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Protein found in humans
Homolog 3 (MSH3) is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system. MSH3 typically
MSH3
Group of diseases involving cell growth
instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–08. doi:10.1093/carcin/bgl079. PMC 2612936
Cancer
Cancer of the colon or rectum
genetic events, hypermutated tumors display mutated forms of ACVR2A, TGFBR2, MSH3, MSH6, SLC9A9, TCF7L2, and BRAF. The common theme among these genes, across
Colorectal_cancer
Protein-coding gene in the species Homo sapiens
to make the human MutSα mismatch repair complex. It also dimerizes with MSH3 to form the MutSβ DNA repair complex. MSH2 is involved in many different
MSH2
Cellular mechanism
instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–08. doi:10.1093/carcin/bgl079. PMC 2612936
DNA_repair
Protein-coding gene in Homo sapiens
although hMSH2 itself can function as a homomultimer or as a heterodimer with hMSH3. Mismatches commonly occur as a result of DNA replication errors, genetic
MSH6
Tumor or other abnormal growth of tissue
instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079. PMC 2612936
Neoplasm
Subtype of DNA
performed in DT40 cells upon removal of MSH3, an essential protein in MMR. The resulting microDNA from the DT40 MSH3-/- cell line had a higher enrichment
MicroDNA
Malignancy that develops from epithelial cells
instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–2408. doi:10.1093/carcin/bgl079
Carcinoma
British neurologist and neuroscientist
important new genetic modifier of disease progression in Huntington's disease (MSH3, a mismatch repair protein), which has opened up new avenues of research
Sarah_Tabrizi
System for fixing base errors of DNA replication
eukaryotes, MutS homologs form two major heterodimers: Msh2/Msh6 (MutSα) and Msh2/Msh3 (MutSβ). The MutSα pathway is involved primarily in base substitution and
DNA_mismatch_repair
Mammalian protein found in Homo sapiens
endonuclease 1 GADD45A GADD45G HDAC1 HUS1 ING1 KCTD13 KIAA0101 Ku70 Ku80 MCL1 MSH3 MSH6 MUTYH P21 POLD2 POLD3 POLDIP2 POLH POLL RFC1 RFC2 RFC3 RFC4 RFC5 Ubiquitin
Proliferating cell nuclear antigen
Proliferating_cell_nuclear_antigen
Topics referred to by the same term
gland, and related to skin pigmentation DNA mismatch repair genes: MSH2 MSH3 MSH4 MSH5 MSH6 Multiple system atrophy Mycothiol, an unusual thiol that is
MSH
Gene known for its role in breast cancer
ESR1 FANCA FANCD2 FHL2 H2AFX JUNB JunD LMO4 MAP3K3 MED17 MED21 MRE11A MSH2 MSH3 MSH6 Myc NBN NMI NPM1 NCOA2 NUFIP1 P53 PALB2 POLR2A PPP1CA Rad50 RAD51 RBBP4
BRCA1
Growth found in bowel wall
syndrome Several genes have been associated with polyposis, such as GREM1, MSH3, MLH3, NTHL1, RNF43 and RPS20. Familial adenomatous polyposis (FAP) is a
Colorectal_polyp
Biological process
"Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease". J. Biol. Chem. 289 (9): 5664–73. doi:10.1074/jbc
Chromosome_segregation
Protein family
alpha-helices, which is similar to the structure of tRNA endonuclease. Yeast MSH3, bacterial proteins involved in DNA mismatch repair, and the predicted protein
MutS-1
Formation of cancer
instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079. PMC 2612936
Carcinogenesis
Tumor of the glial cells of the brain or spine
instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079. PMC 2612936
Glioma
Cell death resulting from a deficiency of or interaction between in two or more genes
instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079. PMC 2612936
Synthetic_lethality
Branched nucleic acid structure
"Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease". J. Biol. Chem. 289 (9): 5664–73. doi:10.1074/jbc
Holliday_junction
Protein-coding gene in humans
The seven DNA mismatch repair proteins in humans are MLH1, MLH3, MSH2, MSH3, MSH6, PMS1 and PMS2. In addition, there are Exo1-dependent and Exo1-independent
MLH1
Damaging changes to a biological cell
instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–2408. doi:10.1093/carcin/bgl079
Cell_damage
Accumulation of mutations
of genetic mutations. Deficiency of DNA repair proteins PMS2, MLH1, MSH2, MSH3, MSH6 or BRCA2 can cause up to 100-fold increases in mutation frequency Epigenetic
Somatic_evolution_in_cancer
High frequency of mutations within the genome of a cellular lineage
instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079. PMC 2612936
Genome_instability
Wildlife sanctuary in Maharashtra, India
The sanctuary is closed on Mondays. Traveling on the Wardha-Nagpur road MSH3, one must turn north at Seloo for Hingi and then to the visitor center at
Bor_Wildlife_Sanctuary
Protein-coding gene in humans
"Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease". J. Biol. Chem. 289 (9): 5664–73. doi:10.1074/jbc
MLH3
HGNC:7321; O60682 9900 MSGN1 HGNC:14907; A6NI15 9901 MSH2 HGNC:7325; P43246 9902 MSH3 HGNC:7326; P20585 9903 MSH4 HGNC:7327; O15457 9904 MSH5 HGNC:7328; O43196
List of human protein-coding genes 5
List_of_human_protein-coding_genes_5
Telangana border via MSH 264) Amravati. Wardha MH SH 244 (From Yavatmal via MSH3) – Pulgaon – Arvi – Talegaon (on NH6) – Ashti – Warud to Multai (MP) Wardha
List of state highways in Maharashtra
List_of_state_highways_in_Maharashtra
DNA mutation involving an increase in number of trinucleotide repeats
intermediate can avoid mismatch repair due to its affinity for the MSH-2-MSH3 complex, which stabilizes the hairpin instead of repairing it. In non-dividing
Trinucleotide repeat expansion
Trinucleotide_repeat_expansion
Protein-coding gene in the species Homo sapiens
number of key interactions with mismatch repair protein complexes MLH1, MSH2, MSH3, and MSH6. Also, it has known interaction in the following repair mechanisms:
RAD9A
Field of study in cancer research
instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–2408. doi:10.1093/carcin/bgl079
Cancer_epigenetics
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MSH3
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