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Protein-coding gene in the species Homo sapiens
channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the TRPM2 gene. The protein encoded by this gene is a non-selective
TRPM2
Chemical compound
cofactor. ADPR binds to and activates the TRPM2 ion channel. ADPR is the most potent agonist of the TRPM2 channel. cADPR also binds to TPRM2, and the
Adenosine_diphosphate_ribose
Class of transport proteins
channel, among others. βTRPMs include, but are not limited to, vertebrate TRPM2, TRPM4, TRPM5, and TRPM8 (the cold and menthol sensor). Two additional major
Transient receptor potential channel
Transient_receptor_potential_channel
Sensation and perception of temperature
detection of capsaicin. Innocuous warm sensation is mediated by activation of TRPM2. Innocuous cool sensation is mediated by activation of TRPM8. TRPA1 is sometimes
Thermoception
Protein found in humans
cells to produce a variety of cytokines. CD38 activation cooperates with TRPM2 channels to initiate physiological responses such as cell volume regulation
CD38
Human chromosome
TRAPPC10: encoding protein Trafficking protein particle complex subunit 10 TRPM2: encoding protein transient receptor potential cation channel subfamily
Chromosome_21
Genetic protein
retinopathy. TMEM217 was also found to have similar expression patterns as TRPM2, a biomarker linked to breast carcinoma. Expression profiles have also linked
Transmembrane_protein_217
Family of transport proteins
magnesium. The mechanism of activation also varies greatly among TRPM channels. TRPM2 is activated by ADP-ribose adenosine 5'-diphosphoribose and functions as
TRPM
Protein found in humans
APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, clusterin External IDs OMIM: 185430; MGI: 88423; GeneCards: CLU Gene location
Clusterin
Chemical compound
converted to adenosine diphosphate ribose, which binds and activates the TRPM2 ion channel. The reaction is catalyzed by ribose-5-phosphate adenylyltransferase
Ribose_5-phosphate
Q9Y210 17478 TRPC7 HGNC:20754; Q9HCX4 17479 TRPM1 HGNC:7146; Q7Z4N2 17480 TRPM2 HGNC:12339; O94759 17481 TRPM3 HGNC:17992; Q9HCF6 17482 TRPM4 HGNC:17993;
List of human protein-coding genes 8
List_of_human_protein-coding_genes_8
Chemical compound
critical step in muscle contraction. cADPR also acts as an agonist for the TRPM2 channel, but less potently than ADPR. cADPR and ADPR act synergistically
Cyclic_ADP-ribose
ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels". The Journal of Biological Chemistry. 280 (7): 6138–48
Loop_modeling
Family of ion channel proteins
voltage gated ion channels. TRPC1; TRPC3; TRPC4; TRPC5; TRPC6; TRPC7 TRPM1; TRPM2; TRPM3; TRPM4; TRPM5; TRPM6; TRPM7; TRPM8 TRPV1; TRPV2; TRPV3; TRPV4; TRPV5;
Cation_channel_superfamily
Chemical compound
TRPML1 and TRPML3 channels. It has been used to demonstrate the role of TRPM2 in immune system function, both triggering release of the chemokine CCL2
ML2-SA1
Index of articles on biophysics
TRPA (channel) TRPC TRPC1 TRPC2 TRPC3 TRPC4AP TRPC5 TRPC6 TRPC7 TRPM TRPM1 TRPM2 TRPM3 TRPM4 TRPM5 TRPM6 TRPM7 TRPM8 TRPML TRPN TRPP TRPP3 TRPV TRPV1 TRPV2
Index_of_biophysics_articles
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