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Animal connective tissue cell
A fibroblast is a type of biological cell typically with a spindle shape that synthesizes the extracellular matrix and collagen, produces the structural
Fibroblast
Dermal fibroblasts are cells within the dermis layer of skin which are responsible for generating connective tissue and allowing the skin to recover from
Dermal_fibroblast
Family of proteins that bind to fibroblast growth factors
The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of
Fibroblast growth factor receptor
Fibroblast_growth_factor_receptor
Growth factor and signaling protein otherwise known as FGF2
Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by
Fibroblast_growth_factor_2
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene
Fibroblast growth factor receptor 2
Fibroblast_growth_factor_receptor_2
Tumour-promoting cell type
cancer-associated fibroblast (CAF) (also known as tumour-associated fibroblast; carcinogenic-associated fibroblast; activated fibroblast) is a cell type
Cancer-associated_fibroblast
Enzyme in humans
Fibroblast activation protein alpha (FAP-alpha) also known as prolyl endopeptidase FAP is an enzyme that in humans is encoded by the FAP gene. Prolyl endopeptidase
Fibroblast activation protein, alpha
Fibroblast_activation_protein,_alpha
Family of proteins involved in anatomical development
Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by the macrophages. They are involved in a wide variety of processes
Fibroblast_growth_factor
Gene involved in the most common form of dwarfism
Fibroblast growth factor receptor 3 (FGFR-3) is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster
Fibroblast growth factor receptor 3
Fibroblast_growth_factor_receptor_3
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 1 (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene
Fibroblast_growth_factor_1
Specialised cell type located inside joints in the synovium
Fibroblast-like synoviocytes (FLS) represent a specialised cell type located inside joints in the synovium. These cells play a crucial role in the pathogenesis
Fibroblast-like_synoviocyte
Mammalian protein found in Homo sapiens
Fibroblast growth factor 18 (FGF-18) is a protein that is encoded by the FGF18 gene in humans. The protein was first discovered in 1998, when two newly-identified
Fibroblast_growth_factor_18
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 8 (FGF-8) is a protein that in humans is encoded by the FGF8 gene. The protein encoded by this gene belongs to the fibroblast
Fibroblast_growth_factor_8
Protein found in humans
Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome
Fibroblast growth factor receptor 1
Fibroblast_growth_factor_receptor_1
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster
Fibroblast growth factor receptor 4
Fibroblast_growth_factor_receptor_4
Protein found in humans
Fibroblast growth factor 23 (FGF-23) is a protein and member of the fibroblast growth factor (FGF) family which participates in the regulation of phosphate
Fibroblast_growth_factor_23
Protein-coding gene in mammals
Fibroblast growth factor 21 (FGF-21) is a protein found in humans and other mammals that is encoded by the FGF21 gene. This protein is a member of the
Fibroblast_growth_factor_21
Mouse embryonic fibroblasts (MEFs) are a type of fibroblast prepared from mouse embryos. MEFs show a spindle shape when cultured in vitro, a typical feature
Mouse_embryonic_fibroblast
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects
FGF19
Genetic disorder of the skull
thumbs and big toes. Pfeiffer syndrome is caused by mutations in the fibroblast growth factor receptors FGFR1 and FGFR2. The syndrome is grouped into
Pfeiffer_syndrome
Series of events that restore integrity to damaged tissue after an injury
macrophage and mast cells release fibroblast growth and chemotactic factors to activate fibroblasts from adjacent tissue. Fibroblasts at this stage loosen themselves
Wound_healing
Inactive mesenchymal cell
protein synthesis. The term fibrocyte contrasts with the term fibroblast. Fibroblasts are activated connective tissue cells characterized by synthesis
Fibrocyte
Area of fibrous tissue that replaces normal skin after an injury
shedding or injury, can scar. Prolonged inflammation, as well as the fibroblast proliferation, can occur. Redness that often follows an injury to the
Scar
Medication
known as recombinant human basic fibroblast growth factor (rhbFGF), is a recombinant form of human basic fibroblast growth factor (bFGF) which is marketed
Trafermin
Cell lines of mouse embryonic fibroblasts
3T3 cells are several cell lines of mouse embryonic fibroblasts. The original 3T3 cell line (3T3-Swiss albino) was established in 1962 by two scientists
3T3_cells
Human recombinant FGF18
Sprifermin (INN; development code AS-902330) is a recombinant human fibroblast growth factor 18 (rhFGF18) analog, originally developed by Merck, and now
Sprifermin
Mammalian protein found in Homo sapiens
Fibroblast growth factor 5 is a protein that in humans is encoded by the FGF5 gene. The majority of FGF family members are glycosaminoglycan binding proteins
FGF5
Connective tissue present within and around synovial joints
synovial cells (type A) and also type B cells, which are also known as fibroblast-like synoviocytes (FLS). Type A cells maintain the synovial fluid by removing
Synovial_membrane
Chemical compound
Balversa, is an anti-cancer medication. It is a small molecule inhibitor of fibroblast growth factor receptor (FGFR) used for the treatment of cancer. FGFRs
Erdafitinib
Pharmaceutical compound
Vesugen is claimed to stimulate proliferation and protein synthesis in fibroblast cells in the skin and to improve the appearance of skin, as well as promoting
Vesugen
New tissue that forms on a wound's surface
polyps. Its histological appearance is characterized by proliferation of fibroblasts and thin-walled, delicate capillaries (angiogenesis), and infiltrated
Granulation_tissue
Protein-coding gene in humans
Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene. It is a polypeptide of 208 amino acids. Human FGF10 gene is highly
FGF10
Investigational drug
evaluated by Loxo Oncology for the treatment of genitourinary cancer. It is a fibroblast growth factor receptor 3 antagonist. "Vepugratinib". AdisInsight. Springer
Vepugratinib
Medical Procedure
activates the basal layer, and (b) thickening and smoothing the epidermis. Fibroblast activity results in extracellular matrix deposition and dermal thickening
Hydradermabrasion
Protein
Fibroblast growth factor 20 is a protein which in humans is encoded by the FGF20 gene. The protein encoded by this gene is a member of the fibroblast
FGF20
Medical condition
developmental disorder caused by an autosomal dominant genetic defect in the fibroblast growth factor receptor 3 gene (FGFR3) that results in a disproportionately
Hypochondroplasia
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene. The protein encoded by this gene is a substrate
FRS3
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 14 is a biologically active protein that in humans is encoded by the FGF14 gene. The protein encoded by this gene is a member
FGF14
Pharmaceutical compound
Fexagratinib (AZD4547) is an experimental drug which acts as an inhibitor of the fibroblast growth factor receptors, having high affinity for FGFR1, FGFR2 and FGFR3
Fexagratinib
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene. The protein encoded by this gene is a member of the fibroblast growth
FGF13
Cell type with functions of both muscular and fibrous connective tissue
cell phenotype that was first described as being in a state between a fibroblast and a smooth muscle cell. Myofibroblasts are contractile web-like fusiform
Myofibroblast
Nemosis is a process of cell activation and death in human fibroblasts. Initially discovered as programmed necrosis, the name nemosis, is a derivative
Nemosis
Enzyme
Interstitial collagenase, also known as fibroblast collagenase and matrix metalloproteinase-1 (MMP-1), is an enzyme that in humans is encoded by the MMP1
Interstitial_collagenase
Protein found in humans
Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene. The protein encoded by this gene is a member of the
Fibroblast growth factor receptor-like 1
Fibroblast_growth_factor_receptor-like_1
Muscular tissue of heart in vertebrates
cells are surrounded by an extracellular matrix produced by supporting fibroblast cells. Specialised modified cardiomyocytes known as pacemaker cells, set
Cardiac_muscle
Genetic disorder of the skull and face
mutation in a gene on chromosome 10 that controls the body's production of fibroblast growth factor receptor 2 (FGFR2). Crouzon syndrome is named for Octave
Crouzon_syndrome
Fibroblast growth factor gene
Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene. The protein encoded by this gene is a member of the fibroblast growth
FGF4
Form of localized cell signaling
can be organized into four major families based on similar structures: fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily
Paracrine_signaling
Protein-coding gene in humans
encoded by the FGF3 gene. FGF-3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a
FGF3
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene. FGFBP1, or HBP17, binds to both acidic FGF1 and basic
FGFBP1
Gelatinous substance within the umbilical cord
chondroitin sulfate). It acts as a mucous connective tissue containing some fibroblasts and macrophages, and is derived from extra-embryonic mesoderm of the
Wharton's_jelly
keratinization. Fibroblasts are the most common cells in extracellular matrix and are important for epithelial morphogenesis. If fibroblasts are absent from
Oral mucosa tissue engineering
Oral_mucosa_tissue_engineering
Connective tissue composed of reticular collagen fibers
type are they dominant. Reticular fibers are synthesized by special fibroblasts called reticular cells. The fibers are thin branching structures. Reticular
Reticular_connective_tissue
Cell type
Corneal keratocytes (corneal fibroblasts) are specialized fibroblasts residing in the stroma. This corneal layer, representing about 85-90% of corneal
Corneal_keratocyte
Class of enzymes
tumors. Fibroblast growth factors comprise the largest family of growth factor ligands at 23 members. The natural alternate splicing of four fibroblast growth
Receptor_tyrosine_kinase
Rare type of blood cancer
marrow are remodeled in a process called osteosclerosis; in addition, fibroblasts secrete collagen and reticulin proteins that are collectively referred
Primary_myelofibrosis
Pharmaceutical compound
Dai X, Huang J, et al. (December 2021). "Targeting senescence-like fibroblasts radiosensitizes non-small cell lung cancer and reduces radiation-induced
FOXO4-DRI
Medication
Allogeneic cultured keratinocytes and fibroblasts in bovine collagen, sold under the brand name Gintuit, is a cellular therapy used for the treatment
Allogeneic cultured keratinocytes and fibroblasts in bovine collagen
Allogeneic_cultured_keratinocytes_and_fibroblasts_in_bovine_collagen
Extreme hypothyroidism
understood, however, two mechanisms predominate: Fibroblast stimulation. It is thought that fibroblast stimulation by the thyroid stimulating hormone (TSH)
Myxedema
that have important roles in cancer development, such as angiogenin and fibroblast growth factor. Born in Germany, Vallee graduated in zoology from the University
Bert_L._Vallee
Protein-coding gene in the species Homo sapiens
rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP". Human Molecular Genetics
ZMYM2
Genetic condition, the most common form of dwarfism
combined immunodeficiency. Achondroplasia is caused by a mutation in the fibroblast growth factor receptor 3 (FGFR3) gene (located in chromosome 4) that results
Achondroplasia
Excess connective tissue in healing
extracellular matrix components, particularly collagen, is produced by fibroblasts, leading to the formation of a permanent fibrotic scar. In response to
Fibrosis
Japanese stem cell researcher (born 1962)
exocrine cells to endocrine cells, fibroblast cells to myoblast cells, fibroblast cells to cardiomyocyte cells, fibroblast cells to neurons Cell replacement
Shinya_Yamanaka
Most abundant structural protein in animals
constitutes 1% to 2% of muscle tissue and 6% by weight of skeletal muscle. The fibroblast is the most common cell creating collagen in animals. Collagen is used
Collagen
Formation of blood vessels
growth factors often act in a paracrine or autocrine fashion; they include fibroblast growth factor, placental growth factor, insulin-like growth factor, hepatocyte
Vascularisation
Protein
Fibroblast growth factor 22 is a protein which in humans is encoded by the FGF22 gene. The protein encoded by this gene is a member of the fibroblast
FGF22
Medical condition
surrounded by epithelioid cells aggregates, T cell lymphocytes and fibroblasts. Granulomatous tubercules eventually develop central caseous necrosis
Tuberculous_lymphadenitis
Phenomenon characterized by the cessation of cell division
1960s, Leonard Hayflick and Paul Moorhead found that normal human fetal fibroblasts in culture reach a maximum of approximately 50 cell population doublings
Cellular_senescence
Pluripotent stem cell generated directly from a somatic cell
in ESCs and used retroviruses to deliver these genes to mouse fibroblasts. The fibroblasts were engineered so that any cells reactivating the ESC-specific
Induced_pluripotent_stem_cell
Novel gene
Fibroblast growth factor receptor oncogene partner 2 (FGFR1OP2) was identified in a study on myeloproliferative syndrome (EMS). The study aimed to identify
FGFR1OP2
Direct extension and penetration by cancer cells into neighboring tissues
genetic mechanisms. Two types of migrating tumor cells, mesenchymal (fibroblast-like) and amoeboid, can be observed in various patterns of cancer cell
Invasion_(cancer)
connects muscles to bones. Tendon cells, also known as tenocytes or tendon fibroblasts, are specialized cells that contribute to the structure, function, and
Tendon_cell
Indian academic (born 1973)
in Cancer (ACTREC) of Tata Memorial Centre. Known for his studies on Fibroblast growth factor receptor, Dutt is a Wellcome Trust / DBT India Alliance
Amit_Dutt
Infectious disease
stage of infection, macrophages, epithelioid cells, lymphocytes and fibroblasts aggregate to form a granuloma, which surrounds and isolates the infected
Tuberculosis
Abnormal growth of scar tissue within the penis
overexpression of transforming growth factor-beta 1 (TGF-β1)—that end in fibroblast proliferation, myofibroblast differentiation, and overproduction of type
Peyronie's_disease
Interstitial cells
further confusion with other interstitial (stromal) cells (e.g., fibroblast (FB), fibroblast-like cells, myofibroblast, mesenchymal cells). Telopodes present
Telocyte
Protein-coding gene in the species Homo sapiens
National Library of Medicine. "Entrez Gene: IFNB1 interferon, beta 1, fibroblast". Biron CA, Nguyen KB, Pien GC (2002). "Innate Immune Responses to LCMV
IFNB1
Synthetic peptide
telomerase activity in human somatic cells in vitro, based on a study in human fibroblast cell cultures. Elongation of telomeres by epitalon was sufficient to surpass
Epitalon
Factor that stimulates the growth of bone tissue
insulin-like growth factor-2 (IGF-2), transforming growth factor beta (TGF-β), fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), parathyroid
Bone_growth_factor
Lowermost layer of the integumentary system in vertebrates
integumentary system in vertebrates. The types of cells found in the layer are fibroblasts, adipose cells, and macrophages. The subcutaneous tissue is derived from
Subcutaneous_tissue
Medical condition
Localized lichen myxedematosus is a group of skin condition caused by fibroblasts producing abnormally large amounts of mucopolysaccharides, a disease
Localized lichen myxedematosus
Localized_lichen_myxedematosus
Pharmaceutical compound
Efimosfermin alfa (development code BOS-580) is a long-acting fibroblast growth factor 21 analog that can be injected once monthly. It was acquired by
Efimosfermin_alfa
Variety of genetically modified laboratory mice
resemble mammoth features, such as golden-colored fur. This included FGF5 (fibroblast growth factor 5), that is involved with the hair growth cycle, and MC1R
Woolly_mouse
Inflammation of the synovial membrane within a joint
many joints affected with osteoarthritis. In rheumatoid arthritis, the fibroblast-like synoviocytes, highly specialized mesenchymal cells found in the synovial
Synovitis
British biologist and academic
impact of mechanical load on the deposition and organisation of dermal fibroblast. Parsons joined King's College London as a Royal Society University Research
Maddy_Parsons
Medication
Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen, sold under the brand name Stratagraft, is a medical treatment used for thermal
Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen
Allogeneic_cultured_keratinocytes_and_dermal_fibroblasts_in_murine_collagen
Medical condition
renal tubules. The mutated PHEX gene causes pathological elevations in fibroblast growth factor 23 (FGF23), a hormone that regulates phosphate homeostasis
Phosphate_diabetes
Premature fusion of bones in the skull
possibly been found in the fibroblast growth factor receptor 3 (FGFR3) and TWIST genes. Fibroblast growth factor and fibroblast growth factor receptors regulate
Craniosynostosis
Multipotent adult stem cells present in multiple tissues
cell imaging.[citation needed] Reviews have classified an MSC as having fibroblast-like structure, characterized by cell-surface markers and a potential
Mesenchymal_stem_cell
Human gene coding for the GAS6 protein
identity. It was originally found as a gene upregulated by growth arrested fibroblasts. Gas6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein
GAS6
Protein-coding gene in the species Homo sapiens
by the FGF7 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic
FGF7
foot and postural injury, deformity, and irritable bowel syndrome. Skin fibroblasts are vital in development and wound repair and they are affected by mechanical
Mechanobiology
Any cell which responds to stimuli and effects some change
reconstructs the Central nervous system after a bone marrow transplant Fibroblast, a cell that is most commonly found within connective tissue Mast cell
Effector_cell
Investigational drug
Biosciences for the treatment of achondroplasia and solid tumors. It is a fibroblast growth factor receptor 3 receptor antagonist. "Dabogratinib - TYRA Biosciences"
Dabogratinib
Protein-coding gene in humans
Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene. The protein encoded by this gene is a member of the fibroblast growth
FGF6
Form taken by the inactive X chromosome in a female somatic cell
Left: DAPI stained female human fibroblast with Barr body (arrow). Right: histone macroH2A1 staining. Arrow points to sex chromatin in DAPI-stained cell
Barr_body
Pharmaceutical compound
readily absorbed into the skin and stimulates collagen synthesis by fibroblasts, which aids wound healing and may help to reduce signs of aging. Dietary
Glycyl-prolyl-hydroxyproline
Experimental drug
an investigational drug developed by Akero Therapeutics, acting as a fibroblast growth factor 21 (FGF21) analog developed to treat metabolic dysfunction-associated
Efruxifermin
Type of biological tissue in animals
are immersed in the body water. The cells of connective tissue include fibroblasts, adipocytes, macrophages, mast cells and leukocytes. The term "connective
Connective_tissue
FIBROBLAST
FIBROBLAST
FIBROBLAST
FIBROBLAST
Girl/Female
Tamil
Anekashastrahasta | அநேகஷஸà¯à®¤à¯à®°à®¹à®¸à®¤à®¾
Possessor of many hand weapons
Female
Swedish
Norwegian and Swedish form of Old Norse Arnbjorg, ANNBORG means "eagle protection."Â
Surname or Lastname
English (Lancashire)
English (Lancashire) : variant of Tuthill.
Girl/Female
British, English
Noble; Shining
Boy/Male
Hindu, Indian, Tamil
Prayer
Boy/Male
Arabic, Hindu, Indian, Muslim
Safeguard
Boy/Male
Muslim/Islamic
Protected
Boy/Male
British, English
Bright Friend
Girl/Female
Tamil
Honest, Night
Boy/Male
Tamil
To rise, Honest
FIBROBLAST
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FIBROBLAST