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Protein-coding gene in humans
Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene. It belongs to the TMPRSS family of proteins, whose members are transmembrane
TMPRSS2
Chemical compound
drug-metabolizing enzyme. Debrisoquine has been identified as a inhibitor of TMPRSS2 protease, which is involved in the viral entry process of SARS-CoV-2. In
Debrisoquine
Antimalarial medication
protein required for viral entry into cells can be accomplished by proteases TMPRSS2 located on the cell membrane, or by cathepsins (primarily cathepsin L)
Hydroxychloroquine
Species of coronavirus causing SARS and COVID-19
Jahn O, Pöhlmann S (January 2014). "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe
SARS-related_coronavirus
Protein-coding gene in humans
unregulated cell proliferation. Examples of these fusion gene products would be TMPRSS2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing’s sarcoma, and FUS-ERG
ERG_(gene)
Male reproductive organ cancer
urine levels of mRNA molecules common to prostate tumors like PCA3 and TMPRSS2 fused to ERG. Several large studies have found that men screened for prostate
Prostate_cancer
Virus that causes COVID-19
entry. Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS‑CoV‑2. The host protein neuropilin 1 (NRP1)
SARS-CoV-2
Subfamily of viruses in the family Coronaviridae
proteases such as cathepsin family and transmembrane protease serine 2 (TMPRSS2) of the host cell. S1 proteins are the most critical components in terms
Coronavirus
Early experimental treatment efforts during the start of COVID-19 pandemic
protein required for viral entry into cells can be accomplished by proteases TMPRSS2 located on the cell membrane, or by cathepsins (primarily cathepsin L)
Chloroquine and hydroxychloroquine during the COVID-19 pandemic
Chloroquine_and_hydroxychloroquine_during_the_COVID-19_pandemic
Chemical compound
N-0385 is an experimental small molecule TMPRSS2-inhibitor being investigated for its potential use in the prevention and treatment of COVID-19. N-0385
N-0385
Class of enzymes
priming virus's Spike protein to show the protein named "fusion protein" (TMPRSS2 activate SARS-CoV-2 fusion). Exogenous snake venom serine proteases cause
Serine_protease
Serine protease inhibitor
pancreatitis. It is an inhibitor of the enzyme transmembrane protease, serine 2 (TMPRSS2). For chronic pancreatitis camostat's typical dose is 600 mg daily, for
Camostat
Medication used to treat malaria
protein required for viral entry into cells can be accomplished by proteases TMPRSS2 located on the cell membrane, or by cathepsins (primarily cathepsin L)
Chloroquine
Type of multinucleate cell
spike protein variants that can enhance syncytia formation. The protease TMPRSS2 is essential for syncytia formation. Syncytia can allow the virus to spread
Syncytium
Exopeptidase enzyme that acts on angiotensin I and II
Entry also requires priming of the spike protein by host serine protease TMPRSS2, a potential therapeutic target, and disruption of spike glycosylation
Angiotensin-converting enzyme 2
Angiotensin-converting_enzyme_2
Medical condition
carboxypeptidase II erbB-3 receptor Early prostate cancer antigen-2 SPINK1 GOLM1 PCA3 TMPRSS2 hPG80 Germ cell tumor NANOG Bladder cancer erbB-3 receptor NMP22 Breast
Germinoma
such as disruption of the tumor suppressor gene PTEN or creation of the TMPRSS2-ERG fusion gene.[citation needed] Chromplexy was originally inferred by
Chromoplexy
Gene formed by the combination of two independent genes
t(8 ; 21)), and TMPRSS2-ERG with an interstitial deletion on chromosome 21, often occurring in prostate cancer. In the case of TMPRSS2-ERG, by disrupting
Fusion_gene
Cell line
model that express the Androgen receptor splice variant, AR-V7, and the TMPRSS2-ERG gene fusion. The cells have an approximate doubling time of 53 hours
VCaP
Human chromosome
protein trefoil factor 3 TIAM1: Rho guanine nucleotide exchange factor TIAM1 TMPRSS2: encoding enzyme transmembrane protease serine 2 TMPRSS3: encoding enzyme
Chromosome_21
Indian scientist, medical researcher
markers and therapeutic targets. In 2005, his group discovered recurrent TMPRSS2-ETS gene fusions in prostate cancer using a bioinformatic outlier-analysis
Arul_Chinnaiyan
Sensory neuron that detects odorants
such damage and infection. In COVID-19, the viral-entry proteins ACE2 and TMPRSS2 are expressed mainly by non-neuronal sustentacular cells rather than by
Olfactory_receptor_neuron
Protein-coding gene in the species Homo sapiens
Laxman B, Cao Q, Prensner JR, et al. (January 2008). "Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer". Cancer Research
SLC45A3
Protein-coding gene in the species Homo sapiens
identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression". Molecular Endocrinology. 23 (11): 1776–1786. doi:10.1210/me
MDN1
Antiandrogen medication used in treatment of prostate cancer
with enzalutamide, the expression of androgen-dependent genes PSA and TMPRSS2 was down regulated in contrast to bicalutamide where the expression was
Enzalutamide
Protein family
Pienta KJ, Rubin MA, Chinnaiyan AM (October 2005). "Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer". Science. 310 (5748):
ETS transcription factor family
ETS_transcription_factor_family
Protein found in humans
the cytoplasmic membrane. Adam17 has similar ACE2 cleavage activity as TMPRSS2, but by forming soluble ACE2, Adam17 may actually have the protective effect
ADAM17
Group of cells allowing a pathogen to infect nearby endothelium
receptors associated with viral entry include ACE2 and co-receptor TMPRSS2. TMPRSS2 is needed to cleave the spike protein for viral fusion to cell membrane
Endothelial_cell_tropism
Investigational cognition and memory disorder drugs
SARS-CoV-2 main protease inhibitor and transmembrane protease serine 2 (TMPRSS2) inhibitor [58] HTL-18318 (HTL-0018318; HTL18318) – muscarinic acetylcholine
List of investigational cognition and memory disorder drugs
List_of_investigational_cognition_and_memory_disorder_drugs
Aspect of genetics
and MOZ-CBP genes expressed in acute myeloid leukemia (AML), and the TMPRSS2-ETS chimera associated with overexpression of the oncogene in prostate
Chimeric_RNA
American gastroenterologist
to locate any increase in the presence of ACE2 (converting enzyme 2) or TMPRSS2 (transmembrane serine protease 2). Later that year, she also published
Maria_T._Abreu
Protein-coding gene in the species Homo sapiens
2015). "Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced
PDE4D
Drug repurposing research related to COVID-19
protein required for viral entry into cells can be accomplished by proteases TMPRSS2 located on the cell membrane, or by cathepsins (primarily cathepsin L)
COVID-19 drug repurposing research
COVID-19_drug_repurposing_research
Glycoprotein spike on a viral capsid or viral envelope
virus, cell type, and local environment. In SARS-CoV, the serine protease TMPRSS2 is important for this process, with additional contributions from cysteine
Coronavirus_spike_protein
Combination in the membranes of cells
104763. PMC 10140059. PMID 37119851. Meng, B; et al. (March 2022). "Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity". Nature
Lipid_raft
Protein-coding gene in the species Homo sapiens
protein required for viral entry into cells can be accomplished by proteases TMPRSS2 located on the cell membrane, or by cathepsins (primarily cathepsin L)
Cathepsin_L1
Protein and gene in humans
known as Prenylated Rab acceptor 1, which assists in vesicle transport. TMPRSS2, also known as Transmembrane protease, serine 2, which has a poorly understood
TMEM128
Protein-coding gene in the species Homo sapiens
(2006). "Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium". J. Virol. 80 (19): 9896–8. doi:10
TMPRSS11D
Chemical compound
Julien JP, Melnyk RA (July 2022). "Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells". Antimicrobial
Bafilomycin
Canadian cell biologist
of Electrical and Electronics Engineers. Nabi, Ivan R. (May 2022). "A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic". Nature
Ivan_R._Nabi
Activation of a protein by exposure to its substrate
and optimal cells fusion. In low cholesterol ACE2 traffics the virus to TMPRSS2 which also cleaves and allows viral entry but through a putative surface
Substrate_presentation
Cao, Qi; Prensner, John R; Rubin, Mark A (February 2008). "Role of the TMPRSS2-ERG Gene Fusion in Prostate Cancer". Neoplasia. 10 (2): 177–188. doi:10
University of Michigan Rogel Cancer Center
University_of_Michigan_Rogel_Cancer_Center
Discrimination based on specific gene mutations
2020). "New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis". BMC Medicine. 18 (1) 216. Bibcode:2020BMCM...18
Genetic_discrimination
Accumulation of mutations
Yu J, Cao X, Wang L, Menon A, et al. (May 2008). "Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer"
Somatic_evolution_in_cancer
Sendai virus, virus of rodents
in malignant neoplasms. For example, transmembrane serine protease 2 (TMPRSS2), which is an F-protein-processing enzyme, is often overexpressed in prostate
Murine_respirovirus
researchers. They found that the protease TMPRSS2 is split by the virus' spike protein to enter the cell and that the TMPRSS2-inhibitors Camostat and, in a second
January–March_2020_in_science
Aspect of viral outbreak
and serine protease TMPRSS2 is implicated in cleaving the spike glycoprotein to allow fusion. Given the lack of ACE2 and TMPRSS2 coexpression in the placenta
Gendered impact of the COVID-19 pandemic
Gendered_impact_of_the_COVID-19_pandemic
17076 TMPO HGNC:11875; P42166, P42167 17077 TMPPE HGNC:33865; Q6ZT21 17078 TMPRSS2 HGNC:11876; O15393 17079 TMPRSS3 HGNC:11877; P57727 17080 TMPRSS4 HGNC:11878;
List of human protein-coding genes 8
List_of_human_protein-coding_genes_8
TMPRSS2
TMPRSS2
TMPRSS2
TMPRSS2
TMPRSS2
TMPRSS2
TMPRSS2
TMPRSS2
TMPRSS2