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HLA DR12

• HLA-DR12

HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group

HLA-DR12



HLA-DR12

• HLA-DR

Subclass of HLA-D antigens that consist of alpha and beta chains

HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR (Human

HLA-DR



HLA-DR

• HLA-DR1

Serotype of cell surface receptors

HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among centenarians. The serology for the

HLA-DR1



HLA-DR1

• HLA-DR5

Broad-antigen serotype

HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes. Except for a few DRB1* alleles, the reactivity

HLA-DR5



HLA-DR5

• HLA-DR11

antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens. The table above describes the efficiency of serological typing

HLA-DR11



HLA-DR11

• HLA-DR6

Broad-antigen serotype

to myasthenia gravis. HLA-DRB1*13 and HLA-DRB1*14 encode serotypes of DR6. derived from IMGT/HLA DR12 - 3%, DR11 - 3% DR5-2% DR12 - 6%, DR11 - 7% DR5-4%

HLA-DR6



HLA-DR6

• HLA-DR13

myastenia gravis HLA-DR13 is genetically linked to DR52 and HLA-DQ6 (HLA-DQ1) serotypes. derived from IMGT/HLA DR12 - 3%, DR11 - 3% DR5-2% DR12 - 6%, DR11 -

HLA-DR13



HLA-DR13

• HLA-DR8

biliary cirrhosis HLA-DR8 is not genetically linked to HLA-DR51 to DR53, but is linked to DQ4 serotypes. derived from IMGT/HLA DR12 - 3% Porto T, Coelho

HLA-DR8



HLA-DR8

• HLA-DR52

HLA-DRB3 is linked to these HLA-DR serotypes and DRB1 allele groups: HLA-DR3 - DRB1*03 HLA-DR5 - HLA-DR11 - DRB1*11 HLA-DR12 - DRB1*12 HLA-DR6 - HLA-DR13

HLA-DR52



HLA-DR52

• HLA-DR7

HLA-DR7 (DR7) is a HLA-DR serotype that recognizes the DRB1*0701 to *0705 gene products. The serological reaction of DR7 is excellent for *0701. The serology

HLA-DR7



HLA-DR7

• HLA-DQ4

Human leukocyte antigen DQ4 serotype

HLA-DQ4 (DQ4) is a serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β4 subset of DQ β-chains.

HLA-DQ4



HLA-DQ4

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