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An RNA helicase is an enzyme that unwinds RNA. The unwinding is powered by the helicase's hydrolysis of ATP. RNA helicases are involved holistically in
RNA_helicase
Protein-coding gene in the species Homo sapiens
ATP-dependent RNA helicase A (RHA; also known as DHX9, LKP, and NDHI) is an enzyme that in humans is encoded by the DHX9 gene. DEAD/DEAH box helicases are proteins
RNA_Helicase_A
Class of enzymes that unpack genetic material
eukaryotic genes code for helicases. The human genome codes for 95 non-redundant helicases: 64 RNA helicases and 31 DNA helicases. Many cellular processes
Helicase
RNA family
ssNA-helicase RNA motif is a conserved RNA structure that was discovered by bioinformatics. Although the ssNA-helicase motif was published as an RNA candidate
SsNA-helicase_RNA_motif
Protein-coding gene in the species Homo sapiens
Exosome RNA helicase MTR4 is an enzyme that in humans is encoded by the MTREX gene (previously SKIV2L2). As an RNA helicase, the protein MTR4 participates
Exosome_RNA_helicase_MTR4
Protein-coding gene in humans
region. Its function as a helicase was determined from its structure. This helicase is then regulated by long noncoding RNA and its ability to dismantle
DDX11
Protein-coding gene in the species Homo sapiens
ATP-dependent RNA helicase DHX58 also known as RIG-I-like receptor 3 (RLR-3) or RIG-I-like receptor LGP2 (RLR) is a RIG-I-like receptor dsRNA helicase enzyme
LGP2
Family of proteins
(SF2) helicases, which are involved in RNA metabolism. DEAD box proteins were first brought to attention in the late 1980s in a study that looked at a group
DEAD_box
Multiprotein and heterotrimeric complex
helicase core results in the formation of a channel for ssRNA. Mtr4p requires ATP or dATP hydrolysis for RNA duplex unwinding mediated by Q-motif. A single-stranded
TRAMP_complex
Protein-coding gene in humans
ATP-dependent RNA helicase DDX3X is an enzyme that in humans is encoded by the DDX3X gene. DEAD box proteins are putative RNA helicases characterized
DDX3X
Protein-coding gene in Homo sapiens
Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.
DDX5
Multiprotein complex
single-stranded RNA (ssRNA) fragments, such as microRNA (miRNA), or double-stranded small interfering RNA (siRNA), the complex functions as a key tool in
RNA-induced_silencing_complex
Mammalian protein found in Homo sapiens
MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. MDA5 is
MDA5
Human RNA helicase
RHAU (RNA Helicase associated with AU-rich element, also known as DHX36 or G4R1) is a 114-kDa human RNA helicase of the DEAH-box family of helicases encoded
RHAU
Protein-coding gene in the species Homo sapiens
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as
DDX6
Protein-coding gene in humans
(Asp- Glu- Ala- His). A wide range of RNA helicases belongs to this family. Specifically, DHX8 acts as an ATP-dependent RNA helicase involved in splicing
DHX8
Rare genetic disorder
is a rare genetic disorder affecting brain development caused by various pathogenic variants in the gene encoding the ATP-dependent RNA helicase DHX30
DHX30_syndrome
Protein-coding gene in the species Homo sapiens
ATP-dependent RNA helicase DHX36 also known as DEAH box protein 36 (DHX36) or MLE-like protein 1 (MLEL1) or G4 resolvase 1 (G4R1) or RNA helicase associated
DHX36
Protein coding gene in Humans
family of ATP-dependant RNA helicases, and plays a critical role in the initiation of cap-dependent eukaryotic protein translation as a component of the eIF4F
EIF4A1
Process of introducing nucleic acids into eukaryotic cells
toll-like receptor 3,7,8 (TLR3, TLR7, TLR8), the RNA helicase RIG1 (RARRES3), protein kinase R (PKR, a.k.a. EIF2AK2), members of the oligoadenylate synthetase
Transfection
Protein-coding gene in the species Homo sapiens
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
DDX21
Protein-coding gene in the species Homo sapiens
ATP-dependent RNA helicase DDX1 is an enzyme that in humans is encoded by the DDX1 gene. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp
DDX1
Gene and Protein
ATP-dependent RNA helicase DHX30 in an enzyme that in humans in encoded by the DHX30 gene. DHX30 (DExH-Box Helicase 30), a type of RNA helicase enzyme. DHX30
DHX30
regulated by Non-coding RNA. It contains the proteins RNA helicase B, RNase E and Polynucleotide phosphorylase. The store of cellular RNA in the cells is constantly
Degradosome
Protein family
the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. The mechanisms governing
EIF4A
Non-coding RNA
modulated by sigB (sarA regulator) and cshA (an ATP-dependant DEAD box RNA helicase) and it most likely contributes to virulence of S. aureus by modulating
Teg49_small_RNA
RNA motif is a conserved non-coding RNA (ncRNA) found in the introns of DEAD-box RNA helicase genes across land plants. It was identified through a comparative
DEAD_RNA_motif
Topics referred to by the same term
Kont Pwofitasyon, Guadeloupe trade union groups RNA Helicase A, a human enzyme Liberty Korea Party, a political party of South Korea This disambiguation
LKP
Biomolecule
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded non-coding RNA molecules, typically
Small_interfering_RNA
Protein-coding gene in the species Homo sapiens
Probable ATP-dependent RNA helicase DDX20, also known as DEAD-box helicase 20 and gem-associated protein 3 (GEMIN3), is an enzyme that in humans is encoded
DDX20
Multiprotein complex used in gene expression
eIF4F complex is composed of three non-identical subunits: the DEAD-box RNA helicase eIF4A, the cap-binding protein eIF4E, and the large "scaffold" protein
Eukaryotic initiation factor 4F
Eukaryotic_initiation_factor_4F
Mammalian protein found in humans
ATP-dependent DExD/H box RNA helicase activated by specific types of RNA. RIG-I recognizes short double-stranded RNA (dsRNA) in the cytosol with a 5' tri- or di-phosphate
RIG-I
Protein-coding gene in the species Homo sapiens
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as
DDX41
Topics referred to by the same term
Royal Horse Artillery RNA helicase, an enzyme Rha may refer to: Rha, Netherlands, a population center in Steenderen Rhamnose, a monosaccharide Volga River
RHA
Protein-coding gene in the species Homo sapiens
Sen1. Sen1 in yeast is a RNA/DNA helicase and the highly conserved sequences between these genes, particularly in the helicase domain, indicates that
SETX
Protein-coding gene in the species Homo sapiens
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
DDX3Y
Protein-coding gene in humans
Probable ATP-dependent RNA helicase DDX47 is an enzyme that in humans is encoded by the DDX47 gene. This gene encodes a member of the DEAD box protein
DDX47
Protein-coding gene in the species Homo sapiens
pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 is an enzyme that in humans is encoded by the DHX15 gene. The protein encoded by this gene is a putative
DHX15
Enzyme found in humans
which occurs upon 2'-5'A binding, and results in cleavage of all RNA in the cell. This can lead to activation of MDA5, an RNA helicase involved in the production
Ribonuclease_L
Protein-coding gene in the species Homo sapiens
ATP-dependent RNA helicase SUPV3L1, mitochondrial is an enzyme that in humans is encoded by the SUPV3L1 gene. GRCh38: Ensembl release 89: ENSG00000156502
SUPV3L1
Protein-coding gene in the species Homo sapiens
(ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes
PIF1_5'-to-3'_DNA_helicase
Species of virus
picornavirus nonstructural proteins: an RNA helicase, a chymotrypsin-like 3C protease and an RNA-dependent RNA polymerase. VP1 is encoded between codons
Deformed_wing_virus
Protein-coding gene in the species Homo sapiens
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
DDX10
Cancer of the lymphatic system
Ming-Qing; Samarajiwa, Shamith A.; Hodson, Daniel J. (October 2021). "Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven
Burkitt_lymphoma
Cellular process of protein synthesis
(2024-08-01). "A novel reporter for helicase activity in translation uncovers DDX3X interactions". RNA. 30 (8): 1041–1057. doi:10.1261/rna.079837.123. ISSN 1355-8382
Translation_(biology)
Cellular process
energy-consuming enzyme families including ATP-dependent RNA helicases, AAA-ATPases, GTPases, and kinases. About 60% of a cell's energy is spent on ribosome production
Ribosome_biogenesis
Protein-coding gene in the species Homo sapiens
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 is an enzyme that in humans is encoded by the DHX16 gene. DEAD box proteins, characterized
DHX16
Multi-protein complex
DEAD-box RNA helicase UAP56 and RNA export adapter ALYREF. This forms the complete TREX complex. At the end of transcription, after the 3'-end of mRNA is formed
TREX_complex
Enzyme that cleaves double-stranded RNA (dsRNA) into short dsRNA fragments
the sRNA products. The helicase domain has been implicated in processing long substrates. RNA interference is a process where the breakdown of RNA molecules
Dicer
Genus of viruses
viral replication protein that consists of a capping enzyme domain, a helicase-like domain, the RNA dependent RNA polymerase, three proteins—the triple gene
Potexvirus
Protein-coding gene in the species Homo sapiens
PMID 30907728. "UPF1 UPF1 RNA helicase and ATPase [ Homo sapiens (human) ]". Lykke-Andersen J (2002). "Identification of a human decapping complex associated
UPF1
Protein-coding gene in the species Homo sapiens
ATP-dependent RNA helicase DDX42 is an enzyme that in humans is encoded by the DDX42 gene. This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box
DDX42
Protein-coding gene in the species Homo sapiens
Tang H, Wong-Staal F (October 2000). "Specific interaction between RNA helicase A and Tap, two cellular proteins that bind to the constitutive transport
NXF1
Protein-coding gene in the species Homo sapiens
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
DDX17
Subclass of viruses
RNA virus is a virus characterized by a ribonucleic acid (RNA) based genome. The genome can be single-stranded RNA (ssRNA) or double-stranded (dsRNA)
RNA_virus
Protein-coding gene in the species Homo sapiens
Putative ATP-dependent RNA helicase DHX57 is an enzyme that in humans is encoded by the DHX57 gene. GRCh38: Ensembl release 89: ENSG00000163214 – Ensembl
DHX57
Protein-coding gene in the species Homo sapiens
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 is an enzyme that in humans is encoded by the DHX32 gene. DEAD box proteins, characterized
DHX32
Protein-coding gene in the species Homo sapiens
Probable ATP-dependent RNA helicase DDX56 is an enzyme that in humans is encoded by the DDX56 gene. This gene encodes a member of the DEAD box protein
DDX56
Protein-coding gene in humans
Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene. This gene encodes a member of the DEAD box protein
DDX23
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
regulated by RNA helicases. There is also evidence that RNA within stress granules is more compacted, compared to RNA in the cytoplasm, and that the RNA is found
Stress_granule
RNA transcript from the CRISPR locus
cause interference guided by the crRNA match. Type-I CRISPR systems are characterized by Cas3, a nuclease-helicase protein, and the multi-subunit Cascade
CRISPR_RNA
Protein-coding gene in the species Homo sapiens
ATP-dependent RNA helicase DDX39 is an enzyme that in humans is encoded by the DDX39 gene. This gene encodes a member of the DEAD box protein family. These
DDX39
Protein-coding gene in the species Homo sapiens
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 is an enzyme that in humans is encoded by the DHX38 gene. DEAD box proteins, characterized by
DHX38
Protein-coding gene in the species Homo sapiens
unspliced mRNA. The TRanscription-EXport (TREX) complex, a key player in mRNA export, includes the THO subcomplex, the RNA helicase UAP56, and the RNA-binding
ALYREF
Protein-coding gene in the species Homo sapiens
Probable ATP-dependent RNA helicase DDX59 is an enzyme that in humans is encoded by the DDX59 gene. GRCh38: Ensembl release 89: ENSG00000118197 – Ensembl
DDX59
Receptor family
coordinate ATP and RNA binding and the hydrolysis of ATP to unwind RNA. A C-terminal domain (CTD; InterPro: IPR021673) follows the helicase core and this domain
RIG-I-like_receptor
Protein-coding gene in the species Homo sapiens
of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary
DHX29
Virus affecting plants of the Solanaceae family
methyltransferase [MT] and RNA helicase [Hel] domains), an RNA-dependent RNA polymerase, a so-called movement protein (MP) and a capsid protein (CP). The coding
Tobacco_mosaic_virus
Protein-coding gene in the species Homo sapiens
Probable ATP-dependent RNA helicase DDX46 is an enzyme that in humans is encoded by the DDX46 gene. This gene encodes a member of the DEAD box protein
DDX46
Protein complex assembled on mRNA
contains the protein eukaryotic initiation factor 4A-III (eIF4A-III; a DEAD-box RNA helicase) bound to an adenosine triphosphate (ATP) analog, as well as the
Exon_junction_complex
Enzyme that synthesizes RNA from DNA during Transcription
catalyzes the chemical reactions that synthesize RNA from a DNA template strand. Along with the enzyme helicase, RNAP locally opens the double-stranded DNA
RNA_polymerase
Protein-coding gene in the species Homo sapiens
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
DDX50
Protein-coding gene in the species Homo sapiens
Spliceosome RNA helicase BAT1 is an enzyme that in humans is encoded by the BAT1 gene. This gene encodes a member of the DEAD box family of RNA-dependent
BAT1
Protein-coding gene in the species Homo sapiens
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
SKIV2L
Protein-coding gene in the species Homo sapiens
it to a series of helicases, most notably the AAA_12 and AAA_11 domains. The entire gene is 97,663 base pairs long and has an unprocessed mRNA that is
Protein_ZGRF1
Family of DNA sequences found in prokaryotic organisms
called CRISPR RNA (crRNA), which remained bound to the protein complex. Cascade, crRNA and a helicase/nuclease (Cas3) were required to provide a bacterial
CRISPR
Japanese immunologist
(TLR)s genes, that TLRs recognize a discrete collection of molecules of microbial origin, and later the RNA helicases, RIG-I (retinoic-acid-inducible protein
Shizuo_Akira
Protein-coding gene in the species Homo sapiens
binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases. GRCh38: Ensembl release 89: ENSG00000146909 – Ensembl, May 2017 GRCm38:
NOM1
Protein-coding gene in humans
eukaryotic cells. Its primary function is to enhance the helicase activity of eIF4A, a DEAD-box RNA helicase, by stimulating its ability to unwind secondary structures
EIF4B
Protein-coding gene in the species Homo sapiens
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
DHX34
RNA component of the ribosome, essential for protein synthesis in all living organisms
ribonucleic acid (rRNA) is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells. rRNA is a ribozyme which carries
Ribosomal_RNA
various types of proteins, including RNA-helicases, Tudor domain proteins, Piwi-clade Argonaute proteins, in addition to a PRMT5 methylosome composed of Capsuléen
Nuage_(cell_biology)
Family of large biological molecules
transfer RNA (tRNA), microRNA (miRNA), small interfering RNA (siRNA), small nucleolar RNA (snoRNAs), Piwi-interacting RNA (piRNA), tRNA-derived small RNA (tsRNA)
RNA
Biological gene-regulation phenomenon
the saRNA and facilitates targeting to the gene promoter. AGO2 is the primary Argonaute protein involved in saRNA-mediated RNAa. RNA Helicase A (RHA):
RNA_activation
Gene known for its role in breast cancer
JD (July 1998). "BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A". Nature Genetics. 19 (3): 254–256. doi:10.1038/930
BRCA1
Protein used in CRISPR
translocase/helicase enzyme that degrades DNA as part of CRISPR based immunity. Cas3 is a "signature" protein of class 1 CRISPR systems and functions in a complex
Cas3
Biological process of gene regulation
RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression by double-stranded
RNA_interference
Protein-coding gene in the species Homo sapiens
STAU1 is bound to the target mRNA, an interaction occurs between STAU1 and RNA helicase UPF1, which enhances its helicase activity and promotes SMD. It
STAU1
Protein-coding gene in the species Homo sapiens
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
DDX24
Protein complex
The primosome consists of seven proteins: DnaG primase, DnaB helicase, DnaC helicase assistant, DnaT, PriA, Pri B, and PriC. At each replication fork
Primosome
Class of enzymes
RecQ helicase is a family of helicase enzymes initially found in Escherichia coli that has been shown to be important in genome maintenance. They function
RecQ_helicase
Gene on human chromosome 6
ATP-dependent RNA helicase DDX43 is an enzyme that in humans is encoded by the DDX43 gene. The protein encoded by this gene is an ATP-dependent RNA helicase in the
DDX43
Mammalian protein found in Homo sapiens
Additionally, this gene is predicted to be a microRNA (miRNA) protein coding host gene, meaning that it may contain miRNA genes in its introns and/or exons. CHLSN
Cholesin
Medications based on ribonucleic acids
on messenger RNA (mRNA), antisense RNA (asRNA), RNA interference (RNAi), RNA activation (RNAa) and RNA aptamers. Of the four types, mRNA-based therapy
RNA_therapeutics
regulators of protein biosynthesis in synapses. BC200 RNA targets an ATP-dependent RNA helicase called eukaryotic initiation factor 4A (eIF4A). eIF4A
BC200_lncRNA
Section of nucleic acid sequence
transcription terminators require a large protein called a Rho factor which exhibits RNA helicase activity to disrupt the mRNA-DNA-RNA polymerase transcriptional
Terminator_(genetics)
Protein-coding gene in the species Homo sapiens
Probable ATP-dependent RNA helicase DDX52 is an enzyme that in humans is encoded by the DDX52 gene. ENSG00000278053 GRCh38: Ensembl release 89: ENSG00000277594
DDX52
Human chromosome
GTP-binding protein 4 HELLS: Lymphoid-specific helicase HKDC1: hexokinase domain containing 1 KIN: DNA/RNA-binding protein KIN17 LHPP: encoding protein
Chromosome_10
Class of enzymes
elongation, the RNA piece is removed by a 5' to 3' exonuclease and refilled with DNA. In bacteria, primase binds to the DNA helicase forming a complex called
Primase
Geneticist and cell biologist
Akhtar also studies the RNA helicase DHX9. Her work revealed a novel UV-induced RNA damage stress response, in which damaged RNAs are sequestered into cytoplasmic
Asifa_Akhtar
RNA HELICASE-A
RNA HELICASE-A
RNA HELICASE-A
RNA HELICASE-A
RNA HELICASE-A
RNA HELICASE-A
RNA HELICASE-A
RNA HELICASE-A
RNA HELICASE-A