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See searches and references containing ORPHAN RECEPTOR!ORPHAN RECEPTOR
Protein with a receptor structure but with unidentified ligand
In biochemistry, an orphan receptor is a protein that is structurally similar to a receptor, but for which no physiological relevant endogenous ligand
Orphan_receptor
Protein
Administration (FDA) approved drugs target nuclear receptors. A number of nuclear receptors, referred to as orphan receptors, have no known (or at least generally
Nuclear_receptor
Cellular receptor
RAR-related orphan receptor gamma (RORγ) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) gene. RORγ is a member of the
RAR-related orphan receptor gamma
RAR-related_orphan_receptor_gamma
Protein-coding gene in the species Homo sapiens
RAR-related orphan receptor alpha (RORα), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor that in humans is
RAR-related orphan receptor alpha
RAR-related_orphan_receptor_alpha
Members of the nuclear receptor family of intracellular transcription factors
The RAR-related orphan receptors (RORs) are members of the nuclear receptor family of intracellular transcription factors. There are three forms of ROR
RAR-related_orphan_receptor
Protein-coding gene in the species Homo sapiens
RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans
RAR-related orphan receptor beta
RAR-related_orphan_receptor_beta
Mammalian protein found in Homo sapiens
also capable of heterodimerising with COUP-TF (an orphan nuclear receptor) and retinoid X receptor (RXR) in mediating transcription in response to retinoids
Nuclear_receptor_4A1
Class of cell surface receptors coupled to G-protein-associated intracellular signaling
protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G
G_protein-coupled_receptor
Human protein-coding gene
TR2 is a member of the nuclear receptor family of transcription factors, and is currently considered an orphan receptor. TR2 combines with 3 other transcription
Testicular_receptor_2
Protein-coding gene in the species Homo sapiens
testicular receptor 4 is a member of the nuclear receptor family of transcription factors. Though currently considered an orphan receptor, it nevertheless
Testicular_receptor_4
Protein-coding gene in the species Homo sapiens
The nuclear receptor 4A3 (NR4A3) (nuclear receptor subfamily 4, group A, member 3) also known as neuron-derived orphan receptor 1 (NOR1) is a protein
Nuclear_receptor_4A3
Protein-coding gene in the species Homo sapiens
ROR1 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family. The protein encoded by this gene is a receptor tyrosine kinase that modulates
ROR1
Topics referred to by the same term
up orphan in Wiktionary, the free dictionary. An orphan is one who has lost both parents. Orphan(s) or The Orphan(s) may also refer to: The Orphan (1920
Orphan_(disambiguation)
Chemical compound
previously orphan receptor GPR139. It has been shown to modulate dopamine release in the brain via interaction with the Dopamine receptor D2, and increases
JNJ-3792165
Protein family
field of molecular biology, receptor tyrosine kinase-like orphan receptors (RORs) are a family of tyrosine kinase receptors that are important in regulating
Receptor tyrosine kinase-like orphan receptor
Receptor_tyrosine_kinase-like_orphan_receptor
Group of receptors to cannabinoid compounds
biology studies have suggested that the orphan receptor GPR55 should in fact be characterised as a cannabinoid receptor, on the basis of sequence homology
Cannabinoid_receptor
Protein-coding gene in the species Homo sapiens
Farnesoid X receptor (FXR), also known as NR1H4 (nuclear receptor subfamily 1, group H, member 4) or bile acid receptor (BAR), is a nuclear receptor that is
Farnesoid_X_receptor
Protein-coding gene in the species Homo sapiens
receptor family of steroid hormone receptors. No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol
Estrogen-related receptor gamma
Estrogen-related_receptor_gamma
Protein-coding gene in the species Homo sapiens
septum, striatum, and hypothalamus. Historically classified as an orphan receptor, activated only by L-tryptophan and L-phenylalanine in very high concentrations
GPR139
Pharmaceutical compound
orphan receptor GPR139. It has been used to investigate the structure and function of the GPR139 receptor, and its interactions with other receptors with
TC-O_9311
Mammalian protein found in Homo sapiens
Willson TM, Moore JT, Kliewer SA (September 1998). "The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression
Pregnane_X_receptor
Mammalian protein found in humans
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by
Androgen_receptor
Pharmaceutical compound
compound which acts as a small-molecule agonist of the previously orphan receptor GPR139. It has been used to investigate the role of GPR139 in various
JNJ-63533054
Protein-coding gene in the species Homo sapiens
Capone JP (1996-04-19). "The Orphan Nuclear Hormone Receptor LXRα Interacts with the Peroxisome Proliferator-activated Receptor and Inhibits Peroxisome Proliferator
Retinoid_X_receptor_alpha
Mammalian protein found in humans
be a receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor. It is now classified as a chemokine receptor able to
ACKR3
Protein-coding gene in the species Homo sapiens
estrogens did not regulate ERRα. Currently, ERRα is considered an orphan nuclear receptor. ERRα has wide tissue distribution but it is most highly expressed
Estrogen-related receptor alpha
Estrogen-related_receptor_alpha
Protein family
structure to CC chemokine receptors than to other CXC chemokine receptors. ACKR3 was originally called RDC-1 (an orphan receptor) but has since been shown
CXC_chemokine_receptors
Nuclear receptor
Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear
Liver_X_receptor
Pharmaceutical compound
selective antagonist (or perhaps inverse agonist) of the receptor RAR-related orphan receptor gamma (RORγ). It has anti-inflammatory effects and has been
Bevurogant
Protein-coding gene in the species Homo sapiens
nociceptin opioid peptide receptor (NOP), also known as the nociceptin/orphanin FQ (N/OFQ) receptor or kappa-type 3 opioid receptor, is a protein that in
Nociceptin_receptor
Protein-coding gene in the species Homo sapiens
membrane proteins which binds neuropeptide S (NPS). It was formerly an orphan receptor, GPR154, until the discovery of neuropeptide S as the endogenous ligand
Neuropeptide_S_receptor
Protein-coding gene in humans
Martinoli MG, Simha D, Moore DD (Mar 1994). "A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic
Constitutive androstane receptor
Constitutive_androstane_receptor
Class of 33 human protein receptors
majority of the adhesion GPCRs are orphan receptors and work is underway to de-orphanize many of these receptors. Adhesion GPCRs get their name from
Adhesion G protein-coupled receptor
Adhesion_G_protein-coupled_receptor
Pharmaceutical compound
a drug which acts as both a selective antagonist of the receptor RAR-related orphan receptor gamma (RORγ), and also an inhibitor of the enzyme dihydroorotate
Izumerogant
Chemical compound
identified as an endogenous ligand for the sigma-2 receptor, which had previously been considered an orphan receptor since its discovery in 1990. Griffiths, William
20S-Hydroxycholesterol
Protein-coding gene in the species Homo sapiens
Nr5a2 was recently identified at a totipotent pioneer factor. The orphan nuclear receptor Nr5a2 has been shown to be important in fertility, ovarian function
Liver_receptor_homolog-1
Protein-coding gene in the species Homo sapiens
Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear
Estrogen_receptor_alpha
American molecular biologist
identified the bile acid and xenobiotic ligands of farnesoid X-receptor, an orphan nuclear receptor he had first purified in 1995, and an upstream regulator
David_Moore_(biologist)
Japanese molecular biologist
endothelin receptor can cause Hirschsprung's disease. Eventually, his interest in endothelin diminished and Yanagisawa switched his focus to orphan receptors, which
Masashi_Yanagisawa
Pharmaceutical compound
which acts as a potent and selective inverse agonist of the receptor RAR-related orphan receptor gamma (RORγ). It has anti-inflammatory effects mediated by
GSK2981278
Protein-coding gene in the species Homo sapiens
makes TLR10 unique among the TLR family. TLR10 was thought to be an "orphan" receptor, however, recent studies have identified ligands for TLR10 and these
Toll-like_receptor_10
Members of the nuclear receptor family of intracellular transcription factors
separate gene (NR2C1 and NR2C2 respectively). These two receptors are considered orphan receptors, but have important functions as transcription factors
Testicular_receptor
Chemical compound
were found to be potent agonists at the G protein-coupled receptor 35, an orphan receptor believed to play a role in inflammatory processes, pain and
Lodoxamide
Protein-coding gene in the species Homo sapiens
nitrogens. Since its discovery in 1990, the sigma-2 receptor has been considered an orphan receptor; however, in 2021 20S-hydroxycholesterol was identified
Sigma-2_receptor
Protein-coding gene in the species Homo sapiens
"Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome
Formyl_peptide_receptor_2
Protein
ROR2 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family. The protein encoded by this gene is a receptor tyrosine kinase and type
ROR2
Topics referred to by the same term
RAR-related orphan receptor, a family of nuclear receptors in molecular biology ROR, abbreviation for receptor tyrosine kinase-like orphan receptors, a family
Ror_(disambiguation)
Biological mechanism that controls circadian rhythm
retinoic acid-related orphan nuclear receptors. REV-ERBa and RORa subsequently compete to bind Retinoid-related orphan receptor response element|retinoic
Circadian_clock
Protein found in humans
mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of
Small_heterodimer_partner
Protein-coding gene in the species Homo sapiens
The nuclear receptor 4A2 (NR4A2) (nuclear receptor subfamily 4 group A member 2) also known as nuclear receptor related 1 protein (NURR1) is a protein
Nuclear_receptor_4A2
Molecular biologist
receptors and discovered the D4 receptor, of importance in psychiatry. Civelli then invented the strategy that uses orphan receptors to discover new neurotransmitters
Olivier_Civelli
Protein-coding gene in the species Homo sapiens
gene. Along with the other previously orphan receptors GPR55 and GPR119, GPR18 has been found to be a receptor for endogenous lipid neurotransmitters
NAGly_receptor
Protein found in humans
Retinoic acid receptor alpha (RAR-α), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1), is a nuclear receptor that in humans is encoded
Retinoic_acid_receptor_alpha
Pharmaceutical compound
(LYC-55716) is a drug which acts as a selective agonist of the receptor RAR-related orphan receptor gamma (RORγ). It was developed for the treatment of certain
Cintirorgon
Protein-coding gene in the species Homo sapiens
et al. (September 2002). "Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility". Circulation Research. 91 (5):
Apelin_receptor
Protein family
InterPro: IPR003056 CD97 EMR hormone receptor InterPro: IPR001740 CELSR1; CELSR2; CELSR3; EMR1; EMR2; EMR3; EMR4 GPR56 orphan receptor InterPro: IPR003910 GPR56;
Secretin_receptor_family
Protein-coding gene in the species Homo sapiens
autoregulation and regulation by retinoic acid receptor-related orphan receptor alpha (RORɑ), another nuclear receptor transcription factor. NR1D1 also contains
Rev-ErbA_alpha
American multinational pharmaceutical company
an antibody-drug conjugate designed to target Tyrosine kinase-like orphan receptor 1 (ROR1) in both hematological and solid tumors. VLS-101 is currently
Merck_&_Co.
Japanese light novel series
explained by his possession of a rare biological characteristic termed an “Orphan Receptor,” which allows him to receive, store, and discharge electrical charges
Occultic;Nine
Protein-coding gene in the species Homo sapiens
Hermansson NO, Leonova J, et al. (Dec 2007). "The orphan receptor GPR55 is a novel cannabinoid receptor". British Journal of Pharmacology. 152 (7): 1092–1101
GPR55
Chemical activating melatonin receptors
Melatonin receptor agonists are analogues of melatonin that bind to and activate the melatonin receptor. Agonists of the melatonin receptor have a number
Melatonin_receptor_agonist
Pharmaceutical compound
which acts as a potent and selective partial agonist of the previously orphan receptor GPR32 (DRV1/RvD1). It stimulates phagocytosis by macrophages in a similar
NCGC00135472
Chemical compound
CGP 52608 is a selective ligand of the RAR-related orphan receptor alpha. It has been used as a biochemical tool to investigate nuclear and membrane signaling
CGP_52608
Protein-coding gene in the species Homo sapiens
Aurora A kinase, CD29 NME3, Protein SET, RAR-related orphan receptor alpha, RAR-related orphan receptor beta, and TERF1. Nucleoside-diphosphate kinase GRCh38:
NME1
Subclass of purinergic P2 receptors
P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as adenosine triphosphate, adenosine diphosphate,
P2Y_receptor
G-protein coupled receptor which binds free fatty acids
as an orphan receptor, i.e., a receptor whose naturally occurring activator(s) is unclear. GPR109A is also termed hydroxycarboxylic acid receptor 2, niacin
Free_fatty_acid_receptor
Protein family
a true (signaling) chemokine receptor. CCR10 is receptor for CCL27 and CCL28 that was originally called orphan receptor GPR2. CCR10 has been implicated
CC_chemokine_receptors
Protein-coding gene in the species Homo sapiens
group H, member 2). The liver X receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands
Liver_X_receptor_beta
Protein-coding gene in humans
Adhesion G protein-coupled receptor L4 is a latrophilin-like orphan receptor of the adhesion G protein-coupled receptor family. In humans this protein
ADGRL4
Neuropeptide that regulates arousal, wakefulness, and appetite
the orexin system as orphan receptors. To this end, they used transgenic cell lines that expressed individual orphan receptors and then exposed them
Orexin
Family of proteins
Rhodopsin-like receptors are a family of proteins that comprise the largest group of G protein-coupled receptors. G-protein-coupled receptors, GPCRs, constitute
Rhodopsin-like_receptors
Group of G protein-coupled receptors
Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression is induced
Retinoic acid-inducible orphan G protein-coupled receptor
Retinoic_acid-inducible_orphan_G_protein-coupled_receptor
Protein-coding gene in the species Homo sapiens
cells to astrocyte-like neural stem cells. TLX was previously an orphan receptor, a receptor without a known endogenous ligand. However, it is now known that
TLX
American biomedical scientist (born 1959)
et al. (December 1997). "An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors". Molecular Cell. 1 (1): 25–34
George_Yancopoulos
Drug increasing motivation in humans
Zhang R, Chen J (December 2023). "Research progress on the role of orphan receptor GPR139 in neuropsychiatric behaviours". Eur J Pharmacol. 960 176150
Motivation-enhancing_drug
Orphan nuclear receptor
The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of
Estrogen-related_receptor
Protein-coding gene in the species Homo sapiens
RN, Forli S, Martemyanov KA (March 2023). "Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR". Science. 379 (6639): 1352–1358. Bibcode:2023Sci
GPR158
Protein-coding gene in the species Homo sapiens
Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear
Estrogen_receptor_beta
Protein-coding gene in the species Homo sapiens
various other glutamate agonists. delta iGluRs have long been considered orphan receptors as their endogenous ligand was unknown. They are now believed to bind
GRID2
Mammalian protein found in Homo sapiens
gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54". The Journal of Biological Chemistry. 276 (37): 34631–34636
KiSS1-derived peptide receptor
KiSS1-derived_peptide_receptor
Class of G protein-coupled receptors
The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline)
Adrenergic_receptor
Nuclear receptors that bind to retinoids
elements. Subtypes include: Retinoic acid receptors (RARs) Retinoid X receptors (RXRs) RAR-related orphan receptors (RORs) Bastien, Julie; Rochette-Egly,
Retinoid_receptor
BDNF-modulating drug for depression and PTSD
regulator of hippocampal neurogenesis in the brain. Previously an orphan receptor, the TLX is now known to have the fatty acid oleic acid as an endogenous
Amdiglurax
Pharmaceutical compound
derivative of tryptamine. The drug is a low-potency agonist of the orphan receptor GPRC5A, with an EC50Tooltip half-maximal effective concentration of
7-Fluorotryptamine
G-protein coupled receptor
acid-inducible orphan G protein-coupled receptors (RAIG) RAIG1 (GPRC5A) RAIG2 (GPRC5B) RAIG3 (GPRC5C) RAIG4 (GPRC5D) Taste receptor Taste receptor, type 1,
Class_C_GPCR
Protein-coding gene in the species Homo sapiens
1997). "Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation
Germ_cell_nuclear_factor
Chemical used in plastics, xenoestrogen
interfering with LH receptor-ligand binding. Bisphenol A's interacts with the estrogen-related receptor γ (ERR-γ). This orphan receptor (endogenous ligand
Bisphenol_A
Protein-coding gene in the species Homo sapiens
receptor (i.e., a receptor that stimulates cells by activating G proteins) was identified. Its protein product was classified as an orphan receptor,
OXGR1
Protein-coding gene in the species Homo sapiens
CN, et al. (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function". Molecular and Cellular
V-erbA-related_gene
Protein found in humans
(Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene. This protein is an orphan nuclear receptor, but
COUP-TFI
Protein-coding gene in the species Homo sapiens
Retinoic acid receptor gamma (RAR-γ), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG
Retinoic_acid_receptor_gamma
Chemical compound
pyrvinium pamoate. Pamoic acid has agonist activity for the orphan G protein-coupled receptor GPR35 by which it activates ERK and beta-arrestin2, and causes
Pamoic_acid
Topics referred to by the same term
RORC may refer to: RAR-related orphan receptor gamma, encoded by the RORC gene Royal Ocean Racing Club Russian Orthodox Old-Rite Church This disambiguation
RORC
Chemical compound
an antagonist at the former orphan receptor GPR18, and is the first selective antagonist characterised for this receptor, with an IC50 of 279nM, and good
PSB-CB5
Protein-coding gene in the species Homo sapiens
terminalis. When originally discovered in 1995, these receptors had no known ligands ("orphan receptors") and were called GPR7 and GPR8, but at least three
Neuropeptides_B/W_receptor_1
Protein-coding gene in the species Homo sapiens
Dyson HJ, Wright PE (April 2003). "Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site
Estrogen-related receptor beta
Estrogen-related_receptor_beta
Chemical compound
the former orphan receptor GPR55. Unlike older GPR55 antagonists such as O-1918, PSB-SB-487 has good selectivity over the related receptor GPR18, with
PSB-SB-487
Protein found in humans
Chrousos GP, Kino T (April 2004). "The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor
COUP-TFII
Protein-coding gene in the species Homo sapiens
interaction with the transcriptional activator Retinoic Acid Receptor-related Orphan Receptor (ROR) and a direct repeat 2 element of RORE known as RevDR2
Rev-ErbA_beta
Synthetic, cannabinoid-like compound
identification of this novel target in microglia as the previously orphan receptor GPR18. Another possible target of abnormal cannabidiol is GPR55, which
Abnormal_cannabidiol
ORPHAN RECEPTOR
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