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Search references for GPR139. Phrases containing GPR139
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Protein-coding gene in the species Homo sapiens
G-protein coupled receptor 139 (GPR139) is a G protein-coupled receptor that in humans is encoded by the GPR139 gene. It is coupled to the Gq/11 pathway
GPR139
Drug increasing motivation in humans
of agomelatine in humans has been questioned and is controversial. The GPR139 agonist zelatriazin (TAK-041; NBI-1065846) has shown pro-motivational effects
Motivation-enhancing_drug
Group of biological receptors
derived from hybridization of two or more of the known opioid receptors. GPR139 has been identified as a novel opioid receptor, specifically of dynorphins
Opioid_receptor
Opioid peptide
κ-opioid receptor (KOR). It produces one of the strongest responses at GPR139 receptor among dynorphins. Additionally, it uniquely modulates NMDA receptor
Big_dynorphin
Chemical compound
Zelatriazin (NBI-1065846 or TAK-041) is a small-molecule agonist of GPR139. It was developed for schizophrenia and anhedonia in depression but trials were
Zelatriazin
Pharmaceutical compound
of the previously orphan receptor GPR139. It has been used to investigate the structure and function of the GPR139 receptor, and its interactions with
TC-O_9311
Pharmaceutical compound
small-molecule agonist of the previously orphan receptor GPR139. It has been used to investigate the role of GPR139 in various behavioral processes including sleep
JNJ-63533054
Chemical compound
which acts as a small-molecule antagonist of the previously orphan receptor GPR139. It has been shown to modulate dopamine release in the brain via interaction
JNJ-3792165
Protein-coding gene in the species Homo sapiens, named for ketazocine
peptides as the primary endogenous ligands, the other being newly deorphanized GPR139 receptor. In addition, oxytocin was found to be a positive allosteric modulator
Κ-opioid_receptor
Metabolite of the amino acid tryptophan
in animals. Tryptamine has been found to act as a potent agonist of the GPR139 and to be involved in sleep regulation. In a published clinical study, tryptamine
Tryptamine
Investigational cognition and memory disorder drugs
– klotho modulator [115] Zelatriazin (TAK-041; NBI-1065846; NBI-846) – GPR139 agonist [116] Zervimesine (CT-1812; Elayta) – sigma σ2 receptor antagonist
List of investigational cognition and memory disorder drugs
List_of_investigational_cognition_and_memory_disorder_drugs
List of pharmaceutical drugs under clinical development for treatment of depression
Zelatriazin (TAK-041; NBI-1065846; NBI-846) – G protein-coupled receptor 139 (GPR139) agonist Ziprasidone (Geodon) – atypical antipsychotic (non-selective monoamine
List of investigational antidepressants
List_of_investigational_antidepressants
Q96N19 6557 GPR137B HGNC:11862; O60478 6558 GPR137C HGNC:25445; Q8N3F9 6559 GPR139 HGNC:19995; Q6DWJ6 6560 GPR141 HGNC:19997; Q7Z602 6561 GPR142 HGNC:20088;
List of human protein-coding genes 3
List_of_human_protein-coding_genes_3
Investigational antipsychotics
psychotic disorders [250] Zelatriazin (TAK-041; NBI-1065846; NBI-846) – GPR139 agonist – schizophrenia [251] Chlorpromazine (Thorazine, Largactil) – dopamine
List of investigational antipsychotics
List_of_investigational_antipsychotics
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