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A randomised non-comparative trial, RNCT (or also non-comparative randomised trial), is a type of clinical trial where participants are randomised to different
Randomised non-comparative trial
Randomised_non-comparative_trial
Form of scientific experiment
Randomised Trials Consort 2010 Statement: Non-Pharmacologic Treatment Interventions "Reporting of surrogate endpoints in randomised controlled trial reports
Randomized_controlled_trial
Operational model for clinical trials
other types of trial activities was reported in less than 25.6% of the 254 protocols in this review. Randomised controlled clinical trials are vital for
Decentralised_clinical_trial
Form of randomised controlled trial
In medicine, a stepped-wedge trial (or SWT) is a type of randomised controlled trial (RCT). An RCT is a scientific experiment that is designed to reduce
Stepped-wedge_trial
Medical research
ClinicalTrials.gov. M., Fransen (May 2015). "Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial
Clinical trials on glucosamine and chondroitin
Clinical_trials_on_glucosamine_and_chondroitin
Phase of clinical research in medicine
studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary in size and cost, and they can involve a single
Clinical_trial
Cholesterol-lowering medication
Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase"
Atorvastatin
Anticoagulant medication sold as Eliquis
patients at high risk of recurrence: a non-inferiority, multicentre, randomised, open-label, blinded endpoint trial". Lancet. 405 (10480). London, England:
Apixaban
Type of therapy to improve mental health
post-traumatic stress disorder: pragmatic, multicentre, randomised controlled non-inferiority trial (RAPID)". BMJ. 377 e069405. doi:10.1136/bmj-2021-069405
Cognitive_behavioral_therapy
Urinary antiseptic drug
study protocol for a multicentre, pragmatic, patient-randomised, non-inferiority trial". Trials. 19 (1) 616. doi:10.1186/s13063-018-2998-4. PMC 6230276
Methenamine
SNRI medication
disorder: a systematic review with meta-analysis and trial sequential analysis of randomised clinical trials". BMJ Open. 15 (2) e082853. doi:10.1136/bmjopen-2023-082853
Duloxetine
Practices with established treatment efficacy for ADHD
disorder: A systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials". PLOS ONE. 12 (6) e0178187. Bibcode:2017PLoSO
Management of attention deficit hyperactivity disorder
Management_of_attention_deficit_hyperactivity_disorder
Diabetes medication
dapagliflozin on proteinuria in non-diabetic patients with chronic kidney disease (DIAMOND): a randomised, double-blind, crossover trial" (PDF). The Lancet. Diabetes
Dapagliflozin
Angiotensin II receptor antagonist
not tolerate angiotensin-converting enzyme inhibitor medicines. Randomised control trials have shown candesartan reduces heart failure hospitalisations
Candesartan
Medication to prevent nausea and vomiting
"Randomised, placebo-controlled trial and meta-analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The TRITON trial". Alimentary
Ondansetron
Heart medication
outcomes in patients with heart rates of 70 bpm or more. The SIGNIFY trial randomised 19102 patients with stable coronary artery disease and an elevated
Ivabradine
Book by David D. Burns
supported bibliotherapy on the topic of CBT was the subject of a randomised controlled trial, in which patients on a waiting list to receive counselling for
Feeling Good: The New Mood Therapy
Feeling_Good:_The_New_Mood_Therapy
American professor
meta-analysis of non-randomised comparative studies of a surgical procedure, the first published direct comparison between a randomised trial and a historical
Ned_Abraham
Chemical compound
PMID 21271613. S2CID 29707062. "A Phase II, Single Centre, Randomised, Placebo-controlled, 3-part Trial to Assess the Safety, Tolerability and Efficacy of Zibotentan
Zibotentan
Pharmaceutical drug
small-cell lung cancer (CASPIAN): updated results from a randomised, controlled, open-label, phase 3 trial". The Lancet. Oncology. 22 (1): 51–65. doi:10
Durvalumab
Intravenous medication used in general anaesthesia
general anaesthesia: A multicentre, single-blind, randomised, parallel-group, phase 3 clinical trial". European Journal of Anaesthesiology. 40 (6): 399–406
Cipepofol
Group of endocrine diseases characterized by high blood sugar levels
and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials". Lancet. 375 (9716): 735–742. doi:10.1016/S0140-6736(09)61965-6
Diabetes
Thiazide-like diuretic drug
in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial". Lancet. 370 (9590): 829–840. doi:10.1016/s0140-6736(07)61303-8
Indapamide
Concept in medicine referring to design of clinical trials
clinical trial endpoint. This is in contrast to traditional single-arm (i.e. non-randomized) clinical trials or randomized clinical trials (RCTs) that
Adaptive_design_(medicine)
Anti-diabetic and anti-obesity medication
August 2025. "A Randomised Controlled Clinical Trial in Type 2 Diabetes Comparing Semaglutide to Placebo and Liraglutide". ClinicalTrials.gov. August 2019
Semaglutide
Medical procedure
regional, or general anaesthesia in groin hernia repair: multicentre randomised trial". Lancet. 362 (9387): 853–858. doi:10.1016/S0140-6736(03)14339-5. ISSN 1474-547X
Inguinal_hernia_surgery
Class of psychoactive drugs
at least a year after therapy. A 2004 meta-analysis of randomised controlled clinical trials that compared benzodiazepines to Z-drugs found few clear
Nonbenzodiazepine
Descriptor of patient compliance with medical advice
incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomised chemoprevention trial". Lancet. 352 (9122): 98–101. doi:10.1016/S0140-6736(98)85012-5
Patient_adherence
Medical disorder of the uterus
HysNiche trial: hysteroscopic resection of uterine caesarean scar defect (niche) in patients with abnormal bleeding, a randomised controlled trial". BMC
Uterine_niche
System for straightening teeth
doctors using passive self-ligating braces. However numerous randomised clinical trials (RCT's) (e.g.), have been conducted on these brackets and the
Damon_system
Nonsteroidal anti-inflammatory drug
gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials". Lancet. 382 (9894).
Diclofenac
Medication used to treat ADHD
treat cognitive disengagement syndrome (CDS), as multiple randomised controlled clinical trials (RCTs) have found that it is an effective treatment. In
Atomoxetine
Anticoagulant drug
Clinical trial number NCT01696110 for "BivaliRudin in Acute Myocardial Infarction vs Glycoprotein IIb/IIIa and Heparin :a Randomised Controlled Trial. (BRIGHT)"
Bivalirudin
System for diagnosing appendicitis
ISSN 2589-8450. PMC 10413131. Douglas, CD (14 October 2000). "Randomised controlled trial of ultrasonography in diagnosis of acute appendicitis, incorporating
Alvarado_score
SSRI antidepressant
depression in dementia – the HTA-SADD trial – a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness
Sertraline
SNRI antidepressant
major depressive disorder: a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis". Epidemiology and Psychiatric
Venlafaxine
Inflammation of the liver
Pentoxifylline for Alcoholic Hepatitis (STOPAH): a 2 × 2 factorial randomised controlled trial". Health Technology Assessment. 19 (102): 1–104. doi:10.3310/hta191020
Hepatitis
Approach to program evaluation
deprescribe in the EMPOWER trial. BMJ Open 7(4): e015959. Bonell C, Fletcher A, Morton M, et al. (2012) Realist randomised controlled trials: A new approach to
Theory-driven_evaluation
Beta-1 selective adrenenergic blocker medication used to treat cardiovascular diseases
1999). "The cardiac insufficiency bisoprolol study II (CIBIS-II): a randomised trial". The Lancet. 353 (9146): 9–13. doi:10.1016/S0140-6736(98)11181-9.
Bisoprolol
Menstrual period with excessive blood flow
Lumsden MA, Heikkilä A, Walker JJ, Cameron IT (June 1998). "Randomised comparative trial of the intrauterine system and norethisterone levonor gestrel
Heavy_menstrual_bleeding
NRI antidepressant drug
tested. In a randomised double-blind placebo-controlled trial reboxetine significantly improved the symptoms of panic disorder. Another randomised controlled
Reboxetine
Species of bacterium
probiotics: Protocol for a double blinded randomised placebo-controlled trial (the PrePOP study)". Contemporary Clinical Trials. 149 107776. doi:10.1016/j.cct.2024
Lactobacillus_crispatus
Scar treatment therapy
in scar management: A systematic review and meta-analysis of randomised controlled trials". International Wound Journal. 17 (3): 765–773. doi:10.1111/iwj
Silicone_gel_sheeting
Antibacterial drug
infection (EAGLE-2 and EAGLE-3): two randomised, controlled, double-blind, double-dummy, phase 3, non-inferiority trials". Lancet. 403 (10428): 741–755. doi:10
Gepotidacin
Long-term U.S. health study
and mortality in men and women living in the community: randomised double blind controlled trial". BMJ. 326 (7387): 469. doi:10.1136/bmj.326.7387.469. PMC 150177
Women's_Health_Initiative
Medication against high blood pressure
daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial". Lancet. 376 (9753). London, England: 1658–1669. doi:10.1016/s0140-6736(10)60310-8
Amlodipine
Human disease
treatment in northern Ethiopia (GoLBet): study protocol for a randomised controlled trial". Trials. 16 307. doi:10.1186/s13063-015-0818-7. PMC 4504163. PMID 26177812
Podoconiosis
Medication
opioid relapse prevention (X:BOT): a multicentre, open-label, randomised controlled trial". Lancet. 391 (10118): 309–318. doi:10.1016/S0140-6736(17)32812-X
Naltrexone
Neurodevelopmental disorder
Cochrane systematic review with meta-analyses and trial sequential analyses of randomised clinical trials". The BMJ. 351 h5203. doi:10.1136/bmj.h5203. PMC 4659414
Attention deficit hyperactivity disorder
Attention_deficit_hyperactivity_disorder
Nonsteroidal anti-inflammatory drug
versus randomised trials". The Lancet. Oncology. 13 (5): 518–27. doi:10.1016/S1470-2045(12)70112-2. PMID 22440112. There is good evidence from randomised trials
Aspirin
Chemical compound
Nifedipine may be associated with a longer postponement of delivery. A 2009 randomised controlled study demonstrated for the first time the direct effects of
Atosiban
Narrowing of the urethra
Urethral Stricture: A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial)". European Urology.
Urethral_stricture
Type of spinal procedure
balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial", Lancet, 373 (9668): 1016–24
Vertebral_augmentation
Death of a region of brain cells due to poor blood flow
PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial". Lancet. 366 (9493): 1279–89. doi:10
Stroke
Adolescent sexuality in the UK
European population. The RIPPLE studies, also known as the "Randomised Intervention trial of PuPil-Led sex Education", was a two phase sexual risk education
Adolescent sexuality in the United Kingdom
Adolescent_sexuality_in_the_United_Kingdom
Nonsteroidal anti-inflammatory drug (NSAID) used to treat pain
gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials". Lancet. 382 (9894):
Naproxen
Ultrasonic, non-invasive, outpatient treatment
and long-term outcomes in diabetic patients with foot ulcers. Randomised controlled trials into the use of ESWT for healing venous leg ulcers are needed
Extracorporeal shockwave therapy
Extracorporeal_shockwave_therapy
Medication for parasite infestations
2020). "Ivermectin for causal malaria prophylaxis: a randomised controlled human infection trial". Tropical Medicine & International Health. 25 (3): 380–386
Ivermectin
Class of drugs to lower cholesterol
"Taking simvastatin in the morning compared with in the evening: randomised controlled trial". BMJ. 327 (7418): 788. doi:10.1136/bmj.327.7418.788. PMC 214096
Statin
Form of pseudoscientific alternative medicine
2009). "Spinal manipulation for asthma: a systematic review of randomised clinical trials". Respiratory Medicine. 103 (12): 1791–95. doi:10.1016/j.rmed
Chiropractic
Medical device for restricting blood flow
two methods of automatic measurement of limb occlusion pressure: a randomised trial". BMC Biomedical Engineering. 3 (1): 8. doi:10.1186/s42490-021-00053-9
Tourniquet
Species of bacterium
spine bone loss in postmenopausal women: a randomised, double-blind, placebo-controlled, multicentre trial". The Lancet Rheumatology. 1 (3): e154–e162
Limosilactobacillus_reuteri
Diabetes medication
in patients with type 2 diabetes. Additionally, large-scale randomised controlled trials have demonstrated that empagliflozin decreases heart failure
Empagliflozin
Tricyclic antidepressant
peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial". Lancet. 400 (10353): 680–690. doi:10.1016/s0140-6736(22)01472-6
Amitriptyline
Influence of clothing on the wearer's mind
attention. The first experiment consisted of 50 randomised trials with 20 being incongruent and 30 non-incongruent. Participants were asked to do this
Enclothed_cognition
One of the five major groups of lipoprotein
treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients". BMJ. 349 g4379. doi:10.1136/bmj
High-density_lipoprotein
American HIV researcher (born 1951)
Study of a clade-B-based HIV-1 vaccine in South Africa: A double-blind, randomised, placebo-controlled test-of-concept phase 2b study". The Lancet Infectious
Julie_McElrath
Psychedelic drug
single-centre, case-control study with nested, randomised, double-blind, placebo-controlled crossover trial". Lancet Diabetes Endocrinol. 11 (7): 454–464
5-MeO-DMT
Disinfectant and antiseptic
with 0.2% chlorhexidine digluconate in maxillofacial surgery: a randomised controlled trial". The British Journal of Oral & Maxillofacial Surgery. 55 (2):
Chlorhexidine
Tetracycline-class antibiotic
doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial". Lancet. 365 (9477): 2116–21. doi:10.1016/S0140-6736(05)66591-9
Doxycycline
Form of arthritis caused by degeneration of joints
and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials". BMJ. 350 h1225. doi:10.1136/bmj.h1225. PMC 4381278. PMID 25828856
Osteoarthritis
Chemical compound
clinical trial have indicated that doses of EMA401 up to 400 mg are safe in humans. Spinifex Pharmaceuticals reported the results of a phase 2 randomised placebo
EMA401
"AI-assisted documentation for behavioural health therapy: a randomised controlled trial". Journal of Medical Internet Research. 25 (1) e46781. doi:10
List of artificial intelligence tools in audio-based healthcare diagnostics
List_of_artificial_intelligence_tools_in_audio-based_healthcare_diagnostics
Atypical antipsychotic medication
rivastigmine and cognitive decline in Alzheimer's disease: randomised double blind placebo controlled trial". BMJ. 330 (7496): 874. doi:10.1136/bmj.38369.459988
Quetiapine
Immunosuppressive drug
microemulsified ciclosporin in liver transplantation: the TMC randomised controlled trial". Lancet. 360 (9340): 1119–1125. doi:10.1016/S0140-6736(02)11196-2
Tacrolimus
Coronary medication
with acute coronary syndromes: a meta-analysis of randomized trials". Journal of Comparative Effectiveness Research. 7 (3): 281–291. doi:10.2217/cer-2017-0074
Ticagrelor
Investigational insomnia drugs
2023). "Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study". J Sleep Res. 32 (3)
List of investigational insomnia drugs
List_of_investigational_insomnia_drugs
Psychedelic drug
the original (PDF) on 22 December 2015. Clinical trial number NCT04673383 for "A Double-blind, Randomised, Placebo-controlled Study of Intravenous Doses
Dimethyltryptamine
Medication used to treat diabetes
with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial". BMJ. 340 c2181. doi:10.1136/bmj.c2181. PMC 2874129. PMID 20488910
Metformin
meta-analysis in Operative Dentistry pooled 14 randomised trials comparing CLEARFIL SE Bond with other adhesives in non-carious cervical lesions and found no statistically
Clearfil_SE_Bond
Antipsychotic medication
schizophrenia--a critical systematic review and meta-analysis of randomised long-term trials". Schizophrenia Research. 127 (13): 83–92. doi:10.1016/j.schres
Risperidone
Chemotherapy and immunosuppressant medication
immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial". The Lancet. Rheumatology. 6 (2): e92–e104. doi:10
Methotrexate
Implantable medical device
fibrillation detection. However, PRAETORIAN-DFT randomised clinical trial is aiming to demonstrate non-inferiority of omitting DFT in patients undergoing
Subcutaneous implantable defibrillator
Subcutaneous_implantable_defibrillator
Drug whose use induces sleep
without insomnia or poor sleep: A systematic review and meta-analysis of randomised studies". Sleep Med Rev. 84 102156. doi:10.1016/j.smrv.2025.102156. PMID 40929927
Hypnotic
Anti-parasite medication
antibody responses to schistosome antigens: results of a randomised, placebo-controlled trial". BMC Infectious Diseases. 9 (32) 32. doi:10.1186/1471-2334-9-32
Praziquantel
Class of medications
recurrent psychotic disorders in England (the RADAR trial): an open, parallel-group, randomised controlled trial". The Lancet Psychiatry. 10 (11): 848–859. doi:10
Antipsychotic
Skin condition characterized by pimples
England and Wales: pragmatic, multicentre, phase 3, double blind, randomised controlled trial". The BMJ. 381 e074349. doi:10.1136/bmj-2022-074349. ISSN 1756-1833
Acne
Central nervous system stimulant
number of non-serious adverse events in children." "Concerning adverse events associated with the treatment, our systematic review of randomised clinical
Methylphenidate
Chemical compound
pain syndrome: A systematic review and network meta-analysis of randomised controlled trials". eClinicalMedicine. 48 101457. doi:10.1016/j.eclinm.2022.101457
Thiocolchicoside
Deliberate infliction of suffering on a person
torture survivors: A systematic review and meta-analysis of randomised controlled trials". PLOS Medicine. 16 (9) e1002919. doi:10.1371/journal.pmed.1002919
Torture
Inflammation of the uvea of the eye
inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial". Lancet
Uveitis
Medication which blocks growth of blood vessels
platinum-sensitive ovarian cancer (ICON6): a randomised, double-blind, placebo-controlled phase 3 trial". Lancet. 387 (10023): 1066–1074. doi:10
Anti-VEGF
Medical intervention
locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial". The Lancet. 393 (10183): 1819–1830
Treatment_of_lung_cancer
Combination of two antibiotic drugs
for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial". Lancet. 383 (9919): 807–814. doi:10.1016/S0140-6736(13)61951-0
Trimethoprim/sulfamethoxazole
Surgical removal of the tonsils
quality of life, reduction of symptoms, and economic benefit. A randomised controlled trial of tonsillectomy versus medical treatment (antibiotics and pain
Tonsillectomy
Antiplatelet medication
transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial". The Lancet. 364 (9431): 331–7. doi:10.1016/S0140-6736(04)16721-4
Clopidogrel
Device to vaporize substances for inhalation
cessation among adults who smoke in the USA: a naturalistic, randomised, controlled clinical trial."". eClinicalMedicine. 63 102142. doi:10.1016/j.eclinm.2023
Vaporizer_(inhalation_device)
Chemical compound
hormone (GnRH) receptor blocker--results from a 1-yr, multicentre, randomised, phase 2 dosage-finding study in the treatment of prostate cancer". European
Degarelix
Iron-carrying protein
supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial". BMJ. 326 (7399): 1124–0. doi:10.1136/bmj
Ferritin
Immunosuppressant medication
for prevention of acute rejection in renal transplantation (MYSS): a randomised trial". Lancet. 364 (9433): 503–12. doi:10.1016/S0140-6736(04)16808-6. PMID 15302193
Mycophenolic_acid
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RANDOMISED NON-COMPARATIVE-TRIAL