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Pseudotyping is the process of producing viruses or viral vectors in combination with foreign viral envelope proteins. The result is a pseudotyped virus
Pseudotyping
envelope proteins have been replaced as described are referred to as pseudotyped viruses. For example, the most popular retroviral vector for use in gene
Vectors_in_gene_therapy
Human retrovirus, cause of AIDS
B, Rohr K, Kräusslich HG, Lehmann MJ (2009). "Visualizing fusion of pseudotyped HIV-1 particles in real time by live cell microscopy". Retrovirology
HIV
Vaccine against Ebola
"rVSVΔG-ZEBOV-GP (also designated V920) recombinant vesicular stomatitis virus pseudotyped with Ebola Zaire Glycoprotein: Standardized template with key considerations
Ebola_vaccine
Blood cancer characterized by overproduction of lymphoblasts
commonly, this is done using a lentivirus that encodes the transgene. Pseudotyped, self-inactivating lentiviruses are an effective method for the stable
Acute_lymphoblastic_leukemia
Species of virus
J (August 2005). "Altering the tropism of lentiviral vectors through pseudotyping". Current Gene Therapy. 5 (4): 387–98. doi:10.2174/1566523054546224.
Indiana_vesiculovirus
Species of virus
(rAAV) to target particular cells, researchers have also explored AAV pseudotyping, the practice of creating hybrids of certain AAV strains to approach
Adeno-associated_virus
Group of cells allowing a pathogen to infect nearby endothelium
where receptor is present on the cell. Conversely, using a surrogate or pseudotyped virus, is also a method of understanding cell tropism. In brief, these
Endothelial_cell_tropism
Partial viruses engineered for study
allow study of the later stages of the viral life cycle. RVPs formed by pseudotyping contain the native form of the viral Envelope (or Spike) protein, but
Reporter_virus_particles
Type of coronavirus detected in 2021
similar testing and research is ongoing. Preclinical data on in vitro pseudotyped virus data demonstrate that some mAbs designed to use highly conserved
SARS-CoV-2_Omicron_variant
Anticoagulant
specific affinity for VSV-G, a viral envelope glycoprotein often used to pseudotype retroviral and lentiviral vectors for gene therapy, allows it to be used
Heparin
Topics referred to by the same term
Pseudovirus can refer to a virus artificially created by pseudotyping to contain envelope proteins from a different virus Pseudovirus (genus), a genus
Pseudovirus
Glycoprotein spike on a viral capsid or viral envelope
of the spike protein of human coronavirus NL63 in receptor binding and pseudotype virus entry". Virus Research. 160 (1–2): 283–293. doi:10.1016/j.virusres
Coronavirus_spike_protein
Biotechnology for gene delivery
tailored by creating recombinant versions from multiple serotypes, termed pseudotyping. Due to their ability to infect and induce longlasting effects within
Viral_vector
Genus of viruses
and retroviral capsids. Such chimeras are termed pseudotyped viruses. Alphaviral envelope pseudotypes of retroviruses or lentiviruses are able to integrate
Alphavirus
Vaccine against Ebola virus disease
"rVSVΔG-ZEBOV-GP (also designated V920) recombinant vesicular stomatitis virus pseudotyped with Ebola Zaire Glycoprotein: Standardized template with key considerations
RVSV-ZEBOV_vaccine
German biochemist
K. Proc Natl Acad Sci U S A. 1994 Jan 18; 91(2):654-8. PMID 8290577 Pseudotyping of murine leukemia virus with the envelope glycoproteins of HIV generates
Klaus_Cichutek
Rare genetic disorder in the human body
diagnosis is based on the presence of the Albright hereditary osteodystrophy pseudotype but without the PTH resistance. Blood tests including calcium, phosphate
Pseudopseudohypoparathyroidism
Pseudopseudohypoparathyroidism
American biochemist
PMID 9311907. US 7033595, "Pseudotyped retroviruses and stable cell lines for their production" US 7981656, "Pseudotyped retrovirus with modified ebola
David_Sanders_(biologist)
Species of virus
Glycosaminoglycans, but This Binding Does Not Lead to Infection in a Pseudotype System". Journal of Virology. 78 (9): 4478–4486. doi:10.1128/JVI.78.9
Hepatitis_C_virus
Species of virus
Characterization of the Bas-Congo virus glycoprotein and its function in pseudotyped viruses. J Virol. 2013;87(17):9558–9568. doi:10.1128/JVI.01183-13 S.
Bas-Congo_virus
Spanish-American academic (born 1964)
; Palese, P.; Moran, T. M.; Garcia-Sastre, A. (2009). "Hemagglutinin-Pseudotyped Green Fluorescent Protein-Expressing Influenza Viruses for the Detection
Adolfo_García-Sastre
Albertini, A; Gaudin, Y; Lingwood, C A; Branch, D R (2010). "A novel VSV/HIV pseudotype approach for the study of HIV microbicides without requirement for level
Function-spacer-lipid Kode construct
Function-spacer-lipid_Kode_construct
American immunologist and academic administrator (born 1956)
assembly and entry, proposed HIV-1 as a Trojan exosome, and natural pseudotyping enables HIV-1 to directly infect epithelial barrier cells in the female
James_E._K._Hildreth
Method of gene modification
self-inactivating plasmids and creating a more universal tropism by pseudotyping a vesicular stomatitis virus glycoprotein. In chronic granulomatous disease
Lentiviral vector in gene therapy
Lentiviral_vector_in_gene_therapy
Software for sequence alignment
recent paper being Discovery and Validation of Alternatives to VSV-G for Pseudotyping of Lentiviral Vectors for In Vivo Delivery of Anti-Tumor Transgenes.
MUSCLE_(alignment_software)
Protein-coding gene in the species Homo sapiens
L-SIGN and DC-SIGN capture and transmit infectious hepatitis C virus pseudotype particles". The Journal of Biological Chemistry. 279 (31): 32035–32045
DC-SIGN
Multiple strains of HIV in one person
immunodeficiency virus (HIV) type 1 can superinfect HIV-2-infected cells: pseudotype virions produced with expanded cellular host range". Proceedings of the
HIV_superinfection
Gene silencing by means of RNA
mildly immunogenic, lasting expression in non-dividing cells, capsid pseudotyping/engineering facilitates specific cell-targeting Lentivirus Up to 13.5
RNA_silencing
American physician and pharmaceutical scientist
tropism assays using replication-competent virus and plasma-derived pseudotyped virions. He demonstrated the impact of low-dose ritonavir on the pharmacokinetics
Charles_Flexner
inside the host cell but has not yet been activated by it. provirus pseudotyping Contents: A B C D E G H I K L M N O P Q R S T U V Z See also References
Glossary_of_virology
Genus of viruses
Characterization of the Bas-Congo virus glycoprotein and its function in pseudotyped viruses. J Virol. 2013;87(17):9558–9568. doi:10.1128/JVI.01183-13 Viralzone:
Tibrovirus
Medical condition
Naldini, Luigi; Follenzi, Antonia; Cantore, Alessio (2024-04-29). "GP64-pseudotyped lentiviral vectors target liver endothelial cells and correct hemophilia
Haemophilia_A
Protein-coding gene in the species Homo sapiens
early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1. It has been shown that an SPG7 variant escapes phosphorylation-regulated
Paraplegin
Technique for mapping neural circuits in the "upstream" direction, from target to source
can be limited to monosynaptic transmission to a neuron of origin by pseudotyping the G protein and putting the gene under Cre-control. This viral spread
Retrograde_tracing
British molecular biologist (1940–2026)
Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison. Journal of General Virology. Volume 89,
Robin_Weiss
Chinese-American neuroscientist
is expressed in response to neuronal activity, thereby enabling EnvA-pseudotyped viruses to specifically infect activated cells and drive stable expression
Fan_Wang_(neuroscientist)
Mammalian protein found in Homo sapiens
S2CID 31079892. Guibinga GH, Friedmann T (April 2005). "Baculovirus GP64-pseudotyped HIV-based lentivirus vectors are stabilized against complement inactivation
Decay-accelerating_factor
British-American virologist
led to a patent on VSV-based gene therapy vectors and vaccines. VSV pseudotypes, which carry the envelope proteins of other viruses, are useful tools
Sean_Whelan_(scientist)
Biologist
PMID 14494904. Rubin, H. (1965). "Genetic control of cellular susceptibility to pseudotypes of rous sarcoma virus". Virology. 26 (2): 270–276. doi:10.1016/0042-6822(65)90274-6
Harry_Rubin_(virologist)
Protein-coding gene in the species Homo sapiens
influenza A virus, IFITM proteins were able to inhibit retrovirus based pseudotyped influenza A virus, indicating that IFITM protein inhibit influenza A
IFITM1
Canadian immunologist and virologist
under the supervision of James Wilson (scientist). Here, he generated pseudotyped HIV particles with fragments from ebolavirus. In 2005, he was recruited
Gary_Kobinger
Species of virus
vectors were based on the Moloney murine leukemia virus (MMLV) which when pseudotyped with GaLV envelope protein, enabled gene transfer to various host cells
Gibbon_ape_leukemia_virus
Experimental lentiviral approach to generating CAR-T cells inside the body
vivo lentiviral CAR-T manufacture commonly relies on broadly tropic pseudotypes such as vesicular stomatitis virus glycoprotein (VSV-G). For systemic
Targeted lentiviral delivery for in vivo CAR T-cell generation
Targeted_lentiviral_delivery_for_in_vivo_CAR_T-cell_generation
"Specific and stable gene transfer to human embryonic stem cells using pseudotyped lentiviral vectors". Stem Cells Dev. 15 (1): 109–17. doi:10.1089/scd
Glutamate synthase (ferredoxin)
Glutamate_synthase_(ferredoxin)
PSEUDOTYPING
PSEUDOTYPING
PSEUDOTYPING
PSEUDOTYPING
Male
Spanish
Spanish form of Visigothic Alewar, ÃLVARO means "guard of all."
Girl/Female
Muslim
Umm-E-Abeeha | عومم- ع- ابیھا
Boy/Male
Arabic, Australian, Muslim
Satisfies Thirst
Boy/Male
Muslim/Islamic
God's gift
Female
English
French form of Roman Latin Lucilla, LUCILLE means "little light."
Surname or Lastname
English
English : apparently a habitational name, from an unidentified place, perhaps in East Anglia, where the surname is most common today.
Boy/Male
Gujarati, Indian, Jain
Lion; Fish
Girl/Female
Muslim
Wind
Girl/Female
Hebrew
God will add.
Girl/Female
Dutch, German, Greek
A Gift of God
PSEUDOTYPING
PSEUDOTYPING
PSEUDOTYPING
PSEUDOTYPING
PSEUDOTYPING