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EXTENDED SYNAPTOTAGMIN-1

  • Extended synaptotagmin-1
  • Protein-coding gene in the species Homo sapiens

    Extended synaptotagmin-1 is a protein in humans that is encoded by the ESYT1 gene. GRCh38: Ensembl release 89: ENSG00000139641 – Ensembl, May 2017 GRCm38:

    Extended synaptotagmin-1

    Extended synaptotagmin-1

    Extended_synaptotagmin-1

  • Synaptotagmin
  • Protein family

    transmembrane (Ferlins, Extended-Synaptotagmin (E-Syt) membrane proteins, and MCTPs) and soluble (RIMS1 and RIMS2, UNC13D, synaptotagmin-related proteins and

    Synaptotagmin

    Synaptotagmin

    Synaptotagmin

  • Extended synaptotagmin-2
  • Protein-coding gene in the species Homo sapiens

    Extended synaptotagmin-2 is a protein that in humans is encoded by the ESYT2 gene. GRCh38: Ensembl release 89: ENSG00000117868 – Ensembl, May 2017 GRCm38:

    Extended synaptotagmin-2

    Extended synaptotagmin-2

    Extended_synaptotagmin-2

  • Active zone
  • then binds to change the conformation of synaptotagmin. This change in conformation of allows synaptotagmin to then dislodge complexin, bind to the SNARE

    Active zone

    Active zone

    Active_zone

  • Cav2.1
  • Protein found in humans

    et al. (August 1997). "Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium

    Cav2.1

    Cav2.1

    Cav2.1

  • Soluble NSF attachment protein
  • Protein family

    Ca2+ into the cell where the molecular clamp protein (a SNARE) called synaptotagmin acts in a Ca2+ sensitive manner to facilitate fusion of the vesicle

    Soluble NSF attachment protein

    Soluble NSF attachment protein

    Soluble_NSF_attachment_protein

  • Ryanodine receptor
  • Class of intracellular transport proteins

    interactions. The cytosolic portion of the structure is made up of an extended α-solenoid scaffold which is able to connect regulatory domains to the

    Ryanodine receptor

    Ryanodine receptor

    Ryanodine_receptor

  • SYNCRIP
  • Protein-coding gene in the species Homo sapiens

    Synaptotagmin-binding, cytoplasmic RNA-interacting protein (SYNCRIP), also known as heterogeneous nuclear ribonucleoprotein (hnRNP) Q or NS1-associated

    SYNCRIP

    SYNCRIP

    SYNCRIP

  • Calpain
  • Protease enzyme present in mammals and other organisms

    (formerly CAPN4)), but have distinct large (80 kDa) subunits, known as calpain 1 and calpain 2 (each encoded by the CAPN1 and CAPN2 genes, respectively). No

    Calpain

    Calpain

    Calpain

  • Super-resolution microscopy
  • Series of techniques in optical microscopy

    Westphal V, Jahn R, Hell SW (April 2006). "STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis". Nature. 440 (7086):

    Super-resolution microscopy

    Super-resolution_microscopy

  • MAFK
  • Protein-coding gene in the species Homo sapiens

    expression of MafK, synaptotagmin I, and syntenin-1, which play roles in neuronal function". Journal of Biomedical Science. 17 (1) 18. doi:10.1186/1423-0127-17-18

    MAFK

    MAFK

    MAFK

  • Excitatory synapse
  • Type of synapse

    entering the presynaptic terminal, the calcium binds a protein called synaptotagmin, which is located on the membrane of the synaptic vesicles. This protein

    Excitatory synapse

    Excitatory synapse

    Excitatory_synapse

  • Alpha sheet
  • Secondary protein structure

    alpha-strand regions or alpha-sheet-patterned hydrogen bonding include synaptotagmin, lysozyme, and potassium channels, where the alpha-strands line the

    Alpha sheet

    Alpha sheet

    Alpha_sheet

  • Recoverin
  • Protein-coding gene in the species Homo sapiens

    Rh* at high [Ca2+] levels by binding to GRK1 rather than Rh*, thereby extending the lifetime of Rh*. Understanding the role of recoverin in light adaptation

    Recoverin

    Recoverin

    Recoverin

  • Calmodulin
  • Messenger protein

    roughly perpendicular to one another, and the central linker forms an extended alpha-helix in the crystal structure, but remains largely disordered in

    Calmodulin

    Calmodulin

    Calmodulin

  • Calnexin
  • Mammalian protein found in humans

    calnexin revealed a globular lectin domain and a long hydrophobic arm extending out. ATP and calcium ions are cofactors involved in substrate binding

    Calnexin

    Calnexin

    Calnexin

  • Gelsolin
  • Mammalian protein found in Homo sapiens

    The β-sheets of the three N-terminal subdomains (S1-S3) join to form an extended β-sheet, as do the β-sheets of the C-terminal subdomains (S4-S6). Among

    Gelsolin

    Gelsolin

    Gelsolin

  • KIF1A
  • Motor protein in humans

    shown to carry cargo that contain SV proteins, such as synaptophysin, synaptotagmin, and Rab3A, that are essential for SV biogenesis and membrane fusion

    KIF1A

    KIF1A

    KIF1A

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EXTENDED SYNAPTOTAGMIN-1

  • Scope
  • n.

    Extended area.

  • Extended
  • imp. & p. p.

    of Extend

  • Extend
  • v. t.

    To enlarge, as a surface or volume; to expand; to spread; to amplify; as, to extend metal plates by hammering or rolling them.

  • Extent
  • a.

    Extended.

  • Intended
  • a.

    Made tense; stretched out; extended; forcible; violent.

  • Extense
  • v. t.

    Outreaching; expansive; extended, superficially or otherwise.

  • Extender
  • n.

    One who, or that which, extends or stretches anything.

  • Extend
  • v. t.

    To increase in quantity by weakening or adulterating additions; as, to extend liquors.

  • Intended
  • a.

    Purposed; designed; as, intended harm or help.

  • Pandiculated
  • a.

    Extended; spread out; stretched.

  • Extend
  • v. t.

    To stretch out; to prolong in space; to carry forward or continue in length; as, to extend a line in surveying; to extend a cord across the street.

  • Porrect
  • a.

    Extended horizontally; stretched out.

  • Intended
  • a.

    Betrothed; affianced; as, an intended husband.

  • Extend
  • v. t.

    To enlarge; to widen; to carry out further; as, to extend the capacities, the sphere of usefulness, or commerce; to extend power or influence; to continue, as time; to lengthen; to prolong; as, to extend the time of payment or a season of trail.

  • Extendedly
  • adv.

    In an extended manner.

  • Inextended
  • a.

    Not extended.

  • Extendible
  • a.

    Capable of being extended, susceptible of being stretched, extended, enlarged, widened, or expanded.

  • Protensive
  • a.

    Drawn out; extended.

  • Longsome
  • a.

    Extended in length; tiresome.

  • Extend
  • v. t.

    To bestow; to offer; to impart; to apply; as, to extend sympathy to the suffering.