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Parasitic disease also known as sleeping sickness
involvement. Ulcer of human African trypanosomiasis Typical fine-spotted pink rash of acute African trypanosomiasis on the skin of the abdomen ("trypanid
African_trypanosomiasis
Medical condition
African trypanosomiasis and Chagas disease (American trypanosomiasis). A number of other diseases occur in other animals. African trypanosomiasis in humans
Trypanosomiasis
Parasitic disease of vertebrates
Animal trypanosomiasis, also known as nagana and nagana pest, or sleeping sickness, is a disease of non-human vertebrates. The disease is caused by trypanosomes
Animal_trypanosomiasis
Mammal parasitic disease
Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by Trypanosoma cruzi. It is spread mostly by insects in
Chagas_disease
Efforts to develop a vaccine for trypanosomiasis
A Trypanosomiasis vaccine is a vaccine against trypanosomiasis. No effective vaccine currently exists, but development of a vaccine is the subject of current
Trypanosomiasis_vaccine
Genus of disease-spreading insects
tsetse-transmitted trypanosome species cause trypanosomiasis, an infectious disease. In humans, tsetse transmitted trypanosomiasis is called sleeping sickness. In
Tsetse_fly
Medical condition
Human trypanosomiasis is a cutaneous condition caused by several species of trypanosomes, with skin manifestations usually being observed in the earlier
Human_trypanosomiasis
Elimination of a disease from all hosts
answered. Early planning by the WHO for the eradication of African trypanosomiasis, also known as sleeping sickness, is underway as the rate of reported
Eradication of infectious diseases
Eradication_of_infectious_diseases
Chemical compound
brand name Ornidyl among others, is a medication used to treat African trypanosomiasis (sleeping sickness) and excessive hair growth on the face in women
Eflornithine
Medication used to treat sleeping sickness
arsenic-containing medication used for the treatment of sleeping sickness (African trypanosomiasis). It is specifically used for second-stage disease caused by Trypanosoma
Melarsoprol
Oral anti-parasitic medical drug
Fexinidazole is a medication used to treat African trypanosomiasis (sleeping sickness) caused by Trypanosoma brucei gambiense. It is effective against
Fexinidazole
2015-02-09. Retrieved 2012-08-01. "CDC - African Trypanosomiasis - General Information - East African Trypanosomiasis FAQs". www.cdc.gov. 2019-04-22. Retrieved
List of human disease case fatality rates
List_of_human_disease_case_fatality_rates
Diverse group of tropical infectious diseases which are common in developing countries
Chagas disease, dracunculiasis, hookworm infection, human African trypanosomiasis, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, schistosomiasis
Neglected_tropical_diseases
Genital ulcer
mouth, penis and vulva. Chancres are also associated with the African trypanosomiasis (sleeping sickness), surrounding the area of the tsetse fly bite. Similarities
Chancre
Antiprotozoal drug to treat sleeping sickness
Neglected Diseases Initiative with Sanofi for the treatment of African trypanosomiasis (sleeping sickness). It is a structurally novel drug described as a
Acoziborole
Topics referred to by the same term
refer to: African trypanosomiasis, also known as African sleeping sickness, is a vector-borne parasitic disease Animal trypanosomiasis, also known as nagana
Sleeping sickness (disambiguation)
Sleeping_sickness_(disambiguation)
Species of protozoan parasite
deadly vector-borne diseases: African trypanosomiasis or sleeping sickness in humans, and animal trypanosomiasis or nagana in cattle and horses. It is
Trypanosoma_brucei
Method of biological control for insect populations
population, rather than livestock or crops. Sleeping sickness or African trypanosomiasis is a parasitic disease in humans. Caused by protozoa of genus Trypanosoma
Sterile_insect_technique
British politician
"Discovery and development of diagnostic biomarkers for human African trypanosomiasis". She then worked on malaria under Jean Langhorne at the Francis Crick
Lauren_Sullivan
Protein-coding gene in the species Homo sapiens
Apolipoprotein L1 is a protein that in humans is encoded by the APOL1 gene. Two transcript variants encoding two different isoforms have been found for
Apolipoprotein_L1
Medical condition
(African trypanosomiasis)". Infectious Disease Clinics of North America. 18 (2). doi:10.1016/j.idc.2004.01.004. PMID 15145378. CDC website on trypanosomiasis
Winterbottom's_sign
French physician (1845–1922)
protozoans as causative agents of infectious diseases such as malaria and trypanosomiasis. Following his father, Louis Théodore Laveran, he took up military
Charles Louis Alphonse Laveran
Charles_Louis_Alphonse_Laveran
Antibiotic drug introduced in the 1910s
deadly infectious diseases syphilis, relapsing fever, and African trypanosomiasis. This organoarsenic compound was the first modern antimicrobial agent
Arsphenamine
Combination drug
drugs, nifurtimox and eflornithine, used in the treatment of African trypanosomiasis (sleeping sickness). It was developed by Drugs for Neglected Diseases
Nifurtimox/eflornithine
do not possess. This has made them lethal killers such as African trypanosomiasis, or Myxobacteria. These evolutionary advantages have proven to increase
Social_motility
Brazilian doctor and scientist (1879–1934)
(2010), "History of the Discovery of American Trypanosomiasis (Chagas Disease)", American Trypanosomiasis, Elsevier, pp. 3–23, doi:10.1016/b978-0-12-384876-5
Carlos_Chagas
American biochemist (1938–2019)
the genetic material in the parasitic organisms that cause African trypanosomiasis, more commonly called sleeping sickness. Born in Worcester, Massachusetts
Paul_Englund
Scottish pathologist (1855–1931)
named Trypanosoma brucei, as the causative pathogen of nagana (animal trypanosomiasis). Working in the Army Medical Services and the Royal Army Medical Corps
David_Bruce_(microbiologist)
Medical antimicrobial drug
Pentamidine is an antimicrobial medication used to treat African trypanosomiasis, leishmaniasis, Balamuthia infections, babesiosis, and to prevent and
Pentamidine
Formulary by the World Health Organization
infection > 8 years For the treatment of 1st and 2nd stage human African trypanosomiasis due to Trypanosoma brucei gambiense infection To be used for the treatment
WHO Model List of Essential Medicines
WHO_Model_List_of_Essential_Medicines
Class of pharmaceuticals used to treat protozoan infections
giardiasis, cryptosporidiosis, microsporidiosis, malaria, babesiosis, trypanosomiasis, Chagas disease, leishmaniasis, and toxoplasmosis. Currently, many
Antiprotozoal
Japanese physician (1871–1957)
He conducted research on other diseases such as tuberculosis and trypanosomiasis, and made many advancements in bacteriology and immunology. Shiga was
Kiyoshi_Shiga
Ecological niche involving feeding on blood
Emojong (2016). "Tsetse Flies (Glossina) as Vectors of Human African Trypanosomiasis: A Review". BioMed Research International. 2016 6201350. doi:10.1155/2016/6201350
Hematophagy
Combination vaccine
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
Influenza and COVID-19 vaccine
Influenza_and_COVID-19_vaccine
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
Use of fetal tissue in vaccine development
Use_of_fetal_tissue_in_vaccine_development
Type of rural landscape in South Africa
Association, Cape Town Steverding, Dietmar (2008). "The history of African trypanosomiasis". Parasites & Vectors. 1 (1): 3. doi:10.1186/1756-3305-1-3. ISSN 1756-3305
Veld
American pathologist (1885–1959)
Institute who helped develop a treatment for African sleeping sickness (trypanosomiasis). Sleeping sickness was a fatal epidemic which had devastated areas
Louise_Pearce
Chemical compound
bacteria, gram-negative bacteria, and can be used in the treatment of trypanosomiasis. Its use in medicine has become less frequent, as safer and more effective
Nitrofurazone
Vaccine to prevent urinary tract infections
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
UTI_vaccine
Agent that carries and transmits pathogens
sleeping sickness (also called African trypanosomiasis) and Chagas disease (also called American trypanosomiasis) are trypanosomatid diseases, caused by
Disease_vector
Argentine physician and epidemiologist
epidemiologist, best known for his strides in helping control American trypanosomiasis, an endemic disease among the rural, poor majority of early 20th century
Salvador_Mazza
Non-profit organization
diseases, notably leishmaniasis, sleeping sickness (human African trypanosomiasis, HAT), Chagas disease, malaria, filarial diseases, mycetoma, paediatric
Drugs for Neglected Diseases Initiative
Drugs_for_Neglected_Diseases_Initiative
1960–1971 state in Central Africa
education. Colonial doctors greatly reduced the spread of African trypanosomiasis, commonly known as sleeping sickness. During World War II, the small
First_Congolese_Republic
Blue-colored dye
analog of trypan blue, suramin, is used pharmacologically against trypanosomiasis. Trypan blue is also known as diamine blue and Niagara blue. The extinction
Trypan_blue
Type of vaccine
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
MRNA_vaccine
Group of single-celled parasitic organisms
are; African trypanosomiasis (sleeping sickness, caused by Trypanosoma brucei and transmitted by tsetse flies), South American trypanosomiasis (Chagas disease
Trypanosomatida
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
List of COVID-19 vaccine authorizations
List_of_COVID-19_vaccine_authorizations
Topics referred to by the same term
agglutination test for trypanosomiasis or card-agglutination trypanosomiasis test, a serologic test used to detect human African trypanosomiasis Center for Advanced
Catt
Clinical trial stages using human subjects
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
Phases_of_clinical_research
West African breed of goat
of the area, and also by some degree of resistance to tsetse-borne trypanosomiasis or "sleeping sickness". Many regional strains or breeds are within
West_African_Dwarf_goats
Genus of parasitic flagellate protist in the Kinetoplastea class
identified the protozoan parasite and the tsetse fly vector of African trypanosomiasis. Many past phylogenetic analyses using the 18S (small subunit) ribosomal
Trypanosoma
Nigerian government agency
Institute for Oil Palm Research (WAIFOR) The West African Institute for Trypanosomiasis Research (WAITR) The West African Stored Products Research Unit (WASPRU)
Agricultural Research Council of Nigeria
Agricultural_Research_Council_of_Nigeria
Species of tsetse fly
(subgenus Nemorhina). Glossina palpalis is an important vector of African trypanosomiasis, including both the form affecting livestock and the one affecting
Glossina_palpalis
Researcher of tropical medicine, parasites, and malaria
1951. From 1951 to 1960, he worked for West African Institute for Trypanosomiasis Research in Vom, Nigeria. In 1960, he joined the University of Malaya
Robert_S._Desowitz
Congolese physician
African Trypanosomiasis: Report of a WHO Expert Committee. World Health Organization. ISBN 978-92-4-120984-7. "Human African trypanosomiasis in the Democratic
Victor_Kande
Combination vaccine
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
DPT_vaccine
Breed of cattle
Africa, it is possible that this is the result of selection against trypanosomiasis challenge. Hanotte, O.; Ronin, Y.; Agaba, M.; Nilsson, P.; Gelhaus
Boran_cattle
Reversal of sleeping tendencies
Encephalopathic causes are varied, but the most prominent example is African trypanosomiasis, or sleep sickness, in those who end up developing CNS (Central Nervous
Sleep_inversion
United States Army research directorate based in Kenya
of military and global public health importance, including malaria, trypanosomiasis, and leishmaniasis, arboviruses, HIV/AIDS, and other emerging infectious
United States Army Medical Research Unit-Africa
United_States_Army_Medical_Research_Unit-Africa
Italian-English physician
PMID 1503005. Cox, Francis E.G (2004). "History of sleeping sickness (African trypanosomiasis)". Infectious Disease Clinics of North America. 18 (2): 231–245. doi:10
Louis_Westenra_Sambon
Viral shedding from a vaccine-induced infection
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
Vaccine_shedding
Research institute
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
National Center for Immunization and Respiratory Diseases
National_Center_for_Immunization_and_Respiratory_Diseases
Tropical medicine teaching and research institution
been one of the world's premier sites of research on African Animal Trypanosomiasis (AAT, nagana), the major livestock disease in Africa. Nine research
Liverpool School of Tropical Medicine
Liverpool_School_of_Tropical_Medicine
American physician and immunologist (born 1959)
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
Drew_Weissman
Appearance of swelling around the eyes
unilateral as well as bilateral. Chagas disease – Also known as American trypanosomiasis. Young patients, often in an acute phase of the disease, manifest Romaña's
Periorbital_puffiness
Class of vaccines against human papillomavirus
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
HPV_vaccine
Vaccine that uses a weakened form of the germ
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
Attenuated_vaccine
Species of tsetse fly
group (subgenus Nemorhina). Glossina tachinoides can transmit African trypanosomiasis, including both the form affecting livestock and the one affecting
Glossina_tachinoides
Species of tsetse fly
tsetse fly species, cause the infectious disease trypanosomiasis. In humans, G. fuscipes trypanosomiasis is also known as sleeping sickness. In animals
Glossina_fuscipes
Vaccines used to prevent tetanus
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
Tetanus_vaccine
an enzyme which causes sleeping sickness in humans (Human African Trypanosomiasis, HAT) and nagana in animals (Animal African Trypanosomiasis, AAT).
Andrew_Jonathan_Nok
Enzymes responsible for polyamine metabolism
in the protozoan parasite Trypanosoma brucei, which causes African trypanosomiasis (sleeping sickness). The T. brucei MTAP has an unusually broad specificity
MTAP
Abnormal change in size of the lymph nodes
lymph nodes. It is also a sign of cutaneous anthrax and human African trypanosomiasis Toxoplasmosis, a parasitic disease, gives a generalized lymphadenopathy
Lymphadenopathy
Vaccine to prevent shingles
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
Zoster_vaccine
COVID-19 vaccine candidate produced in a plant
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
CoVLP
brucei gambiense and Trypansoma brucei rhodesiense) which cause African Trypanosomiasis (sleeping sickness). Ticks and lice form another large group of invertebrate
List of diseases spread by arthropods
List_of_diseases_spread_by_arthropods
American-Israeli agricultural geneticist (1931–2026)
Alan J. (1997). "Localization of genes controlling resistance to trypanosomiasis in mice". Nature Genetics. 16 (2). Springer Science and Business Media
Morris_Soller
Combination vaccine
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
DTaP-Hib_vaccine
British parasitologist (1929–2011)
diseases, in particular phlebotomine sandflies. His work on malaria, trypanosomiasis, leishmaniasis and other parasitological infections are numerous and
Robert_Killick-Kendrick
Former British medical project
to investigate the outbreak of African sleeping sickness or African trypanosomiasis in Africa at the turn of the 20th century. The outbreak of the disease
Sleeping_Sickness_Commission
Species of rodent
lives up to 13 years. The lowland paca can carry leishmaniasis and trypanosomiasis. The lowland paca is mostly nocturnal and solitary and does not vocalize
Lowland_paca
Superfamily of flies
contains the tsetse flies, economically important as the vectors of trypanosomiasis. The enigmatic Mormotomyiidae are believed to belong to the Ephydroidea
Hippoboscoidea
Anti-parasitic medical drug
Chagas disease (American Trypanosomiasis), caused by Trypanosoma cruzi. Nifurtimox has also been used to treat African trypanosomiasis (sleeping sickness)
Nifurtimox
Place in Mpumalanga, South Africa
Emanzimhlope translates to 'White Waters' in siSwati. Malaria and animal trypanosomiasis pervasive in the lowveld in the 19th century meant that white settlers
White_River,_Mpumalanga
Biological entity that causes disease in its host
cryptosporidiosis, trichomoniasis, Chagas disease, leishmaniasis, African trypanosomiasis (sleeping sickness), Acanthamoeba keratitis, and primary amoebic meningoencephalitis
Pathogen
Pharmaceutical drug classification
ATC code P01 Antiprotozoals is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed
ATC_code_P01
Vaccine against hantavirus infections
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
Hantavirus_vaccine
Vaccine candidate against COVID-19
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
NDV-HXP-S
Medical condition
as manganese, as a side effect of melarsoprol treatment for African trypanosomiasis, adverse effects to prescription drugs, or exposure to extreme concentrations
Toxic_encephalopathy
Place in KwaZulu-Natal, South Africa
and where Bruce discovered the causative agent of nagana, African trypanosomiasis ("sleeping sickness") and its transmission by the tsetse fly were discovered
Ubombo
Species of parasitic euglenoids (protozoans)
triatomine, where they revert to epimastigotes, completing the cycle. Trypanosomiasis in humans progresses with the development of the trypanosome into a
Trypanosoma_cruzi
1987–1991 communist state in Ethiopia and Eritrea
concentrated in the highland areas, which were free of malaria and trypanosomiasis. Both the Emperor's and Mengistu's regimes had tried to resettle people
People's Democratic Republic of Ethiopia
People's_Democratic_Republic_of_Ethiopia
Invasion of an organism's body by pathogenic agents
lymphatic filariasis, leishmaniasis, onchocerciasis, schistosomiasis and trypanosomiasis. "WHO | The top 10 causes of death". WHO. Archived from the original
Infection
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
Timeline_of_human_vaccines
English physician (1749–1823)
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
Edward_Jenner
Cargo ship carrying slaves onboard from Africa to the Americas
scurvy, measles, typhoid fever, hookworm, tapeworm, sleeping sickness, trypanosomiasis, yaws, syphilis, leprosy, elephantiasis, and melancholia resulted in
Slave_ship
Australian policy initiative
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
No_Jab,_No_Pay
Epidemiologic metric
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
Number_needed_to_vaccinate
Vaccine candidate against COVID-19
Hepatitis C Herpes simplex HIV Zika Protozoan Malaria RTS,S research: Trypanosomiasis Helminthiasis research: Hookworm Schistosomiasis Other Androvax (androstenedione
MRNA-1283
Disease prevalent in or unique to tropical and subtropical regions
year for tropical diseases per 100,000 inhabitants. These include trypanosomiasis, chagas disease, schistosomiasis, leishmaniasis, lymphatic filariasis
Tropical_disease
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