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Protein found in humans
Interleukin 32 (IL32) is proinflammatory cytokine that in humans is encoded by the IL32 gene. Interleukin 32 can be found in higher mammals but not in
Interleukin_32
Group of cytokines
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes)
Interleukin
Cytokine protein
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the
Interleukin_6
Drugs to suppress IL-6 signalling
Anti-interleukin-6 agents are a class of therapeutics. Interleukin 6 is a cytokine relevant to many inflammatory diseases and many cancers. Hence, anti-IL6
Anti-interleukin-6
Protein-coding gene in the species Homo sapiens
Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene. IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor
IL31RA
Protein-coding gene in the species Homo sapiens
Interleukin 11 (IL-11 or adipogenesis inhibitory factor) is a protein that in humans is encoded by the IL11 gene. IL-11 is a cytokine that was first isolated
Interleukin_11
Type of cytokine
Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin 5
Interleukin_5
Protein-coding gene in the species Homo sapiens
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene. The protein encoded by
Interleukin_18
Mammalian protein found in humans
Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system. It regulates the activities of
Interleukin_2
Group of proteins
Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. They are produced by a group of T helper cell known as T helper
Interleukin_17
Protein-coding gene in the species Homo sapiens
Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. Sometimes also called colony-stimulating factor
Interleukin_3
Interleukin
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid
Interleukin_12
Mammalian protein found in humans
Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells,
Interleukin_8
Anti-inflammatory cytokine
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is
Interleukin_10
Protein, encoded in humans by IL22 gene
Interleukin-22 (IL-22) is a protein that in humans is encoded by the IL22 gene. IL-22 is an α-helical cytokine. IL-22 binds to a heterodimeric cell surface
Interleukin_22
Growth factor secreted by stromal cells in the bone marrow and thymus
Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone
Interleukin_7
Heterodimeric cytokine acting as mediator of inflammation
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit
Interleukin_23
Mammalian protein found in Homo sapiens
Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and
Interleukin_1_beta
Mammalian protein found in Homo sapiens
two subunits of the cytokine Interleukin-23. Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an Interleukin 23 alpha subunit and an IL-12p40
Interleukin_23_subunit_alpha
Monoclonal antibody against IL-17
psoriatic arthritis, and hidradenitis suppurativa. It binds to the protein interleukin (IL)-17A and is marketed by Novartis. Secukinumab is used to treat psoriasis
Secukinumab
Mammalian protein found in Mus musculus
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells
Interleukin_4
Drug used to treat allergic diseases
the brand name Dupixent, is a monoclonal antibody blocking interleukin 4 and interleukin 13 receptor signalling (IL-4R, IL-13R), used for allergic diseases
Dupilumab
Mammalian protein found in Homo sapiens
The interleukin-3 receptor (CD123) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune
Interleukin-3_receptor
Protein-coding gene in the species Homo sapiens
The interleukin 4 receptor is a type I cytokine receptor. It is a heterodimer, that is, composed of two subunits. IL4R is the human gene coding for IL-4Rα
Interleukin-4_receptor
Protein-coding gene in the species Homo sapiens
The interleukin-23 receptor is a type I cytokine receptor. It is encoded in human by the IL23R gene. In complex with the interleukin-12 receptor β1 subunit
Interleukin-23_receptor
Protein and coding gene in humans
Interleukin 13 (IL-13) and its relative interleukin-4 are signalling proteins of the adaptive immune systems of vertebrates. They are immunoregulatory
Interleukin_13
Group of cytokine proteins
The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to
Interleukin-1_family
Protein-coding gene in the species Homo sapiens
Interleukin-29 (IL-29) is a cytokine and it belongs to type III interferons group, also termed interferons λ (IFN-λ). IL-29 (alternative name IFNλ1) plays
Interleukin_29
Protein-coding gene in the species Homo sapiens
Interleukin-1 alpha (IL-1 alpha) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene. In
Interleukin_1-alpha
Protein that in humans is encoded by the IL33 gene
Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene. Interleukin 33 is a member of the IL-1 family that potently drives production
Interleukin_33
Pharmaceutical drug
antibody targeted at interleukin-1β. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha. Common side
Canakinumab
Protein-coding gene in the species Homo sapiens
Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. Interleukin 6 (IL6) is a potent pleiotropic
Interleukin-6_receptor
Pharmaceutical drug
disease. It is a slightly modified recombinant version of the human interleukin 1 receptor antagonist protein. It is marketed by Swedish Orphan Biovitrum
Anakinra
Protein in the species Homo sapiens
Interleukin-31 (IL-31) is a protein that in humans is encoded by the IL31 gene that resides on chromosome 12. IL-31 is an inflammatory cytokine that helps
Interleukin_31
Cell surface proteins
Interleukin-3 receptor Interleukin-4 receptor Interleukin-5 receptor Interleukin-6 receptor Interleukin-7 receptor Interleukin-9 receptor Interleukin-11 receptor
Interleukin_receptor
Protein-coding gene in the species Homo sapiens
Interleukin 34 (IL-34) is a protein belonging to a group of cytokines called interleukins. It was originally identified in humans, by large scale screening
Interleukin_34
Immunosuppressive drug
antibody of the immunoglobulin IgG1 subclass against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays an important role in
Tocilizumab
Protein-coding gene in the species Homo sapiens
Interleukin 9, also known as IL-9, is a pleiotropic cytokine (cell signalling molecule) belonging to the group of interleukins. IL-9 is produced by variety
Interleukin_9
Cytokine with structural similarity to Interleukin-2
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2
Interleukin_15
Biopharmaceutical drug
subcutaneous injection. The antibody targets a subunit of human interleukin 12 and interleukin 23, which are naturally occurring proteins that regulate the
Ustekinumab
Monoclonal antibody
used for the treatment of atopic dermatitis (atopic eczema). It is an interleukin 13 antagonist. It is given by subcutaneous injection. The most common
Lebrikizumab
Protein-coding gene in the species Homo sapiens
Interleukin-17A is a protein that in humans is encoded by the IL17A gene. In rodents, IL-17A used to be referred to as CTLA8, after the similarity with
Interleukin-17A
Monoclonal antibody
under the brand name Tremfya) is a human monoclonal antibody against interleukin-23 used for the treatment of plaque psoriasis, psoriatic arthritis, ulcerative
Guselkumab
Medication used to treat autoimmune diseases
form of a humanized monoclonal antibody. The substance acts by binding interleukin 17A and neutralizing it, reducing inflammation. The most common side
Ixekizumab
Protein and coding gene in humans
The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. IL-1RA was initially called the IL-1 inhibitor
Interleukin-1 receptor antagonist
Interleukin-1_receptor_antagonist
Protein-coding gene in the species Homo sapiens
Interleukin 16 is a pro-inflammatory pleiotropic cytokine. Its precursor, pro-interleukin-16 is a protein that in humans is encoded by the IL16 gene.
Interleukin_16
Pharmaceutical drug
human and mouse proteins) monoclonal antibody that binds to interleukin-6. It is an interleukin-6 (IL-6) antagonist. The common adverse reactions include
Siltuximab
Mammalian protein found in humans
Interleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene. Interleukin-21 is a cytokine that has potent regulatory effects on cells
Interleukin_21
Protein-coding gene in the species Homo sapiens
Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also denotes its human gene. The
Interleukin-9_receptor
Medication
Muckle–Wells syndrome; deficiency of interleukin-1 receptor antagonist; and recurrent pericarditis. Rilonacept is an interleukin 1 inhibitor. Rilonacept is a
Rilonacept
Protein-coding gene in the species Homo sapiens
Interleukin 19 (IL-19) is an immunosuppressive protein that belongs to the IL-10 cytokine subfamily. Human IL-19 is encoded by the IL19 gene which codes
Interleukin_19
Protein-coding gene in the species Homo sapiens
Interleukin 36 receptor antagonist (IL-36RA) is a member of the interleukin-36 family of cytokines. It was previously named Interleukin-1 family member
Interleukin 36 receptor antagonist
Interleukin_36_receptor_antagonist
Cell surface receptors specific for interleukin-5
The interleukin-5 receptor is a type I cytokine receptor. It is a heterodimer of the interleukin 5 receptor alpha subunit and CSF2RB. The IL-5 receptor
Interleukin-5_receptor
Protein found on the surface of cells
The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer
Interleukin-7_receptor
Protein-coding gene in the species Homo sapiens
Interleukin 20 (IL20) is a protein that is in humans encoded by the IL20 gene which is located in close proximity to the IL-10 gene on the 1q32 chromosome
Interleukin_20
Protein complex
Interleukin-15 receptor is a type I cytokine receptor, binding interleukin-15. The IL-15 receptor is composed of the IL-2Rβ and γc subunits, along with
Interleukin-15_receptor
Monoclonal antibody
of rheumatoid arthritis. It acts against the proinflammatory cytokine Interleukin 6 (IL-6). Sirukumab is currently under development by Johnson & Johnson's
Sirukumab
Chemical compound
drug, is an aglycosylated, humanized rabbit monoclonal antibody against interleukin-6. Clazakizumab was developed by Bristol Myers Squib and Alder Biopharmaceuticals
Clazakizumab
Type of interleukin receptor
Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human
Interleukin 1 receptor, type I
Interleukin_1_receptor,_type_I
Monoclonal antibody
States and in the European Union. Tildrakizumab was designed to block interleukin-23 (IL-23), a cytokine that plays a key role in managing the immune system
Tildrakizumab
Cytokine receptor which binds interleukin 1
Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1. Two forms of the receptor exist. The type I receptor is primarily responsible
Interleukin-1_receptor
Protein-coding gene in the species Homo sapiens
Interleukin-26 (IL-26) is a protein that in humans is encoded by the IL26 gene. IL-26 is the most recently identified member of the IL-20 cytokine subfamily
Interleukin_26
Monoclonal antibody
Fasenra, is a monoclonal antibody directed against the alpha chain of the interleukin-5 receptor (CD125). It was developed by MedImmune for the treatment of
Benralizumab
7-transmembrane protein
The interleukin-8 receptors (IL-8R) are two 7-transmembrane proteins in the G-protein coupled-receptor family: interleukin-8 receptor A (IL-8RA) and interleukin-8
Interleukin-8_receptor
Group of cytokines
Interleukin 36, or IL-36, is a group of cytokines in the IL-1 family with pro-inflammatory effects. The role of IL-36 in inflammatory diseases is under
Interleukin_36
Cell surface receptor for interleukin-10
Interleukin-10 receptor (IL-10R) is a type II cytokine receptor. The receptor is tetrameric, composed of 2α and 2β subunits. The α subunit (encoded in
Interleukin-10_receptor
Lymphocyte receptor specific for Interleukin-2
The interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds
IL-2_receptor
Protein-coding gene in the species Homo sapiens
Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R
Interleukin-7_receptor-α
Monoclonal antibody
improved with other treatments. Brodalumab binds to the interleukin-17 receptor and so prevents interleukin 17 (IL-17) from activating the receptor. This mechanism
Brodalumab
Monoclonal antibody medication
and prevents it from binding to its receptor, more specifically the interleukin 5 receptor alpha subunit, on the surface of eosinophil white blood cells
Mepolizumab
Protein-coding gene in the species Homo sapiens
beta of interleukin 12 (also known as IL-12B, natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor p40, or interleukin-12 subunit
Interleukin-12_subunit_beta
Immunoglobulin superfamily
very wide interleukin-1 receptor (IL-1R) family are characterized by extracellular immunoglobulin-like domains and intracellular Toll/Interleukin-1 receptor/Resistance
Interleukin-1_receptor_family
Mammalian protein found in Homo sapiens
The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2
IL2RA
Type I cytokine receptor for interleukin-27
The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit
Interleukin-27_receptor
Cytokine that belongs to the IL-17 cytokine family
Interleukin-25 (IL-25) – also known as interleukin-17E (IL-17E) – is a protein that in humans is encoded by the IL25 gene on chromosome 14. IL-25 was discovered
Interleukin_25
Protein-coding gene in the species Homo sapiens
Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human
Interleukin 1 receptor, type II
Interleukin_1_receptor,_type_II
Topics referred to by the same term
IL32 or IL-32 may be: Ilyushin Il-32, a Cold War-era Soviet heavy glider Interleukin 32, a proinflammatory cytokine Illinois Route 32, a state highway
Il-32
Human monoclonal antibody medication
name Kevzara, is a human monoclonal antibody medication against the interleukin-6 receptor. Regeneron Pharmaceuticals and Sanofi developed the drug for
Sarilumab
Monoclonal antibody
discontinued in the U.S. and Europe. Like ustekinumab, the antibody targets the interleukins 12 and 23. The candidate drug was discovered by Cambridge Antibody Technology
Briakinumab
Cell surface receptors for interleukin-13
The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by IL13RA1 and IL4R, respectively
Interleukin-13_receptor
Mammalian cytokine
Interleukin 40 (IL-40), also known with other name C17orf99, is a protein belonging to a group of cytokines called interleukins. It is encoded by a gene
Interleukin_40
Pharmaceutical drug
heterodimer) Interleukin 26 (signals through IL-20Rα/IL-10Rβ heterodimer) Interleukin 32 Interleukin 34 (signals through M-CSFR/CSF1R) Interleukin 35 Unsorted:
Basiliximab
Monoclonal antibody
arthritis and COVID-19. It is a humanized monoclonal antibody against the interleukin-6 (IL-6). IL-6 is a cytokine that plays an important role in immune response
Olokizumab
Protein-coding gene in the species Homo sapiens
Interleukin 20 receptor, beta subunit (IL20R2 or IL20RB) is a subunit of the interleukin-20 receptor and interleukin-22 receptor. It is believed to be
Interleukin 20 receptor, beta subunit
Interleukin_20_receptor,_beta_subunit
Protein involved in immune suppression
Interleukin 35 (IL-35) is an anti-inflammatory cytokine from the IL-12 family largely produced by regulatory T and B cells (Tregs and Bregs respectively)
Interleukin_35
Member of the interleukin 1 receptor family
The ST2 cardiac biomarker (also known as soluble interleukin 1 receptor-like 1) is a protein biomarker of cardiac stress encoded by the IL1RL1 gene. ST2
ST2_cardiac_biomarker
Interleukin receptor
The interleukin-18 receptor (IL-18R) is an interleukin receptor of the immunoglobulin superfamily. Endometrial IL-18 receptor mRNA and the ratio of IL-18
Interleukin-18_receptor
Protein-coding gene in the species Homo sapiens
Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene. The protein encoded by this gene is a cytokine receptor for interleukin
Interleukin-21_receptor
Protein-coding gene in the species Homo sapiens
Interleukin 24 (IL-24) is a protein in the interleukin family, a type of cytokine signaling molecule in the immune system. In humans, this protein is encoded
Interleukin_24
Monoclonal antibody
the treatment of atopic dermatitis. Tralokinumab targets the cytokine interleukin 13. The most common side effects include upper respiratory tract infections
Tralokinumab
Protein and coding gene in humans
Interleukin-12 receptor, beta 1, or IL-12Rβ1 in short, is a subunit of the interleukin 12 receptor and the interleukin 23 receptor. IL12RB1, is the name
Interleukin 12 receptor, beta 1 subunit
Interleukin_12_receptor,_beta_1_subunit
Type I cytokine receptor
Interleukin 12 receptor is a type I cytokine receptor, binding interleukin 12 and consisting of beta 1 and beta 2 subunits. Chua AO, Chizzonite R, Desai
Interleukin-12_receptor
Protein-coding gene in the species Homo sapiens
Interleukin 15 receptor, alpha subunit is a subunit of the interleukin 15 receptor that in humans is encoded by the IL15RA gene. The IL-15 receptor is
Interleukin 15 receptor, alpha subunit
Interleukin_15_receptor,_alpha_subunit
Protein-coding gene in the species Homo sapiens
lambda receptor encoded by the IFNLR1 gene. It was formerly known as interleukin 28 receptor, alpha subunit. IL28RA is its human gene. The protein encoded
Interferon_lambda_receptor_1
Receptors on the surface of cells
Interleukin-3 receptor Interleukin-4 receptor Interleukin-5 receptor Interleukin-6 receptor Interleukin-7 receptor Interleukin-9 receptor Interleukin-11 receptor
Type_I_cytokine_receptor
Protein-coding gene in the species Homo sapiens
Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene. In mice, CD4+ helper T-cells differentiate into type
Interleukin 27 receptor, alpha subunit
Interleukin_27_receptor,_alpha_subunit
Pharmaceutical drug
Cinqair and Cinqaero, is a humanized monoclonal antibody against human interleukin-5 (IL-5). Reslizumab binds specifically to IL-5, a key cytokine responsible
Reslizumab
Protein-coding gene in the species Homo sapiens
Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. Interleukin 11 is a stromal cell-derived
Interleukin 11 receptor alpha subunit
Interleukin_11_receptor_alpha_subunit
Type I cytokine receptor
The interleukin 11 receptor is a type I cytokine receptor, binding interleukin 11. It is a heterodimer composed of an interleukin 11 receptor alpha subunit
Interleukin-11_receptor
Mammalian protein found in Homo sapiens
Interleukin 8 receptor, alpha is a chemokine receptor. This name and the corresponding gene symbol IL8RA have been replaced by the HGNC approved name
Interleukin_8_receptor,_alpha
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