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EPPTB

  • EPPTB

    • Chemical compound

    EPPTB, also known as RO5212773 or RO-5212773, is a drug developed by Hoffmann-La Roche which acts as a potent and selective antagonist or inverse agonist

    EPPTB

    EPPTB

    EPPTB

  • RTI-7470-44

    • Potent human TAAR1 antagonist

    TAAR1 to be identified, following the potent mouse TAAR1 inverse agonist EPPTB in 2009. The affinity (Ki) of RTI-7470-44 for the human TAAR1 is 0.3 nM

    RTI-7470-44

    RTI-7470-44

    RTI-7470-44

  • 3-Iodothyronamine

    • Chemical compound

    effects were absent with TAAR1 knockout mice or with the TAAR1 antagonist EPPTB. In addition, T1AM-mediated TH phosphorylation appeared to be mediated by

    3-Iodothyronamine

    3-Iodothyronamine

    3-Iodothyronamine

  • Monoaminergic activity enhancer

    • Class of compounds in the nervous system

    the trace amine-associated receptor 1 (TAAR1). Antagonists of MAEs, like EPPTB (a known TAAR1 antagonist), 3-F-BPAP, and rasagiline, have been identified

    Monoaminergic activity enhancer

    Monoaminergic activity enhancer

    Monoaminergic_activity_enhancer

  • TAAR1

    • Protein found in humans

    RO5256390, the TAAR1 partial agonist RO5263397, and the TAAR1 antagonists EPPTB and RTI-7470-44. Selective TAAR1 agonists are used in scientific research

    TAAR1

    TAAR1

    TAAR1

  • 5-Hydroxytryptophan

    • Chemical compound

    is reduced by the trace amine-associated receptor 1 (TAAR1) antagonist EPPTB. In addition, the HTR of 5-HTP is abolished by indolethylamine N-methyltransferase

    5-Hydroxytryptophan

    5-Hydroxytryptophan

    5-Hydroxytryptophan

  • RO5073012

    • Pharmaceutical compound

    RO5256390 – TAAR1 partial or full agonist RO5263397 – TAAR1 partial agonist EPPTB – TAAR1 antagonist/inverse agonist Revel FG, Meyer CA, Bradaia A, Jeanneau

    RO5073012

    RO5073012

    RO5073012

  • Compound 22 (TAAR1 antagonist)

    • Pharmaceutical compound

    mechanisms underlying these effects being unknown. Compound 22, along with EPPTB and RTI-7470-44, is one of the only TAAR1 antagonists that has been identified

    Compound 22 (TAAR1 antagonist)

    Compound 22 (TAAR1 antagonist)

    Compound_22_(TAAR1_antagonist)

  • Locomotor activity

    • Behavioral measure in animals

    RO5263397 did not affect locomotor activity in monkeys. The TAAR1 antagonist EPPTB does not affect basal locomotor activity in rodents. The TAAR1 full agonists

    Locomotor activity

    Locomotor activity

    Locomotor_activity

  • Ulotaront

    • Investigational antipsychotic

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Ulotaront

    Ulotaront

    Ulotaront

  • Phenethylamine

    • Organic compound, a stimulant in humans

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Phenethylamine

    Phenethylamine

    Phenethylamine

  • MDMA

    • Psychoactive drug, often called ecstasy

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    MDMA

    MDMA

    MDMA

  • Guanfacine

    • Medication used for high blood pressure and ADHD

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Guanfacine

    Guanfacine

    Guanfacine

  • Dopamine

    • Organic chemical that functions both as a hormone and a neurotransmitter

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Dopamine

    Dopamine

    Dopamine

  • RO5203648

    • Pharmaceutical compound

    suppresses their firing rates, but is analogous to the TAAR1 antagonist EPPTB, which dramatically increases their firing rates. RO5203648 failed to show

    RO5203648

    RO5203648

    RO5203648

  • RO5263397

    • TAAR1 agonist

    but is similar to the increased firing rates with the TAAR1 antagonist EPPTB, supporting a partially agonistic profile of RO5263397 at the mTAAR1. RO5263397

    RO5263397

    RO5263397

    RO5263397

  • RO5166017

    • Chemical compound

    overflow by RO5166017 could be reversed by the TAAR1 antagonist EPPTB. Neither RO5166017 nor EPPTB had any effect on measures of dopamine reuptake or clearance

    RO5166017

    RO5166017

    RO5166017

  • Psilocybin

    • Chemical compound found in some species of mushrooms

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Psilocybin

    Psilocybin

    Psilocybin

  • Monoamine neurotransmitter

    • Monoamine that acts as a neurotransmitter or neuromodulator

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Monoamine neurotransmitter

    Monoamine neurotransmitter

    Monoamine_neurotransmitter

  • Methamphetamine

    • Central nervous system stimulant

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Methamphetamine

    Methamphetamine

    Methamphetamine

  • Ralmitaront

    • Investigational antipsychotic

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Ralmitaront

    Ralmitaront

    Ralmitaront

  • 3-F-BPAP

    • Monoaminergic activity enhancer antagonist

    receptor subtypes. In contrast to 3-F-BPAP however, the TAAR1 antagonist EPPTB antagonizes the MAE effects of both BPAP and selegiline. 3-F-BPAP has a

    3-F-BPAP

    3-F-BPAP

    3-F-BPAP

  • Amphetamine

    • Central nervous system stimulant

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Amphetamine

    Amphetamine

    Amphetamine

  • Para-Methoxymethamphetamine

    • Stimulant and entactogen designer drug

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Para-Methoxymethamphetamine

    Para-Methoxymethamphetamine

    Para-Methoxymethamphetamine

  • Trimethylamine

    • Chemical compound responsible for rotten fish odor

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Trimethylamine

    Trimethylamine

    Trimethylamine

  • Mescaline

    • Naturally occurring psychedelic compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Mescaline

    Mescaline

    Mescaline

  • Thyroid hormones

    • Hormones produced by the thyroid gland

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Thyroid hormones

    Thyroid hormones

    Thyroid_hormones

  • Cathinone

    • Chemical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Cathinone

    Cathinone

    Cathinone

  • Catecholamine

    • Class of chemical compounds

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Catecholamine

    Catecholamine

    Catecholamine

  • 3-Methylmethcathinone

    • Substituted cathinone designer drug

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    3-Methylmethcathinone

    3-Methylmethcathinone

    3-Methylmethcathinone

  • 4-Hydroxyamphetamine

    • Group of stereoisomers

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    4-Hydroxyamphetamine

    4-Hydroxyamphetamine

    4-Hydroxyamphetamine

  • Phenylpropylaminopentane

    • Stimulant drug of the substituted phenethylamine class

    receptor 1 (TAAR1) agonism. This was evidenced by the TAAR1 antagonist EPPTB reversing the MAE effects of BPAP and selegiline, among other findings.

    Phenylpropylaminopentane

    Phenylpropylaminopentane

    Phenylpropylaminopentane

  • Histamine

    • Organic compound involved in immune responses

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Histamine

    Histamine

    Histamine

  • Benzofuranylpropylaminopentane

    • Chemical compound

    receptor 1 (TAAR1) agonism. This was evidenced by the TAAR1 antagonist EPPTB reversing its MAE effects, among other findings. Another compound, rasagiline

    Benzofuranylpropylaminopentane

    Benzofuranylpropylaminopentane

    Benzofuranylpropylaminopentane

  • C20H21F3N2O2

    • Index of chemical compounds with the same molecular formula

    molecular formula C20H21F3N2O2 (molar mass: 378.387 g/mol) may refer to: EPPTB Tilapertin This set index page lists chemical structure articles associated

    C20H21F3N2O2

    C20H21F3N2O2

  • Tyramine

    • Chemical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Tyramine

    Tyramine

    Tyramine

  • 2C-P

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    2C-P

    2C-P

    2C-P

  • Levoamphetamine

    • CNS stimulant and isomer of amphetamine

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Levoamphetamine

    Levoamphetamine

    Levoamphetamine

  • Adderall

    • Drug mixture used mainly to treat ADHD and narcolepsy

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Adderall

    Adderall

    Adderall

  • Isoprenaline

    • Medication for slow heart rate

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Isoprenaline

    Isoprenaline

    Isoprenaline

  • 2,5-Dimethoxy-4-bromoamphetamine

    • Chemical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    2,5-Dimethoxy-4-bromoamphetamine

    2,5-Dimethoxy-4-bromoamphetamine

    2,5-Dimethoxy-4-bromoamphetamine

  • N,N-Dimethylethylamine

    • Chemical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    N,N-Dimethylethylamine

    N,N-Dimethylethylamine

    N,N-Dimethylethylamine

  • 2C-T-2

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    2C-T-2

    2C-T-2

    2C-T-2

  • 25I-NBOMe

    • Synthetic hallucinogen

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    25I-NBOMe

    25I-NBOMe

    25I-NBOMe

  • 2C-I

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    2C-I

    2C-I

    2C-I

  • Serotonin

    • Monoamine neurotransmitter

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Serotonin

    Serotonin

    Serotonin

  • Phentermine

    • Weight loss medication

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Phentermine

    Phentermine

    Phentermine

  • Etilamfetamine

    • Chemical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Etilamfetamine

    Etilamfetamine

    Etilamfetamine

  • Biscaline

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Biscaline

    Biscaline

    Biscaline

  • Selutaront

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Selutaront

    Selutaront

    Selutaront

  • Thyronamine

    • Chemical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Thyronamine

    Thyronamine

    Thyronamine

  • Β-Methylphenethylamine

    • Chemical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Β-Methylphenethylamine

    Β-Methylphenethylamine

    Β-Methylphenethylamine

  • Biogenic amine

    • Biogenic substance with one or more amine groups

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Biogenic amine

    Biogenic_amine

  • Indolylpropylaminopentane

    • Synthetic monoaminergic activity enhancer drug

    Naphthylpropylaminopentane (NPAP) Phenylpropylaminopentane (PPAP) Antagonists 3-F-BPAP EPPTB Rasagiline See also: Receptor/signaling modulators • Monoamine releasing

    Indolylpropylaminopentane

    Indolylpropylaminopentane

    Indolylpropylaminopentane

  • Ractopamine

    • Animal feed additive

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Ractopamine

    Ractopamine

    Ractopamine

  • Trace amine

    • Amine receptors in the mammalian brain

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Trace amine

    Trace amine

    Trace_amine

  • 2C-B-FLY

    • Psychedelic drug

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    2C-B-FLY

    2C-B-FLY

    2C-B-FLY

  • Methylenedioxyphenylpropylaminopentane

    • Pharmaceutical compound

    Naphthylpropylaminopentane (NPAP) Phenylpropylaminopentane (PPAP) Antagonists 3-F-BPAP EPPTB Rasagiline See also: Receptor/signaling modulators • Monoamine releasing

    Methylenedioxyphenylpropylaminopentane

    Methylenedioxyphenylpropylaminopentane

    Methylenedioxyphenylpropylaminopentane

  • Norepinephrine

    • Catecholamine hormone and neurotransmitter

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Norepinephrine

    Norepinephrine

    Norepinephrine

  • RO5256390

    • Chemical compound

    agonist RO5203648 – TAAR1 partial agonist RO5263397 – TAAR1 partial agonist EPPTB – TAAR1 antagonist/inverse agonist Wu R, Li JX (December 2021). "Potential

    RO5256390

    RO5256390

    RO5256390

  • Head-twitch response

    • Head movement in rodents upon 5-HT2A receptor activation

    receptor agonists like N6-cyclopentyladenosine, and the TAAR1 antagonist EPPTB, have been reported to inhibit the HTR induced by serotonergic psychedelics

    Head-twitch response

    Head-twitch response

    Head-twitch_response

  • 2,5-Dimethoxy-4-methylamphetamine

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    2,5-Dimethoxy-4-methylamphetamine

    2,5-Dimethoxy-4-methylamphetamine

    2,5-Dimethoxy-4-methylamphetamine

  • Monoamine releasing agent

    • Class of compounds

    2022.10.010. PMID 36369028. A study using the TAAR1-specific antagonist EPPTB showed that presynaptic blockade of TAAR1 reversed its ability to inhibit

    Monoamine releasing agent

    Monoamine releasing agent

    Monoamine_releasing_agent

  • RG-7351

    • TAAR1 agonist

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    RG-7351

    RG-7351

  • 4-AcO-DMT

    • Psychedelic drug

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    4-AcO-DMT

    4-AcO-DMT

    4-AcO-DMT

  • 3C-BOH

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    3C-BOH

    3C-BOH

    3C-BOH

  • N-Methyltyramine

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    N-Methyltyramine

    N-Methyltyramine

    N-Methyltyramine

  • Dextroamphetamine

    • CNS stimulant and isomer of amphetamine

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Dextroamphetamine

    Dextroamphetamine

    Dextroamphetamine

  • 25-NB

    • Family of serotonergic psychedelics

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    25-NB

    25-NB

    25-NB

  • 2C (psychedelics)

    • Family of phenethylamine psychedelics

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    2C (psychedelics)

    2C (psychedelics)

    2C_(psychedelics)

  • LY03020

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    LY03020

    LY03020

  • Tryptamine

    • Metabolite of the amino acid tryptophan

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Tryptamine

    Tryptamine

    Tryptamine

  • 2,5-Dimethoxy-4-iodoamphetamine

    • Chemical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    2,5-Dimethoxy-4-iodoamphetamine

    2,5-Dimethoxy-4-iodoamphetamine

    2,5-Dimethoxy-4-iodoamphetamine

  • 3,4-Methylenedioxyamphetamine

    • Entactogen, stimulant, and psychedelic drug of the amphetamine family

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    3,4-Methylenedioxyamphetamine

    3,4-Methylenedioxyamphetamine

    3,4-Methylenedioxyamphetamine

  • 2,4,5-Trimethoxyamphetamine

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    2,4,5-Trimethoxyamphetamine

    2,4,5-Trimethoxyamphetamine

    2,4,5-Trimethoxyamphetamine

  • 2C-O-22

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    2C-O-22

    2C-O-22

    2C-O-22

  • 2,5-Dimethoxy-4-ethylamphetamine

    • Psychedelic drug

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    2,5-Dimethoxy-4-ethylamphetamine

    2,5-Dimethoxy-4-ethylamphetamine

    2,5-Dimethoxy-4-ethylamphetamine

  • O-Phenyl-3-iodotyramine

    • Chemical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    O-Phenyl-3-iodotyramine

    O-Phenyl-3-iodotyramine

    O-Phenyl-3-iodotyramine

  • 2C-E

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    2C-E

    2C-E

    2C-E

  • Di-β-phenylisopropylamine

    • Central nervous system stimulant

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Di-β-phenylisopropylamine

    Di-β-phenylisopropylamine

  • Fluoroproscaline

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Fluoroproscaline

    Fluoroproscaline

    Fluoroproscaline

  • Selegiline

    • Medication

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Selegiline

    Selegiline

    Selegiline

  • Deprenyl

    • Pharmaceutical drug

    Naphthylpropylaminopentane (NPAP) Phenylpropylaminopentane (PPAP) Antagonists 3-F-BPAP EPPTB Rasagiline See also: Receptor/signaling modulators • Monoamine releasing

    Deprenyl

    Deprenyl

    Deprenyl

  • 4-Fluoroselegiline

    • Chemical compound

    Naphthylpropylaminopentane (NPAP) Phenylpropylaminopentane (PPAP) Antagonists 3-F-BPAP EPPTB Rasagiline See also: Receptor/signaling modulators • Monoamine releasing

    4-Fluoroselegiline

    4-Fluoroselegiline

    4-Fluoroselegiline

  • Solriamfetol

    • Medication used for the treatment of excessive sleepiness

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Solriamfetol

    Solriamfetol

    Solriamfetol

  • Psilocin

    • Psychedelic drug

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Psilocin

    Psilocin

    Psilocin

  • Lysergamides

    • Class of chemical compounds

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Lysergamides

    Lysergamides

    Lysergamides

  • NM-2-AI

    • Chemical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    NM-2-AI

    NM-2-AI

    NM-2-AI

  • Octopamine

    • Group of stereoisomers

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Octopamine

    Octopamine

    Octopamine

  • 2C-T-7

    • Psychedelic phenthylamine drug

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    2C-T-7

    2C-T-7

    2C-T-7

  • 3-Methoxyphenethylamine

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    3-Methoxyphenethylamine

    3-Methoxyphenethylamine

    3-Methoxyphenethylamine

  • LK00764

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    LK00764

    LK00764

  • Methylenedioxycathinone

    • Chemical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Methylenedioxycathinone

    Methylenedioxycathinone

    Methylenedioxycathinone

  • 2-Methoxyphenethylamine

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    2-Methoxyphenethylamine

    2-Methoxyphenethylamine

    2-Methoxyphenethylamine

  • TAAR3

    • Human pseudogene

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    TAAR3

    TAAR3

    TAAR3

  • Difluoromescaline

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Difluoromescaline

    Difluoromescaline

    Difluoromescaline

  • 2C-D

    • Pharmaceutical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    2C-D

    2C-D

    2C-D

  • Para-Methoxyamphetamine

    • Chemical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    Para-Methoxyamphetamine

    Para-Methoxyamphetamine

    Para-Methoxyamphetamine

  • Desmethylselegiline

    • Chemical compound

    Naphthylpropylaminopentane (NPAP) Phenylpropylaminopentane (PPAP) Antagonists 3-F-BPAP EPPTB Rasagiline See also: Receptor/signaling modulators • Monoamine releasing

    Desmethylselegiline

    Desmethylselegiline

    Desmethylselegiline

  • 4-PrO-DMT

    • Chemical compound

    Ulotaront (SEP-363856) Antagonists Compound 22 EPPTB (RO-5212773) RTI-7470-44 Inverse agonists EPPTB (RO-5212773) TAAR5Tooltip Trace amine-associated

    4-PrO-DMT

    4-PrO-DMT

    4-PrO-DMT

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