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HLA DRB3

  • HLA-DRB3
  • Protein-coding gene in the species Homo sapiens

    HLA class II histocompatibility antigen, DRB3-1 beta chain is a protein that in humans is encoded by the HLA-DRB3 gene. The protein encoded by this gene

    HLA-DRB3

    HLA-DRB3

    HLA-DRB3

  • HLA-DR
  • Subclass of HLA-D antigens that consist of alpha and beta chains

    DRB1*. The HLA-DRB1 locus is ubiquitous and encodes a very large number of functionally variable gene products (HLA-DR1 to HLA-DR17). The HLA-DRB3 locus encodes

    HLA-DR

    HLA-DR

    HLA-DR

  • Inflammatory demyelinating diseases of the central nervous system
  • Human disease

    behaviour has been reported according to the presence of different HLA genes. In HLA DRB3 cases, autoimmune reactions against the enzyme GDP-L-fucose synthase

    Inflammatory demyelinating diseases of the central nervous system

    Inflammatory_demyelinating_diseases_of_the_central_nervous_system

  • Human leukocyte antigen
  • Genes on human chromosome 6

    encoded by HLA-DQB1 locus HLA-DR α-chain encoded by HLA-DRA locus 4 β-chains (only 3 possible per person), encoded by HLA-DRB1, DRB3, DRB4, DRB5 loci The other

    Human leukocyte antigen

    Human leukocyte antigen

    Human_leukocyte_antigen

  • HLA A1-B8-DR3-DQ2
  • Human genotype

    HLA A1-B8-DR3-DQ2 haplotype (Also: AH8.1, COX, Super B8, ancestral MHC 8.1 or 8.1 ancestral haplotype) is a multigene haplotype that covers a majority

    HLA A1-B8-DR3-DQ2

    HLA_A1-B8-DR3-DQ2

  • HLA-DR52
  • HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. Three allele groups can produce 35 isoforms. DRB3, DRB4, and DRB5 are

    HLA-DR52

    HLA-DR52

    HLA-DR52

  • HLA-DRB1
  • Protein-coding gene in the species Homo sapiens

    HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. DRB1 encodes the most prevalent beta

    HLA-DRB1

    HLA-DRB1

    HLA-DRB1

  • HLA-DR3
  • DQA1*05:01) DR3 is genetically linked to HLA-DR52, DRB3*02:02 allele, and HLA-DQ2 (DQ2.5). derived from IMGT/HLA Wiencke K, Karlsen TH, Boberg KM, Thorsby

    HLA-DR3

    HLA-DR3

    HLA-DR3

  • HLA-DRA
  • Protein-coding gene in the species Homo sapiens

    DRB1, and two of any DRB3, DRB4, or DRB5 alleles. Thus there is the potential that any given individual can form 4 different HLA-DR isoforms (2 alleles

    HLA-DRA

    HLA-DRA

    HLA-DRA

  • HLA-DR12
  • disease DRB1*1201:DRB3*01/03: colorectal cancer HLA-DR12 is genetically linked to DR52 and HLA-DQ7 serotypes. derived from IMGT/HLA DR8 - 2% Gao X, Barnardo

    HLA-DR12

    HLA-DR12

    HLA-DR12

  • HLA DR3-DQ2
  • HLA DR3-DQ2 is a double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. Certain HLA DR and DQ

    HLA DR3-DQ2

    HLA_DR3-DQ2

  • HLA-DR14
  • PMID 16769963. S2CID 41206495. Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol

    HLA-DR14

    HLA-DR14

    HLA-DR14

  • HLA-DR51
  • HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5. DRB3, DRB4, and DRB5 are minor DR beta encoding loci

    HLA-DR51

    HLA-DR51

    HLA-DR51

  • HLA-DRB4
  • Protein-coding gene in the species Homo sapiens

    class II, DR beta 4, also known as HLA-DRB4, is a human gene. The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The

    HLA-DRB4

    HLA-DRB4

    HLA-DRB4

  • MHC class II
  • Protein of the immune system

    (HLA). Class II HLAs are composed of the classical HLA-DP, HLA-DQ, and HLA-DR and non-classical HLA-DM and HLA-DO MHC molecules. Mutations in the HLA gene

    MHC class II

    MHC class II

    MHC_class_II

  • HLA-B45
  • Human leukocyte antigen serotype

    novel Italian haplotype predominates in HLA-B45-positive bone marrow donors: HLA-A2, CW*1601, B45, DRB1*1101, DRB3*0301, DQA1*0102, DQB1*0502". Tissue Antigens

    HLA-B45

    HLA-B45

    HLA-B45

  • Chromosome 6
  • Human chromosome

    3) HLA-DQA1 and HLA-DQB1 form HLA-DQ heterodimer MHC class II, DQ: Celiac1, IDDM (6p21.3) HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5 forms HLA-DR

    Chromosome 6

    Chromosome 6

    Chromosome_6

  • HLA-DR18
  • myositis. HLA-DR18 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501

    HLA-DR18

    HLA-DR18

    HLA-DR18

  • A30-Cw5-B18-DR3-DQ2 (HLA Haplotype)
  • Multigene haplotype

    HLA A30-Cw5-B18-DR3-DQ2 (A30::DQ2) is a multigene haplotype that extends across a majority of the major histocompatibility complex on human chromosome

    A30-Cw5-B18-DR3-DQ2 (HLA Haplotype)

    A30-Cw5-B18-DR3-DQ2_(HLA_Haplotype)

  • HLA-DR11
  • HLA-DR11 (DR11) is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA-DR5 serotype group which

    HLA-DR11

    HLA-DR11

    HLA-DR11

  • HLA-DR13
  • 10.004. PMID 15003812. Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol

    HLA-DR13

    HLA-DR13

    HLA-DR13

  • HLA-DR5
  • Broad-antigen serotype

    longevity in the Dutch. HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52). derived from IMGT/HLA DR8 - 2% Raffoux C, David

    HLA-DR5

    HLA-DR5

    HLA-DR5

  • Major histocompatibility complex
  • Cell surface proteins, part of the acquired immune system

    a couple of genes HLA-DQ (DQA1 and DQB1, for α and β chains), one gene HLA-DRα (DRA1), and one or more genes HLA-DRβ (DRB1 and DRB3, -4 or -5). That means

    Major histocompatibility complex

    Major histocompatibility complex

    Major_histocompatibility_complex

  • HLA-DRB5
  • Protein-coding gene in the species Homo sapiens

    HLA class II histocompatibility antigen, DRB5 beta chain is a protein that in humans is encoded by the HLA-DRB5 gene. The protein encoded by this gene

    HLA-DRB5

    HLA-DRB5

    HLA-DRB5

  • Neonatal alloimmune thrombocytopenia
  • Disease that affects babies

    implicated. Studies have shown a relationship between maternal HLA type DRw52a (DRB3* 0101) and the development of anti-HPA-1a. The offending antibodies

    Neonatal alloimmune thrombocytopenia

    Neonatal_alloimmune_thrombocytopenia

  • HLA-DR53
  • HLA-DR53 is an HLA-DR serotype that recognizes gene products of HLA-DRB4 locus. There are 13 alleles at this locus that encode 7 proteins. DRB3, DRB4

    HLA-DR53

    HLA-DR53

    HLA-DR53

  • Immunoglobulin C1-set domain
  • Protein domain

    HLA-A; HLA-B; HLA-B35; HLA-B57; HLA-C; HLA-CW; HLA-Cw; HLA-D; HLA-DMA; HLA-DMB; HLA-DOA; HLA-DOB; HLA-DP; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA2; HLA-DQB1;

    Immunoglobulin C1-set domain

    Immunoglobulin C1-set domain

    Immunoglobulin_C1-set_domain

  • History and naming of human leukocyte antigens
  • Classification of leukocyte antigens

    Human leukocyte antigens (HLA) began as a list of antigens identified as a result of transplant rejection. The antigens were initially identified by categorizing

    History and naming of human leukocyte antigens

    History_and_naming_of_human_leukocyte_antigens

  • HLA-DR17
  • syndrome HLA-DR17 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501

    HLA-DR17

    HLA-DR17

    HLA-DR17

  • Biomarkers of multiple sclerosis
  • same happens with B-Cells Specially interesting is the case of DRB3*02:02 patients (HLA-DRB3*–positive patients), which seem to have a clear autoimmune reaction

    Biomarkers of multiple sclerosis

    Biomarkers_of_multiple_sclerosis

  • GDP-L-fucose synthase
  • been reported that some cases of multiple sclerosis that present the HLA variant DRB3, present also autoimmunity against GDP-L-fucose synthase. The same

    GDP-L-fucose synthase

    GDP-L-fucose_synthase

  • Tissue typing
  • recipient, including HLA Class I A, B, and C genes, as well as HLA Class II DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1, and DPB1 genes. HLA typing is made more

    Tissue typing

    Tissue_typing

  • Minor histocompatibility antigen
  • known MiHAs, the variant of genes encode MiHA peptides and their restricted HLA alleles. The MiHAs bound to a MHC presented on a cell surface may be recognized

    Minor histocompatibility antigen

    Minor histocompatibility antigen

    Minor_histocompatibility_antigen

  • Pathophysiology of multiple sclerosis
  • Disease pathology and physiology

    (2018). "GDP-l-fucose synthase is a CD4+ T cell–specific autoantigen in DRB3*02:02 patients with multiple sclerosis" (PDF). Science Translational Medicine

    Pathophysiology of multiple sclerosis

    Pathophysiology of multiple sclerosis

    Pathophysiology_of_multiple_sclerosis

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