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ZBP1

  • ZBP1
  • Protein-coding gene in the species Homo sapiens

    host transcription termination, are detected by ZBP1 to initiate NF-κB signalling and PANoptosis. ZBP1 is an abbreviation for chicken or rat β-actin zipcode-binding

    ZBP1

    ZBP1

    ZBP1

  • PANoptosis
  • Inflammatory cell death pathway

    inflammatory conditions, and cancer. Several PANoptosome complexes, such as the ZBP1-, AIM2-, RIPK1-, NLRP3 and NLRC5- and NLRP12-PANoptosomes, have been characterized

    PANoptosis

    PANoptosis

  • Messenger RNA
  • RNA that is read by the ribosome to produce a protein

    as β-actin mRNA. For export from the nucleus, actin mRNA associates with ZBP1 and later with 40S subunit. The complex is bound by a motor protein and is

    Messenger RNA

    Messenger RNA

    Messenger_RNA

  • Thirumala-Devi Kanneganti
  • Indian immunologist

    have identified several critical innate immune sensors—including NLRP3, ZBP1, AIM2, NLRC5, and NLRP12 —that drive inflammatory cell death, and defined

    Thirumala-Devi Kanneganti

    Thirumala-Devi Kanneganti

    Thirumala-Devi_Kanneganti

  • Cell death
  • Biological cell ceasing to carry out its functions

    To date, several PANoptosome complexes have been characterized, including ZBP1-, AIM2-, RIPK1-, NLRC5-/NLRP12-, and NLRP3-PANoptosomes. PANoptosis is critical

    Cell death

    Cell death

    Cell_death

  • Dendrite
  • Small projection on a neuron that receives signals

    circuitry. For example, it was shown that β-actin zip code binding protein 1 (ZBP1), contributes to proper dendritic branching. Dendritic arborization has been

    Dendrite

    Dendrite

    Dendrite

  • Jan Karlseder
  • Austrian molecular biologist

    dysfunction with inflammation and cell death during replicative crisis identified ZBP1 as novel regulator of the innate RNA sensing machinery. He discovered that

    Jan Karlseder

    Jan_Karlseder

  • Inflammasome
  • Cytosolic multiprotein complex that mediates the activation of Caspase 1

    inflammasome is also an essential component of several PANoptosomes, including the ZBP1-, RIPK1-, and NLRP12-PANoptosome. NLRC4 is the only member of the NLRC family

    Inflammasome

    Inflammasome

    Inflammasome

  • AIM2
  • Protein-coding gene in the species Homo sapiens

    Kalathur RC, Kanneganti TD (2021-09-01). "AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense". Nature. 597 (7876): 415–419. Bibcode:2021Natur

    AIM2

    AIM2

    AIM2

  • Adenosine deaminase z-alpha domain
  • Protein domain

    signature. Genes encoding proteins containing this domain include ADAR and ZBP1. Schade M, Turner CJ, Kühne R, Schmieder P, Lowenhaupt K, Herbert A, Rich

    Adenosine deaminase z-alpha domain

    Adenosine deaminase z-alpha domain

    Adenosine_deaminase_z-alpha_domain

  • RNA-binding protein
  • Type of protein

    are only translated in their intended regions. One of these proteins is ZBP1. ZBP1 binds to beta-actin mRNA at the site of transcription and moves with mRNA

    RNA-binding protein

    RNA-binding_protein

  • List of human protein-coding genes 9
  • O75132 18488 ZBED5 HGNC:30803; Q49AG3 18489 ZBED6 HGNC:33273; P86452 18490 ZBP1 HGNC:16176; Q9H171 18491 ZBTB1 HGNC:20259; Q9Y2K1 18492 ZBTB2 HGNC:20868;

    List of human protein-coding genes 9

    List_of_human_protein-coding_genes_9

  • RIPK1
  • Enzyme found in humans

    Via the intermediate domain, RIP can interact with TRAF2, NEMO, RIPK3, ZBP1, OPTN and other small molecules and proteins, depending on cellular context

    RIPK1

    RIPK1

    RIPK1

  • CRD-BP
  • that show close a relation to the chicken β-actin zipcode-binding protein ZBP1 and the human forms of the protein IMP-1, IMP-2 and IMP-3. Because of their

    CRD-BP

    CRD-BP

  • Necroptosis
  • Necrotic cell death regulated by intracellular signaling, exerted by activated MLKL

    activates MLKL. Standing alone from the TLRs and TNF superfamily members, ZBP1, a cytosolic DNA-recognising protein can also provide the stimulus for necroptosis

    Necroptosis

    Necroptosis

    Necroptosis

  • Vishva Dixit
  • Kenyan molecular biologist

    laboratory elucidated how RHIM-containing proteins including RIPK1, RIPK3, ZBP1, and TRIF assemble signaling complexes that determine cellular responses

    Vishva Dixit

    Vishva Dixit

    Vishva_Dixit

  • NLRP3
  • Human protein and coding gene

    mediating PANoptosis) associated with the sensor molecules NLRP12, NLRC5, and ZBP1. Through its roles in driving cytokine release and inflammatory cell death

    NLRP3

    NLRP3

    NLRP3

  • Z-DNA
  • One of many possible double helical structures of DNA

    properties of DNA Proteopedia Z-DNA Satellite DNA Z-DNA binding protein 1 (ZBP1) Zuotin Mitsui, Y.; Langridge, R.; Shortle, B. E.; Cantor, C. R.; Grant,

    Z-DNA

    Z-DNA

    Z-DNA

  • IGF2BP1
  • Protein-coding gene in the species Homo sapiens

    IGF2BP1 Identifiers Aliases IGF2BP1, CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1, insulin like growth factor 2 mRNA binding protein 1 External IDs OMIM: 608288;

    IGF2BP1

    IGF2BP1

    IGF2BP1

  • NLRC5
  • Protein-coding gene in the species Homo sapiens

    "PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis". Current Opinion in Immunology

    NLRC5

    NLRC5

    NLRC5

  • Stress granule
  • Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress

    Lederer M, Reinke C, Meyer S, Hatzfeld M, Singer RH, et al. (November 2006). "ZBP1 regulates mRNA stability during cellular stress". The Journal of Cell Biology

    Stress granule

    Stress granule

    Stress_granule

  • Itaconic acid
  • Chemical compound

    Martinez J, Gale M, Loo YM, Oberst A (January 2019). "The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic

    Itaconic acid

    Itaconic acid

    Itaconic_acid

  • Synaptic tagging
  • by RNA binding proteins, of which some potential candidates are MARTA and ZBP1. They recognize the TEs, and this interaction results in formation of ribonucleotide

    Synaptic tagging

    Synaptic_tagging

  • PSMB9
  • Protein found in humans

    Further studies also indicate a role for PMSB9, in a panel with 9 other genes (Zbp1, Mx2, Irf7, Lfi47, Tapbp, Timp1, Trafd1, Tap2) in the development of influenza

    PSMB9

    PSMB9

    PSMB9

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