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California-based biopharmaceutical company
2020-07-06. "Cytokinetics Inc (CYTK) IPO." Nasdaq. 29 Apr 2004 "New CEO at Cytokinetics." San Francisco Business Times. 22 Jan 2007. [1] "Cytokinetics: Keeping
Cytokinetics
Chemical compound
hypertrophic cardiomyopathy. It is a cardiac myosin inhibitor developed by Cytokinetics. Aficamten binds directly to the motor domain of cardiac myosin and prevents
Aficamten
Cellular formation during cytokinesis
An actomyosin ring, contractile ring, or cytokinetic ring is a prominent structure during cytokinesis. It forms perpendicular to the axis of the spindle
Actomyosin_ring
Final stage of cell division
steps: anaphase spindle reorganization, division plane specification, cytokinetic ring assembly and contraction, and abscission. Faithful partitioning
Cytokinesis
Japanese pharmaceutical company
December 2014, Astellas expanded its 18-month-old collaboration with Cytokinetics, focusing on the R&D and commercialization of skeletal muscle activators
Astellas_Pharma
Protein-coding gene in humans
Polymeric immunoglobulin receptor (pIgR) is a transmembrane protein that in humans is encoded by the PIGR gene. It is an Fc receptor which facilitates
Polymeric immunoglobulin receptor
Polymeric_immunoglobulin_receptor
American multinational biopharmaceutical company
Amgen also announced that it would terminate its collaboration with Cytokinetics and transition the development and commercialization rights for omecamtiv
Amgen
List of companies in the S&P 400
Electronic Equipment & Instruments Stamford, Connecticut reports CYTK Cytokinetics Health Care Biotechnology South San Francisco, California reports DAR
List_of_S&P_400_companies
Chemical compound
sclerosis. It is a troponin activator. "Reldesemtiv - Astellas Pharma/Cytokinetics". AdisInsight. Springer Nature Switzerland AG. Collibee SE, Bergnes G
Reldesemtiv
Enlargement of the heart muscle
(FDA) (Press release). 22 December 2025. Retrieved 22 December 2025. "Cytokinetics Announces FDA Approval of Myqorzo (aficamten) for the Treatment of Adults
Hypertrophic_cardiomyopathy
Bermuda-domiciled professional services firm
Pharmaceuticals Avantor Bio-Rad Laboratories BioMarin Pharmaceutical Bruker Cytokinetics Dentsply Sirona Doximity Elanco Encompass Health Exelixis Globus Medical
Genpact
(2000– ) Cyclacel (1997– ) Cynapsus (subsidiary of Sunovion; 1984- ) Cytokinetics (1997– ) CytRx (1985– ) Daewoong (1945– ) Daiichi Sankyo (2005– ) Danco
List of pharmaceutical companies
List_of_pharmaceutical_companies
American bank holding company
Pharmaceuticals Avantor Bio-Rad Laboratories BioMarin Pharmaceutical Bruker Cytokinetics Dentsply Sirona Doximity Elanco Encompass Health Exelixis Globus Medical
Flagstar_Bank
Network of filamentous proteins that forms the internal framework of cells
important model organism), actin forms cortical patches, actin cables, and a cytokinetic ring and the cap. Cortical patches are discrete actin bodies on the membrane
Cytoskeleton
American chemist
also the Senior Vice President of Regulatory Affairs and Compliance at Cytokinetics. Bonnie Charpentier completed a bachelor's degree in anthropology in
Bonnie_A._Charpentier
American venture capital and growth equity firm
Ascendis, Blueprint Medicines, CG Oncology, Color Genomics, Cue Health, Cytokinetics, DNAnexus,[citation needed] Editas Medicine, Eikon Therapeutics, Element
Foresite_Capital
Protein pathway in cells
cellular processes including multivesicular body (MVB) biogenesis and cytokinetic abscission. Multivesicular body (MVB) biogenesis is a process in which
ESCRT
research. As a cofounder and consultant of the biotechnology company Cytokinetics, Inc. he has also had an active role in private industry. Goldstein has
Lawrence_S.B._Goldstein
American real estate software services company
Pharmaceuticals Avantor Bio-Rad Laboratories BioMarin Pharmaceutical Bruker Cytokinetics Dentsply Sirona Doximity Elanco Encompass Health Exelixis Globus Medical
AppFolio
Rare congenital neuromuscular disorder
Reldesemtiv (CK-2127107, CK-107) is a skeletal troponin activator developed by Cytokinetics in cooperation with Astellas. The drug aims at increasing muscle reactivity
Spinal_muscular_atrophy
Protein-coding gene in the species Homo sapiens
actin. PRC1’s role in midzone microtubule formation, essential to the cytokinetic machinery of mammals, is made possible through its collaboration with
PRC1
U.S. nonprofit organization
Squibb Camurus Catalyst Pharmaceuticals CRISPR Therapeutics CSL Behring Cytokinetics Daiichi Sankyo Editas Medicine Eli Lilly and Company Foundation Medicine
National Organization for Rare Disorders
National_Organization_for_Rare_Disorders
American scientist
serving on the scientific advisory board of PTC, he does likewise with Cytokinetics and Solid Biosciences He is also on the scientific advisory board of
Lee_Sweeney
Increase of the total mass of a cell
recruited to similar nodes; these nodes eventually condense to form the cytokinetic ring. A previously uncharacterized protein, Blt1, was found to colocalize
Cell_growth
American scientist and professor
Review of Cell and Developmental Biology. In 1998 Spudich co-founded Cytokinetics Inc. in San Francisco, along with Ron Vale and James Sabry from UCSF
James_Spudich
Family of motor proteins
unconventional myosin VIII in plant cells and its localization at the post-cytokinetic cell wall". The Plant Journal. 19 (5): 555–567. doi:10.1046/j.1365-313X
Myosin
American venture capital firm
Biopharmaceuticals, Capstone Turbine, Ciena, Citrix Systems, Compaq, Cyrix, Cytokinetics, Electronic Arts, NetLogic Microsystems, Silicon Graphics, MetaCarta
Sevin_Rosen_Funds
Protein
mDia1 is highly homologous to Drosophila diaphanous, regulating the cytokinetic ring during cytokinesis. Homologues in other species are known as well
MDia1
Human protein
staining from Thermo Fisher Scientific shows presence of KIAA1143 in a cytokinetic bridge, which is involved in cellular cytokinesis. This indicates KIAA1143
KIAA1143
Chemical compound
S2CID 9411257. Mast J (9 October 2020). "R&D Amgen's big cardiovascular bet with Cytokinetics hits PhIII primary but dramatically disappoints investors". Endpoints
Omecamtiv_mecarbil
Protein family
cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments". The Journal of Cell Biology. 143 (5):
Rho-associated_protein_kinase
American cell biologist
cytokinesis in animal cells, experiments that focused on understanding how the cytokinetic furrow is positioned, and understanding the nature of the stimulus from
Ray_Rappaport
Mammalian protein found in Homo sapiens
2005). "Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas
ANLN
Family of proteins in molecular biology
coiled coils. ZapA interacts with FtsZ, where FtsZ is part of a mid-cell cytokinetic structure termed the Z-ring that recruits a hierarchy of fission related
ZapA_family
Physical force that originates from thermodynamics instead of fundamental interactions
Here, the actin-bundling protein anillin drives actin contractility in cytokinetic rings. Some forces that are generally regarded as conventional forces
Entropic_force
Abstracts 0.049, 0.428, 0.058 Cytoplasm, nucleoplasm, microtubules, cytokinetic bridge Component of cullin-RING-based BCR E3 ubiquitin-protein ligase
KLHL36
complex Interacts with RhoA and Rac during furrow ingression Recruits cytokinetic effector proteins such as ECT2 Binds microtubule plus-end overlaps characteristic
Centralspindlin
localized to the microtubules and centrosome and sometimes localized to the cytokinetic bridge. The gene is highly expressed in the cerebral cortex of the brain
CRACD-like_protein
Protein-coding gene in the species Homo sapiens
JADE1S moderate overexpression augmented the number of cytokinetic cells indicative of cytokinetic delay. Inhibition of Aurora B kinase by specific small
JADE1
Mammalian protein found in Homo sapiens
severing positive regulation of protein processing in phagocytic vesicle cytokinetic process cell-cell adhesion microtubule-based movement Sources:Amigo /
MYH9
Motor protein found in humans
migration microtubule-based movement positive regulation of mitotic cytokinetic process neural tube closure protein localization to microtubule regulation
KIF20B
Protein-coding gene in the species Homo sapiens
cytoskeleton cytoplasm cytosol Biological process cell cycle mitotic cytokinetic process centrosome separation cell division centriole replication regulation
CNTROB
American oncologist
Marc J. "Cytokinetic Chemotherapy Design for the Treatment of Advanced Lung Cancer 1, 2." Cancer treatment reports 63.5–8 (1979): 767. Cytokinetic analysis
Marc_Straus
Protein
reticulum to Golgi vesicle-mediated transport protein hexamerization cytokinetic process axonogenesis positive regulation of microtubule depolymerization
Spastin
Structure in dividing plant cells that builds the daughter cell wall
Divergent Cellular Role for the FUSED Kinase Family in the Plant-Specific Cytokinetic Phragmoplast". Current Biology. 15 (23): 2107–2111. Bibcode:2005CBio
Phragmoplast
Bacterial protein that is related to actin
is involved in bacterial cell division, where it serves to tether the cytokinetic ring formed by FtsZ to the cytoplasmic membrane prior to division. Along
FtsA
Channel in cell walls of plants and some algae
unconventional myosin VIII in plant cells and its localization at the post-cytokinetic cell wall". Plant Journal. 19 (5): 555–569. doi:10.1046/j.1365-313x.1999
Plasmodesma
reversal involves the reassembly of the mitotic spindle, retraction of the cytokinetic furrow, dissolution of the newly formed nuclear envelope, and recondensation
Mitotic_exit
American microbiologist
FtsZ, the ancestral homologue of eukaryotic tubulin, assembles into a cytokinetic ring (Z ring) that drives cell division in most bacteria, some archaea
Joe_Lutkenhaus
Protein-coding gene in humans
5 (Astrin) whose inappropriate accumulation at the midbody triggers cytokinetic arrest, multinucleated cells, and cell death. MID2 has been shown to
MID2
E., F. M. Schabel, Jr., et al. (1970). "Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal
Fractional_kill
History of components of the S&P 400
DECK Deckers Brands Market capitalization changes. March 18, 2024 CYTK Cytokinetics CALX Calix Market capitalization changes. March 18, 2024 AIT Applied
Historical components of the S&P 400
Historical_components_of_the_S&P_400
Protein-coding gene in the species Homo sapiens
promising preclinical studies, ispinesib (SB-715992; Cytokinetics/GSK), SB-743921 from Cytokinetics/GSK, MK-0731 from Merck, filanesib (ARRY-520) (Array
Kinesin-like_protein_KIF11
Protein
regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process". Journal of Biological Chemistry. 278 (10): 8526–8530. doi:10
Aurora_kinase_B
American biochemist (born 1959)
the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission". eLife. 11 e77779. doi:10.7554/eLife.77779. ISSN 2050-084X
Wesley_Sundquist
Virginia; Echard, Arnaud (24 November 2022). "Mechanics and regulation of cytokinetic abscission". Frontiers in Cell and Developmental Biology. 10 1046617
Intercellular_communication
American biologist
dynamic microtubules coordinately shape the myosin activation zone during cytokinetic furrow formation". Journal of Cell Biology. 183 (3): 457–470. doi:10
Victoria_Foe
American physiologist, radiation biologist, and cell biologist
43.3.357. PMID 13941891. Lala, Peeyush K.; Patt, Harvey M. (1966). "Cytokinetic Analysis of Tumor Growth". Proceedings of the National Academy of Sciences
Harvey_M._Patt
Protein-coding gene in the species Homo sapiens
spindle organization centriole assembly positive regulation of mitotic cytokinetic process positive regulation of protein localization to centrosome centrosome
Nuclear_pore_glycoprotein_p62
Australian biologist
control of the division process in bacteria. She discovered that the cytokinetic ring, which is a polymer of the tubulin-like protein, FtsZ, forms at
Elizabeth_Harry
History of components of the S&P 600
of the small cap market space. March 18, 2024 CALX Calix, Inc. CYTK Cytokinetics CALX was moved from the S&P 400 as it was more representative of the
Historical components of the S&P 600
Historical_components_of_the_S&P_600
Class of enzymes
129.6.1617. PMC 2291169. PMID 7790358. Mulvihill DP, Hyams JS (2002). "Cytokinetic actomyosin ring formation and septation in fission yeast are dependent
Polo_kinase
Protein-coding gene in the species Homo sapiens
process cell division response to calcium ion phagocytosis cell cycle cytokinetic process Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA:
Annexin_A11
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