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Pharmaceutical drug
Eculizumab, sold under the brand name Soliris among others, is a recombinant humanized monoclonal antibody used to treat paroxysmal nocturnal hemoglobinuria
Eculizumab
Blood disease in which red blood cells are attacked by the immune system
monoclonal antibody eculizumab reduces the need for blood transfusions and improves quality of life for those affected by PNH. Eculizumab dramatically alters
Paroxysmal nocturnal hemoglobinuria
Paroxysmal_nocturnal_hemoglobinuria
Pharmaceutical drug
activity in people who are clinically stable after having been treated with eculizumab for at least the past six months. The most common side effects are upper
Ravulizumab
Disease of blood and kidneys after bacterial infection
drive the process of microangiopathy leading to worsening TTP. While eculizumab is being used to treat atypical hemolytic uremic syndrome, no evidence
Hemolytic–uremic_syndrome
Life-threatening immune-related blood disease
components (e.g. anti–factor H antibodies). Prior to availability of eculizumab (Soliris) and ravulizumab (Ultomiris), an estimated 33–40% of patients
Atypical hemolytic uremic syndrome
Atypical_hemolytic_uremic_syndrome
American healthcare company
specializing in orphan drugs for rare diseases. Its products include eculizumab (Soliris) and ravulizumab (Ultomiris), both used to treat the rare disorders
Alexion_Pharmaceuticals
Medical condition
symptoms with the use of eculizumab and treprostinil. Discovered by dermatopathologist, Cynthia Magro, response to eculizumab is often immediate and dramatic
Degos_disease
Monoclonal antibody
COMMODORE 1 is a phase III randomized clinical trial comparing crovalimab vs eculizumab in people with paroxysmal nocturnal hemoglobinuria treated with C5 inhibitors
Crovalimab
Medical condition
clinical condition. Kurolap and colleagues treated patients with off-label eculizumab, a humanized anti-C5 monoclonal antibody and complement inhibitor, and
CD55_deficiency
French businessman
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Pascal_Soriot
Medication
medication. Danicopan is indicated as add-on therapy to ravulizumab or eculizumab for the treatment of extravascular hemolysis in adults with paroxysmal
Danicopan
Intravenous medication used in anesthesia
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Propofol
Statin medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Rosuvastatin
Medical study concerned with the kidneys
also used in these conditions and include rituximab, basiliximab and eculizumab. Blood products including intravenous immunoglobulin and a process known
Nephrology
Autoimmune disease
GBS, it has been suggested that complement inhibitors (such as the drug eculizumab) may be effective. In animals, it is called acute polyradiculoneuritis
Guillain–Barré_syndrome
Medication used to treat paroxysmal nocturnal hemoglobinuria
who had not received a complement inhibitor or had previously received eculizumab. These trials demonstrated that 1–2 years of pegcetacoplan treatment effectively
Pegcetacoplan
Vaccines used to prevent infection by Neisseria meningitidis
warned of an increased risk of anemia or hemolysis in people treated with eculizumab (Soliris). The highest risk was when individuals "received a dose of Soliris
Meningococcal_vaccine
Atypical antipsychotic medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Quetiapine
Medication to treat gastroesophageal reflux disease and other conditions
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Omeprazole
Medication which reduces stomach acid
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Esomeprazole
Swedish-British pharmaceutical company
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
AstraZeneca
Acute inflammation diseases of the optic nerve and spinal cord
of AQP4-IgG binding), sivelestat (neutrophil elastase inhibitor), and eculizumab (complement inhibitor). There is little research into the primary causes
Neuromyelitis optica spectrum disorder
Neuromyelitis_optica_spectrum_disorder
Combination drug
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Budesonide/glycopyrronium bromide/formoterol
Budesonide/glycopyrronium_bromide/formoterol
Antibiotic medication
"Unusual Neisseria species as a cause of infection in patients taking eculizumab". J Infect. 78 (2): 113–118. doi:10.1016/j.jinf.2018.10.015. PMC 7224403
Vancomycin
Beta blocker medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Atenolol
Chemical compound
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Savolitinib
British multinational pharmaceutical company
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Zeneca
Swedish multinational pharmaceutical company
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Astra_AB
Medication for asthma & chronic obstructive pulmonary disease
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Budesonide/formoterol
Medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Roflumilast
Viral vector vaccine for prevention of COVID-19
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Oxford–AstraZeneca COVID-19 vaccine
Oxford–AstraZeneca_COVID-19_vaccine
Beta blocker medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Metoprolol
Monoclonal antibody
Camrelizumab† Cedelizumab Certolizumab pegol Crizanlizumab Daclizumab Eculizumab Efalizumab‡ Epratuzumab Erlizumab Etrolizumab† Fontolizumab Frexalimab†
Theralizumab
Type of corticosteroid medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Budesonide
Medication used to treat high blood potassium
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Sodium zirconium cyclosilicate
Sodium_zirconium_cyclosilicate
Chemical compound
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Isosorbide_mononitrate
Angiotensin II receptor antagonist
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Candesartan
Diabetes medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Dapagliflozin
Medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Salbutamol/budesonide
Anti-anemia medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Roxadustat
Chemical compound
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Anastrozole
Biopharmaceutical company, acquired by AstraZeneca in 2007
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
MedImmune
Medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Andexanet_alfa
Antiandrogen medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Bicalutamide
iodide (INN) ecromeximab (INN, USAN) Ecstasy ectylurea (INN) eculizumab (USAN) eculizumab-aeeb edaravone (INN) edatrexate (INN) Edecrin edelfosine (INN)
List_of_drugs:_E–El
Pharmaceutical drug
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Durvalumab
Coronary medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Ticagrelor
Selective estrogen receptor modulator
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Tamoxifen
Scottish chemist
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Tom_McKillop
Monoclonal antibody
Camrelizumab† Cedelizumab Certolizumab pegol Crizanlizumab Daclizumab Eculizumab Efalizumab‡ Epratuzumab Erlizumab Etrolizumab† Fontolizumab Frexalimab†
Spartalizumab
Medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Dapagliflozin/sitagliptin
Abnormally increased hemoglobin in urine
reaction and medication induced hemolysis. Complement inhibitors like eculizumab are used to treat PNH, with hematopoietic stem cell transplant reserved
Hemoglobinuria
Monoclonal antibody
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Motavizumab
Pharmaceutical drug
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Palivizumab
French businessman (1942–2025)
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Louis_Schweitzer
Chemical compound (cancer therapy drug)
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Olaparib
Pharmaceutical drug classification
Sibeprenlimab L04AG19 Axatilimab L04AH01 Sirolimus L04AH02 Everolimus L04AJ01 Eculizumab L04AJ02 Ravulizumab L04AJ03 Pegcetacoplan L04AJ04 Sutimlimab L04AJ05 Avacopan
ATC_code_L04
Variant of a biopharmaceutical
2024 aflibercept-jbvf/Yesafili aflibercept/Eylea May 2024 eculizumab-aeeb/Bkemv eculizumab/Soliris June 2024 ustekinumab-ttwe/Pyzchiva ustekinumab/Stelara
Biosimilar
Abnormal breakdown of red blood cells upon exposure to cold
immunosuppression. Monoclonal antibodies e.g. rituximab (anti-CD20) and eculizumab (anti-C5) have been used but the therapeutic benefits are controversial
Paroxysmal cold hemoglobinuria
Paroxysmal_cold_hemoglobinuria
Protein found in humans
susceptibility to liver fibrosis and to rheumatoid arthritis. The drug eculizumab (trade name Soliris) prevents cleavage of C5 into C5a and C5b. GRCh38:
Complement_component_5
Chemical compound
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Acalabrutinib
CD3E cancer Ecromeximab mab chimeric GD3 ganglioside malignant melanoma Eculizumab Soliris mab humanized C5 Y paroxysmal nocturnal hemoglobinuria, atypical
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
Chemical compound
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Brompheniramine
Chemical compound
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Disufenton_sodium
Chemical compound
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Goserelin
Pharmaceutical compound
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Sebelipase_alfa
Regulatory class of pharmaceutical drug
researchers agreed, that the sky-high price of orphan drugs, such as eculizumab, was not related to research, development and manufacturing costs. Their
Orphan_drug
Monoclonal antibody used as vaccine against RSV
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Nirsevimab
negotiations for prices on ten drugs in its first three years, including for eculizumab, and estimated it had saved approximately $50,000,000. A. Scott Carson;
Pan-Canadian Pharmaceutical Alliance
Pan-Canadian_Pharmaceutical_Alliance
Platelet reduction following transfusion
include thrombopoietin receptor agonists, complement inhibitors such as eculizumab, and slow infusion. Colman, Robert W.; Marder, Victor J.; Clowes, Alexander
Platelet transfusion refractoriness
Platelet_transfusion_refractoriness
Medical condition
investigational treatment therapies include high doses of Rituxan (Rituximab) and eculizumab, which are both humanized monoclonal antibodies that target B cell malignancies
Catastrophic antiphospholipid syndrome
Catastrophic_antiphospholipid_syndrome
Monoclonal antibody
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Anifrolumab
Pharmaceutical drug
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Asfotase_alfa
Anticoagulant
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Ximelagatran
Medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Exenatide
Medication used in treatment of migraines
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Zolmitriptan
Medication used for cancer
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Gefitinib
Form of immunotherapy
5/1/2017 intravenous fully human PD-L1 Urothelial carcinoma 761069 Link eculizumab Soliris Alexion 3/16/2007 intravenous humanized Complement component 5
Monoclonal_antibody_therapy
Monoclonal antibody treatment for COVID-19
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Tixagevimab/cilgavimab
Nasal influenza vaccine
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Live attenuated influenza vaccine
Live_attenuated_influenza_vaccine
complement system have led to the development of successful drugs including Eculizumab. There are two primary mechanisms by which dysfunction of complement can
Complement_control_protein
Part of the innate immune system
treatment with the complement-inhibitory anti-C5 monoclonal antibody, eculizumab, is found to be highly effective. C3a - the other fragment C3 is cleaved
C3b
Hormonal antineoplastic drug
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Fulvestrant
products are produced using the NS0 cell line including daclizumab and eculizumab. Barnes, LM; Bentley, CM; Dickson, AJ (February 2000). "Advances in animal
NS0_cell
Chemical compound
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Zafirlukast
American geneticist
Arcadi; Slijper, Nadav; Steinberg, Ran; Zohar, Yaniv (March 2019). "Eculizumab Is Safe and Effective as a Long-term Treatment for Protein-losing Enteropathy
Michael_J._Lenardo
Medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Trastuzumab_deruxtecan
Monoclonal antibody
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Benralizumab
Chemical compound, used as a medication to treat lung cancer
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Osimertinib
Class of enzymes
in a Phase 2 clinical trial for Factor D inhibition when combined with eculizumab. Patients treated with Factor D inhibitors must be immunized against infections
Factor_D
adrenal hyperplasia (CAH) Danicopan As add-on therapy to ravulizumab or eculizumab for the treatment of extravascular hemolysis (EVH) in adults with paroxysmal
List of drugs granted breakthrough therapy designation
List_of_drugs_granted_breakthrough_therapy_designation
Chemical compound
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Saxagliptin
British biotechnology company (1989–2007)
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Cambridge_Antibody_Technology
Combination medication
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Glycopyrronium bromide/formoterol
Glycopyrronium_bromide/formoterol
Chemical compound
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Vandetanib
Overview of and topical guide to immunology
Antibodies Monoclonal Serum target (noncellular) Complement component 5 Eculizumab Ravulizumab TNF Adalimumab Afelimomab Certolizumab pegol Golimumab Infliximab
Outline_of_immunology
Chemical compound
bromide/formoterol Candesartan Dapagliflozin Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol
Selumetinib
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