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Drug used for the treatment of symptoms of metabolic syndrome
PPAR agonists are drugs which act upon the peroxisome proliferator-activated receptor. They are used for the treatment of symptoms of the metabolic syndrome
PPAR_agonist
Chemical compound
proliferator-activated receptor (PPAR) agonist and is the first medication that targets PPAR-alpha, PPAR-beta, and PPAR-gamma simultaneously. As of 2023
Lanifibranor
Anti-diabetic and anti-obesity medication
peptide-1 (GLP-1), modified with a side chain, and acts as a GLP-1 receptor agonist. The most common side effects include nausea, vomiting, diarrhea, abdominal
Semaglutide
Group of nuclear receptor proteins
Malaguarnera R (2009). "PPAR-gamma Agonists and Their Effects on IGF-I Receptor Signaling: Implications for Cancer". PPAR Res. 2009 830501. doi:10.1155/2009/830501
Peroxisome proliferator-activated receptor
Peroxisome_proliferator-activated_receptor
Chemical compound
pharmaceutical company Eli Lilly and Company. It is a triple hormone receptor agonist on the GLP-1, GIP, and glucagon receptors. GLP-1 receptors improve insulin
Retatrutide
Chemical compound
acts as a dual PPAR agonist at the subtypes α (alpha) and γ (gamma) of the peroxisome proliferator-activated receptor (PPAR). Agonist action on PPARα
Saroglitazar
Abandoned metabolic and cardiovascular drug
Newsholme SJ (2009). PS 895 - Rat carcinogenicity study with GW501516, a PPAR delta agonist (PDF). 48th Annual Meeting of the Society of Toxicology. Baltimore:
GW501516
Group of similar medications
(atherosclerosis). However, not all PPAR agonists are fibrates, not all triglyceride-lowering agents are PPAR agonists, and not all drugs used to treat atherosclerosis
Drug_class
Diabetes medication
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Dapagliflozin
Drugs that lower blood glucose levels to treat diabetes
mellitus by decreasing glucose levels in the blood. Most GLP-1 receptor agonists (liraglutide, exenatide, tirzepatide, pramlintide and others) are administered
Diabetes_medication
Chemical compound
dual PPARα/δ agonist. Elafibranor and its main active metabolite GFT1007 are peroxisome proliferator-activated receptor (PPAR) agonists, both of which
Elafibranor
Diabetes medication
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Empagliflozin
Topics referred to by the same term
Alpha agonist may refer to: Alpha-adrenergic agonist, drugs that selectively stimulate alpha adrenergic receptors PPAR-alpha agonist, drugs which act upon
Alpha_agonist
Gastrointestinal peptide hormone involved in glucose homeostasis
preserved in patients with type 2 diabetes. Glucagon-like peptide-1 receptor agonists gained approval as drugs to treat diabetes and obesity starting in the
Glucagon-like_peptide-1
Anti-diabetic and anti-obesity medication
is a gastric inhibitory polypeptide (GIP) analog and a GLP-1 receptor agonist. It is used as an antidiabetic medication to treat type 2 diabetes and
Tirzepatide
Anti-obesity medication
name Foundayo, is an oral, non-peptide, small-molecule GLP-1 receptor agonist developed as a weight loss drug by Eli Lilly and Company. It was discovered
Orforglipron
Blood pressure medication
renin–angiotensin system, telmisartan acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ), a central regulator of insulin and glucose
Telmisartan
Chemical compound
type 2 diabetes. It is a peroxisome proliferator-activated receptor (PPAR) agonist. In China, chiglitazar is approved for glycemic control in adult patients
Chiglitazar
Autoimmune disease of the liver
2024. Elafibranor is a peroxisome proliferator-activated receptor (PPAR) agonist, and while the mechanism of action is not fully understood, it is thought
Primary_biliary_cholangitis
Class of drugs used to treat diabetes
GLP1 poly-agonist peptides are a class of drugs that activate multiple peptide hormone receptors including the glucagon-like peptide-1 (GLP-1) receptor
GLP1_poly-agonist_peptides
Anti-diabetic medication
the skin. Liraglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) also known as incretin mimetics. It works by increasing insulin
Liraglutide
PPAR β/δ receptor Agonist compound
and fitorine) is a PPARδ/β agonist that has been investigated for drug use by GlaxoSmithKline. It is mixed PPAR-B agonist antagonist depending on its
GW0742
Medication used to treat diabetes
conclusive evidence of improved live birth rates was found. In long GnRH-agonist protocols there was uncertainty in the evidence of improved live birth
Metformin
Diabetes medication
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Sitagliptin
Pharmaceutical drug
combination therapy with a peroxisome proliferator-activated receptor (PPAR) agonist (i.e., a thiazolidinedione) as an adjunct to diet and exercise in people
Sitagliptin/metformin
Class of medication
systematic review and network meta-analysis comparing SGLT-2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors demonstrated that use of SGLT2 inhibitors was associated
SGLT2_inhibitor
Chemical compound
February 2025. Retrieved 27 February 2025. Billin AN (October 2008). "PPAR-beta/delta agonists for Type 2 diabetes and dyslipidemia: an adopted orphan still looking
Seladelpar
Enzyme blocker and diabetes treatment drug
of Sodium-Glucose Cotransporter 2 Inhibitors, Glucagon-like Peptide 1 Agonists, and Dipeptidyl Peptidase 4 Inhibitors With All-Cause Mortality in Patients
Dipeptidyl peptidase-4 inhibitor
Dipeptidyl_peptidase-4_inhibitor
Long-acting insulin
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Insulin_glargine
Class of chemical compounds
specific for PPARγ (PPAR-gamma, PPARG). They are thus the PPARG agonists subset of PPAR agonists. The endogenous ligands for these receptors are free fatty
Thiazolidinedione
Diabetes medication
incretin mimetics, as it is a glucagon-like peptide-1 receptor agonist (GLP-1 agonist) consisting of GLP-1(7-37) covalently linked to an Fc fragment of
Dulaglutide
Pharmaceutical compound
United States Adopted Name; developmental code name LY-3537031) is a dual agonist of glucagon-like peptide-1 (GLP-1) receptors and gastric inhibitory polypeptide
Brenipatide
Chemical compound
receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) and to a lesser extent PPAR-α. It modulates the transcription of the genes involved in
Pioglitazone
Modified forms of synthetic insulin
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Insulin_analogue
Chemical compound
Chen, Calvin Yu-Chian (2014). "In Silico Identification of Potent PPAR-γ Agonists from Traditional Chinese Medicine: A Bioactivity Prediction, Virtual
Abrine
Nuclear receptor protein found in humans
contrast to statins. PPAR-α, agonists may carry therapeutic value for the treatment of non-alcoholic fatty liver disease. PPAR-alpha may also be a site
Peroxisome proliferator-activated receptor alpha
Peroxisome_proliferator-activated_receptor_alpha
Rapid-acting man-made insulin
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Insulin_aspart
Chemical compound
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Biguanide
Class of organic compounds used in medicine and agriculture
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Sulfonylurea
GLP1 poly-agonist drug
Mazdutide (also known as IBI362 or LY3305677) is a dual agonist of the GLP-1 receptor and glucagon receptor. It is an analog of oxyntomodulin (OXM). The
Mazdutide
consistently, allowing for prolonged action. Liraglutide, a GLP-1 receptor agonist, mimics the effects of incretin hormones by enhancing insulin secretion
List of commercially available insulins
List_of_commercially_available_insulins
Medication
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Glimepiride
Chemical compound
Study of Diabetes consider either a SGLT2 inhibitor or GLP-1 receptor agonist a reasonable second line medication in those with heart disease. Canagliflozin
Canagliflozin
Ultralong-acting basal insulin analogue
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Insulin_degludec
Chemical compound
v t e Androgen receptor modulators ARTooltip Androgen receptor Agonists Testosterone derivatives: 4-Androstenediol 4-Dehydroepiandrosterone (4-DHEA)
Bisphenol_A_diglycidyl_ether
Medication
unclear safety. Exenatide is a glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) also known as incretin mimetics. It works by increasing insulin
Exenatide
Nuclear receptor protein found in humans
genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of
Peroxisome proliferator-activated receptor gamma
Peroxisome_proliferator-activated_receptor_gamma
Chemical compound
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Acarbose
Chemical compound
randomized-controlled trial to investigate the effects of rivoglitazone, a novel PPAR gamma agonist on glucose-lipid control in type 2 diabetes". Diabetes, Obesity &
Rivoglitazone
Chemical compound
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Vildagliptin
Chemical compound
thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed
Rosiglitazone
Chemical compound
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Glibenclamide
Chemical compound
thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ, it works as an insulin sensitizer by binding to the PPAR receptors in fat cells and making
Lobeglitazone
Chemical compound
Danuglipron is a small-molecule GLP-1 receptor agonist, formerly under development by Pfizer that, in an oral formulation, was under investigation as
Danuglipron
SPPARMs of the PPARγ, BADGE, EPI-001, INT-131, MK-0533, and S26948. PPAR agonist Fruchart, Jean-Charles; Santos, Raul D.; Aguilar-Salinas, Carlos; Aikawa
Selective_PPAR_modulator
Rapid-acting insuline analog
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Insulin_lispro
Nuclear receptor protein found in humans
increase in type I fibers. Both PPAR-delta and AMPK agonists are regarded as exercise mimetics. In adipose tissue PPAR-β/δ increases both oxidation as
Peroxisome proliferator-activated receptor delta
Peroxisome_proliferator-activated_receptor_delta
Chemical compound
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Glipizide
Use of insulin protein and analogs as medical treatment
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Insulin_(medication)
Chemical compound
caused by danazol, chlorpromazine, glucocorticoids, progestogens, or β-2 agonists. Its hypoglycemic action may be potentiated by phenylbutazone, alcohol
Gliclazide
Chemical compound
PPARδ receptor agonist developed by GlaxoSmithKline. While it is primarily active at the PPARδ receptor, it is considered a pan agonist with activity at
Sodelglitazar
Pharmaceutical compound
5-HT2B receptors, an inverse agonist at the 5-HT7 receptor, a partial agonist at D2, D5, and 5-HT6 receptors, and an agonist at 5-HT1A and D4 receptors
Nuciferine
Chemical compound
Leriglitazone is a PPAR-gamma agonist and metabolite of the glitazone pioglitazone. It is developed for adrenomyeloneuropathy, and other neurodegenerative
Leriglitazone
Anti-diabetic drug
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Alogliptin
Chemical compound
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Repaglinide
Chemical compound
Aleglitazar is a peroxisome proliferator-activated receptor agonist (hence a PPAR modulator) with affinity to PPARα and PPARγ, which was under development
Aleglitazar
Ultralong-acting basal insulin analogue
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Insulin_icodec
Chemical compound
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Enavogliflozin
Chemical compound
(incl. AASTooltip anabolic–androgenic steroid) ARTooltip Androgen receptor agonists Testosterone derivatives: Androstenediol dipropionate Boldenone undecylenate
EPI-001
Antidiabetic medication
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Bexagliflozin
Medication
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Insulin_efsitora_alfa
Intermediate acting insulin formulation
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
NPH_insulin
Pharmaceutical drug
Liraglutide belongs to the class of diabetes medicines known as GLP-1 receptor agonists It acts in the same way as incretins (hormones produced in the gut) by
Insulin_degludec/liraglutide
Chemical compound
Lotiglipron is a non-peptide GLP-1 receptor agonist which was under development by Pfizer as a weight loss drug. However, it was withdrawn from development
Lotiglipron
Chemical compound
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Sotagliflozin
Chemical compound
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Ciglitazone
Chemical compound
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Linagliptin
Pharmaceutical compound
developmental code name HDM1002) is a glucagon-like peptide-1 (GLP-1) receptor agonist which is under development for the treatment of type 2 diabetes, obesity
Conveglipron
Chronic disease of the liver, characterized by fibrosis
AJ, et al. (October 2021). "A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH". The New England Journal of Medicine. 385 (17):
Cirrhosis
Oral anti-diabetic drugs
Therapy: Metformin, Alpha-Glucosidase Inhibitors, Pioglitazone, GLP-1 Agonists, DPP-IV Inhibitors, and SGLT-2 Inhibitors. Michelle DeGeeter, PharmD, CDE
Alpha-glucosidase_inhibitor
Combination drug
American Diabetes Association, combination treatment of a GLP-1 receptor agonist with basal insulin should occur after HbA1C levels remain above target
Insulin_glargine/lixisenatide
Chemical compound
dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidation"
Tetradecylthioacetic_acid
Short-acting insulin formulation
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Regular_insulin
Pharmaceutical compound
EHP-102, also known as VCE-003.2, is a cannabinoid CB2 receptor agonist and PPARγ agonist which is under development for the treatment of Parkinson's disease
EHP-102
Chemical compound
moiety, potentially giving it vitamin E-like activity in addition to its PPAR activation. It has been shown to reduce inflammation. Troglitazone use was
Troglitazone
Pharmaceutical drug
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Vildagliptin/metformin
Chemical compound
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Buformin
Combination drug
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Glibenclamide/metformin
Diabetes medication
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Pramlintide
Medication
operates through the same mechanism as endogenous glucagon, acting as an agonist at glucagon receptors expressed throughout the body, which are G-coupled
Dasiglucagon
Cellular therapy medication
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Donislecel
Long-acting man-made insulin
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Insulin_detemir
Chemical compound
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Fidarestat
Combination drug
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Empagliflozin/linagliptin/metformin
Empagliflozin/linagliptin/metformin
Pharmaceutical compound
combination of dronabinol (Δ9-THC), a cannabinoid CB1 and CB2 receptor agonist, and palmidrol (palmitoylethanolamide; PEA), an endocannabinoid-like fatty
Dronabinol/palmidrol
Powdered insulin delivered with an inhaler
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Inhalable_insulin
Historical formulation of insulin as medication
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Lente_insulin
Medication
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Velagliflozin
Chemical compound
PPAR agonists Ciglitazone§ Darglitazone§ Englitazone§ Lobeglitazone Netoglitazone§ Pioglitazone Rivoglitazone† Rosiglitazone Troglitazone‡ Dual PPAR agonists
Tofogliflozin
Selective PPAR modulator (SPPARM) including SPPARMγ (affecting the PPARγ) and SPPARMα (PPARα) Agonist–antagonist Selective glucocorticoid receptor agonist (SEGRA)
Selective_receptor_modulator
PPAR AGONIST
PPAR AGONIST
PPAR AGONIST
PPAR AGONIST
PPAR AGONIST
PPAR AGONIST
PPAR AGONIST
PPAR AGONIST
PPAR AGONIST