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Organic compounds of the form RC(=O)NR′R″
In organic chemistry, an amide, also known as an organic amide or a carboxamide, is a compound with the general formula R−C(=O)−NR′R″, where R, R', and
Amide
Class of chemical compounds
signalling. The signalling is controlled in part by fatty acid amide hydrolases, which convert the amide to the parent fatty acid. One example of signaling is
Fatty_acid_amide
Dietary supplement and medication
consists of a pyridine ring to which a primary amide group is attached in the meta position. It is an amide of nicotinic acid. As an aromatic compound, it
Nicotinamide
Chemical compound
Sodium amide, commonly called sodamide (systematic name sodium azanide), is the inorganic compound with the formula NaNH2. It is a salt composed of the
Sodium_amide
Organic compound
formula CO(NH2)2. This amide has two amino groups (−NH2) joined by a carbonyl functional group (−C(=O)−). It is thus the simplest amide of carbamic acid. Urea
Urea
Chemical compound
Ergine, also known as lysergic acid amide (LSA or LAA) as well as LA-111, is a psychoactive compound of the ergoline and lysergamide families related
Ergine
Cleavage of chemical bonds by the addition of water
for the hydrolysis of proteins, fats, oils, and carbohydrates. Ester and amide hydrolysis occurs through nucleophilic acyl substitution where water acts
Hydrolysis
Chemical compound
Potassium amide is an inorganic compound with the chemical formula KNH2. Like other alkali metal amides, it is a white solid that hydrolyzes readily.
Potassium_amide
Macromolecule with repeating units linked by amide bonds
A polyamide is a polymer with repeating units linked by amide bonds. Polyamides occur both naturally and artificially. Examples of naturally occurring
Polyamide
Chemical compound
Lithium amide or lithium azanide is an inorganic compound with the chemical formula LiNH2. It is a white solid with a tetragonal crystal structure. Lithium
Lithium_amide
Covalent bond between amino acids in a protein chain
In organic chemistry, a peptide bond is an amide type of covalent chemical bond linking two consecutive alpha-amino acids from C1 (carbon number one)
Peptide_bond
Chemical compound
the amide derived from the fatty acid oleic acid. It is a colorless waxy solid and occurs in nature. Sometimes labeled as a fatty acid primary amide (FAPA)
Oleamide
In chemistry, the term amide (/ˈæmaɪd/ or /ˈæmɪd/ or /ˈeɪmaɪd/) is a compound with the functional group RnE(=O)xNR2, where x is not zero, E is some element
Amide_(functional_group)
Common name for more than 1,000 species of flowering plants in the family Convolvulaceae
and/or psychedelic lysergamides ergine (lysergic acid amide; LSA) and isoergine (isolysergic acid amide; iso-LSA), which are closely structurally related
Morning_glory
Dopaminergic agent
DopAmide, or L-DopAmide, is a synthetic levodopa (L-DOPA) analogue that can serve as a levodopa and dopamine prodrug and is of potential interest in the
DopAmide
Chemical compound
hydroxyethylamide (LSH or LAH), also known as lysergic acid N-(α-hydroxyethyl)amide or as lysergic acid methyl carbinolamide, is a lysergamide alkaloid related
Lysergic acid hydroxyethylamide
Lysergic_acid_hydroxyethylamide
Chemical compound
Lithium bis(trimethylsilyl)amide is a lithiated organosilicon compound with the formula LiN(Si(CH3)3)2. It is commonly abbreviated as LiHMDS or Li(HMDS)
Lithium bis(trimethylsilyl)amide
Lithium_bis(trimethylsilyl)amide
Topics referred to by the same term
A transition metal amide complex may refer to: A transition metal carboxamide complex A transition metal inorganic amide This disambiguation page lists
Transition metal amide complex
Transition_metal_amide_complex
Anion derived from deprotonation of ammonia
referred to as alkali metal amides. Examples include lithium amide, sodium amide, and potassium amide. These salt-like solids are produced by treating liquid
Azanide
Thermoplastic elastomer
Polyether block amide or PEBA is a thermoplastic elastomer (TPE). It is known under the tradename of PEBAX® (Arkema) and VESTAMID® E (Evonik Industries)
Polyether_block_amide
Chemical compound
Erucamide is a fatty acid amide resulting from the formal condensation of erucic acid with ammonia. It has a role as a metabolite in humans and other
Erucamide
Chemical compound
act as a nucleophile under certain conditions. Lithium amide Lithium bis(trimethylsilyl)amide (LiHMDS) Lithium tetramethylpiperidide (LiTMP) Evans pKa
Lithium_diisopropylamide
azanides) are a class of coordination compounds composed of a metal center with amide ligands of the form NR2−. Amido complexes of the parent amido ligand NH2−
Metal_amides
Pharmaceutical compound
Isoergine, also known as isolysergic acid amide (iso-LSA or iso-LA-819), isolysergamide, or erginine, is a serotonergic psychedelic of the ergoline and
Isoergine
Organic reaction where amide is converted to Amine or Aldehyde
Amide reduction is a reaction in organic synthesis where an amide is reduced to either an amine or an aldehyde functional group. Catalytic hydrogenation
Amide_reduction
Chemical compound
commonly used for activation of carboxylic acids, particularly for amide synthesis. Amide coupling is one of the most common reactions in organic chemistry
DMTMM
Glutathione amide reductase (EC 1.8.1.16, GAR) is an enzyme with systematic name glutathione amide:NAD+ oxidoreductase. This enzyme catalyses the following
Glutathione_amide_reductase
Mammalian protein found in Homo sapiens
Fatty-acid amide hydrolase 1 (FAAH) is a member of the serine hydrolase family of enzymes. It was first shown to break down anandamide (AEA), an N-acylethanolamine
Fatty-acid_amide_hydrolase_1
Chemical compound
Sodium bis(trimethylsilyl)amide is the organosilicon compound with the formula NaN(Si(CH3)3)2. This species, usually called NaHMDS (sodium hexamethyldisilylamide)
Sodium bis(trimethylsilyl)amide
Sodium_bis(trimethylsilyl)amide
Glutathione amide-dependent peroxidase (EC 1.11.1.17) is an enzyme with systematic name glutathione amide:hydrogen-peroxide oxidoreductase. This enzyme
Glutathione amide-dependent peroxidase
Glutathione_amide-dependent_peroxidase
Chemical reaction
the synthesis of aldehydes by reduction of the amide with an excess of lithium aluminum hydride (see amide reduction). The major advantage of this method
Weinreb_ketone_synthesis
Chemical compound
to activate carboxylic acids for reaction with amines in the context of amide bond formation and peptide synthesis. TCFH is commercially available. It
TCFH
Small motifs in proteins and polypeptides
Amide rings are small motifs in proteins and polypeptides. They consist of rings formed by two CO...HN hydrogen bonds between a side chain amide group
Amide_ring
Chemical compound
N-Acetylcysteine amide (abbrev. NACA, AD4 and also known as acetylcysteinamide) is an amide derivative of N-acetylcysteine (NAC) that appears to have better
Acetylcysteinamide
carboxamide complexes are coordination complexes containing one or more amide ligands (RC(O)NH2 being the simplest members) bound to a transition metal
Transition metal carboxamide complex
Transition_metal_carboxamide_complex
Class of chemical compounds
The simplest lysergamides are ergine (lysergic acid amide; LSA) and isoergine (iso-lysergic acid amide; iso-LSA). In terms of pharmacology, the lysergamides
Lysergamides
Chemical compound
CH3CH2C=O(NH2). It is the amide of propanoic acid. This organic compound is a mono-substituted amide. Organic compounds of the amide group can react in many
Propanamide
Chemical compound
Potassium bis(trimethylsilyl)amide (commonly abbreviated as KHMDS, Potassium(K) HexaMethylDiSilazide) or potassium hexamethyldisilazane is the chemical
Potassium bis(trimethylsilyl)amide
Potassium_bis(trimethylsilyl)amide
Organic chemical compound
Acrylamide (or acrylic amide) is an organic compound with the chemical formula CH2=CHC(O)NH2. It is a white odorless solid, soluble in water and several
Acrylamide
Type of chemical reaction
rearrangement (Hofmann degradation) is the organic reaction of a primary amide to a primary amine with one less carbon atom. The reaction involves oxidation
Hofmann_rearrangement
Class of enzymes that can form bonds between molecules
In biochemistry, a ligase is an enzyme that can catalyze the joining (ligation) of two molecules by forming a new chemical bond. This is typically via
Ligase
Cyclic amide
cyclic amide, formally derived from an amino carboxylic acid through cyclization reactions. The term is a portmanteau of the words lactone + amide. Greek
Lactam
Pharmaceutical compound
LA-3Cl-SB, also known as Cl-LSB or as lysergic acid N-(3-chloro-sec-butyl)amide, is a putative serotonergic psychedelic of the lysergamide family related
LA-3Cl-SB
Digestive enzyme
Chymotrypsin preferentially cleaves peptide amide bonds where the side chain of the amino acid N-terminal to the scissile amide bond (the P1 position) is a large
Chymotrypsin
Family of neuropeptides
Vaudry H, Seong JY (2014). "Does Kisspeptin Belong to the Proposed RF-Amide Peptide Family?". Front Endocrinol (Lausanne). 5: 134. doi:10.3389/fendo
RFamide_peptide_family
Method for producing 2-aminopyridine derivatives
producing 2-aminopyridine derivatives by the reaction of pyridine with sodium amide. It was reported by Aleksei Chichibabin in 1914. The following is the overall
Chichibabin_reaction
Chemical compound
N-Nitrosodimethylamine Names Preferred IUPAC name N,N-Dimethylnitrous amide Identifiers CAS Number 62-75-9 Y 3D model (JSmol) Interactive image ChEBI
N-Nitrosodimethylamine
Chemical compound
a carboxyl activating agent for the coupling of primary amines to yield amide bonds. While other carbodiimides like dicyclohexylcarbodiimide (DCC) or
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide
Chemical compound
Dansyl amide is a fluorescent dye that forms in a reaction between dansyl chloride and ammonia. It is the simplest representative of the class of dansyl
Dansyl_amide
Chemical compound
deprotonation of bis(trimethylsilyl)amine. For example, lithium bis(trimethylsilyl)amide (LiHMDS) is prepared using n-butyllithium: [(CH3)3Si]2NH + BuLi → [(CH3)3Si]2NLi
Bis(trimethylsilyl)amine
Chemical reaction
The von Braun amide degradation is the chemical reaction of a monosubstituted amide with phosphorus pentachloride or thionyl chloride to give a nitrile
Von_Braun_amide_degradation
Class of chemical compounds
Chloramines refer to derivatives of ammonia and organic amines wherein one or more N−H bonds have been replaced by N−Cl bonds. Two classes of compounds
Chloramines
L-proline amide hydrolase (EC 3.5.1.101, S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase, LaaA, L-amino acid amidase) is an enzyme with
L-proline_amide_hydrolase
Class of chemical compounds
of local anesthetics. They are named for their ester bond and are unlike amide local anaesthetics. Structurally, amino esters consist of three molecular
Amino_esters
Protein-coding gene in the species Homo sapiens
RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein. The 26-amino acid RF-amide peptide, P518 functions as a high-affinity
QRFP
Chemical compound
2-Methylacrylamide; 2-Methylpropenamide; α-Methyl acrylic amide; Methacrylic acid amide; Methacrylic amide; Methylacrylamide Identifiers CAS Number 79-39-0 Y
Methacrylamide
Psychoactive drug, often called ecstasy
Lysergamides No substitutions: Ergine (LSA, LA-111) Isoergine (iso-LSA, iso-LA) Amide-substituted lysergamides: DAL DAM (DAM-57) DiPLA DPL EcPLA EiPLA EPLA (LEP;
MDMA
Chemical compound
Isovaleramide is an organic compound with the formula (CH3)2CHCH2C(O)NH2. The amide derived from isovaleric acid, it is a colourless solid. Isovaleramide is
Isovaleramide
Chemical compound
(INNTooltip International Nonproprietary Name), is an endogenous fatty acid amide, and lipid modulator. PEA is not a classic endocannabinoid because it lacks
Palmitoylethanolamide
Spicy food additive
vanillylamide or PAVA, is an organic compound and a capsaicinoid. It is an amide of pelargonic acid (n-nonanoic acid) and vanillyl amine. It is present in
Nonivamide
Chemical compound
potency as a dopamine reuptake inhibitor to cocaine. It is synthesized by an amide condensation reaction between benzoylecgonine and dimethylamine.
RTI-160
Chemical compound
ethanamide) is an organic compound with the formula CH3CONH2. It is an amide derived from ammonia and acetic acid. It finds some use as a plasticizer
Acetamide
Chemical compound
with Hünig's base (N,N-diisopropylethylamine), or triethylamine to form amide bonds. Typically dimethylformamide is used as solvent, although other polar
HATU
Pharmaceutical compound
3-dimethylaziridin-1-yl)lysergamide or as lysergic acid-(2,3-dimethylaziridinyl)amide, is a chemical compound of the lysergamide family related to lysergic acid
LA-Aziridine
Chemical compound
organic compound with the chemical formula of C7H7NO. It is the simplest amide derivative of benzoic acid. In powdered form, it appears as a white solid
Benzamide
unstable because its amide group has the amine lone pair and the carbonyl group not properly aligned, as may be expected for an amide, as a result of steric
Quinuclidone
catalyzes the chemical reaction [peptide]-(2S)-2-hydroxyglycine = [peptide]-amide + glyoxylate This enzyme belongs to the family of lyases, specifically amidine
Peptidylamidoglycolate_lyase
Organosulfur compound
diamide Preferred IUPAC name Sulfamide Other names Sulphamide Sulfuryl amide Identifiers CAS Number 7803-58-9 Y 3D model (JSmol) Interactive image ChEBI
Sulfamide
Chemical compound
2-dimethylpropanamide, or NDEPA), a simple amide substituted with a tert-butyl group having the chemical formula: tBu-CO-NH2. It is the amide of pivalic acid. N-Pivalamide
Pivalamide
Chemical compound
it a useful organic reagent. It is commonly used as the hindered base in amide coupling reactions between a carboxylic acid (typically activated, for example
N,N-Diisopropylethylamine
Quasiparticle used to model vibrations within proteins
quasiparticle representing an excitation propagating along the self-trapped amide I groups within the α-helices of proteins. It is a solution of the Davydov
Davydov_soliton
Class of synthetic fiber related to nylon
lightweight consumer items, such as phone cases and tennis rackets. Individual amide molecules forming the aramid chain polymerise in the direction of the fiber
Aramid
Chemical compound
and hydrogen bonding due to its cis-amide conformation. NMP is produced industrially by a typical ester-to-amide conversion, by treating gamma-butyrolactone
N-Methyl-2-pyrrolidone
The α-Ketoacid-Hydroxylamine (KAHA) Amide-Forming Ligation is a chemical reaction that is used to join two unprotected fragments in peptide synthesis
KAHA_Ligation
Protein family
enzyme that catalyzes the hydrolysis of an amide. In this way, the two substrates of this enzyme are an amide and H2O, whereas its two products are monocarboxylate
Amidase
Organic compound (CH3COCl)
Acetyl chloride (CH3COCl) is an acyl chloride derived from acetic acid (CH3COOH). It belongs to the class of organic compounds called acid halides. It
Acetyl_chloride
Class of chemical compounds
Ethanolamides are chemical compounds which are amides formed from carboxylic acids and ethanolamine. Some ethanolamides are naturally occurring, such as
Ethanolamide
Chemical reaction
hydrolysis of the amide. When the alkyl group is an aliphatic chain (n typically 0 to 5), multiple reactions take place with the amide group always ending
Willgerodt_rearrangement
Pharmaceutical compound
lysergic acid diethylamide (LSD). It is the analogue of LSD in which the amide group has two propyl substitutions instead of two ethyl substituents. The
Lysergic_acid_dipropylamide
Chemical compound
Hexamethylphosphoramide, often abbreviated HMPA, is a phosphoramide (an amide of phosphoric acid) with the formula [(CH3)2N]3PO. This colorless liquid
Hexamethylphosphoramide
Synthetic polymer with unique physical and biodegradable properties
Polyesteramides are a class of synthetic polymers connected by ester and amide bonds. Common polyesteramides can be separated in to two different types
Polyesteramide
Gastrointestinal peptide hormone involved in glucose homeostasis
the two truncated and equipotent biologically active forms, GLP-1 (7–36) amide and GLP-1 (7–37). Active GLP-1 protein secondary structure includes two
Glucagon-like_peptide-1
Chemical compound (fatty acid neurotransmitter)
from the Sanskrit word ananda (आनन्द), meaning "joy, bliss, delight," plus amide. Anandamide, the first discovered endocannabinoid, engages with the body's
Anandamide
Production of peptides
production of peptides, compounds where multiple amino acids are linked via amide bonds, also known as peptide bonds. Peptides are chemically synthesized
Peptide_synthesis
Enzyme
N-acylethanolamine acid amide hydrolase (NAAA) EC 3.5.1.- is a member of the choloylglycine hydrolase family, a subset of the N-terminal nucleophile hydrolase
N-acylethanolamine acid amide hydrolase
N-acylethanolamine_acid_amide_hydrolase
Chemical compound
N,N′-Dicyclohexylcarbodiimide (DCC or DCCD) is an organic compound with the chemical formula (C6H11N)2C. It is a waxy white solid with a sweet odor. Its
N,N'-Dicyclohexylcarbodiimide
Chemical compound
pantothenic acid. While pantothenic acid is the amide of D-pantoate and β-alanine, hopantenic acid is the amide of D-pantoate and γ-aminobutyric acid (GABA)
Hopantenic_acid
Drug that causes anesthesia
suffix "–caine" in their names. Local anesthetics can be either ester- or amide-based. Ester local anesthetics are generally unstable in solution and fast-acting
Anesthetic
Local anesthetic
the brand name Xylocaine among others, is a local anesthetic of the amino amide type. It is also used to treat ventricular tachycardia and ventricular fibrillation
Lidocaine
Protein-coding gene in humans
Fatty acid amide hydrolase 2 or FAAH2 is a member of the serine hydrolase family of enzymes. Fatty acid amide hydrolase 2 degrades many types of fatty
FAAH2
New alkyl group
benzyl quaternary ammonium salts. The reagent is sodium amide or another alkali metal amide and the reaction product a N,N-dialkylbenzylamine with a
Sommelet–Hauser_rearrangement
Chemical compounds and groups containing nitrogen with a lone pair (:N)
substituted-ammonium carboxylate salt → dehydration heat N | R 2 R 1 | − C O ‖ − R 3 ⏟ amide + H 2 O ⏟ water {\displaystyle {\underbrace {\ce {H-\!\!{\overset {\displaystyle
Amine
Chemical compound
Piperlonguminine is an alkaloid amide isolated from Piper longum, commonly known as the long pepper. Kim, KS; Kim, JA; Eom, SY; Lee, SH; Min, KR; Kim
Piperlonguminine
Species of plant
ergoline alkaloids such as ergine (lysergic acid amide; LSA) and isoergine (isolysergic acid amide; iso-LSA). A study reported stereoisomers of ergine
Argyreia_nervosa
Chemical compound
proposed. The main difficulty arises from the ambiguous use of the word amide to mean an acylated (including sulfonylated) amine or the anionic form of
Bistriflimide
Group of chemicals
complexes composed of a cationic metal M with anionic bis(trimethylsilyl)amide ligands (the −N(Si(CH3)3)2 monovalent anion, or −N(Si(CH3)3)2 monovalent
Metal bis(trimethylsilyl)amides
Metal_bis(trimethylsilyl)amides
Organic compounds of the form >C=O
is employed to protect ketones. With sodium amide resulting in C–C bond cleavage with formation of the amide RCONH2 and the alkane or arene R'H, a reaction
Ketone
Medication to treat cardiac arrhythmias
carboxylic acid derivatives consisting of an amide with a benzamide moiety and a triethylamine attached to the amide nitrogen. In certain lines, the para-amino
Procainamide
Chemical group (R–C=O)
amide bond between the carbonyl carbon and the amide nitrogen has significant double bond character. The energy barrier for rotation about an amide bond
Acyl_group
Local anaesthetic drug
may also increase the length of labor. It is a local anaesthetic of the amide group. Bupivacaine was discovered in 1957. It is on the World Health Organization's
Bupivacaine
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