen for male contraception". Ann. Med. 25 (2): 199–205. doi:10.3109/07853899309164168. PMID 8489761. Corona G, Rastrelli
Trestolone
Protein-coding gene in the species Homo sapiens
ERB-79 and its active enantiomer ERB-26 ERB-196 (WAY-202196) Erteberel (SERBA-1, LY-500307) FERb 033 – 62-fold selectivity for ERβ over ERα Genistein
Estrogen_receptor_beta
Endogenous weak androgen
normally 30–200 ng/dL (1.0–7.0 nmol/L) in females and 40–150 ng/dL (1.4–5.2 nmol/L) in males. [citation needed] In premature infants, serum androstenedione
Androstenedione
Compounds from outside the body that mimic estrogen
axillary and pubic hair, body odor and acne (adrenarche) usually appears 2 years later. Onset of menstruation (menarche) is a late event (median 12.8
Xenoestrogen
Chemical compound
It has a relatively short elimination half-life and mean residence time of 2 days and 4 days, respectively. As such, it has a short duration of action
Testosterone_propionate
625 mg, 0.9 mg, 1.25 mg, 2.5 mg Esterified estrogens (Amnestrogen, Estratab, Evex, Femogen, Menest) – 0.3 mg, 0.625 mg, 1.25 mg, 2.5 mg Estradiol (Estradiol
List of estrogens available in the United States
List_of_estrogens_available_in_the_United_States
Isoflavandiol estrogen metabolized from daidzein
ERα (Ki = 50 nM) with 3.5-fold selectivity over ERβ. (S)-Equol has about 2% of estradiol's binding affinity for human estrogen receptor alpha (ERα) and
Equol
Chemical compound
relative transactivational capacities of estrone at the ERα and ERβ were 2.6% and 4.3% of those of estradiol, respectively. In accordance, the estrogenic
Estrone
Chemical compound
progesterone, DHEA has been found to bind to microtubule-associated protein 2 (MAP2), specifically the MAP2C subtype (Kd = 27 μM). However, it is unclear
Dehydroepiandrosterone
Chemical compound
Metabolism. Lippincott Williams & Wilkins. pp. 1185–. ISBN 978-0-7817-1750-2. Archived from the original on 17 May 2020. Retrieved 3 January 2018. Llewellyn
Testosterone_undecanoate
Human glycoprotein that binds to androgens and estrogens
N1-acetyltransferase family member 2 (SAT2). Nearby are the genes for p53 and ATP1B2, and fragile X mental retardation, autosomal homolog 2 (FXR2) on the complementary
Sex_hormone–binding_globulin
Medication and naturally occurring steroid hormone
"Testosterone in Psychiatry". Archives of General Psychiatry. 57 (2): 155. doi:10.1001/archpsyc.57.2.155. ISSN 0003-990X. Johnson JM, Nachtigall LB, Stern TA (2013)
Testosterone_(medication)
Chemical compound
phenol ring at various locations, usually the 4- and, to lesser extent, the 2-positions, and can be either branched or linear. A branched nonylphenol, 4-nonylphenol
Nonylphenol
Chemical compound
(ERB-041, WAY-202041) Propylpyrazoletriol Quadrosilan SC-3296 SC-4289 SERBA-2 SKF-82,958 Terfluranol Triphenylbromoethylene Triphenylchloroethylene
Etamestrol
Organic compound and a form of vitamin B3
nicotinic acid was shown to cause hepatotoxicity and increase risk of type 2 diabetes. Nicotinic acid prescriptions in the United States had peaked in
Nicotinic_acid
Chemical compound
2-Phenyl-1-benzothiophene is an aromatic chemical compound commonly used as an intermediate in the production of medication. Derivatives of the compound
2-Phenyl-1-benzothiophene
Progestin medication
United States. The improvement in acne symptoms is believed to be due to a 2- to 3-fold increase in sex hormone-binding globulin (SHBG) levels and a consequent
Norethisterone
Medication
inducing feminization, suggesting potential usefulness in the treatment of type 2 diabetes. Alfatradiol/dexamethasone (Ell-Cranell Dexa) Estradiol 17α-dehydrogenase
Alfatradiol
Chemical compound
prolactinoma in a transgender woman treated with 10 mg estradiol enanthate every 2 weeks exists. While DHPA was not mentioned in this instance, estradiol enanthate
Estradiol_enanthate
Protein-coding gene in the species Homo sapiens
receptor knockout mouse". Laboratory Animal Research. 28 (2): 71–76. doi:10.5625/lar.2012.28.2.71. PMC 3389841. PMID 22787479. Hevener AL, Correa SM (June
Estrogen_receptor_alpha
Chemical compound
and clinical opportunities". Molecular and Cellular Endocrinology. 389 (1–2): 71–83. doi:10.1016/j.mce.2014.02.002. PMC 4040308. PMID 24530924. SUGAWARA
Chlordecone
Asian American actress (born 2007)
original on August 2, 2018. Retrieved December 12, 2021. "Rim of the World". Rotten Tomatoes. Fandango Media. Retrieved December 12, 2021. Serba, John (May 24
Miyako_(actress)
Steroidal hormone medication
in the treatment of therapy-naive breast cancer and orally at low doses (2 to 6 mg/day) in the treatment of breast cancer in women who were previously
Estradiol_(medication)
Estrogen medication
preparation (brand name FemHRT) containing very low doses of ethinylestradiol (2.5 and 5 μg) plus a progestin in an oral tablet that remains in use for menopausal
Ethinylestradiol
Chemical in plants
flavone synthase (FNS) have been described; FNS I, a soluble enzyme that uses 2-oxogluturate, Fe2+, and ascorbate as cofactors and FNS II, a membrane bound
Apigenin
Estrogen medication
the treatment of prostate cancer in men. It has been used at a dosage of 2.5 mg three times per day (7.5 mg/day total) for prostate cancer. CEEs are
Conjugated_estrogens
Chemical compound
there was a 67% (14/21) incidence of cardiovascular morbidity and a 9.5% (2/21) incidence of cardiovascular mortality. The cardiovascular morbidity in
Estradiol_undecylate
Estrogen medication
used by intramuscular injection at a dosage of 0.1 to 2 mg per week, or 0.1 to 0.5 mg given 2 or 3 times per week, for the treatment of menopausal symptoms
Estrone_(medication)
Chemical compound
tentative brand name Stilbostat), also known as diethylstilbestrol (DES) bis(di(2-chloroethyl)carbamate), is a synthetic, nonsteroidal estrogen and cytostatic
ICI-85966
Chemical compound
either resistant or intolerant of docetaxel, has a WHO performance status of <2, and his disease has not since become progressive since treatment with PBS-subsidised
Abiraterone_acetate
Chemical compound
dieldrin in the US peaked in the mid-1960s at about 20 million pounds a year (2 million pounds of dieldrin) and then declined. The chemicals dieldrin and
Dieldrin
Chemical compound
human liver microsomes". Drug Metabolism and Disposition. 32 (2): 272–9. doi:10.1124/dmd.32.2.272. PMID 14744951. Fu ML, Wang W, Chen F, Dong YC, Liu Xj
8-Prenylnaringenin
(ERB-041, WAY-202041) Propylpyrazoletriol Quadrosilan SC-3296 SC-4289 SERBA-2 SKF-82,958 Terfluranol Triphenylbromoethylene Triphenylchloroethylene
List_of_estrogens
Chemical compound
(ERB-041, WAY-202041) Propylpyrazoletriol Quadrosilan SC-3296 SC-4289 SERBA-2 SKF-82,958 Terfluranol Triphenylbromoethylene Triphenylchloroethylene
Diosgenin
Type of medication
for VTE risk, as 1 mg/day oral estradiol increased VTE incidence by 2.2-fold while 2 mg/day oral estradiol increased VTE incidence by 4.5-fold (both in
Estrogen_(medication)
Chemical compound
seeking ban on Monday". The Hindu. Chennai, India. 1 May 2011. Retrieved 2 May 2011. "Australia should ban endosulfan: Greens". Weekly Times. News Limited
Endosulfan
2023 film directed by Domingo González
it at least arrives with a self-aware wink and two likable leads". John Serba of Decider.com gave My Fault a negative review, deeming it to be "an atrocious
My_Fault_(film)
Chemical compound
has also been found to be a weak inhibitor of steroid sulfatase (Ki = 2.3–8.2 μM), the enzyme that converts DHEA-STooltip dehydroepiandrosterone sulfate
Danazol
Chemical compound
the affinity of estradiol for the ER whereas tamoxifen had 2.8% and N-desmethyltamoxifen had 2.4%. The exact mechanism by which endoxifen exerts its therapeutic
Endoxifen
Combined oral contraceptive medication
0.075 mg mestranol and 5 mg noretynodrel as well as 0.1 mg mestranol and 2.5 mg noretynodrel were subsequently introduced. One formulation also contained
Mestranol/noretynodrel
Chemical compound
kidneys. Trilostane, also known as 4α,5-epoxy-3,17β-dihydroxy-5α-androst-2-ene-2-carbonitrile, is a synthetic androstane steroid and a derivative of 5α-reduced
Trilostane
Chemical compound
(ERB-041, WAY-202041) Propylpyrazoletriol Quadrosilan SC-3296 SC-4289 SERBA-2 SKF-82,958 Terfluranol Triphenylbromoethylene Triphenylchloroethylene
27-Hydroxycholesterol
Combination drug
review of its use as an oral contraceptive". Treatments in Endocrinology. 2 (1): 49–70. doi:10.2165/00024677-200302010-00005. PMID 15871554. S2CID 209144694
Ethinylestradiol/drospirenone
Chemical compound
delayed puberty as well as physique- and performance-enhancing purposes and 2.5 mg/day in women for menopausal symptoms. Higher dosages of 50 to 200 mg/day
Methyltestosterone
Chemical compound
to give the isoflavone. The enzymes involved are isoflavonoid synthase and 2-hydroxyisoflavanone dehydratase. naringenin Synthase 2,4',5,7-
Genistein
Chemical compound
(ERB-041, WAY-202041) Propylpyrazoletriol Quadrosilan SC-3296 SC-4289 SERBA-2 SKF-82,958 Terfluranol Triphenylbromoethylene Triphenylchloroethylene
1-Keto-1,2,3,4-tetrahydrophenanthrene
1-Keto-1,2,3,4-tetrahydrophenanthrene
glucuronide (13–30%), 2-hydroxyestrone (2.6–10.1%), unchanged estradiol (5.2–7.5%), estriol (2.0–5.9%), and 16α-hydroxyestrone (1.0–2.9%). Following an intravenous
Pharmacokinetics_of_estradiol
Chemical compound
agonist of ERβ. It possesses 68-fold selectivity for ERβ over ERα (EC50 = 2 nM and 155 nM, respectively). WAY-200070 has been found to enhance serotonergic
WAY-200070
Chemical compound
2-Hydroxyestrone (2-OHE1), also known as estra-1,3,5(10)-trien-2,3-diol-17-one, is an endogenous, naturally occurring catechol estrogen and a major metabolite
2-Hydroxyestrone
SERBA 2
SERBA 2
SERBA 2
SERBA 2
SERBA 2
SERBA 2
SERBA 2
SERBA 2
SERBA 2