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Chemical compound
Tolcapone, sold under the brand name Tasmar, is a medication used to treat Parkinson's disease (PD). It is a selective, potent and reversible nitrocatechol-type
Tolcapone
Medication
Marketed Entacapone (Comtan, Comtess, Stalevo) Opicapone (Ongentys) Tolcapone (Tasmar) Not marketed Nebicapone (BIA 3-202) Neluxicapone Nitecapone (OR-462)
Catechol-O-methyltransferase inhibitor
Catechol-O-methyltransferase_inhibitor
Abandoned COMT inhibitor
and tolcapone. The drug shows peripheral selectivity and does not significantly act in the brain. In contrast to the centrally penetrant tolcapone, nebicapone
Nebicapone
Memory of autobiographical events
the CNS penetrant specific catecholamine-O-methyltransferase inhibitor Tolcapone. Furthermore, episodic memory is enhanced through AZD3480, a selective
Episodic_memory
Class of enzymes
and tolcapone ... have been demonstrated to reduce the dose of L-DOPA required and also cause improvement in clinical symptoms, although tolcapone emerged
Catechol-O-methyltransferase
COMT inhibitor
structurally related to other catechol COMT inhibitors like entacapone, tolcapone, and nebicapone. COMT inhibitors are used in conjunction with levodopa
Neluxicapone
Drug increasing motivation in humans
selective monoamine oxidase B (MAO-B) inhibitor; but see more below), tolcapone (a centrally-acting catechol-O-methyltransferase (COMT) inhibitor), and
Motivation-enhancing_drug
Substance related to dopamine functions
opicapone, and tolcapone, which are used in the treatment of Parkinson's disease. Entacapone and opicapone are peripherally selective, but tolcapone significantly
Dopaminergic
Disease
tolcapone "orphan drug status" in studies aiming at the treatment of transthyretin familial amyloidosis (ATTR). However, as of 2015[update] tolcapone
Wild-type transthyretin amyloid
Wild-type_transthyretin_amyloid
Class of chemical compounds
of the sympathetic nervous system.[citation needed] Some drugs, like tolcapone (a central COMT-inhibitor), raise the levels of all the catecholamines
Catecholamine
Group of psychiatric and neurological conditions
Centrally active catechol-O-methyltransferase inhibitors (COMTIs) like tolcapone, which are likewise dopaminergic agents, have been studied in the treatment
Disorders of diminished motivation
Disorders_of_diminished_motivation
Timepidium bromide – an anticholinergic (acetylcholine receptor antagonist) Tolcapone – a catechol-O-methyltransferase inhibitor used in combination with levodopa
Peripherally_selective_drug
Type of drug
multiple severe side effects and cannot be prescribed to pregnant women. Tolcapone — used in patients with Parkinson's disease who are not appropriate candidates
Drug_of_last_resort
Progressive neurodegenerative disease
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Parkinson's_disease
Brazil's federal drug control statute
Tiagabine Tianeptine Tiapride Thioproperazine Thioridazine Thiothixene Tolcapone Topiramate Tranylcypromine Trazodone Triclofos Trifluoperazine Trifluperidol
Brazilian Controlled Drugs and Substances Act
Brazilian_Controlled_Drugs_and_Substances_Act
Chemical compound
L-DOPA. Compounds capable of decreasing 3-O-methyldopa, like entacapone, tolcapone and opicapone (COMT inhibitors), when administered in combination with
3-O-Methyldopa
Syndrome characterized by tremor, slowed movements, rigidity, and imbalance
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Parkinsonism
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
LBT-3627
Abandoned cardiovascular drug
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Etamicastat
Antihistamine medication
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Diphenhydramine
Investigational Parkinson's disease drugs
Ongentys; ONO-2370) – catechol O-methyltransferase (COMT) inhibitor [341] Tolcapone (RO-407592; Tasmar) – catechol O-methyltransferase (COMT) inhibitor [342]
List of investigational Parkinson's disease drugs
List_of_investigational_Parkinson's_disease_drugs
Pargyline • Rasagiline • Safinamide Entacapone • Nitecapone • Opicapone • Tolcapone Bupicomide • Disulfiram • Dopastin • Fusaric acid • Nepicastat • Phenopicolinic
List_of_dopaminergic_drugs
Mental disorder involving eccentricity and social isolation in afflicted individuals
"Improvement of prepulse inhibition and executive function by the COMT inhibitor tolcapone depends on COMT Val158Met polymorphism". Neuropsychopharmacology. 33 (13):
Schizotypal personality disorder
Schizotypal_personality_disorder
South American psychoactive decoction
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Ayahuasca
Chemical compound
rhabdomyolysis have been rarely observed under the older COMT inhibitors tolcapone and entacapone. This typically occurs shortly after the beginning of a
Opicapone
Abandoned antiparkinsonian agent
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Botiacrine
Medication
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Mepacrine
Parasympathetic nervous system inhibitors
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Anticholinergic
Dopamine agonist medication
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Pramipexole
Chemical compound
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Entacapone
Pharmaceutical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
3-APBT
Chemical compound
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Carbidopa
Chemical compound
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Apomorphine
Pharmaceutical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
4-Methylthiomethamphetamine
DMT-infused smoking blend
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Changa_(drug)
Treatment of Parkinson's disease
motor complications when compared to immediate-release preparations. Tolcapone inhibits the catechol-O-methyltransferase (COMT) enzyme, which degrades
Management of Parkinson's disease
Management_of_Parkinson's_disease
Pharmaceutical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
6-Fluorotryptamine
Pharmaceutical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
4-(2-Aminopropyl)indole
Chemical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Disulfiram
Main receptor for most antipsychotic drugs
Wallace DL, Al-Zughoul A, Kayser AS, D'Esposito M (April 2018). "Effects of tolcapone and bromocriptine on cognitive stability and flexibility". primary. Psychopharmacology
Dopamine_receptor_D2
Psychedelic drug
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Bromo-DragonFLY
Medication used to treat Alzheimer's disease
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Memantine
Type of medication
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Monoamine_oxidase_inhibitor
Anti-hypertension medication
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Hydralazine
Antibiotic for treatment of tuberculosis
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Isoniazid
Endogenous enzyme
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Monoamine_oxidase_A
Blue dye also used as a medication
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Methylene_blue
Investigational obsessive–compulsive disorder drugs
CD20 Serotonin 5-HT6 receptor agonists (e.g., WAY-181187, WAY-208466) Tolcapone (Tasmar) – catechol-O-methyltransferase (COMT) inhibitor Escitalopram
List of investigational obsessive–compulsive disorder drugs
List_of_investigational_obsessive–compulsive_disorder_drugs
Dopaminergic medication
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Levodopa
Chemical compound
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Nitecapone
Parkinson's medication
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Carbidopa/levodopa
Group of chemical compounds
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Harmala_alkaloid
Chemical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Ampyzine
Chemical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
N-Methylnorsalsolinol
Irreversible non-selective MAO inhibitor and antidepressant drug
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Tranylcypromine
Dopamine agonist medication
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Ropinirole
Skeletal muscle relaxant
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Orphenadrine
Chemical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
9-Methyl-β-carboline
Sustained-release levodopa prodrug
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
XP-21279
Antispasmodic drug
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Trihexyphenidyl
Pharmaceutical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Harmalacidine
Medication for movement disorders
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Benzatropine
Adenosine A2A receptor antagonist and MAO-B inhibitor
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
3-Chlorostyrylcaffeine
Chemical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Amezinium_metilsulfate
Chemical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Aquayamycin
Chemical compound
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Cabergoline
Drug that binds to but does not activate muscarinic cholinergic receptors
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Muscarinic_antagonist
(Tienilic acid) 1980 Germany, France, UK, US, others Liver toxicity and death Tolcapone (Tasmar) 1998 European Union, Canada, Australia Hepatotoxicity Tolrestat
List_of_withdrawn_drugs
Dopamine agonist medication
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Bromocriptine
Medication used to treat high blood pressure
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Methyldopa
Medication
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Selegiline
Chemical compound
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Rasagiline
Experimental cardiovascular drug
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Zamicastat
Irreversible non-selective MAO inhibitor and antidepressant drug
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Phenelzine
Pharmaceutical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Harmine
Chemical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Harmaline
Chemical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Α-Methyltryptamine
Pharmaceutical drug
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Safrazine
Group of stereoisomers
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Biperiden
Agricultural product processed from the leaves of plants in the genus Nicotiana
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Tobacco
Stimulant and entactogen designer drug
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Para-Methoxymethamphetamine
Pharmaceutical drug classification
Rotigotine N04BD01 Selegiline N04BD02 Rasagiline N04BD03 Safinamide N04BX01 Tolcapone N04BX02 Entacapone N04BX03 Budipine N04BX04 Opicapone N04CX01 Istradefylline
ATC_code_N04
Medication used to treat dyskinesia
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Amantadine
Chemical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Zalsupindole
Combination medication
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Foscarbidopa/foslevodopa
Pharmaceutical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
5-APBT
Experimental antiparkinsonian agent and adamantane derivative
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Hemantane
Chemical compound often used as medication
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Benserazide
Chemical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Tryptoline
Chemical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
SKF-91488
Drug used to treat influenzavirus A infection
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Rimantadine
Chemical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Furazolidone
Pharmaceutical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
N,N-Dimethyl-4-methylthioamphetamine
N,N-Dimethyl-4-methylthioamphetamine
Pharmaceutical drug
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Deprenyl
Group of chemical compounds
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Β-Carboline
Chemical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
CX157
Chemical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Desmethylselegiline
Medication
Rasagiline Safinamide Selegiline COMT inhibitors Entacapone Opicapone Tolcapone AAAD inhibitors Benserazide (+levodopa) Carbidopa# (+carbidopa, +melevodopa
Levodopa/benserazide
Chemical compound
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Para-Methoxyamphetamine
Monoamine metabolism inhibitor
Entacapone Nebicapone Neluxicapone Nitecapone Opicapone Quinalizarin Tolcapone Tryptamines (serotonin, melatonin) TPHTooltip Tryptophan hydroxylase
Α-Methylphenylalanine
TOLCAPONE
TOLCAPONE
TOLCAPONE
TOLCAPONE
TOLCAPONE
TOLCAPONE
TOLCAPONE
TOLCAPONE
TOLCAPONE