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Pharmaceutical compound
Hexapeptide-10 (SIKVAV, Serilesine) is a hexapeptide that is composed of a sequence Ser-Ile-Lys-Val-Ala-Val found at the C-terminus of the laminin α1 chain
Hexapeptide-10
Chemical compound
Acetyl hexapeptide-8, also known as acetyl hexapeptide-8 amide and Argireline (also incorrectly referred to as acetyl hexapeptide-3), is a synthetic hexapeptide
Acetyl_hexapeptide-8
Pharmaceutical compound
Hexapeptide-12 (Elastin hexapeptide) is a hexapeptide with the sequence VGVAPG, which is derived from a sequence found in the connective tissue protein
Hexapeptide-12
Short chains of 2–50 amino acids
amino acids. A pentapeptide has five amino acids. (e.g., enkephalin). A hexapeptide has six amino acids. (e.g., angiotensin IV). A heptapeptide has seven
Peptide
Chemical compound
(developmental code name SKF-110679), also known as growth hormone-releasing hexapeptide, is one of several synthetic met-enkephalin analogues that include unnatural
GHRP-6
the same spectrum of activity; certain members of the family such as hexapeptide-12 actually have a primarily pro-aging effect and are used in research
Matrikine
Pharmaceutical compound
anti-aging effects. KPV tripeptide GHK-Cu Glycyl-prolyl-hydroxyproline Hexapeptide-10 Palmitoyl pentapeptide-4 Palmitoyl Tripeptide-38 Silk peptides Farwick
Tetrapeptide-21
Chemical compound
secretagogue which was developed by Mediolanum Farmaceutici. It is a hexapeptide with the amino acid sequence His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2
Examorelin
Chemical compound
Wang, S; Zhou, Y; Wei, C; Gu, F; Qin, Y (20 October 2017). "Therapeutic hexapeptide (PGPIPN) prevents and cures alcoholic fatty liver disease by affecting
Casomorphin
Chemical compound
Bouvardin is a bicyclic hexapeptide isolated from Bouvardia ternifolia. Its chemical formula is C40H48N6O10. It is derived from the amino acid sequence
Bouvardin
Pharmaceutical compound
BIM-23027 is a cyclic hexapeptide which acts as a selective agonist at somatostatin receptor 2. It inhibits secretion of various hormones and increases
BIM-23027
Chemical compound
factor determining its biological activity.[unreliable source?] Acetyl hexapeptide-3 BPC-157 CyRL-QN15 Glutathione Glycyl-prolyl-hydroxyproline KPV tripeptide
Copper_peptide_GHK-Cu
Chemical compound
Other studies, however, have been done in similar amide systems (i.e. hexapeptide). The hydrogen bonds of the amides can be broken by NMMO. NMO, as an
N-Methylmorpholine_N-oxide
Antibiotic medication
a hexapeptide-PCP conjugate by the halogenase involved in vancomycin biosynthesis" (PDF). Organic & Biomolecular Chemistry. 12 (30): 5574–7. doi:10.1039/C4OB00474D
Vancomycin
Group of chemical compounds
hexapeptoids. Caspofungin, micafungin, and anidulafungin are similar cyclic hexapeptide antibiotics linked to long modified N-linked acyl fatty acid chains.
Echinocandin
Chemical compound
Echinocandin B, a lipopeptide, is a naturally occurring cyclic hexapeptide with a linoleoyl side chain. It belongs to a class of antifungal agents called
Echinocandin_B
Natural water-soluble glycoprotein
has numerous medical, pharmaceutical and cosmetic applications. Acetyl hexapeptide-3 GHK-Cu Glycyl-prolyl-hydroxyproline Hyaluronic acid KPV tripeptide
Silk_peptides
Mammalian protein found in humans
amyloidogenic hexapeptides in amelioration of inflammatory brain disease". The Journal of Experimental Medicine. 211 (9): 1847–56. doi:10.1084/jem.20140107
Programmed cell death protein 1
Programmed_cell_death_protein_1
Chemical compound
Toxicity for the Small Cationic Hexapeptide RWRWRW-NH2". Frontiers in Cell and Developmental Biology. 4: 86. doi:10.3389/fcell.2016.00086. PMC 4999427
MP196
Group of peptide hormones in mammals
Amino acid sequence: Arg | Val-Tyr-Ile-His-Pro-Phe Angiotensin IV is a hexapeptide that, like angiotensin III, has some lesser activity. Angiotensin IV
Angiotensin
Broad-spectrum serine protease
proteinase K with a substrate analogue hexapeptide inhibitor at 2.2-A resolution". J. Biol. Chem. 268 (21): 15854–8. doi:10.1016/S0021-9258(18)82332-8. PMID 8340410
Proteinase_K
Pituitary hormone
Residue in Hexapeptide Segments". Stability and Characterization of Protein and Peptide Drugs. Pharmaceutical Biotechnology. Vol. 5. pp. 201–20. doi:10
Adrenocorticotropic_hormone
ATP-binding protein sequence motifs
phosphate-sized concavity with the NH groups pointing inwards. The synthetic hexapeptide SGAGKT has been shown to bind inorganic phosphate strongly; since such
Walker_motifs
Mammalian protein found in humans
Fassina G (January 1995). "Binding of the LXCXE insulin motif to a hexapeptide derived from retinoblastoma protein". Biochemical and Biophysical Research
Retinoblastoma_protein
Chemical compound
with EGFR-mutated (EGFRm) NSCLC". Annals of Oncology. 31: S1189–S1190. doi:10.1016/j.annonc.2020.08.2295. S2CID 225184933. Krop, Ian E.; Masuda, Norikazu;
Deruxtecan
American molecular biologist
Westler, W.M., Prendergast, F.G., Ward, W.W. "Chemical structure of the hexapeptide chromophore of the Aequorea green-fluorescent protein". Biochemistry
Douglas_Prasher
Class of enzymes
shown to be activated autocatalytically by cleavage of an N-terminal hexapeptide. The more precise IUBMB name enteropeptidase has been in existence since
Enteropeptidase
peptides and proteins". Nature Biotechnology. 22 (10): 1302–1306. Bibcode:2004NatBi..22.1302F. doi:10.1038/nbt1012. ISSN 1087-0156. PMID 15361882. S2CID 41481025
Protein aggregation predictors
Protein_aggregation_predictors
Viral protein in bacteriophages
fate. It is six amino acids(aa) long, and so is also referred to as a hexapeptide. It is produced when a phage infects a bacterial host and signals to
Arbitrium
Protein family
plant and bacterial enzymes; it is located in the middle of a conserved hexapeptide. Other enzymes also belong to this family including carboxyvinyl-carboxyphosphonate
Isocitrate_lyase_family
Class of enzymes
outside the (103-108)-hexapeptide region that fits into the enzyme's active-site cleft". The Biochemical Journal. 244 (3): 553–8. doi:10.1042/bj2440553. PMC 1148031
Chymosin
Mammalian protein found in Homo sapiens
as well as the carboxyy-terminal peptide containing the inhibitory hexapeptide LLRVKR, functions as an inhibitor of prohormone convertase 1/3, which
Proprotein convertase subtilisin/kexin type 1 inhibitor
Proprotein_convertase_subtilisin/kexin_type_1_inhibitor
Chemical compound
Journal of Labelled Compounds and Radiopharmaceuticals. 33 (2): 137. doi:10.1002/jlcr.2580330208. https://web.archive.org/web/20120204123305/http://www
Gusperimus
Oxytocin receptor antagonist
4-Methylenedioxymethamphetamine". ACS Chemical Neuroscience. 9 (10): 2408–2427. doi:10.1021/acschemneuro.8b00155. PMC 6197894. PMID 30001118. Wronikowska-Denysiuk
Tocinoic_acid
BOINC based volunteer computing project researching protein folding
energy match to a structure similar to that of a known fibril forming hexapeptide, RosettaDesign was able to identify peptides twice as likely to form
Rosetta@home
Species of fungus
of cell-penetrating antifungal peptides using the rationally designed hexapeptide PAF26 as a model". Fungal Biology Reviews. Revealing diverse modes of
Penicillium_digitatum
Protein-coding gene in the species Homo sapiens
cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. Reches M, Gazit E (2005). "Amyloidogenic hexapeptide fragment of medin: homology to functional
MFGE8
Precursor form of trypsin, a digestive enzyme
the presence of a large negative charge on the conserved N-terminal hexapeptide of trypsinogen, which repels the aspartate on the back of trypsin's specificity
Trypsinogen
Species of bacterium
novel antibacterial cyclic hexapeptides from Streptomyces alboflavus 313". Chemistry & Biodiversity. 9 (8): 1567–78. doi:10.1002/cbdv.201100364. PMID 22899617
Streptomyces_alboflavus
Polysaccharides found in animal tissue
sulfate domain of aggrecan consists of a series of tandemly repeated hexapeptides with a consensus sequence of E(E/L)PFPS. Additionally, for three other
Glycosaminoglycan
Class of peptides derived from β-amino acids
secondary structure of a -hexapeptide in solution and its stability towards pepsin". Helvetica Chimica Acta. 79 (4): 913–941. doi:10.1002/hlca.19960790402
Beta-peptide
Protein found in humans
bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell. 96 (4): 587–597. doi:10.1016/S0092-8674(00)80662-5
PBX1
Species of bacterium
Zhang, Weimin; Zhang, Jingren; Ju, Jianhua (22 August 2014). "Cyclic Hexapeptides from the Deep South China Sea-Derived SCSIO ZJ46 Active Against Pathogenic
Streptomyces_scopuliridis
small three-dimensional protein motifs". BMC Bioinformatics. 10 (1): 60. doi:10.1186/1471-2105-10-60. PMC 2651126. PMID 19210785. Newell, NE (2025). "ExploreTurns:
Beta_bulge_loop
Protein-coding gene in the species Homo sapiens
proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes & Development. 9 (6): 663–74. doi:10.1101/gad.9.6.663
PKNOX1
Aligning molecular sequences using sequence and structural information
Distance-matrix ALIgnment method, which breaks the input structures into hexapeptide fragments and calculates a distance matrix by evaluating the contact
Structural_alignment
Chemical process
precipitate. Moreover, single-walled carbon nanotube and nano fibrous hexapeptide can be also used as templating seeds. This method can be extended to
Nanofiber_seeding
Chemical compound
pneumocandin A0 production, and (3S)-hydroxyl-L-proline occupies the hexapeptide core's position 6, resulting in exclusive production of pneumocandin
Pneumocandin_B0
Chemical compound
siderophores contains at least 20 structurally distinct members of cyclic hexapeptides that chelate ferric iron via an octahedral coordination geometry through
Ferrichrome_A
Protein-coding gene in the species Homo sapiens
heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell. 96 (4): 587–97. doi:10.1016/S0092-8674(00)80662-5.
HOXB1
peptides: crystal structure of a hexapeptide with a C-terminus 6→1 hydrogen bond" (PDF). Biopolymers. 50 (1): 13–22. doi:10.1002/(sici)1097-0282(199907)50:1<13::aid-bip2>3
Schellman_loop
Process in bioinformatics that identifies equivalent sites within molecular sequences
structural alignments based on contact similarity patterns between successive hexapeptides in the query sequences. It can generate pairwise or multiple alignments
Sequence_alignment
Bacterial microcompartment containing the enzyme RuBisCo
CcmM are required for beta-carboxysome assembly. CcmN contains multiple hexapeptide-repeat domains on its N-terminus and a short α-helical encapsulation
Carboxysome
Protein-coding gene in humans
Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. Gerhard DS, Wagner L
CPA4_(gene)
Principle in chemical kinetics
Scheuer, Paul J.; Kelly-Borges, Michelle (1995). "Kapakahine B, a cyclic hexapeptide with an .alpha.-carboline ring system from the marine sponge Cribrochalina
Curtin–Hammett_principle
Protein-coding gene in humans
"Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–674. doi:10.1101/gad.9.6.663. PMID 7729685
HOXB7
Protein-coding gene in the species Homo sapiens
SRT1720 - primarily a SIRT1 activator, but also weakly activates SIRT2 Hexapeptide-12 (VGVAPG) - upregulates SIRT2 gene expression through an indirect pathway
Sirtuin_2
Protein-coding gene in the species Homo sapiens
FPR1-stimulating formyl peptides including FMLP. However, fMMYALF, a N-formyl hexapeptide derived from the mitochondrial protein, NADH dehydrogenase subunit 6
Formyl_peptide_receptor_3
American bacteriologist and immunologist
of a hexapeptide sequence in the anchor region of surface proteins from Gram-positive cocci". Molecular Microbiology. 4 (9): 1603–1605. doi:10.1111/j
Vincent_Fischetti
Iron-carrying compounds
predominantly produce ferrichromes. This group of siderophores consist of cyclic hexapeptides and consequently are highly resistant to environmental degradation associated
Siderophore
Species of actinobacteria isolated from moonmilk and producing ferroverdin A
Frédérich, Michel; Rigali, Sébastien (2023-01-06). "Lunaemycins, New Cyclic Hexapeptide Antibiotics from the Cave Moonmilk-Dweller Streptomyces lunaelactis MM109T"
Streptomyces_lunaelactis
Virus
finally reaching the short central intron where 2 different C-terminal hexapeptides can be added. The R3 transcript produces capsid proteins VP1 and VP2
Minute_virus_of_mice
Italian chemist
DNA point mutations. He has been involved in the development of large hexapeptide libraries for the identification of unique protein sequences, and in
Pier_Giorgio_Righetti
Intracranial drug administration using nanotechnology
delivery of a drug across the BBB occurred in 1995. The drug used was hexapeptide dalargin, an anti-nociceptive peptide that cannot cross the BBB alone
Nanoparticles for drug delivery to the brain
Nanoparticles_for_drug_delivery_to_the_brain
Molecular binding feature
phospholipase A2. They are also observed in synthetic peptides and in cyclic hexapeptides made from alternating D,L amino acids. The conformation of a catgrip
Catgrip
Chemical compound
U-II and urotensin II-Related Peptide (URP) is known as the core. It is hexapeptide (-CYS-TYR-LYS-TRP-PHE-CYS-), and is connected at the two ends by a disulfide
Urotensin-II
Protein family
plant and bacterial enzymes; it is located in the middle of a conserved hexapeptide. Most ICLs that have been characterised to date contain only one domain
Isocitrate_lyase
Protein-coding gene in the species Homo sapiens
endoplasmic reticulum (ER). One of the cytosolic regions of SCAP contains a hexapeptide amino acid sequence, MELADL, that functions to detect cellular cholesterol
SREBP cleavage-activating protein
SREBP_cleavage-activating_protein
Taiwanese chemist
Specific Conformations of Cyclic Hexapeptides". Biophysical Journal. 116 (3): 433–444. Bibcode:2019BpJ...116..433C. doi:10.1016/j.bpj.2018.12.015. ISSN 0006-3495
Yu-Shan_Lin
Experimental drug
Disease". The American Journal of Gastroenterology. 116 (12): 2399–2409. doi:10.14309/ajg.0000000000001375. ISSN 0002-9270. PMC 8631161. PMID 34382947. Finnigan
AXA1125
activity of the enzyme. The hydrophobic region around Ser152, which has the hexapeptide sequence Val-Gly-His-Ser-Gln-Gly, is essential for the catalytic activity
Discovery and development of gastrointestinal lipase inhibitors
Discovery_and_development_of_gastrointestinal_lipase_inhibitors
Protein-coding gene in the species Homo sapiens
proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes & Development. 9 (6): 663–74. doi:10.1101/gad.9.6.663
HOXB6
Protein-coding gene in the species Homo sapiens
gene Glued". Nature. 351 (6327): 579–83. Bibcode:1991Natur.351..579H. doi:10.1038/351579a0. PMID 1828535. S2CID 4263574. Urnavicius L, Zhang K, Diamant
DCTN1
Pharmaceutical compound
sequence different for all species. URP has the same cysteine bridged hexapeptide ring with the sequence CFWKYC as UII. This is known as the core and is
Urotensin_II–related_peptide
Compound isolated from fungi for medicinal benefit
Aspergillus versicolor isolated from red sea algae". Arch Pharm Res. 35 (10): 1749–56. doi:10.1007/s12272-012-1006-x. PMID 23139125. S2CID 25106490. Shao CL, Wang
Fungal_isolate
3193–3207. doi:10.1002/prot.23154. PMID 21989939. S2CID 8761012. Bianchi, A; Giorgi A; Ruzza P; Toniolo C (2013). "A synthetic hexapeptide designed to resemble
Nest (protein structural motif)
Nest_(protein_structural_motif)
Structural model of a folded, globular protein
doi:10.1038/138242a0. S2CID 4065283. Bernal JD (1939). "Structure of proteins". Nature. 143 (3625): 663–667. Bibcode:1939Natur.143..663B. doi:10.1038/143663a0
Cyclol
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