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See searches and references containing TRAF2!TRAF2
Protein-coding gene in humans
receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene. The protein encoded by this gene is a member of the TNF receptor associated
TRAF2
Immune system messenger protein which induces inflammation
binding to tmTNF, TNFR2 trimerizes and directly recruits TRAF2, as well as TRAF1 or TRAF3. TRAF2 is central to the TNFR2 signaling complex and recruits
Tumor_necrosis_factor
Chemical compound
the treatment of idiopathic pulmonary fibrosis (IPF). It targets TNIK (TRAF2 and NCK-interacting protein kinase). It is asserted to be the first drug
Rentosertib
Protein-coding gene in the species Homo sapiens
factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit
TRAF_interacting_protein
Mammalian protein found in humans
receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction
CD30
Protein-coding gene in the species Homo sapiens
binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This
TRADD
Protein-coding gene in the species Homo sapiens
TRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the TNIK gene. TNIK is involved in various cellular processes, including
TNIK
Protein-coding gene in the species Homo sapiens
adherens junctions. TNFAIP3 has been shown to interact with TNIP1, TRAF1, TRAF2, IKBKG, TAX1BP1, YWHAB, YWHAZ, TRAF6 and YWHAH. The TNFAIP3 locus is implicated
TNFAIP3
Currently, seven TRAF proteins have been characterized in mammals: TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6, and TRAF7. TRAF3, TRAF5, and TRAF6 share identical
TNF receptor associated factor
TNF_receptor_associated_factor
Form of programmed cell death
domain protein (FADD). cIAP1/2 can inhibit TNF signaling by binding to TRAF2. FLIP inhibits the activation of caspase-8. Binding of this receptor can
Apoptosis
Binding domain of TRAFs
a major one, [PSAT]x[QE]E and a minor one, PxQxxD. The structure of the TRAF2 protein reveals a trimeric self-association of the MATH domain. The domain
MATH_domain
Species of tree
NCBI: 709072 Open Tree of Life: 1090387 Plant List: kew-2516925 PLANTS: TRAF2 POWO: urn:lsid:ipni.org:names:856719-1 Tropicos: 21301002 WFO: wfo-0000456573
Treculia_africana
Protein-coding gene in the species Homo sapiens
by bacterial peptidoglycans, they oligomerize and recruit cIAP1, cIAP2, TRAF2 and RIP2. This allows cIAP1 mediated ubiquitination of RIP2, which leads
Baculoviral IAP repeat-containing protein 2
Baculoviral_IAP_repeat-containing_protein_2
Fibrosis of lungs due to unknown causes
October 2025. Rentosertib is an investigational new drug that targets TNIK (TRAF2 and NCK-interacting protein kinase). It is asserted to be the first drug
Idiopathic_pulmonary_fibrosis
Protein-coding gene in the species Homo sapiens
protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in
TANK_(gene)
Membrane receptor protein found in humans
the ubiquitination and degradation of TNF-receptor-associated factor 2 (TRAF2), which mediates anti-apoptotic signals. Knockout studies in mice also suggest
Tumor necrosis factor receptor 2
Tumor_necrosis_factor_receptor_2
Necrotic cell death regulated by intracellular signaling, exerted by activated MLKL
TNFR-associated death protein TRADD and TNF receptor-associated factor 2 TRAF2 signals to RIPK1 which recruits RIPK3 forming the necrosome also named ripoptosome
Necroptosis
Mammalian protein found in humans
of B cell haematopoiesis. CD40 (protein) has been shown to interact with TRAF2, TRAF3, TRAF6, TRAF5 and TTRAP. The remaining member of TRAF4 family, namely
CD40
Protein-coding gene in the species Homo sapiens
transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation
TRAF1
Protein found in humans
atherosclerotic inflammatory lesions. CD137 has been shown to interact with TRAF2. CD137 is also involved in cancer having been found upregulated in cancerous
TNFRSF9
Protein in the tumor necrosis factor receptor superfamily
signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2, TRAF3, and TRAF5 have been shown to mediate the signaling process of this
CD27
Protein-coding gene in humans
Th2 mediated reactions in vivo. OX40 binds TRAF2, 3 and 5 as well as PI3K by an unknown mechanism. TRAF2 is required for survival via NF-κB and memory
TNFRSF4
Membrane receptor protein found in humans
BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory
Tumor necrosis factor receptor 1
Tumor_necrosis_factor_receptor_1
Protein-coding gene in humans
kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. A recent study showed
MAP4K2
Protein-coding gene in the species Homo sapiens
repeat-containing protein 3 has been shown to interact with: CASP9, RIPK1, TRAF1, TRAF2, and UBE2D2. GRCh38: Ensembl release 89: ENSG00000023445 – Ensembl, May
Baculoviral IAP repeat-containing protein 3
Baculoviral_IAP_repeat-containing_protein_3
Cellular stress response
IRE-1α also recruits tumor necrosis factor receptor-associated factor 2 (TRAF2). This kinase cascade that is dependent on IRE-1α and JNK mediates ER stress–induced
Unfolded_protein_response
Software for the visualisation of macromolecules
RasMol RasMol ribbon diagram rendering of TRAF2 trimer PDB:1DOA Original author Roger A. Sayle Developer Herbert J. Bernstein Release 1992; 34 years ago (1992)
RasMol
Family of transcription factor protein complexes
is because NF-κB regulates anti-apoptotic genes especially the TRAF1 and TRAF2 and therefore abrogates the activities of the caspase family of enzymes
NF-κB
Enzyme found in humans
survival and is important in necroptosis induction. RIP interacts with TRAF2 via the kinase domain. The KD can also interact with Necrostatin-1, which
RIPK1
Protein-coding gene in humans
Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2". Mol. Cell. Biol. 22 (3): 737–49. doi:10.1128/MCB.22.3.737-749.2002. PMC 133545
MAP3K11
Protein found in humans
appear to compete with TNF-α receptor-associated factor 2 (TRAF2), an ASK1 activator. TRAF2 and TRAF6 are then recruited to ASK1 to form a larger molecular
ASK1
Protein-coding gene in the species Homo sapiens
SPRY1, ZNF500, KRT34, YIF1A, BAG4, TPM2, SYP, KRTAP10-8, KRTAP1-1, AP1B1, TRAF2, GRB10, MESD, TRIP6, CCDC152, BEX5, FHL5, MORN3, DGAT2L6, ZNF438, KCTD17
FARS2
Protein family
RNF213, RNF215, RNFT1, SH3MD4, SH3RF1, SH3RF2, SYVN1, TIF1, TMEM118, TOPORS, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6, TRAF7, TRAIP, TRIM2, TRIM3, TRIM4, TRIM5, TRIM6
RING_finger_domain
Protein-coding gene in the species Homo sapiens
activation of MAPK. Later analysis of syngenic mice that harbour mutations in TRAF2, UBE2N, Map3k1 and Map3k7 identified critical regulators of cytokine-induced
MAP3K1
Protein-coding gene in the species Homo sapiens
AIP1-IRE1 complex cytoplasm integral component of membrane mitochondrion IRE1-TRAF2-ASK1 complex IRE1-RACK1-PP2A complex nuclear inner membrane Ire1 complex
ERN1
Protein-coding gene in the species Homo sapiens
regulates osteoblasts. HIVEP3 has been shown to interact with TRAF1 and TRAF2. GRCh38: Ensembl release 89: ENSG00000127124 – Ensembl, May 2017 GRCm38:
HIVEP3
Mammalian protein found in Homo sapiens
et al. (September 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Molecular Cell. 2 (3): 389–95. doi:10.1016/S1097-2765(00)80283-X. PMID 9774977
Transcription_factor_Jun
Protein-coding gene in the species Homo sapiens
distinct isoforms have been reported. EDARADD has been shown to interact with TRAF2. GRCh38: Ensembl release 89: ENSG00000186197 – Ensembl, May 2017 GRCm38:
EDARADD
Protein-coding gene in the species Homo sapiens
Aronheim A (October 2018). "WDR62 mediates TNFα-dependent JNK activation via TRAF2-MLK3 axis". Molecular Biology of the Cell. 29 (20): 2470–2480. doi:10.1091/mbc
WDR62
Protein-coding gene in humans
"Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine"
ATF3
Type of protein
When CD40 is stimulated by CD40L, Act1 binds to TRAF3, with the help of TRAF2 and 5 in order to activate the JNK proteins. The precise function of TRAF3
Act_1_adaptor_protein
Signal to activate immune cells
complexes are kept preassembled on the membrane. It interacts with TRAF1 and TRAF2 adaptor proteins, which are involved in pathway eventually leading to NFκB
Co-stimulation
Abandoned drug
transactivation modulation of the AR with an IP of 25 nM and Emax of 78% and has a TRAF2 Emax of 29% and an N/C interaction (virilization-related) counterscreen
MK-0773
Protein-coding gene in the species Homo sapiens
RJ, Gamble JR, Vadas MA (March 2002). "Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling". The Journal of Biological
SPHK2
Protein found in humans
metabolism. TANK-binding kinase 1 has been shown to interact with: NCK1, TANK, TRAF2 and TBKBP1 aka SINTBAD Transcription factors activated upon TBK1 activation
TANK-binding_kinase_1
Protein-coding gene in the species Homo sapiens
shown to interact with B-cell activating factor, TRAF6, TRAF5, TNFSF13, TRAF2 and CAMLG. GRCh38: Ensembl release 89: ENSG00000240505 – Ensembl, May 2017
Transmembrane activator and CAML interactor
Transmembrane_activator_and_CAML_interactor
Protein-coding gene in the species Homo sapiens
TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting
TNIP1
Yongchang; Wang Jack; Lin Lih-Ling (Apr 2003). "Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism
Lymphotoxin_beta_receptor
Protein-coding gene in the species Homo sapiens
platelet-derived growth factor and serum. SPHK1 has been shown to interact with TRAF2. GRCh38: Ensembl release 89: ENSG00000176170 – Ensembl, May 2017 GRCm38:
Sphingosine_kinase_1
Protein-coding gene in the species Homo sapiens
Miyazono K, Ichijo H (Sep 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Molecular Cell. 2 (3): 389–95. doi:10.1016/s1097-2765(00)80283-x. PMID 9774977
TRAF5
Mammalian protein found in humans
CD70 leads to the recruitment of intracellular adaptor proteins, such as TRAF2 and TRAF5, which then activate signaling pathways, including the NF-κB and
CD70
Protein-coding gene in the species Homo sapiens
kinase binding glutathione peroxidase activity Cellular component vesicle TRAF2-GSTP1 complex plasma membrane intracellular anatomical structure mitochondrion
GSTP1
Human protein-coding gene
has been shown to interact with: FSCN1, MAGEH1, NDN, NGFRAP1 NGF, PRKACB, TRAF2, and TRAF4. Nogo-66 receptor c-Jun N-terminal kinases RhoA Rho GDP dissociation
Low-affinity nerve growth factor receptor
Low-affinity_nerve_growth_factor_receptor
Protein-coding gene in the species Homo sapiens
X, et al. (2005). "TNF-α induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination". EMBO J. 24 (10): 1886–98
UBE2J1
Protein-coding gene in the species Homo sapiens
TAB1, MAP3K7IP3, MAP3K7, NFKB1, NUMBL, Nuclear receptor co-repressor 1, TRAF2, and TRAF6. GRCh38: Ensembl release 89: ENSG00000055208 – Ensembl, May 2017
MAP3K7IP2
Protein-coding gene in the species Homo sapiens
IKBKG IRAK1, NFKBIA, MAP3K14, NFKB1, NFKBIB, NCOA3, PPM1B, TNFRSF1A, and TRAF2. GRCh38: Ensembl release 89: ENSG00000104365 – Ensembl, May 2017 GRCm38:
IKK2
Protein-coding gene in the species Homo sapiens
forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines
MAP3K7IP3
Protein-coding gene in the species Homo sapiens
cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and
B-cell_maturation_antigen
Without CD28, OX40 expression is delayed and reduced. OX40 also binds TRAF2, 3 and 5 and PI3K. OX40 gene mutations can cause a type of immunodeficiency
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Protein-coding gene in the species Homo sapiens
NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". The Journal of Biological Chemistry
TRAF3
Protein-coding gene in the species Homo sapiens
transcription regulation (nuclear adaptor protein p100, HP-1, PAP-1 and TRAF2 / SNX6), and regulation of the JAK/STAT pathway (SOCS1 and SOCS3). Furthermore
PIM1
Protein-coding gene in humans
IKK2, IRAK1, MAP3K14, MAP3K7, MAP3K8, NFKBIA, NCOA3, PPM1B, PRKDC, and TRAF2. GRCh38: Ensembl release 89: ENSG00000213341 – Ensembl, May 2017 GRCm38:
CHUK
Protein-coding gene in humans
these proteins: CARD10, CARD11, CARD14, CARD9 CRADD, IKBKG, MALT1, and TRAF2. GRCh38: Ensembl release 89: ENSG00000142867 – Ensembl, May 2017 GRCm38:
BCL10
Protein-coding gene in the species Homo sapiens
Ichijo H (September 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Mol. Cell. 2 (3): 389–95. doi:10.1016/s1097-2765(00)80283-x. PMID 9774977
MAPK8
Secreted protein of the TNF superfamily
hepatocytes. LIGHT has been shown to interact with TNFRSF14, TNFRSF6B, BIRC2, TRAF2 and TRAF3. Similar to how CD4 is the primary mediating receptor in HIV infection
LIGHT_(protein)
Protein-coding gene in the species Homo sapiens
TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting
TNIP2
kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2". Molecular and Cellular Biology. 22 (3): 737–749. doi:10.1128/MCB.22.3
RAF_kinase
A6NFA1 17298 TRADD HGNC:12030; Q15628 17299 TRAF1 HGNC:12031; Q13077 17300 TRAF2 HGNC:12032; Q12933 17301 TRAF3 HGNC:12033; Q13114 17302 TRAF3IP1 HGNC:17861;
List of human protein-coding genes 8
List_of_human_protein-coding_genes_8
Protein-coding gene in the species Homo sapiens
NIK, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-κB activity. It is a critical kinase of the alternative
MAP3K14
Protein-coding gene in the species Homo sapiens
expression may be regulated by MITF. TNFRSF14 has been shown to interact with TRAF2, TNFSF14 and TRAF5. Mutations in this gene have been recurrently been associated
Herpesvirus_entry_mediator
Protein-coding gene in the species Homo sapiens
protein in AIDS. CDK9 is also known to associate with other proteins such as TRAF2, and be involved in differentiation of skeletal muscle. In healthy cellular
Cyclin-dependent_kinase_9
Protein found in humans
growth factor receptor, endothelin receptor type B, PDGFRB, PDGFRA, PTGS2, TRAF2, estrogen receptor alpha, caveolin 2, PLD2, Bruton's tyrosine kinase, and
Caveolin_1
Protein-coding gene in the species Homo sapiens
role in Fas-mediated apoptosis. CASP8AP2 has been shown to interact with TRAF2. ENSG00000288475 GRCh38: Ensembl release 89: ENSG00000118412, ENSG00000288475
CASP8AP2
Prostaglandin subset
sequestration of TRAF2 may suppress inflammatory responses. PGA1 has similar although less potent effects on protein translation and TRAF2 sequestration
Cyclopentenone_prostaglandins
Mammalian protein found in Homo sapiens
coupling between the two. RANK has been shown to interact with: TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6. RANKL Osteoprotegerin Osteoimmunology GRCh38:
RANK
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
Kim WJ, Back SH, Kim V, Ryu I, Jang SK (March 2005). "Sequestration of TRAF2 into stress granules interrupts tumor necrosis factor signaling under stress
Stress_granule
Protein-coding gene in the species Homo sapiens
and NF-κB activating kinase (NAK, i.e. TANK-binding kinase-1 (TBK1) and TRAF2-associated kinase (T2K)). The fact that RELA can be modified by a collection
RELA
Protein-coding gene in the species Homo sapiens
described for this gene. MAP4K5 has been shown to interact with CRKL and TRAF2. GRCh38: Ensembl release 89: ENSG00000012983 – Ensembl, May 2017 GRCm38:
MAP4K5
Sendai virus, virus of rodents
induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1". The Journal of Biological Chemistry. 284 (16): 10774–10782. doi:10
Murine_respirovirus
Protein found in humans
several proteins listed that interact with CCDC130, including EEF1A1, NINL, TRAF2, ZBTB16, ZNF165, and ZNF24. EEF1A1 is a eukaryotic elongation factor that
CCDC130
Protein-coding gene in the species Homo sapiens
postreplication repair. UBE2N has been shown to interact with: AURKA, HLTF, TRAF2, TRAF6, and UBE2V1. GRCh38: Ensembl release 89: ENSG00000177889 – Ensembl
UBE2N
Protein-coding gene in the species Homo sapiens
infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2". Journal of Virology. 76 (9): 4567–79. doi:10.1128/JVI.76.9.4567-4579.2002
MAP3K8
Mammalian protein found in humans
PMID 18172167. Carpentier I, Coornaert B, Beyaert R (October 2008). "Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK
Ubiquitin_C
Protein-coding gene in the species Homo sapiens
Wooters J, Qiu Y, Wang J, Lin LL (April 2003). "Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism
Diablo_homolog
American biologist
"Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2". Nature. 465 (7301): 1084–1088. Bibcode:2010Natur.465.1084A. doi:10.1038/nature09128
Sarah_Spiegel_(biologist)
Protein-coding gene in the species Homo sapiens
signaling is propagated via recruiting TRAF-family members, specifically TRAF1, TRAF2 and TRAF5, to the GITR-signaling complex. The signaling is then mediated
TNFRSF18
PMID 18927080. Carpentier I, Coornaert B, Beyaert R (Oct 2008). "Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK
SMURF2
Protein found in humans
Ichijo H (September 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Mol. Cell. 2 (3): 389–95. doi:10.1016/s1097-2765(00)80283-x. PMID 9774977
TRAF6
receptor Many, including nucleus Affinity chromography technology IntAct TRAF2 and NCK Interacting Kinase (TNIK) Ser/thr kinase that activates Wnt signaling
LUZP2
Protein-coding gene in the species Homo sapiens
Sassoon D, Bowtell DD, Ronai Z (November 2002). "Stress-induced decrease in TRAF2 stability is mediated by Siah2". The EMBO Journal. 21 (21): 5756–65. doi:10
SIAH2
Protein-coding gene in the species Homo sapiens
(2004). "AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation". J. Biol. Chem. 279 (43): 44955–65. doi:10
DAB2IP
Protein-coding gene in the species Homo sapiens
(2004). "AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation". J. Biol. Chem. 279 (43): 44955–65. doi:10
RALBP1
Protein-coding gene in humans
PY, Yeh WC (2013). "Physiological Roles and Mechanisms of Signaling by TRAF2 and TRAF5". Madame Curie Bioscience Database [Internet]. Austin (TX): Landes
CPNE1
TRAF2
TRAF2
TRAF2
TRAF2
Girl/Female
Indian
Somebody who gives shelter, Goddess Lakshmi
Girl/Female
Muslim
Phrase from the holy Quran
Girl/Female
Gujarati, Indian, Kannada, Punjabi, Sikh
Gem
Boy/Male
Shakespearean
Much Ado About Nothing' A Constable.
Boy/Male
Muslim
Prayer to Allah
Girl/Female
Biblical
Making sweet, binding together.
Boy/Male
Muslim
Tender hearted
Boy/Male
Shakespearean
The Merchant of Venice' Friend to Antonio and Bassanio.
Girl/Female
Indian
Shade, Shadow
Girl/Female
Hindu, Indian
Water; Beloved; Dear
TRAF2
TRAF2
TRAF2
TRAF2
TRAF2