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Class of chemical compounds
In pharmacology, the fibrates are a class of amphipathic carboxylic acids and esters. They are derivatives of fibric acid (phenoxyisobutyric acid). They
Fibrate
Drug of the fibrate class, mainly used to reduce cholesterol levels
under the brand name Tricor among others, is an oral medication of the fibrate class used to treat abnormal blood lipid levels. It is less commonly used
Fenofibrate
Abnormally elevated levels of lipids or lipoproteins in the blood
include diet control, fibrates and niacins. Although statins are typically the first line treatment for hyperlipidemias, fibrates are actually better at
Hyperlipidemia
Group of similar medications
types of classifications are organized into a hierarchy. For example, fibrates are a chemical class of drugs (amphipathic carboxylic acids) that share
Drug_class
Chemical compound
Ciprofibrate is a fibrate that was developed as a lipid-lowering agent. It was patented in 1972 and approved for medical use in 1985. Fischer J, Ganellin
Ciprofibrate
Esters of fatty acid or triglycerides
would increase the risk of pancreatitis is treated with a drug from the fibrate class. Niacin and omega-3 fatty acids as well as drugs from the statin
Fat
Combination drug
of niacin and fibrates used in combination with statin drugs, citing growing evidence that the benefits of combining niacin or fibrate drugs with statin
Niacin/simvastatin
Species of alga
and finely branched marine alga in the Rhodophyta. The branches of P. fibrate are numerous and much interwoven forming tufts up to 20 cm long. They are
Polysiphonia_fibrata
Chemical compound
Clinofibrate (INN; trade name Lipoclin) is pharmaceutical drug of the fibrate class that is used for managing hyperlipidemia and associated conditions
Clinofibrate
Medical condition
saturated, after which VLDL levels elevate. Both conditions are treated with fibrate drugs, which act on the peroxisome proliferator-activated receptors (PPARs)
Combined_hyperlipidemia
Abnormal amount of lipids in the blood
they improved cardiovascular outcomes. The cholesterol lowering effect of fibrates is due to their ability to activate a nuclear receptor called peroxisome
Dyslipidemia
Autoimmune disease of the liver
the PPAR agonists elafibranor and seladelpar, and the off-label use of fibrates. Obeticholic acid (OCA) is FDA-approved for the treatment of PBC in individuals
Primary_biliary_cholangitis
Chemical compound
Bezafibrate (marketed as Bezalip and various other brand names) is a fibrate drug used as a lipid-lowering agent to treat hyperlipidaemia. It helps to
Bezafibrate
Drugs for heart or blood vessels diseases
Antihyperlipidemic agents most often prescribed are statins, ezetimibe and fibrates. They either lower low-density lipoprotein cholesterol (LDL-C) or triglyceride
Cardiovascular_agents
Chemical compound
Ronifibrate is a fibrate, a hypolipidemic agent. It is a combined ester of clofibric acid and niacin (nicotinic acid) with 1,3-propanediol. In the body
Ronifibrate
Indian social entrepreneur (born 1961)
wood pulp from a supplier in Mumbai, and the machines would grind, de-fibrate, press and sterilize the pads under ultraviolet light before packaging
Arunachalam_Muruganantham
High triglyceride blood levels
would increase the risk of pancreatitis is treated with a drug from the fibrate class. Niacin and omega-3 fatty acids as well as drugs from the statin
Hypertriglyceridemia
Chemical compound
Clofibride is a fibrate. Clofibride is a derivative of clofibrate. In the body it is converted into 4-chlorophenoxyisobutyric acid (clofibric acid), which
Clofibride
Nuclear receptor protein found in humans
PPAR-α is the pharmaceutical target of fibrates, a class of drugs used in the treatment of dyslipidemia. Fibrates effectively lower serum triglycerides
Peroxisome proliferator-activated receptor alpha
Peroxisome_proliferator-activated_receptor_alpha
Substance used to diagnose, cure, treat, or prevent disease
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Medication
Class of drugs to lower cholesterol
observed with high-intensity statin therapy. They have less effect than the fibrates or niacin in reducing triglycerides and raising HDL-cholesterol ("good
Statin
Chemical compound
Aluminium clofibrate (or alfibrate) is a fibrate. Clofibrate v t e
Aluminium_clofibrate
Drugs used to achieve relief from pain
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Analgesic
Medication used to treat high cholesterol
may have significant medication interactions with ciclosporin and with fibrates other than fenofibrate. Common adverse drug reactions (≥1% of patients)
Ezetimibe
Drug that inhibits activity of immune system
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Immunosuppressive_drug
Pharmaceutical compound
Metaglidasen was a fibrate-like drug candidate developed by Metabolex, Inc. that acts as a selective receptor modulator of the peroxisome proliferator-activated
Metaglidasen
Class of medications
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Antipsychotic
Drug that increases alertness
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Stimulant
Chemical compound
cholesterol and triacylglyceride level in the blood. It belongs to the class of fibrates. It increases lipoprotein lipase activity to promote the conversion of
Clofibrate
Skin cancer originating in melanocytes
against sun damage. A 2005 review found tentative evidence that statin and fibrate medication may decrease the risk of melanoma. A 2006 review however did
Melanoma
Substance having effect(s) on the body of an individual
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Drug
Hallucinogenic class of psychoactive drug
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Psychedelic_drug
Painful sensations in muscle tissue
infections Compression injury leading to crush syndrome Drug-related Commonly fibrates and statins Occasionally ACE inhibitors, cocaine, and some retroviral drugs
Myalgia
Science of drugs and medications and their effects
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Pharmacology
Substance that relieves stomach problems
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Antacid
Class of corticosteroids
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Glucocorticoid
One of the five major groups of lipoprotein
mortality, despite lowered cholesterol levels. Other developed and tested fibrates, e.g. fenofibric acid have had a better track record and are primarily
Low-density_lipoprotein
Medical condition
consists of beginning an individual on fibrate therapy in an attempt to normalize triglyceride levels. Fibrates such as fenofibrate or gemfibrozil are
Familial_hypertriglyceridemia
Cluster of diseases occurring with obesity
first-line therapy for lowering low-density lipoprotein cholesterol (LDL-C). Fibrates or omega-3 fatty acids may be added for persistent severe hypertriglyceridaemia
Metabolic_syndrome
Agents that relax and loosen the bowels and stools
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Laxative
Condition in which damaged skeletal muscle breaks down rapidly
increase the risk of rhabdomyolysis. The most important ones are: Statins and fibrates, both used for elevated cholesterol, especially in combination; cerivastatin
Rhabdomyolysis
Chemical compound
Simfibrate (JAN/INN; trade name Cholesolvin) is a fibrate that has been used for the treatment of hyperlipidemia. The substance is a double ester of clofibric
Simfibrate
Cholesterol-lowering medication
simvastatin) have been evaluated in clinical trials in combination with fibrates to manage dyslipidemia in people who also have type 2 diabetes, and a high
Atorvastatin
Pharmaceutical drug classification
ATC code C10 Lipid modifying agents is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes
ATC_code_C10
Category of drugs
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Disease-modifying antirheumatic drug
Disease-modifying_antirheumatic_drug
Fat reducing drug
damage (myopathy and rhabdomyolysis) with statins. Fibrates are indicated for hypertriglyceridemia. Fibrates typically lower triglycerides by 20% to 50%. Level
Lipid-lowering_agent
Medication
in pregnancy and breastfeeding is of unclear safety. It belongs to the fibrates group of medications and works by decreasing the breakdown of lipids in
Gemfibrozil
Substance that reduces or suppresses inflammation
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Anti-inflammatory
American biotechnology entrepreneur, physician scientist and naturalist
(July 18, 2006). "The reduction of inflammatory biomarkers by statin, fibrate, and combination therapy among diabetic patients with mixed dyslipidemia:
Richard_B._Lanman
Drug that causes anesthesia
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Anesthetic
One of the five major groups of lipoprotein
therapy to increase the level of HDL cholesterol includes use of fibrates and niacin. Fibrates have not been proven to have an effect on overall deaths from
High-density_lipoprotein
Class of medications used to alleviate anxiety
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Anxiolytic
Medication taken to relieve cold symptoms
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Cold_medicine
Pharmaceutical fungicide or fungistatic used to treat and prevent mycosis
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Antifungal
Drug used for the treatment of symptoms of metabolic syndrome
could trigger dendritic activation. PPARα (alpha) is the main target of fibrate drugs, a class of amphipathic carboxylic acids (clofibrate, gemfibrozil
PPAR_agonist
Drug used to prevent nausea or vomiting
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Antiemetic
Chemical compound
North Sea. Some derivatives of clofibric acid are in a drug class called fibrates. Phenoxy herbicides to which the compound is chemically related Salgado
Clofibric_acid
Dietary lipid
protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors". European Heart
Cholesteryl_ester
Class of psychoactive drugs that produce empathic experiences
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Entactogen
Medical condition
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Steroid_dementia_syndrome
Chemical compound
Etofibrate is a fibrate. It is a combination of clofibrate and niacin, linked together by an ester bond. In the body, clofibrate and niacin separate and
Etofibrate
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Anti-protist
High levels of cholesterol in the blood
mainstay of therapy in childhood. Other agents that may be used include fibrates, nicotinic acid, and cholestyramine. These, however, are only recommended
High_cholesterol
Class of medications
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Anticonvulsant
Type of steroid hormone
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Sex_hormone
Drug that reduces excitement without inducing sleep
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Sedative
Drug for skeletal muscle function
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Muscle_relaxant
Class of drugs
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Anticoagulant
Sterol biosynthesized by all animal cells
often followed by one of various hypolipidemic agents, such as statins, fibrates, cholesterol absorption inhibitors, monoclonal antibody therapy (PCSK9
Cholesterol
Psychiatric medication used to treat mood disorders
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Mood_stabilizer
Widening of blood vessels
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Vasodilation
Agent that prevents fibrinolysis
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Antifibrinolytic
Treatment of cancer using drugs that inhibit cell division or kill cells
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Chemotherapy
Medication class with multiple uses
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Beta_blocker
Chemical compound
and its resultant kidney failure. Risks were higher in patients using fibrates, mainly gemfibrozil (Lopid), and in patients using the highest (0.8 mg/day)
Cerivastatin
Medication used to treat mental disorders
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Psychiatric_medication
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Lists of investigational drugs
Lists_of_investigational_drugs
Class of drugs
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Hallucinogen
Impaired flow of bile from the liver to the small intestine
dyslipidemia, which may present a risk for coronary artery disease. Statins and fibrates are generally used as lipid lowering therapy to treat patients with cholestatic
Cholestasis
Drugs that disrupt movement of calcium across calcium channels
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Calcium_channel_blocker
Class of medication used to treat depression and other conditions
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Antidepressant
Substance that stops bleeding
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Antihemorrhagic
Compound intended to improve cognitive function
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Nootropic
Medications to reversibly block pain
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Local_anesthetic
Symptoms resulting from kidney damage
the use of hypolipidaemic drugs may be necessary (these include statins, fibrates, and resinous sequesters of bile acids). Thrombophilia: low molecular weight
Nephrotic_syndrome
Drugs that lower neurotransmission levels, reducing brain activity
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Depressant
Drugs that block the action of histamine
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
H1_antagonist
Protein found in humans
(calcium channel blocker) buprenorphine (semisynthetic opioid) clofibrate (fibrate) clotrimazole (antifungal) desipramine (tricyclic antidepressant) disulfiram
CYP2A6
Genetic disorder characterized by high cholesterol levels
sequestrants (cholestyramine or colestipol), nicotinic acid preparations or fibrates. Control of other risk factors for cardiovascular disease is required,
Familial_hypercholesterolemia
Class of psychoactive drugs
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Dissociative
Heart rhythm medication
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Antiarrhythmic_agent
Class of medications
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Antiparasitic
Substance that promotes the production of urine
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Diuretic
Antiparasitic drugs that expel parasitic worms (helminths) from the body
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Anthelmintic
Class of steroid hormones
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Corticosteroid
Class of drug
occasionally used as an adjunct to the statins as an alternative to the fibrates (another major group of cholesterol-lowering drugs), which are thought
Bile_acid_sequestrant
Lipid-lowering medication
lowering LDL-cholesterol concentration, but they are less effective than the fibrates in reducing triglyceride concentration. However, statins reduce cardiovascular
Simvastatin
Class of pharmaceutical compounds
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics Antipsoriatics
Antimycobacterial
Medical condition characterized by narrow, hardened, enlarged arteries and veins
inhibitors and diuretics can be used to relieve hypertension. Statins and fibrates can also be prescribed to lower blood cholesterol level and hence reducing
Blood_vessel_disorder
Metabolic disorder in which lipids accumulate in non-fat tissue
cases. The current accepted treatments for lipotoxicity in renal cells are fibrate therapy and intensive insulin therapy. An excess of free fatty acids in
Lipotoxicity
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