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Protein-coding gene in the species Homo sapiens
encoded by the UGT2B10 gene. It is responsible for glucuronidation of nicotine and cotinine. Due to common hypomorphic alleles of UGT2B10, glucuronidation
UGT2B10
Allergy medication
sequence in normal metabolizers. First, N-glucuronidation of desloratadine by UGT2B10; then, 3-hydroxylation of desloratadine N-glucuronide by CYP2C8; and finally
Desloratadine
Triazolobenzodiazepine
Bromazolam N-glucuronidation was found to be catalysed by UGT1A4 and UGT2B10. The formation of α-hydroxy bromazolam glucuronide was catalysed by UGT2B4
Bromazolam
TAAR1 agonist
preclinical research. It is mainly metabolized by N-glucuronidation in humans. UGT2B10 polymorphisms can result in profoundly altered exposure to RO5263397 in
RO5263397
Class of enzymes
UGT1A7, UGT1A8, UGT1A9, UGT1A10 UGT2A1, UGT2A2, UGT2A3, UGT2B4, UGT2B7, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28 Mulichak AM, Lu W, Losey HC, Walsh
Glucuronosyltransferase
17862 UGT2B4 HGNC:12553; P06133 17863 UGT2B7 HGNC:12554; P16662 17864 UGT2B10 HGNC:12544; P36537 17865 UGT2B11 HGNC:12545; O75310 17866 UGT2B15 HGNC:12546;
List of human protein-coding genes 8
List_of_human_protein-coding_genes_8
Protein-coding gene in the species Homo sapiens
genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms". Cancer Research. 70 (19): 7543–52. doi:10.1158/0008-5472
UGT2B17
UGT2B10
UGT2B10
UGT2B10
UGT2B10
UGT2B10
UGT2B10
UGT2B10
UGT2B10
UGT2B10