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Stimulant designer drug
6-APDB, also known as 6-(2-aminopropyl)-2,3-dihydrobenzofuran or as 4-desoxy-MDA, is an entactogen of the phenethylamine, amphetamine, and dihydrobenzofuran
6-APDB
Psychoactive drug
system has been replaced with a benzofuran ring. 6-APB is also the unsaturated benzofuran derivative of 6-APDB. It may appear as a tan or brown grainy powder
6-APB
Chemical compound
methylene bridge. 6-APDB is an analogue of 5-APDB where the 4-position oxygen has been replaced by a methylene bridge instead. 5-APDB was developed by
5-APDB
Pharmaceutical compound
concentration = 600 nM). 6-APBT was first described in the scientific literature by 2020. Substituted benzothiophene 5-APBT 6-APB 6-APDB 6-API 3-APBT SDA (3T-MDA)
6-APBT
Class of psychoactive drugs that produce empathic experiences
Baggott that few to no MDMA analogues, including MBDB, methylone, 6-APDB, 5-APDB, 6-APB, 5-APB, MDAT, and MDAI among others, reproduce the full quality
Entactogen
Psychoactive drug, often called ecstasy
MDOH, MDMOH (FLEA), N-t-BOC-MDMA, methylone (MDMC), MBDB, 5-MAPB, 6-MAPB, 5-MAPBT, 6-MAPBT, SDMA, ODMA, SeDMA, TDMA, MDAI, and MDAT, among many others
MDMA
Central nervous system stimulant
the treatment of methamphetamine dependence". BMC Res Notes. 6 220. doi:10.1186/1756-0500-6-220. PMC 3679734. PMID 23734766. Newton TF, Roache JD, De La
Methamphetamine
Pharmaceutical compound
F, or F-1, also known as 5-methoxy-6-(2-aminopropyl)-2,3-dihydrobenzofuran (5-methoxy-6-APDB), is a putative psychedelic drug of the phenethylamine, DOx
F_(psychedelic)
Recreational drug
reduced (producing 3), or the tolyl group can be oxidised (producing 6). Both 5 and 6 are thought to be further metabolised by conjugation to the glucuronide
Mephedrone
Medication, stimulant and decongestant
(range 53–79%) excreted unchanged. The elimination half-life of ephedrine is 6 hours. Its duration of action orally is 2 to 4 hours and via intravenous or
Ephedrine
Chemical compound
derived section of the NPsG. Substituted amphetamine Aminopropylindole 6-APB 6-APBT 6-APDB "New Psychoactive Substances Act (Neue-psychoaktive-Stoffe-Gesetz)
6-(2-Aminopropyl)indole
Class of chemical compounds
disorders and seizures in 2000 and 2006. 5-APB and 6-APB are often confused with 5-APDB and 6-APDB. The pharmacology of various benzofurans and 2,3-dihydrobenzofurans
Substituted_benzofuran
Psychedelic drug
described an effective dose range of 8 to 10 mg orally and a duration of 6 to 8 hours. Threshold effects occur at a dose of 4 mg orally. A wider recreational
2C-B
Psychedelic drug
5-chloro-DMT, 5-bromo-DMT, 6-fluoro-DMT, 5,6-dibromo-DMT, 4,5-MDO-DMT, 4,5-DHP-DMT, 5,6-MDO-DMT, 5-MeS-DMT, 6-methyl-DMT, 6-HO-DMT, 6-MeO-DMT, 7-methyl-DMT
Dimethyltryptamine
Monoamine neurotransmitter
"Phytoserotonin: a review". Plant Signaling & Behavior. 6 (6): 800–809. Bibcode:2011PlSiB...6..800A. doi:10.4161/psb.6.6.15242. PMC 3218476. PMID 21617371. Erspamer
Serotonin
Chemical compound
analogues that lack the full quality of MDMA include MBDB, methylone, 6-APDB, 5-APDB, 6-APB, 5-APB, MDAT, and MDAI, among others. In addition to its use on
5-MAPB
Pharmaceutical compound
phenethylamine, amphetamine, and benzofuran families. It is the derivative of 6-APDB with two methyl groups at the 2 position and a methoxy group at the 5 position
F-22_(drug)
Substituted cathinone designer drug
pigs in relation to pharmacodynamics". Journal of Psychopharmacology. 29 (6): 734–43. doi:10.1177/0269881115576687. PMID 25804420. S2CID 26012927.
3-Methylmethcathinone
Entactogen drug
following oral administration of doses of 50 to 200 mg ranged from 5.8 to 6.9 hours. The onset of action and duration of action of methylone in humans
Methylone
Species of amphibian
streams, temporary pools or man-made structures that hold water. Eggs are 1.6 mm in diameter, 5–7 mm apart, and encased in a long single tube of jelly with
Colorado_River_toad
Common name for more than 1,000 species of flowering plants in the family Convolvulaceae
Argyreia nervosa. A case-orientated demonstration]". Der Nervenarzt. 73 (9): 892–6. doi:10.1007/s00115-002-1374-4. PMID 12215884. Vargas, Theresa (2006-05-03)
Morning_glory
Chemical compound
Elsevier. pp. 272–273. doi:10.1016/c2013-0-12543-3. ISBN 978-1-4832-3296-6. LCCN 66030086. OCLC 332437. OL 35255701M. Schayer, Richard W. (1952). "Synthesis
Adrenochrome
Central nervous system stimulant prodrug
ISBN 978-0-07-182770-6. The ARAS consists of several different circuits including the four main monoaminergic pathways discussed in Chapter 6. The norepinephrine
Lisdexamfetamine
Entactogen, stimulant, and psychedelic drug of the amphetamine family
derivative of MDA. Some other analogues of MDA include 5-APB, 6-APB, 5-APDB, 6-APDB, 5-APBT, 6-APBT, and SDA (3T-MDA), among others. MDA constitutes part
3,4-Methylenedioxyamphetamine
Chemical compound
6-(2-Aminopropyl)tetralin (6-APT), also sometimes called tetralinylaminopropane (TAP), is a drug of the amphetamine class which acts as a selective serotonin
6-APT
Synthetic decongestant
the original on 6 July 2017. Retrieved 6 July 2017. "New govt: Pseudoephedrine to go back on shelves after ban". 1 News. Retrieved 6 February 2024. "Kontrole
Pseudoephedrine
Chemical compound
approximately 10 to 25 mg of tyramine is required for a severe reaction, compared to 6 to 10 mg for a mild reaction. Tyramine, like phenethylamine, is a monoaminergic
Tyramine
Chemical compound found in some species of mushrooms
peak effects occur in about 1 to 2 hours, and its duration is about 4 to 6 hours. Psilocybin mushrooms were used ritualistically in pre-Columbian Mexico
Psilocybin
Designer drug combination mimicking MDMA
5‑HT and 5-HIAA in all brain regions assessed 24 hours and two weeks after 6 mg/kg 5‑MAPB, with no statistically significant differences in monoamine levels
Borax_combo
Genus of plants
synopsis of Racosperma (C. Mart.) (Leguminosae: Mimosoideae)". Austrobaileya. 6 (3): 445–496. doi:10.5962/p.299681. JSTOR 41738994. Orchard, Anthony E.; Maslin
Acacia
Species of fungus
species bears the provisional name Psilocybe ochraceocentrata. The cap is 1.6–8 cm (3⁄4–3+1⁄4 in), conic to convex with a central papilla when young, becoming
Psilocybe_cubensis
South American psychoactive decoction
1 Part 2. Springer Science & Business Media. p. 199. ISBN 978-3-7643-5165-6. Gorman, Peter (2010). Ayahuasca in My Blood: 25 Years of Medicine Dreaming
Ayahuasca
Fungi of the genus Claviceps
Production Fields". Journal of Economic Entomology. 94 (6): 1471–1476. doi:10.1603/0022-0493-94.6.1471. PMID 11777051. S2CID 8725020. Poinar, George Jr
Ergot
Naturally occurring psychedelic compound
of 2 to 4 hours, and a duration that increases with dose and ranges from 6 to 14 hours. Mescaline primarily acts as a partial agonist at serotonin 5-HT2A
Mescaline
DMT-infused smoking blend
Cham: Springer Nature Switzerland. p. 121–146. doi:10.1007/978-3-032-22705-8_6. ISBN 978-3-032-22704-1. Retrieved 3 June 2026. The World Ayahuasca Diaspora:
Changa_(drug)
Chemical compound
active ingredient of khat (Catha edulis)". East African Medical Journal. 77 (6): 329–332. doi:10.4314/eamj.v77i6.46651. PMID 12858935. Widler P, Mathys K
Cathinone
Organic compound, a stimulant in humans
Constants of Adrenergic Amines". Journal of the American Chemical Society. 73 (6): 2611–3. Bibcode:1951JAChS..73.2611L. doi:10.1021/ja01150a055. Boulton AA
Phenethylamine
Psychoactive drug taken by mouth
interstitial cells in vitro". Molecular Pharmacology. 63 (6): 1223–1229. doi:10.1124/mol.63.6.1223. PMID 12761331. S2CID 839426.{{cite journal}}: CS1 maint:
(R)-MDMA
Chemical compound
Known and Loved), Alexander Shulgin lists the dose of 5-MeO-MiPT as 4 to 6 mg orally and 12 to 20 mg smoked. A wider recreational dose range of 0.5 to
5-MeO-MiPT
Chemical compound
structurally related to drugs like 6-APDB and 6-MAPB, which have similar effects to MDMA and have been used as recreational drugs. 6-MAPDB has never been studied
6-MAPDB
Psychedelic drug found in toads, mushrooms and plants
Addictions. 28 (6): 521–538. doi:10.3109/10826089309039645. PMID 8486435. The Dog Who Loved to Suck on Toads. NPR. Accessed on May 6, 2007. Psychoactive
Bufotenin
Weight loss medication
and has a ratio of norepinephrine release versus dopamine release of about 6.6:1 compared to dextroamphetamine's ratio of about 3.5:1. It is more than 3-fold
Phentermine
Decongestant medication
epinephrine's prevalence in the US". J Dent Anesth Pain Med. 23 (6): 293–302. doi:10.17245/jdapm.2023.23.6.293. PMC 10703557. PMID 38076507. Phenylephrine, a synthetic
Phenylephrine
Pharmaceutical compound
βk-6-MAPB, or BK-6-MAPB, also known as NM-PrBF6 or as 6-[2-(methylamino)propanoyl]benzofuran, is a putative entactogen of the benzofuran and cathinone
BK-6-MAPB
4-HA 5-DM-DOM Benzofurans (e.g., 5-APB, 5-APDB, 6-APB, 6-APDB, F, F-2, F-22) Benzothiophenes (e.g., 5-APBT, 6-APBT) BMB-202 CT-5172 DMAs (e.g., 2,4-DMA
List_of_psychedelic_drugs
Beta-lactam antibiotic
Amoxicillin was one of several semisynthetic derivatives of 6-aminopenicillanic acid (6-APA) developed by the Beecham Group in the 1960s. It was invented
Amoxicillin
Mescaline-containing cactus
dark green stems, sometimes glaucous, with a diameter of 6–15 cm (2.4–5.9 in) and usually 6–8 ribs. The whitish areoles may produce up to seven yellow
Echinopsis_pachanoi
Sympathomimetic agent
Psychopharmacology: Clinical and Experimental. 12 (6): 527–546. doi:10.1002/(SICI)1099-1077(199711/12)12:6<527::AID-HUP932>3.0.CO;2-U. ISSN 0885-6222. "Adderall
Phenylpropanolamine
Perennial flowering plant in the coffee family Rubiaceae
of approximately 5 m (16 ft). Its branches span a diameter of about 2 m (6 ft 7 in)[unreliable source?] In the middle and lower parts of the stem, situated
Psychotria_viridis
Metabolite of the amino acid tryptophan
serotonin, dopamine, and norepinephrine, in that order of potency (EC50 = 32.6 nM, 164 nM, and 716 nM, respectively). That is, it acts as a
Tryptamine
SNRI antidepressant
stress disorder". Expert Review of Neurotherapeutics. 7 (6): 603–615. doi:10.1586/14737175.7.6.603. PMID 17563244. S2CID 25215502. Phelps NJ, Cates ME
Venlafaxine
Topical nasal decongestant
eliminated in urine and recovery of levomethamphetamine is 20 to 60% (or about 2–6 mg) while that of levoamphetamine is 9 to 30% (or about 1–3 mg). Levomethamphetamine
Levomethamphetamine
Psychoactive stimulant
methcathinone (Ephedrone) abuse". Archives of Neurology. 64 (6): 886–9. doi:10.1001/archneur.64.6.886. PMID 17562938. "Convention on Psychotropic Substances
Methcathinone
Mushrooms containing psychoactive indole alkaloids
(116 species), Gymnopilus (14), Panaeolus (13), Copelandia (12), Pluteus (6) Inocybe (6), Pholiotina (4) and Galerina (1). Guzmán increased his estimate of
Psilocybin_mushroom
Food containing hallucinogenic substances
4-HA 5-DM-DOM Benzofurans (e.g., 5-APB, 5-APDB, 6-APB, 6-APDB, F, F-2, F-22) Benzothiophenes (e.g., 5-APBT, 6-APBT) BMB-202 CT-5172 DMAs (e.g., 2,4-DMA
Mushroom_edible
Chemical compound
aftereffects such as tachycardia, hypertension, and mild stimulation lasting from 6 to 8 hours. High doses have been observed to cause intense, prolonged panic
Methylenedioxypyrovalerone
Class of chemical compounds
associated with impaired working memory and cognitive flexibility". PLOS ONE. 6 (6) e20602. Bibcode:2011PLoSO...620602C. doi:10.1371/journal.pone.0020602. PMC 3115937
Substituted_cathinone
Drug mixture used mainly to treat ADHD and narcolepsy
2020. Retrieved 6 February 2020. "Generic Adderall XR Availability". Drugs.com. Archived from the original on 6 February 2020. Retrieved 6 February 2020
Adderall
Psychedelic drug
phenethylamine, amphetamine, and benzofuran families. It is the derivative of 6-APDB with a methyl group at the 2 position and a methoxy group at the 5 position
F-2_(drug)
Species of psychoactive cactus
alkaloids—primarily mescaline—at concentrations of about 0.4% when fresh and up to 6% when dried. Peyote is a slow-growing cactus that can be cultivated more rapidly
Peyote
Pharmaceutical compound
4-HA 5-DM-DOM Benzofurans (e.g., 5-APB, 5-APDB, 6-APB, 6-APDB, F, F-2, F-22) Benzothiophenes (e.g., 5-APBT, 6-APBT) BMB-202 CT-5172 DMAs (e.g., 2,4-DMA
VCU-1012
Species of fungus
Bluegrass Seed Production Fields". J. Econ. Entomol. 94 (6): 1471–1476. doi:10.1603/0022-0493-94.6.1471. PMID 11777051. S2CID 8725020. Mr Gonod d'Artemare
Claviceps_purpurea
Chemical compound
4-MA 4-MMA 4-MTA 5-APB 5-APBT 5-APDB 5-EAPB 5-IT 5-MAPB 5-MAPDB 6-APB 6-APDB 6-APBT 6-Chloro-MDMA 6-EAPB 6-IT 6-MAPB 6-MAPDB EDA IAP 2,3-MDA 3,4-MDA (tenamfetamine)
2-Phenyl-3,6-dimethylmorpholine
2-Phenyl-3,6-dimethylmorpholine
Species of fungus in the family Hymenogastraceae, native to Europe
dark purplish-brown en masse, ellipsoid in shape, and measure 10.5–15 by 6.5–8.5 μm. The mushroom grows in grassland habitats, especially wetter areas
Psilocybe_semilanceata
SNRI antidepressant
"Post-SSRI Sexual Dysfunction: A Literature Review". Sexual Medicine Reviews. 6 (1): 29–34. doi:10.1016/j.sxmr.2017.07.002. PMID 28778697. Healy D, Le Noury
Desvenlafaxine
Species of fungus
brown to purplish black. The stipe is 9–20 cm (3.5–7.9 in) in length and 3–6 mm (0.1–0.2 in). It is thick, silky white to dingy brown with age. It is hollow
Psilocybe_azurescens
Central nervous system stimulant
ISBN 978-0-07-182770-6. The ARAS consists of several different circuits including the four main monoaminergic pathways discussed in Chapter 6. The norepinephrine
Amphetamine
Retail outlet selling hallucinogenic mushroom products
prevalence of magic mushroom use was declining since 2000 (last year prevalence of 6.3% in 2000 to 2.9% in 2005), and further declined after possession and use
Psychedelic_mushroom_store
Short-acting bronchodilator used for acute asthma
relatively short elimination half-life of the drug, estimated at between 5 and 6 hours following oral administration of 4 mg. Salbutamol has been studied in
Salbutamol
Dopaminergic medication
(L-DOPS), a norepinephrine precursor and prodrug. 6-Hydroxydopa, a prodrug of 6-hydroxydopamine (6-OHDA), is a potent dopaminergic neurotoxin used in
Levodopa
Pharmaceutical compound
Quantitative Structure-Activity Relationships. 18 (6): 548–560. doi:10.1002/(SICI)1521-3838(199912)18:6<548::AID-QSAR548>3.0.CO;2-B. ISSN 0931-8771. Retrieved
N-DEAOP-NMT
Synthetic hallucinogen
usually last 6–10 hours if taken sublingually, or buccally (between gum and cheek). When it is insufflated (snorted), effects usually last 4–6 hours. 25I-NBOMe
25I-NBOMe
Drug combination prescribed for weight loss; later withdrawn from market
intravenously on more than 100 Black and Hispanic boys between the ages of 6 and 10, with delinquent older brothers, to test the theory that delinquent
Fenfluramine/phentermine
1991 book by Alexander Shulgin and Ann Shulgin
4-desmethyl-4-ethyl-DOM) Iris (5-desmethoxy-5-ethoxy-DOM; DOM-5-EtO) Juno (6-methyl-DOM) As with the essential amphetamines, not all of these compounds
PiHKAL
Serotonin-norepinephrine-dopamine reuptake inhibitor
inhibition have been reported to be 6 nM for norepinephrine, 38 nM for dopamine, and 83 nM for serotonin. Hence, the drug shows 6.3-fold preference for inhibition
Centanafadine
Class of psychoactive drugs
MA: Springer US. pp. 243–333. doi:10.1007/978-1-4757-0510-2_6. ISBN 978-1-4757-0512-6. Luethi D, Liechti ME (October 2018). "Monoamine Transporter and
Substituted methylenedioxyphenethylamine
Substituted_methylenedioxyphenethylamine
Psychedelic drug
Shulgin lists the same dose range of 10 to 20 mg orally and duration of 3 to 6 hours for psilocin, psilocybin, and 4-AcO-DMT. Another publication gave a
4-AcO-DMT
Drug class
monoamine transporter substrates". Current Topics in Medicinal Chemistry. 6 (17): 1845–1859. doi:10.2174/156802606778249766. PMID 17017961. Heal DJ, Smith
Norepinephrine–dopamine releasing agent
Norepinephrine–dopamine_releasing_agent
Anxiolytic, sedative, and pain medication
linear pharmacokinetics with a rapid distribution half-life of approximately 6 minutes in healthy volunteers, and a longer and more variable distribution
Dexmedetomidine
Chemical compound
(2-methyl-6-amino-2-heptanol), iproheptine (N-isopropyl-1,5-dimethylhexylamine), isometheptene (2-methyl-6-methylamino-2-heptene), octodrine (2-amino-6-methylheptane
Methylhexanamine
Pharmaceutical drug
serotonergic psychedelics like LSD, DOM, and DMT. (+)-Mefloquine showed about 1.6-fold lower affinity, 8.8-fold lower potency, and about the same efficacy as
Mefloquine
Codrug of amphetamine and theophylline
bust in Dubai, 5.6 tonnes of captagon seized". Khaleej Times. 26 February 2020. Archived from the original on 31 March 2020. Retrieved 6 May 2020. "Saudi
Fenethylline
Class of compounds
4-APB, 5-APB, 5-MAPB, 6-APB, 6-MAPB, 5-APDB, 5-MAPDB, 6-APDB, 6-MAPDB, 7-APB, IBF5MAP) Benzofuranylisobutylamines (e.g., 5-MBPB, 6-MBPB) Benzothiophenylaminopropanes
Monoamine_releasing_agent
Species of plant
4-HA 5-DM-DOM Benzofurans (e.g., 5-APB, 5-APDB, 6-APB, 6-APDB, F, F-2, F-22) Benzothiophenes (e.g., 5-APBT, 6-APBT) BMB-202 CT-5172 DMAs (e.g., 2,4-DMA
Ipomoea_corymbosa
Pharmaceutical compound
HBL20016, also known as 5-methylthio-6-fluoro-N,N-dimethyltryptamine (5-MeS-6-F-DMT), is a non-selective serotonin receptor agonist and serotonergic psychedelic
HBL20016
Pharmaceutical compound
2026. "4-HO-MET PROP (4-propanoyloxy MET)". АИПСИН (in Russian). Retrieved 6 January 2026. Orange Book: List of Controlled Substances and Regulated Chemicals
4-PrO-MET
Species of fungus
4-HA 5-DM-DOM Benzofurans (e.g., 5-APB, 5-APDB, 6-APB, 6-APDB, F, F-2, F-22) Benzothiophenes (e.g., 5-APBT, 6-APBT) BMB-202 CT-5172 DMAs (e.g., 2,4-DMA
Psilocybe_mexicana
Medication
selegiline patch in terms of depressive symptom improvement (SMD = −1.49, k = 6, n = 282 vs. SMD = −0.27, k = 4, n = 1,026, respectively; p = 0.03). However
Selegiline
Species of plant
long. Each compound leaf contains 15–33 pairs of bright green leaflets 5–6 mm (0.20–0.24 in) long. The tree itself grows up to 8 m (26 ft) tall and it
Mimosa_tenuiflora
Pharmaceutical compound
4-CAB 4-FA 4-FMA 4-HA 4-MTA 4-ME 5-APB 5-APBT 5-APDB 5-MAPB 5-Methyl-MDA 6-APB 6-APBT 6-APDB 6-MAPB 6-Methyl-MDA AEMMA Amiflamine BDB BOH Brephedrone
Isocyclamine
Central nervous system stimulant
methylphenidate may increase the risk of liver toxicity. Dexmethylphenidate has a 4–6 hour duration of effect. A long-acting formulation, Focalin XR, which spans
Dexmethylphenidate
Species of cactus
colonization and weathering of igneous rocks". Plant Biology. 6 (5). Stuttgart: 629–42. Bibcode:2004PlBio...6..629P. doi:10.1055/s-2004-821100. PMID 15375735. Puente
Pachycereus_pringlei
CNS stimulant and isomer of amphetamine
ISBN 978-0-07-182770-6. The ARAS consists of several different circuits including the four main monoaminergic pathways discussed in Chapter 6. The norepinephrine
Dextroamphetamine
Pharmaceutical compound
4-HA 5-DM-DOM Benzofurans (e.g., 5-APB, 5-APDB, 6-APB, 6-APDB, F, F-2, F-22) Benzothiophenes (e.g., 5-APBT, 6-APBT) BMB-202 CT-5172 DMAs (e.g., 2,4-DMA
1Fe-LSD
Class of chemical compounds
(flyscaline) 9-Aminomethyl-9,10-dihydroanthracene (AMDA) F (F-1; 5-methoxy-6-APDB) Substituted phenethylamine Substituted amphetamine Substituted benzofuran
FLY_(psychedelics)
Class of chemical compounds
N-benzylamphetamine derivatives as monoamine oxidase inhibitors". Bioorg Med Chem. 17 (6): 2452–2460. doi:10.1016/j.bmc.2009.01.074. PMID 19243954. Yoneda F, Moto
Substituted naphthylethylamine
Substituted_naphthylethylamine
Class of chemical compounds
Knapp DR (June 1971). "Structural analogs of lysergic acid". J Pharm Sci. 60 (6): 809–814. doi:10.1002/jps.2600600602. PMID 4942861. Nichols DE, Oberlender
Partial_lysergamide
Medication used to treat dyskinesia
South Korea, and the United States, respectively. By 2006, 90.6% of H3N2 strains and 15.6% of H1N1 were amantadine resistant. A majority of the amantadine-resistant
Amantadine
Chemical compound
the dose range of 4-HO-MET as 10 to 20 mg orally and its duration as 4 to 6 hours. However, a wider recreational dose range of 2 to 45 mg or more orally
4-HO-MET
Species of plant
8%), isolysergic acid hydroxyethylamide (iso-LSH) (4.0%), elymoclavine (3.6%), chanoclavine I (2.7%), ergometrinine (1.8%), agroclavine (1.1%), and others
Argyreia_nervosa
6 APDB
6 APDB
6 APDB
6 APDB
6 APDB
6 APDB
6 APDB
6 APDB
6 APDB