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Group of anti-viral cytokines
The type III interferon group is a group of anti-viral cytokines that in humans consists of a singular family, IFN-λ (lambda). Their function is similar
Interferon_type_III
Signaling proteins released by host cells in response to the presence of pathogens
further induction of Th1 immune response. Interferon type III IFN type III signals through the interferon-lambda receptor (IFNLR) consisting of IL10R2
Interferon
Cytokine
The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses
Interferon_type_I
InterPro Family
Interferon gamma (IFN-γ) is a family of dimerized soluble cytokines in the type II class of interferons. In humans, IFN-γ is the only type II family and
Interferon_gamma
Transmembrane proteins
for interferon types, I, II, and III are all known. Type II cytokine receptors are tyrosine-kinase-linked receptors. The intracellular domain of type II
Type_II_cytokine_receptor
Protein-coding gene in the species Homo sapiens
beta (IL10RB). The receptor complex has been shown to interact with interferon type III (IL28A, IL28B, IL29). The expression of all three cytokines can be
Interferon_lambda_receptor_1
Interleukin
stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and
Interleukin_12
Formation of blood cellular components
the unique ability to give rise to all of the different mature blood cell types and tissues. HSCs are self-renewing cells: when they differentiate, at least
Haematopoiesis
Pharmaceutical drug
Pegylated interferon alfa-2b is a drug used to treat melanoma, as an adjuvant therapy to surgery. Also used to treat hepatitis C (typically, in combination
Peginterferon_alfa-2b
Pharmaceutical drug
Interferon alfa-2b is an antiviral or antineoplastic drug. It is a recombinant form of the protein interferon alpha-2 that was originally sequenced and
Interferon_alfa-2b
Immune system messenger protein which induces inflammation
interferon-γ, and TNF itself. TNF transcription is activated by a variety of signaling pathways and transcription factors, depending on the cell type
Tumor_necrosis_factor
Pharmaceutical drug
Pegylated interferon alfa-2a, sold under the brand name Pegasys among others, is medication used to treat hepatitis C and hepatitis B. For hepatitis C
Peginterferon_alfa-2a
Category of small signaling proteins
cancer patients. Interferon gamma is used to treat chronic granulomatous disease and osteopetrosis Interferon-alpha, an interferon type I, was identified
Cytokine
Cytokine protein
LT, Sehgal PB, Ruddle FH (April 1988). "Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene
Interleukin_6
Mammalian protein found in Homo sapiens
virus type 1 infection induces upregulation of interleukin-23 (p19) mRNA expression in trigeminal ganglia of BALB/c mice". Journal of Interferon & Cytokine
Interleukin_23_subunit_alpha
Group of cytokines
6 (IL6), also referred to as B-cell stimulatory factor-2 (BSF-2) and interferon beta-2, is a cytokine involved in a wide variety of biological functions
Interleukin
Heterodimeric cytokine acting as mediator of inflammation
killer cells also express the IL-23 receptor. They respond with increased interferon-γ secretion and enhanced antibody-dependent cellular cytotoxicity. IL-23
Interleukin_23
Gene that can be expressed in response to stimulation by interferon
controlling intracellular pathogens and tumor suppressor genes. Type III interferon consists of INF-λ and is associated with viral immune response and
Interferon-stimulated_gene
Type of signaling molecule
(IL-1), IL-6, IL-12, and IL-18, tumor necrosis factor alpha (TNF-α), interferon gamma (IFNγ), and granulocyte-macrophage colony stimulating factor (GM-CSF)
Inflammatory_cytokine
Veterinary medication
alpha interferons, but the Ueda team deemed it an "omega-type" interferon due to some motifs. Phylogenic analysis in 2007 puts it as an alpha-type interferon
Recombinant feline interferon omega
Recombinant_feline_interferon_omega
Group of cytokine proteins
PMID 8666798. S2CID 30629282. Billiau A (1996). "Interferon-γ: Biology and Role in Pathogenesis". Interferon-gamma: biology and role in pathogenesis. Advances
Interleukin-1_family
Mammalian protein found in humans
C-X-C motif chemokine ligand 10 (CXCL10), also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10, is an 8.7 kDa protein
CXCL10
Protein-coding gene in the species Homo sapiens
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene. The protein encoded by
Interleukin_18
Mammalian protein found in Mus musculus
S2CID 85495400. Apte SH, Baz A, Groves P, Kelso A, Kienzle N (November 2008). "Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T
Interleukin_4
Type II cytokine receptor
cytokine receptor found largely in epithelial cells. It binds the type III interferons (IFN-λs), which in humans include IFN-λ1 (IL29), IFN-λ2 (IL28A),
Interferon-lambda_receptor
Molecules involved in immune response
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
Transfer_factor
Mammalian protein found in humans
CXC chemokine family that is also known as monokine induced by gamma interferon (MIG). CXCL9 is one of the chemokines that play a role chemotaxis induction
CXCL9
Class of proteins produced by muscle
in 2002 by two independent groups of researchers. Irisin (fibronectin type III domain-containing protein 5 or FNDC5), a recently described myokine hormone
Myokine
Mammalian protein found in humans
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
CCL8
Mammalian protein found in humans
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
CCL28
Type of cytokine produced primarily by monocytes and macrophages
monokines are: interleukin 1 tumor necrosis factor-alpha alpha and beta interferon colony stimulating factors Monokines released from macrophages can attract
Monokine
Protein family
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
Macrophage inflammatory protein
Macrophage_inflammatory_protein
Protein-coding gene in the species Homo sapiens
Interferon beta is a protein that in humans is encoded by the IFNB1 gene. The natural and recombinant protein forms have antiviral, antibacterial, and
IFNB1
Mammalian protein found in humans
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
CCL22
Pharmaceutical drug
used to treat polycythemia vera and essential thrombocythemia. It is an interferon. It is given by injection. The most common side effects include low levels
Ropeginterferon_alfa-2b
Protein-coding gene in the species Homo sapiens
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
Interleukin_37
Cytokine with structural similarity to Interleukin-2
oligonucleotides, lipopolysaccharide (LPS) through Toll-like receptors (TLR), interferon gamma (IFN-γ) or after infection of monocytes herpes virus, Mycobacterium
Interleukin_15
Mammalian protein found in humans
Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system. It regulates the activities of
Interleukin_2
Protein-coding gene in the species Homo sapiens
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
Cardiotrophin_1
Mammalian protein found in Homo sapiens
et al. (February 1996). "Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state". The EMBO
Oncostatin_M
Mammalian protein found in Homo sapiens
repeat) type of inflammasome is activated by various stimuli and there are documented several diseases connected to NLRP3 activation like type 2 diabetes
Interleukin_1_beta
Cytokine in the interferon family
Interferon beta-1b is a cytokine in the interferon family used to treat the relapsing-remitting and secondary-progressive forms of multiple sclerosis (MS)
Interferon_beta-1b
Protein-coding gene in the species Homo sapiens
Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene. Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon
Interferon_alpha-1
Family of interleukins
and IL-26. Some sources also include the type III interferons IL-28 and IL-29. It is well-accepted interferons are class 2 cytokines just like the IL-10
IL-10_family
Protein-coding gene in humans
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
C-C_motif_chemokine_ligand_24
Protein-coding gene in the species Homo sapiens
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
Interleukin_16
Mammalian protein found in humans
IL-10, IL-35, transforming growth factor-beta 1 (TGF-β1), interferon-alpha (IFN-α), interferon-beta (IFN-β), glucocorticoids (GCs), lipoxins, vitamin D
Interleukin_8
Protein-coding gene in the species Homo sapiens
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
Interleukin 36 receptor antagonist
Interleukin_36_receptor_antagonist
Mammalian protein found in humans
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
CXCL14
Protein-coding gene in the species Homo sapiens
preferentially expressed by alpha beta TCR + CD4-CD8-T cells". Journal of Interferon & Cytokine Research. 16 (8): 611–617. doi:10.1089/jir.1996.16.611. PMID 8877732
Interleukin-17A
Cytokine produced by lymphocytes
Interleukin 5 Interleukin 6 Granulocyte-macrophage colony-stimulating factor Interferon-gamma The T helper cell secretes many lymphokines that are important when
Lymphokine
Protein and coding gene in humans
L, Marquet S, et al. (October 2004). "Interleukin-13 in the skin and interferon-gamma in the liver are key players in immune protection in human schistosomiasis"
Interleukin_13
Protein-coding gene in the species Homo sapiens
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
FMS-like tyrosine kinase 3 ligand
FMS-like_tyrosine_kinase_3_ligand
Mammalian protein found in humans
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
CCL19
Protein or other substance that stimulates cellular proliferation
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
Growth_factor
InterPro Family
histocompatibility complex, and adhesion molecules. LT-αβ, which is produced by activated Type 1 T helper cells (Th1), CD8+ T cells, and natural killer (NK) cells, is known
Lymphotoxin
Protein-coding gene in the species Homo sapiens
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
Interleukin_20
Protein found in humans
receptors for human tumour necrosis factor and their regulation by gamma-interferon". Nature. 318 (6047): 665–667. doi:10.1038/318665a0. PMID 3001529. Ruddle
Lymphotoxin_alpha
Anti-inflammatory cytokine
IL-24 (Mda-7), IL-26 and interferons type-I (IFN-alpha, -beta, -epsilon, -kappa, -omega), type-II (IFN-gamma) and type-III (IFN-lambda, including IL-28A
Interleukin_10
Protein-coding gene in the species Homo sapiens
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
Alpha-taxilin
Protein found in humans
immunosuppressive cell types in some cancer types. These effects of IL-32 support tumor growth. On the other hand, in other cancer types it can also induce
Interleukin_32
Protein-coding gene in the species Homo sapiens
PMID 1385305. Shirazi Y, Pitha PM (1993). "Interferon alpha-mediated inhibition of human immunodeficiency virus type 1 provirus synthesis in T-cells". Virology
IFNA16
Protein and coding gene in humans
(March 2023). "Tumour necrosis factor alpha, interleukin 1 beta and interferon gamma have detrimental effects on equine tenocytes that cannot be rescued
Interleukin-1 receptor antagonist
Interleukin-1_receptor_antagonist
Mammalian protein found in Homo sapiens
protein that in humans is encoded by the TNFSF11 gene. RANKL is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily
RANKL
Growth factor secreted by stromal cells in the bone marrow and thymus
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
Interleukin_7
Protein-coding gene in the species Homo sapiens
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
MST1
Protein-coding gene in the species Homo sapiens
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
Interleukin_34
Group of proteins
often referred to as CTLA8. The biologically active IL-17 interacts with type I cell surface receptor IL-17R. There are at least three variants of IL-17R
Interleukin_17
Protein-coding gene in the species Homo sapiens
in early antibody isotype switching. Interleukin 3 is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response
Interleukin_3
Mammalian protein found in humans
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
CXCL16
Mammalian protein found in humans
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
CCL3
Mammalian protein found in humans
muscle endothelial cells, epithelial cells, parenchymal cells and other cell types. After the binding of CCL5 to CCR5, phosphoinositide 3-kinase (PI3K) is
CCL5
Protein-coding gene in humans
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
CX3CL1
Protein family
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
OX40_ligand
Mammalian protein found in Homo sapiens
amino acids, respectively. All intron-exon boundaries are of the phase 0 type, thus alternative exon splicing maintains the reading frame of the OPN gene
Osteopontin
Mammalian protein found in humans
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
CCL23
Protein-coding gene in the species Homo sapiens
with IFNL4. Interferon lambda genes encode cytokines classified as type III interferons, which are distantly related to type I interferons and the IL-10
Interferon_lambda_3
Mammalian protein found in humans
concentration of cytoplasmic free calcium in monocytes but not in other type of cells. Furthermore, CCL1 inhibits apoptosis in thymic cell lines by the
CCL1
Mammalian protein found in humans
macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, and gamma interferon-inducible protein 10 by human neutrophils stimulated with group B meningococcal
CCL4
Mammalian protein found in humans
chemotactic protein-3 in mononuclear leukocytes and fibroblasts by interferon-alpha/beta and interferon-gamma reveals MCP-3 heterogeneity". European Journal of Immunology
CCL7
Mammalian protein found in humans
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
CXCL6
Mammalian protein found in Homo sapiens
recently reviewed. There are 3 types of IFNs: Interferon type I, Interferon type II and Interferon type III. The type II IFN, also called IFNγ, is produced
IFNA2
Protein that in humans is encoded by the IL33 gene
based in part on the molecules β-trefoil structure, a conserved structure type described in other IL-1 cytokines, including IL-1α, IL-1β, IL-1Ra and IL-18
Interleukin_33
Protein, encoded in humans by IL22 gene
(August 2010). "IL-28A, IL-28B, and IL-29: promising cytokines with type I interferon-like properties". Cytokine & Growth Factor Reviews. 21 (4): 237–51
Interleukin_22
Protein-coding gene
family of type I interferons. IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω are among the many cytokine subtypes that comprise the type I interferon family. A
IFNK
Protein-coding gene in the species Homo sapiens
chromosome 19, and encodes a 23 kDa protein. IL-11 is a member of the IL-6-type cytokine family, distinguished based on their use of the common co-receptor
Interleukin_11
Protein found in humans
interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-α) as well as interferon-gamma (IFN-γ). The expression of FasL in immune cells gets significantly
Fas_ligand
Protein involved in immune suppression
(July 2015). "Interleukin-35: Expanding Its Job Profile". Journal of Interferon & Cytokine Research. 35 (7): 499–512. doi:10.1089/jir.2015.0015. PMC 4507123
Interleukin_35
Protein-coding gene in humans
recognized by the ectodysplasin A receptor. The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form
Ectodysplasin_A
Small cytokines or signaling proteins secreted by cells
cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells. In addition to playing a major
Chemokine
Mammalian protein found in humans
S2CID 25314791. Huber MA, Kraut N, Addicks T, Peter RU (March 2000). "Cell-type-dependent induction of eotaxin and CCR3 by ionizing radiation". Biochemical
CCL11
Protein-coding gene in the species Homo sapiens
Interleukin-29 (IL-29) is a cytokine and it belongs to type III interferons group, also termed interferons λ (IFN-λ). IL-29 (alternative name IFNλ1) plays an
Interleukin_29
Mammalian protein found in humans
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
CXCL13
Protein found in humans
serum. The latter plays an important role in the vascular complications of type 2 diabetes. CCL2 induces amylin expression through ERK1/ERK2/JNK-AP1 and
CCL2
Protein-coding gene in the species Homo sapiens
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
IL36A
Mammalian protein found in humans
also been observed in eosinophils, and can be inhibited with the type II interferon IFN-γ. This chemokine stimulates the chemotaxis of neutrophils possessing
CXCL5
Mammalian protein found in humans
Other IL14 IL16 IL32 IL34 Type II IL10 family IL10/IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5
CCL26
Group of cytokines
activate the cytokines differentially. IL-36 is expressed by many cells types, most predominantly keratinocytes, respiratory epithelium, various nervous
Interleukin_36
Protein-coding gene in the species Homo sapiens
protein that in humans is encoded by the LTB gene. Lymphotoxin-beta (LTB) is a type II membrane protein belonging to the TNF family. It forms heterotrimers with
Lymphotoxin_beta
Protein involved in blood clotting, wound healing and inflammation
Patient With Monoclonal Gammopathy of Thrombotic Significance Unmasks New Type of Platelet-Activating Anti-Platelet Factor 4 Antibody". The Hematologist
Platelet_factor_4
INTERFERON TYPE-III
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INTERFERON TYPE-III
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INTERFERON TYPE-III
INTERFERON TYPE-III