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Chemical compound
Vindoline is a chemical precursor to vinblastine. Vindoline is formed through biosynthesis from Tabersonine. Lochnericine Dimerization of catharanthine
Vindoline
Species of flowering plant in the family Apocynaceae
are biosynthesized from the coupling of the alkaloids catharanthine and vindoline. The newer semi-synthetic chemotherapeutic agent vinorelbine, used in
Catharanthus_roseus
Chemical process
Catharanthine and vindoline are terpenoid indole alkaloids naturally produced within the Madagascar periwinkle plant (Catharanthus roseus) whose dimerization
Dimerization of catharanthine and vindoline
Dimerization_of_catharanthine_and_vindoline
Chemical compound
Catharanthine is one of the two precursors that form vinblastine, the other being vindoline. (+)-Catharanthine competitively inhibits α9α10 nAChRs with potencies
Catharanthine
Genus of flowering plants
vinblastine are produced by the coupling the smaller indole alkaloids vindoline and catharanthine. In addition, the nootropic agent vincamine is derived
Vinca
Class of naturally occurring chemical compounds
vincristine, which are formed from the coupling of catharanthine and vindoline. The newer semi-synthetic chemotherapeutic agent vinorelbine is used in
Alkaloid
Alkaloid agents from the Cape periwinkle
for a number of important natural products, including catharanthine and vindoline and the vinca alkaloids it produces from them: leurosine and the chemotherapy
Vinca_alkaloid
Pharmaceutical drug
for a number of important natural products, including catharanthine, vindoline, and the vinca alkaloids it produces from them: leurosine and the chemotherapy
Vinorelbine
Chemical compound
16-hydroxytabersonine. Tabersonine is the first intermediate leading to the formation of vindoline one of the two precursors required for vinblastine biosynthesis. Tabersonine
Tabersonine
Linked series of chemical reactions occurring within a cell
by relatively ineffient extraction and purification of the precursors vindoline and catharanthine from the plant Catharanthus roseus, which are then chemically
Metabolic_pathway
vindoline + coenzyme A The two substrates of this enzyme are deacetylvindoline and acetyl-CoA. Its products are vindoline and coenzyme
Deacetylvindoline O-acetyltransferase
Deacetylvindoline_O-acetyltransferase
Treatment of cancer using drugs that inhibit cell division or kill cells
Miura Y (1994). "Catharanthus roseus L. (Periwinkle): Production of Vindoline and Catharanthine in Multiple Shoot Cultures". In Bajaj YP (ed.). Biotechnology
Chemotherapy
Chemical compound
deacetylvindoline O-acetyltransferase (DAT) which acetylates a hydroxy group to form vindoline, one of the two immediate precursors for the formation of the pharmacetucially
Deacetylvindoline
Chemotherapy medication
biological producer, along with several of its precursors, catharanthine and vindoline. Extraction is costly and yields of vinblastine and its precursors are
Vinblastine
Chemical compound; chemotherapy medication
Vincristine is created through the semi-synthesis coupling of indole alkaloids vindoline and catharanthine in the vinca plant. It can also now be synthesized through
Vincristine
Laußermair E, Deus-Neumann B, Stöckigt J (December 1985). "Late enzymes of vindoline biosynthesis : S-Adenosyl-L-methionine: 11-O-demethyl-17-O-deacetylvindoline
Tabersonine 16-O-methyltransferase
Tabersonine_16-O-methyltransferase
Superfamily of enzymes
Periwinkle’. This enzyme is involved in the synthesis of the alkaloid vindoline. In plants, BAHD acyltransferases are often involved in the production
BAHD_acyltransferase
Chemical compound
Younggi; Boger, Dale L. (2006). "Total Synthesis of (−)- andent-(+)-Vindoline and Related Alkaloids". Journal of the American Chemical Society. 128
Bis(trimethylsilyl)peroxide
Class of enzymes
and T11H. It participates in indole alkaloid biosynthesis leading to vindoline. Enzyme 1.14.14.103 at KEGG Pathway Database. St-Pierre B, De Luca V (1995)
Tabersonine_16-hydroxylase
Index of chemical compounds with the same molecular formula
mass: 454.52 g/mol) may refer to: 7-Acetoxymitragynine β-Funaltrexamine Vindoline This set index page lists chemical structure articles associated with
C25H32N2O6
Chemical compound
Catharanthus roseus. The metabolite is an intermediate in the formation of vindoline, a precursor needed for formation of the pharmaceutically valuable vinblastine
16-Hydroxytabersonine
Chemical compound
for a number of important natural products, including catharanthine and vindoline and the vinca alkaloids it produces from them: leurosine and the chemotherapy
Bis(cyclopentadienyl)titanium(III) chloride
Bis(cyclopentadienyl)titanium(III)_chloride
Cell division inhibitor
dramatically increased the in vivo activity. Most of the SAR studies involve the vindoline portion of bis-indole alkaloids because modification at C-16 and C-17
Mitotic_inhibitor
Class of enzymes
V (1993). "Partial purification of an N-methyltransferase involved in vindoline biosynthesis in Catharanthus roseus". Phytochemistry. 32 (3): 673–678
3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase
3-hydroxy-16-methoxy-2,3-dihydrotabersonine_N-methyltransferase
Organic reaction where amide is converted to Amine or Aldehyde
PMID 19784999. Taber, Douglass F (5 June 2006). "The Boger Route to (-)-Vindoline". Org. Chem. Highlights. Discussion of (12)→(13). Leighty, M. W.; Spletstoser
Amide_reduction
Alkaloid
Toshifumi; Lee, Siu-Leung (1980). "Formation of catharanthine, akuammicine and vindoline in Catharanthus roseus suspension cells". Phytochemistry. 19 (3): 488–489
Akuammicine
Chemical compound
seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast. Proceedings of the National Academy of Sciences
16-Methoxytabersonine
Chemical compound
2-oxoglutarate dependent-dioxygenase involved in the biosynthesis of vindoline in Catharanthus roseus (L.) G. Don". Plant Molecular Biology. 34 (6):
Desacetoxyvindoline
kinetic analysis of a 2-oxoglutarate-dependent dioxygenase involved in vindoline biosynthesis from Catharanthus roseus". J. Biol. Chem. 268 (8): 5504–11
Desacetoxyvindoline 4-hydroxylase
Desacetoxyvindoline_4-hydroxylase
Chemical compound
Vincenzo (1993). "Partial purification of an N-methyltransferase involved in vindoline biosynthesis in Catharanthus roseus". Phytochemistry. 32 (3): 673–678
3-Hydroxy-16-methoxy-2,3-dihydrotabersonine
3-Hydroxy-16-methoxy-2,3-dihydrotabersonine
Chemical compound
L; Gao, Z; Wan, P; Hu, L; Jiang, H; Shen, X (2013). "Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis
Vincoline
English organic chemist (1925–2018)
biosynthesis of the indole alkaloids ajmalicine, corynantheal, catharanthine and vindoline was shown to involve the precursors tryptamine and loganin. To Alan Battersby's
Alan_R._Battersby
VINDOLINE
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Girl/Female
Indian
Heedful of God
Boy/Male
Tamil
Chief, Worthy of admiration
Girl/Female
English
and Kayla, meaning: keeper of the keys; pure.
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Extremely Kind; Sea of Mercy
Boy/Male
Tamil
Dancer, Body, Playful, Peacock, Another, Peacock
Boy/Male
Teutonic
God's truth.
Boy/Male
Biblical
The Lord that converts; or recalls from captivity.
Girl/Female
Hindu, Indian, Malayalam
Shy
Girl/Female
Hindu
Brilliant
Boy/Male
Tamil
Lord Shiva, Lord Ram
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