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Abnormally increased sensitivity to pain
Hyperalgesia (/ˌhaɪpərælˈdʒiːziə/ or /-siə/; hyper from Greek ὑπέρ (huper) 'over' + -algesia from Greek ἄλγος (algos) 'pain') is an abnormally increased
Hyperalgesia
Pain caused by opioid addiction
Opioid-induced hyperalgesia (OIH) or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia, is an uncommon condition of generalized
Opioid-induced_hyperalgesia
Muscle pain after exercise
characteristic symptom of DOMS, is also referred to as "muscular mechanical hyperalgesia". Although there is variance among exercises and individuals, the soreness
Delayed_onset_muscle_soreness
Array of painful conditions in humans
pinprick stimulation of a CRPS affected limb was painful (mechanical hyperalgesia) and showed a "significantly increased activation" of not just the S1
Complex regional pain syndrome
Complex_regional_pain_syndrome
2015 studio album by Victorian Halls
Hyperalgesia is the second full-length studio album by American alternative rock band Victorian Halls. The album, that contains 11-tracks, was recorded
Hyperalgesia_(album)
Feeling of pain from stimuli which do not normally elicit pain
cold or warm water over it, can be very painful. It is different from hyperalgesia, an exaggerated response from a normally painful stimulus. The term comes
Allodynia
Transduction of mechanical stimuli into neural signals
responsible for hearing and balance. States of neuropathic pain, such as hyperalgesia and allodynia, are also directly related to mechanosensation. A wide
Mechanosensation
Abnormal increase in sensitivity to sensory stimuli
refer to an increase in sensitivity where there is both allodynia and hyperalgesia. In psychology, Jeanne Siaud-Facchin uses the term by defining it as
Hyperesthesia
Drugs used to achieve relief from pain
opioid-induced hyperalgesia. The symptoms of these two conditions can appear very similar but the mechanism of action is different. Opioid-induced hyperalgesia is
Analgesic
Musical group from the United States
Cameron Webb's recording studio. Their second full-length studio album, "Hyperalgesia" was recorded in Gossip Studios, Chicago, and released in May 2015 with
Victorian_Halls
Uncomfortable skin sensation
(punctuate hyperalgesia). Touch-evoked hyperalgesia requires continuous firing of primary afferent nociceptors, and punctuate hyperalgesia does not require
Itch
Spectrum of disorders
severe sensitivity to light (photophobia) in the worst cases, to mild hyperalgesia or dysesthesia such as a sensation of dryness, stinging, or foreign body
Ocular_neuropathic_pain
Type of pain in the organs
affected by secondary hyperalgesia - especially when the causative visceral pain has been recurrent or chronic. Secondary hyperalgesia may persist after the
Visceral_pain
Pharmaceutical compound
analgesic effects, showing efficacy against atypical pain syndromes such as hyperalgesia and allodynia. It is being researched as a potential treatment for neuropathy
ART26.12
Class of drug
unwanted side effects. Long-term opioid use can cause opioid-induced hyperalgesia, which is a condition in which the patient has increased sensitivity
Opioid
Aspect of psychology
lethargy, depression, anxiety, malaise, loss of appetite, sleepiness, hyperalgesia, reduction in grooming and failure to concentrate. Sickness behavior
Sickness_behavior
Group of neurons in medulla of brain
a dermorphin-saporin conjugate reduced the duration of allodynia and hyperalgesia caused by a nerve injury. Treatment with the dermorphin-saporin conjugate
Rostral_ventromedial_medulla
Chronic multi-symptomatic pain disorder
resulting in cognitive problems. People with fibromyalgia may experience hyperalgesia (abnormally increased sensitivity to pain) and allodynia (pain from a
Fibromyalgia
Dissociative anesthetic and anti-depressant
and the control of procedural pain. It may also prevent opioid-induced hyperalgesia and postanesthetic shivering. For chronic pain, ketamine is used as an
Ketamine
Chemical compound
activity. Yangonin significantly reduces nociception and inflammatory hyperalgesia via spinal CB1 receptors in rats, highlighting its potential as a promising
Yangonin
Chemical compound
was developed as a potential analgesic, and blocks the development of hyperalgesia following exposure to cold temperatures or chronic morphine administration
RQ-00203078
Medical condition
in central sensitization, which manifests clinically as allodynia and hyperalgesia of CTTH. Additionally, CTTH patients exhibit decreased thermal and pain
Tension_headache
Extreme perception of pain from normally painful stimuli
inclusion of hyperalgesia explicitly. Previously hyperalgesia was implied, since hyperesthesia was mentioned in the previous note and hyperalgesia is a special
Hyperpathia
General anesthesia method
patients may be subjected to an elevated risk of anesthesia awareness, hyperalgesia and neurotoxicity. Considering these risks, special consideration is
Total_intravenous_anaesthesia
Chronic medical condition
orthostatic hypotension, a drop in blood pressure after standing. Pain and hyperalgesia (an abnormally increased sensitivity to pain) are common in ME/CFS. The
Myalgic encephalomyelitis/chronic fatigue syndrome
Myalgic_encephalomyelitis/chronic_fatigue_syndrome
Human protein for regulating body temperature
stimuli. This manifests as an increased sensitivity to painful stimuli (hyperalgesia) or pain sensation in response to non-painful stimuli (allodynia). Most
TRPV1
Harmful effect from negative belief
hypersensitivity are caused by the nocebo effect. Verbal suggestion can cause hyperalgesia (increased sensitivity to pain) and allodynia (perception of a tactile
Nocebo
Brazilian physician and pharmacologist (1934–2016)
on the basic mechanisms involved in the development of inflammatory hyperalgesia led to the discovery that a select class of analgesics like metamizole
Sérgio_Henrique_Ferreira
Species of mammal
edema (swelling via fluid buildup) which can lead to an excruciating hyperalgesia (heightened sensitivity to pain) that can last as long as months. The
Platypus
Pharmaceutical compound
over the closely related receptor NPFF2. It prevented opioid-induced hyperalgesia in animal models. Journigan VB, Mésangeau C, Vyas N, Eans SO, Cutler
MES207
Pharmaceutical compound
receptors. In animal studies, RF3286 potently inhibited the development of hyperalgesia produced by mu-opioid agonists while also increasing analgesia. Quillet
RF3286
Dopamine agonist medication
Common side effects of pramipexole include: Headache Peripheral edema Hyperalgesia (body aches and pains) Nausea and vomiting Sedation and somnolence Decreased
Pramipexole
Injury caused by a bullet
early dementia, amputations, chronic pain and pain with light touch (hyperalgesia), deep venous thrombosis with pulmonary embolus, limb swelling and debility
Gunshot_wound
CR was opposite to the effects of morphine, and the rats experienced hyperalgesia. Siegel suggested that compensatory CRs allow the organism to maintain
Conditioned compensatory response
Conditioned_compensatory_response
Gamma-aminobutyric acid analog
an inpatient therapy program, particularly by reducing opioid-induced hyperalgesia and drug craving. There is insufficient evidence for its use in cannabis
Gabapentin
Chemical compound
neuropathic pain model, LF22-0542 reversed the thermal hyperalgesia, but not the mechanical hyperalgesia. "Safotibant INN". Mednet. Retrieved 31 March 2016
Safotibant
Drug
receptor in as yet poorly understood processes such as allodynia and hyperalgesia. AS-19 E-55888 LP-44 LP-211 Godínez-Chaparro B, Barragán-Iglesias P,
LP-12
One of three classes of nerve fiber in the nervous system
can be caused by an increased neuronal response to a noxious stimulus (hyperalgesia), a larger neuronal receptive field, or spread of the hyper-excitability
Group_C_nerve_fiber
Neurological disorder
Rolan, Paul (2012). "Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach
Cluster_headache
Pharmaceutical compound
effects of mu-opioid agonists while decreasing some side effects such as hyperalgesia. Simonin F, Schmitt M, Laulin JP, Laboureyras E, Jhamandas JH, MacTavish
RF9_(drug)
Substance derived from opium
morphine, and thus M3G, are associated with neurotoxic side effects such as hyperalgesia, allodynia and myoclonus. Oxymorphone is a congener of morphine. It is
Opiate
Form of sickle cell crisis in sickle cell anaemia
vaso-occlusive crisis present with pain (mild to severe) and a history of sickle cell anemia. Differential diagnosis Neuropathic pain, hyperalgesia, osteomyelitis
Vaso-occlusive_crisis
Condition characterized by amplified and chronic pain
tolerance to pain. This can help with symptoms such as allodynia and hyperalgesia in AMPS, as well as indirectly help with other common symptoms by relieving
Amplified musculoskeletal pain syndrome
Amplified_musculoskeletal_pain_syndrome
Unpleasant, abnormal sense of touch
affected paws as well. These results indicate that the rats exhibited hyperalgesia, allodynia, and dysesthesia.[citation needed] In a study in which researchers
Dysesthesia
Phytocannabinoid discovered in 1940
2004). "Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin". The Journal of Pharmacology and Experimental
Cannabidiol
intrinsic anterograde amnesia effect. Barbiturates are known to induce hyperalgesia, i.e. aggravation of pain and for sleeplessness due to pain, if barbiturates
Automatism_(toxicology)
Symptom
referring to a hyperexcitability of the nervous system, usually including hyperalgesia (increased sensitivity to pain), and allodynia (painful perception of
Nociplastic_pain
Drug
tolerance and dependence, as well as the development of side effects such as hyperalgesia and allodynia, which can cause long-term use of opioid analgesics to
(+)-Naloxone
Group of physiologically active lipid compounds
release of histamine (increasing allergy response) ↑ pain perception hyperalgesia (wild type EP3 expression) ↑ autonomic neurotransmitters ↑ platelet response
Prostaglandin
Drug discovery
in these sites is a key factor in the development of inflammation and hyperalgesia. COX-2 inhibitors have analgesic and anti-inflammatory activity by blocking
Discovery and development of cyclooxygenase 2 inhibitors
Discovery_and_development_of_cyclooxygenase_2_inhibitors
Pharmaceutical compound
In animal studies it reduced tolerance to morphine but also produced hyperalgesia and anxiety. Related compounds such as AC-099 with Cl or CF3 replacing
AC-263093
Chemical compound
accumulation of this metabolite include convulsions, agitation, hallucinations, hyperalgesia, and coma. The enzyme UDP-Glucuronosyltransferase-2B7 converts morphine
Morphine-3-glucuronide
Cluster of neurons in a dorsal root of a spinal nerve
compound that sensitizes neurons to mechanical stimuli and mechanical hyperalgesia), which further supports a role for HT channels in the transduction of
Dorsal_root_ganglion
Protein-coding gene in humans
sensitization increases the sensation of cold pain, also known as cold hyperalgesia. An experiment was done in a double-blind two-way crossover study by
TRPM8
Venom produced by the platypus
obtained from case studies shows that the pain develops into a long-lasting hyperalgesia that can persist for months but usually lasts from a few days to a few
Platypus_venom
distress in the context of opioid abuse. Hyperkatifeia and opioid-induced hyperalgesia can be seen with long-term use of illicit street opioids e.g. heroin
Hyperkatifeia
Pharmaceutical compound
nitroglycerin-evoked hyperalgesia model in rodents used to screen candidates for potential utility in acute migraine [16], TRV250 significantly reduced hyperalgesia (Data
TRV250
Chemical compound
anti-inflammatory and analgesic effects in carrageenan-evoked thermal hyperalgesia. Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-α
Paeonol
Heritable connective tissue disorder
joint movement. Chronic pain: Recurrent joint pain that can develop into hyperalgesia, with a higher rate of small fiber neuropathy in some individuals. Disturbed
Hypermobility spectrum disorder
Hypermobility_spectrum_disorder
Enzyme
novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action". The
Adenosine_kinase
Nerve cell that converts environmental stimuli into corresponding internal stimuli
pain - a severe pain condition resulting from a damaged sensory nerve Hyperalgesia - an increased sensitivity to pain caused by sensory ion channel, TRPM8
Sensory_neuron
Medical condition
syndrome (CAPS) D2. Narcotic bowel syndrome (NBS)/ Opioid-induced GI hyperalgesia E1. Biliary pain E1a. Functional gallbladder disorder E1b. Functional
Functional gastrointestinal disorder
Functional_gastrointestinal_disorder
Chemical compound
Ho WH, Pons J, Rosenthal A (July 2005). "Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis". Pain. 116 (1–2): 8–16. doi:10
Tanezumab
Sensory neuron that detects pain
commonly known as hyperalgesia. Inflammation is one common cause that results in the sensitization of nociceptors. Normally hyperalgesia ceases when inflammation
Nociceptor
Type of unpleasant bodily feeling
medications can cause paradoxical side effects, such as opioid-induced hyperalgesia (severe generalized pain caused by long-term opioid use). Sugar (sucrose)
Pain
Glutamate receptor and ion channel protein found in nerve cells
NCT00188383 for "Effects of N-Methyl-D-Aspartate (NMDA)-Receptor Antagonism on Hyperalgesia, Opioid Use, and Pain After Radical Prostatectomy" at ClinicalTrials
NMDA_receptor
Group of venomous snakes from Asia
protein component specific to this species, causes hypolocomotion and hyperalgesia in experimental mice. It is believed that it contributes to neurotoxicity
King_cobra
Pain that lasts longer than three months
abnormally changed due to continuous stimulation and can cause allodynia or hyperalgesia. In chronic pain, this process is difficult to reverse or stop once established
Chronic_pain
2011 studio album by Victorian Halls
Producer Victorian Halls Victorian Halls chronology Charlatan (2011) Hyperalgesia (2015) Singles from Victorian Halls "A Crush is a Crush" Released: 2011
Charlatan_(album)
Protein and coding gene in humans
Hepoxilin#Pain perception) directly activate TRPA1 and thereby contribute to the hyperalgesia and tactile allodynia responses of mice to skin inflammation. In this
TRPA1
Pharmaceutical compound
Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats". eNeuro. 5 (3). doi:10.1523/ENEURO.0153-18
JNJ-63533054
Physical effects resulting from activation of the immune system
released mediators such as bradykinin increase the sensitivity to pain (hyperalgesia, dolor). The mediator molecules also alter the blood vessels to permit
Inflammation
Raised body temperature caused by disease
which consists of lethargy, depression, loss of appetite, sleepiness, hyperalgesia, dehydration, and the inability to concentrate. Sleeping with a fever
Fever
Medical condition
jeans nerve compression syndrome neurectomy paresthesia dysesthesia hyperalgesia Pearce JM (2006). "Meralgia paraesthetica (Bernhardt-Roth syndrome)"
Meralgia_paraesthetica
Medical condition
contributing to the generation of hyperalgesia in the PCN model. The mechanism(s) responsible for the generation of hyperalgesia in the early stages on the PTN
Peripheral_mononeuropathy
Cranial nerve responsible for the face's senses and motor functions
mechanisms leading to sensory symptoms such as parasthesias, dysesthesias, or hyperalgesia in the affected nerve distribution including the distribution of the
Trigeminal_nerve
Functional gastrointestinal disorder
in the colon of IBS patients. A role of 5-HT7 receptor in intestinal hyperalgesia was demonstrated in mouse models with visceral hypersensitivity, of which
Irritable_bowel_syndrome
Chemical compound
analgesic effects in its own right, but prevents the development of hyperalgesia, and also shows antidepressant effects in animal studies. JTC-801 J-113
SB-612,111
How an organism receives and responds to painful stimuli
increases as the pain stimulus continues, leading to a condition called hyperalgesia. Nociception can also cause generalized autonomic responses before or
Nociception
Protein-coding gene in the species Homo sapiens, named for ketazocine
pain reversal and chronic stimulation leads to receptor tolerance and hyperalgesia with allodynia. Mechanisms such as activation of NMDA receptors on spinal
Κ-opioid_receptor
Peripheral vascular disease
dependence Opioids SID Opioid overdose Opioid withdrawal Opioid-induced hyperalgesia (OIH) Opioid-induced endocrinopathy (OIE) Opioid-induced constipation
Cannabis_arteritis
Conclusion of the human pregnancy
actually increase sensitivity to pain through the process of nocebo hyperalgesia. At the same time positive expectations can reduce pain through placebo
Childbirth
characteristic of pain (in mammals at least) is that pain can result in hyperalgesia (a heightened sensitivity to noxious stimuli) and allodynia (a heightened
Pain_in_fish
Semi-synthetic opioid
and causes". Mayo Clinic. Retrieved 5 September 2022. "Opioid-Induced Hyperalgesia: How Opioids Can Increase Pain". Hospital for Special Surgery. Retrieved
Dihydrocodeine
Chronic pain following back surgeries
Schäfers M, Marziniak M, Toyka KV (June 2001). "Etanercept reduces hyperalgesia in experimental painful neuropathy". Journal of the Peripheral Nervous
Persistent spinal pain syndrome
Persistent_spinal_pain_syndrome
Synthetic opioid analgesic
increase in the dosage in cats can achieve analgesia and anti-nociception. Hyperalgesia and tolerance has been demonstrated in rodents and rabbits but not dogs
Remifentanil
HPV Vaccination program in Japan
fluid, suggesting possible involvement in central sensitization and hyperalgesia. A research group led by Professor Noriomi Matsumura (松村謙臣) and Professor
HPV_vaccination_in_Japan
Opiate and prodrug of morphine used to treat pain
Like morphine, codeine causes TLR4 signaling which causes allodynia and hyperalgesia. It does not need to be converted to morphine to increase pain sensitivity
Codeine
Sensation and perception of temperature
Hyperesthesia Hypoesthesia Paresthesia Tactile hallucination Nociception (pain) Hyperalgesia Hypoalgesia Pain dissociation Phantom pain Proprioception Asomatognosia
Thermoception
Distress in human infants
rendering the scale unreliable in acute or prolonged cases. In addition, hyperalgesia and allodynia, occur more quickly and more extensively in babies than
Pain_in_babies
Protein-coding gene in the species Homo sapiens
expressing these mutant channels, thus causing extreme sensitivity to pain (hyperalgesia). While the expression of PE Nav1.7 mutations produces hyperexcitability
Sodium voltage-gated channel alpha subunit 9
Sodium_voltage-gated_channel_alpha_subunit_9
Chemical compound
preventing the development of tolerance to morphine, the prevention of hyperalgesia induced by intracerebroventricular administration of nociceptin (orphanin
J-113,397
Condition negatively affecting an organism
illness can include lethargy, depression, loss of appetite, sleepiness, hyperalgesia, and inability to concentrate. Disorder A disorder is a functional abnormality
Disease
Opioid medication used for pain relief
produce excitatory neurotoxic effects such as restlessness, myoclonus and hyperalgesia. Patients with compromised kidney function and older patients are at
Hydromorphone
Protein-coding gene in the species Homo sapiens
after detecting a noxious stimulus. Therefore, Nav1.8 contributes to hyperalgesia (increased sensitivity to pain) and allodynia (pain from stimuli that
Nav1.8
Type of brain cell
transmitters, which in turn control synaptic activity. In the past, hyperalgesia was thought to be modulated by the release of substance P and excitatory
Astrocyte
characteristic of pain (in mammals at least) is that pain can result in hyperalgesia (a heightened sensitivity to noxious stimuli) and allodynia (a heightened
Pain_in_crustaceans
Therapeutic technique
"Effectiveness of transcutaneous electrical nerve stimulation for treatment of hyperalgesia and pain". Current Rheumatology Reports. 10 (6): 492–499. doi:10.1007/s11926-008-0080-z
Transcutaneous electrical nerve stimulation
Transcutaneous_electrical_nerve_stimulation
Inflammation of the tendon connecting the kneecap to the shinbone
Brink M., Heugen N., Van Wilgen P. "Evidence of Widespread Mechanical Hyperalgesia but Not Exercise-Induced Analgesia in Athletes with Mild Patellar Tendinopathy
Patellar_tendinitis
Medical condition
their vulva. Insults to the highly innervated vulval vestibule lead to hyperalgesia in a process thought to be similar to post-herpetic neuralgia. In some
Vaginal_yeast_infection
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