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Drug delivery method
Selective organ targeting (SORT) is a novel approach in the field of targeted drug delivery that systematically engineers multiple classes of lipid nanoparticles
Selective_organ_targeting
Topics referred to by the same term
(typesetting), a piece of metal type Sort, Lleida, a town in Catalonia Selective organ targeting, a drug delivery method Special Operations Response Team, a tactical
Sort
Semipermeable capillary interface between blood and the brain
circuits—the circumventricular organs and choroid plexus—have in contrast highly permeable capillaries. The BBB results from the selectivity of the tight junctions
Blood–brain_barrier
Pharmaceutical compound
the prototypical selective HDAC1 and HDAC2 inhibitor. However, subsequent findings suggest that BRD-6929 may not actually be selective for HDAC1 and HDAC2
BRD-6929
Class of pharmaceutical drugs
Selective androgen receptor modulators (SARMs) are a class of drugs that selectively activate the androgen receptor in specific tissues, promoting muscle
Selective androgen receptor modulator
Selective_androgen_receptor_modulator
Drugs acting on the estrogen receptor
Selective estrogen receptor modulators (SERMs), also known as estrogen receptor agonists/antagonists (ERAAs), are a class of drugs that act on estrogen
Selective estrogen receptor modulator
Selective_estrogen_receptor_modulator
Class of antidepressant medication
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
In biochemistry, the preference of ligands to bind with one receptor over another
chemistry, binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex. Binding selectivity describes how a ligand
Binding_selectivity
Drug class
due to lack of selectivity and activation of the closely related serotonin 5-HT2B receptor, may have the potential to produce organ fibrosis and associated
Serotonin 5-HT2A receptor agonist
Serotonin_5-HT2A_receptor_agonist
Method of delivering medication
Active targeting of drug-loaded nanoparticles enhances the effects of passive targeting to make the nanoparticle more specific to a target site. There
Targeted_drug_delivery
Tube attached to the intestine
2000s, the appendix was reassessed and is no longer considered a vestigial organ. The appendix may serve as a reservoir for beneficial gut bacteria. The
Appendix_(anatomy)
Physiological capacity
surroundings through the detection of stimuli. During sensation, sense organs collect various stimuli (such as a sound or smell) for transduction, meaning
Sense
other organ, the brain is remarkably heterogeneous in its cellular composition. The wide variety of cell types might thus be the basis for selective vulnerability
Pathoclisis
German hematologist, oncologist
tumor through the stimulation of effector cells. Dual targeting provides selective binding and selective killing of the cancer cells, thus leading to high
Fuat_Oduncu
Medical imaging technique
image blood perfusion in organs, measure blood flow rate in the heart and other organs, and for other applications. Targeting ligands that bind to receptors
Contrast-enhanced_ultrasound
Interfaces between the brain and the circulatory system
ependymal cells known as tanycytes. These contribute to the organ's ability to selectively allow macromolecules to pass from the central to the peripheral
Circumventricular_organs
Medication class with multiple uses
the use of non-selective beta blockers in asthmatics, while allowing for the use of cardio selective beta blockers. Cardio selective beta blocker (β1
Beta_blocker
Type of substances designed to affect the nervous system
to adrenergic receptors in target tissues of organs to cause physiological responses. Adrenergic receptors are the target of many autonomic drugs that
Autonomic_drug
Process of cells digesting parts of themselves
non-selective autophagy; in the meantime, Daniel J. Klionsky discovered the cytoplasm-to-vacuole targeting (CVT) pathway, which is a form of selective autophagy
Autophagy
Pharmaceutical compound
signalling factor thymosin beta-4 by the enzyme prolyl oligopeptidase. It is a selective inhibitor of haematopoietic cell proliferation and has antiinflammatory
Ac-SDKP
Protein-coding gene in the species Homo sapiens
prognosis. The over expression of SSTR2 in tumors can be exploited to selectively deliver radio-peptides to tumors to either detect or destroy them. Somatostatin
Somatostatin_receptor_2
Nanotechnology simulation of human organ function
An organ-on-a-chip (OOC) is a multi-channel 3D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological
Organ-on-a-chip
Chemical compound
against aphids, whiteflies, and thrips. It disrupts insect chordotonal organs that can affect hearing, balance, movement to cause cessation of feeding
Flonicamid
Class of drugs
use. Some drugs, being non-selective, can exert actions on 2 or more different receptors. Examples include non-selective beta blocker, which block both
Adrenergic_blocking_agent
Evolutionary process
palatable species of an unpalatable or noxious species (the model), gaining a selective advantage as predators avoid the model and therefore also the mimic. Mimicry
Adaptation
to target and eliminate the drug to increase efficacy and minimize undesirable side effects. The new drugs thus designed achieve selective organ and/or
Retrometabolic_drug_design
Organism composed of cells of different genotypes
called a hybrid. Another way that chimerism can occur in animals is by organ transplantation, giving one individual tissues that developed from a different
Chimera_(genetics)
Protein-coding gene in the species Homo sapiens
ERα selective over ERβ include: Methylpiperidinopyrazole (MPP) ERα plays a role in the physiological development and function of a variety of organ systems
Estrogen_receptor_alpha
Chemical compound
medication used as an immunosuppressant to prevent rejection of organ transplants and as a targeted therapy in the treatment of renal cell cancer and other tumours
Everolimus
Biomolecule
"small activating RNA" (saRNA), targeting gene promoters were found to induce potent transcriptional activation of target genes. RNAa has been demonstrated
Small_interfering_RNA
Hormone therapy for cancer
most familiar example of hormonal therapy in oncology is the use of the selective estrogen-response modulator tamoxifen for the treatment of breast cancer
Hormonal_therapy_(oncology)
Drug class
Inhibits S1P1 selectively. Ceralifimod: Selective inhibitor of S1P1 and S1P5. Zectivimod: Selective inhibitor of S1P1. Cenerimod: Selective inhibitor of
Sphingosine-1-phosphate receptor modulator
Sphingosine-1-phosphate_receptor_modulator
Nonsteroidal anti-inflammatory drug
Following the identification of increased risks of heart attacks with the selective COX-2 inhibitor rofecoxib in 2004, attention has focused on all the other
Diclofenac
Chemical compound
pests, such as aphids and whiteflies, in agricultural settings. It selectively targets the nervous system of sap-feeding insects, causing them to cease
Pymetrozine
Class of drugs used to treat malignant tumors
their lack of sufficient selectivity for cancer cells, cause varying degrees of damage to normal tissue cells while targeting cancer cells. However, with
Antineoplastic
Species of mole
provided a selective advantage for a more elaborate sensory structure. Furthermore, in wild caught moles of many species, the Eimer's organs show obvious
Star-nosed_mole
Compounds to increase women's capacity to conceive
such as ovulatory disorders, structural abnormalities in reproductive organs and aging. Ovulatory disorders result in infrequent ovulation (Oligoovulation)
Female_fertility_agents
Sensory organ in insect legs
The femoral chordotonal organ is a group of mechanosensory neurons found in an insect leg (Figure 1) that detects the movements and the position of the
Femoral_chordotonal_organ
ignore it. Mr. Grimes (Ray Teal) and Mr. Collins (Lester Dorr) from the Selective Service Board realize that Arnold never showed up. After going to the
List_of_Green_Acres_episodes
Investigational selective androgen receptor modulator
and by the developmental code names GTx-024, MK-2866, and S-22, is a selective androgen receptor modulator (SARM) which is under development for the
Enobosarm
Medical intervention
Targeted therapy of lung cancer refers to using agents specifically designed to selectively target molecular pathways responsible for, or that substantially
Targeted therapy of lung cancer
Targeted_therapy_of_lung_cancer
Neural prosthesis to improve balance
but the risk of damage and selectivity vary depending on the technique and the patient. To stimulate the otolithic organs, the electrode is placed in
Vestibular_implant
Class of therapeutic drug
are two general types of NSAIDs available: non-selective and COX-2 selective. Most NSAIDs are non-selective, and inhibit the activity of both COX-1 and COX-2
Nonsteroidal anti-inflammatory drug
Nonsteroidal_anti-inflammatory_drug
Field of study
of noncoding RNA that is responsible for altering gene expression by targeting and marking mRNA transcripts for degradation. Since this process is a
Pharmacoepigenetics
Class of psychoactive drugs that produce empathic experiences
associated with the traumatic memories and engage in therapy. MDMA acts by targeting the body's stress response in order to cause this therapeutic effect.
Entactogen
Drug for skeletal muscle function
drugs Diabetes medication Vitamins Dietary minerals blood and blood forming organs (B) Antithrombotics Antiplatelets Anticoagulants Thrombolytics / fibrinolytics
Muscle_relaxant
Brain capacity to filter out stimuli
not selectively attended to. The filter model was hypothesized to work in the following way: as information enters the brain through sensory organs (in
Cocktail_party_effect
(SWNTs) has proven to enhance solubility and allow for efficient tumor targeting/drug delivery. It prevents SWNTs from being cytotoxic and altering the
Carbon_nanotubes_in_medicine
Murder of women or girls because of their gender
includes domestic violence and forced abortions. Some cultures use gender-selective infanticide and geronticide to perform femicide.[citation needed] Until
Femicide
deliberately targeting children". BBC. Retrieved 25 June 2026. "Israel continues to commit genocide, atrocity crimes by deliberately targeting Palestinian
Human rights violations against Palestinians by Israel
Human_rights_violations_against_Palestinians_by_Israel
Subtype of serotonin receptor
subtype selective antagonists (35 g: 60-fold). 5-MeO-NBpBrT AMDA and related derivatives – family of selective 5-HT2A antagonists. Atypical
5-HT2A_receptor
Drug classification system
system that classifies the active ingredients of drugs according to the organ or system on which they act and their therapeutic, pharmacological and chemical
Anatomical Therapeutic Chemical Classification System
Anatomical_Therapeutic_Chemical_Classification_System
Antihypertensive medication
Abbott in 2009) under the brand name Physiotens and Moxon. Moxonidine is a selective agonist at the imidazoline receptor subtype 1 (I1). This receptor subtype
Moxonidine
Experimental lentiviral approach to generating CAR-T cells inside the body
reviews are targeting specificity, control of in vivo pharmacology, and long-term safety. If transduction is not sufficiently selective, non-target cells may
Targeted lentiviral delivery for in vivo CAR T-cell generation
Targeted_lentiviral_delivery_for_in_vivo_CAR_T-cell_generation
Family of cell adhesion molecules
stage of metastasis. The selectins and selectin ligands determine the organ selectivity of metastasis. Several factors may explain the seed and soil theory
Selectin
Class of compounds
structures. Tivantinib strongly inhibits c-Met autoactivation by selectively targeting the inactive form of the kinase between the N- and C- lobes and
C-Met_inhibitor
Loose connective tissue composed mostly by adipocytes
specialized metabolism without inducing it in other organs. A review on the eventual therapeutic targeting of brown fat to treat human obesity was published
Adipose_tissue
Engaging in sexual relations in exchange for payment
the Comintern to the last stages of political prostitution." Besides targeting political figures, the term is used in relation to organizations and even
Prostitution
Spreading of a disease inside a body
2010). "Using the transcription factor inhibitor of DNA binding 1 to selectively target endothelial progenitor cells offers novel strategies to inhibit tumor
Metastasis
Disease in which fibrous connective tissue turns into bone
patient. It is the only known medical condition in which tissue of one organ system changes into that of another. Surgical removal of ossified bone causes
Fibrodysplasia ossificans progressiva
Fibrodysplasia_ossificans_progressiva
Violations of laws of war
targets. Research conducted by Dr. Yagil Levy at the Open University of Israel confirmed the +972 report, stating Israel was "deliberately targeting residential
Israeli war crimes in the Gaza war
Israeli_war_crimes_in_the_Gaza_war
Species of moth
markings (as in "vine-ripened" tomatoes). M. sexta has mechanisms for selectively sequestering and secreting the neurotoxin nicotine present in tobacco
Manduca_sexta
Pharmaceutical drugs for preventing bone loss
disorders, including myocardial infarction. In postmenopausal women, the selective estrogen receptor modulator raloxifene is occasionally administered instead
Bisphosphonate
Process of biological interventions on extracted fragments of organisms
example is selective in situ perfusion during surgery, such as isolated hepatic perfusion (IHP), which is used for targeted chemotherapy. Organ culture typically
Ex_vivo
aptamers offer customizable selectivity and stability. This is particularly evident in biosensor applications targeting low-molecular-weight entities
Electrochemical aptamer-based biosensors
Electrochemical_aptamer-based_biosensors
Monoamine neurotransmitter
5-hydroxyindoleacetic acid (5-HIAA). Serotonin is targeted by several classes of antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and
Serotonin
Mammalian protein found in humans
transition in T-lymphocytes. Thus, it is used as an immunosuppressant following organ transplantation. Interest in rapamycin was renewed following the discovery
MTOR
Mammalian protein found in Homo sapiens
been shown to have a major role in embryonic organ development, specifically in myogenesis, in adult organ regeneration, and in wound healing. Hepatocyte
Hepatocyte_growth_factor
epithelial cells and organs, sarcomas of connective tissues and bones, and lymphomas or leukemias of the circulatory system. Selective breeding of dogs has
Cancer_in_dogs
Protein-coding gene in humans
expressed in keratinocytes, the pituitary gland, B-cells and T-cells. Selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA
CHRNA9
Class of pharmaceutical drugs
2011). "Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor
MTOR_inhibitors
Blood pressure medication
ingredient (API). Losartan is a selective, competitive angiotensin II receptor type 1 (AT1) antagonist, reducing the end organ responses to angiotensin II
Losartan
utilized for treating various diseases in all organ systems. An agonist is a drug that binds to a target and mimics the action of the natural ligand. An
Liminal_BioSciences
Activation or suppression of the immune system to treat disease
the patients. The in vivo targeting approaches comprise administering specific cytokines (e.g., Flt3L, GM-CSF) and targeting the DCs with antibodies to
Immunotherapy
establishment of maternal selectivity in sheep. Animal, 4(12), p.2057-2064. Booth, K., 2006. The significance of the vomeronasal organ for offspring recognition
Olfactory_imprinting_in_sheep
2005 film by Michael Bay
"lottery" is actually a system to selectively remove inhabitants from the compound, where the "winner" is then used for organ harvesting, surrogate pregnancies
The_Island_(2005_film)
Species of annelid worm
worms ingest sediments, selectively digest bacteria, and absorb molecules through their body walls. Tubifex tubifex tend to target the size range of <63
Tubifex_tubifex
Medical condition, an iron metabolism disease
hemosiderosis Idiopathic pulmonary hemosiderosis Transfusional diabetes Organs affected: Hemosiderin deposition in the lungs is often seen after diffuse
Hemosiderosis
Chemical compound
Brequinar (DuP-785) is a drug that acts as a potent and selective inhibitor of the enzyme dihydroorotate dehydrogenase. It blocks synthesis of pyrimidine
Brequinar
Injury caused by a bullet
a bullet) shot from a gun. Damage may include bleeding, bone fractures, organ damage, wound infection, and loss of the ability to move part of the body
Gunshot_wound
Type of passive movement of a skeletal joint
target joint during the procedure. They are generally divided into five grades. The different grades of manipulation are known to produce selective activation
Joint_mobilization
Soviet military intermediate rifle cartridge
whole range of infantry weapons, including a semi-automatic carbine, a selective fire submachine gun (in modern terms, a select-fire weapon firing an intermediate
7.62×39mm
Gene editing method
efficient and highly selective editing became possible. Cas9, derived from the bacterial species Streptococcus pyogenes, has facilitated targeted genomic modification
CRISPR_gene_editing
Involution (shrinking) of the thymus after the neonatal period
been linked to immunosenescence, it is not induced by senescence as the organ starts involuting from a young age: in humans, as early as the first year
Thymic_involution
Synthetic neuroactive steroids
various medical conditions. Pherines specifically target nasal chemosensory cells and mediate selective modulation of brain areas like the limbic amygdala
Pherine
Class of medications used to alleviate anxiety
antiepileptics, antipsychotics, and beta blockers. Antidepressants include selective serotonin reuptake inhibitors (SSRIs), serotonin–norepinephrine reuptake
Anxiolytic
Injury to the innermost layer of the aorta
Vomiting, sweating, and lightheadedness may also occur. Damage to other organs may result from the decreased blood supply, such as stroke, lower extremity
Aortic_dissection
American biochemist and pharmacologist (1918–1999)
hepatitis, arthritis, gout, organ transplant rejection (azathioprine), as well as herpes (acyclovir, which was the first selective and effective drug of its
Gertrude_B._Elion
Drug brand name
some 'sciencey looking documents' that confirmed that Ibuprofen was 'Non-selective'.[citation needed] In March 2015, the Australian Competition & Consumer
Nurofen
Chemical compound
contested, and it is now considered a relative contraindication (however, selective adenosine antagonists are being investigated for use in treatment of asthma)
Adenosine
Abnormal formation of clumps of inflammatory cells (granulomata)
eyes, liver, heart, and brain, though any organ can be affected. The signs and symptoms depend on the organ involved. Often, no symptoms or only mild
Sarcoidosis
Study of the form or morphology of fishes
complement each other, the former dealing with the structure of a fish, its organs or component parts and how they are put together, as might be observed on
Fish_anatomy
workplace may exist even if it is not targeted at any particular employee. United States, Oklahoma: Sex-selective abortions were banned in Oklahoma. Scotland:
Timeline of women's legal rights (other than voting)
Timeline_of_women's_legal_rights_(other_than_voting)
Hallucinogenic class of psychoactive drug
(1) differences in selectivity for the serotonin 5-HT2A receptor or off-target activity; (2) differences in functional selectivity for different serotonin
Psychedelic_drug
Alternative medicine diagnostic procedure
uses this data in place of data from standard BDORT on the patient. The selective drug uptake enhancement method is a central component of BDORT-derived
BDORT
Anatomical process in plants to produce flowers
each organ are only partly understood. Genome-wide binding studies identify thousands of potential targets of the MADS-box quartets, and selectivity arises
Flower_differentiation
International tribunal organisation
prosecute criminals. It is distinct from the International Court of Justice, an organ of the United Nations that hears disputes between states. The ICC can generally
International_Criminal_Court
American attorney and politician (born 1958)
and criminal penalties on anyone knowingly attempting to perform a sex-selective abortion. Becerra argued before the United States Court of Appeals for
Xavier_Becerra
Abandoned metabolic and cardiovascular drug
testing showed that the drug caused cancer to develop rapidly in several organs. In 2007, research was published showing that high doses of GW501516 given
GW501516
Combination of cancer diagnosis and treatment
waves, thus targeting a specific area chosen by the sonographer. Another approach involves linking monoclonal antibodies (capable of targeting different
Theranostics
SELECTIVE ORGAN-TARGETING
SELECTIVE ORGAN-TARGETING
SELECTIVE ORGAN-TARGETING
SELECTIVE ORGAN-TARGETING
SELECTIVE ORGAN-TARGETING
SELECTIVE ORGAN-TARGETING
SELECTIVE ORGAN-TARGETING
SELECTIVE ORGAN-TARGETING
SELECTIVE ORGAN-TARGETING