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Protein-coding gene in the species Homo sapiens
Transcription factor EB is a protein that in humans is encoded by the TFEB gene. TFEB is a master gene for lysosomal biogenesis. It encodes a transcription
TFEB
Species of bacterium
signalling causes the nuclear translocation of transcription factor EB (TFEB). TFEB is a master regulator of lysosome biogenesis and its translocation to
Treponema_pallidum
Medical condition
Renal cell carcinoma with t(6;11) translocation or TFEB-amplified Renal Cell Carcinomas is rare subtype of renal cell carcinoma. The t(6;11)(p21;q12) translocation
Renal cell carcinoma with t(6;11) translocation
Renal_cell_carcinoma_with_t(6;11)_translocation
Mammalian protein found in humans
their normal cell precursors. MITF, together with transcription factor EB (TFEB), TFE3 and TFEC, belong to a subfamily of related bHLHZip proteins, termed
Microphthalmia-associated transcription factor
Microphthalmia-associated_transcription_factor
Set of three serine threonine-specific protein kinases
needed] Akt1 regulates TFEB, a master controller of lysosomal biogenesis, by direct phosphorylation at serine 467. Phosphorylated TFEB is excluded from the
Protein_kinase_B
Protein-coding gene
demonstrating conservation of a GAP function for FLCN in lower organisms. TFE3 and TFEB are members of the microphthalmia-associated transcription factor (MiTF)
Folliculin
Italian scientist and academic professor
mutations responsible for many rare genetic diseases. His discovery of the TFEB gene, which controls the functioning of lysosomes, has had a major impact
Andrea_Ballabio
Series of biochemical reactions
Akt regulates TFEB, a master controller of lysosomal biogenesis, by direct phosphorylation of TFEB at serine 467. Phosphorylated TFEB is excluded from
Akt/PKB_signaling_pathway
Protein structural motif
SREBF2; TAL1; TAL2; TCF12; TCF15; TCF21; TCF3; TCF4; TCFL5; TFAP4; TFE3; TFEB; TFEC; TWIST1; TWIST2; USF1; USF2. Basic helix-loop-helix leucine zipper
Basic_helix–loop–helix
Unspecialized biological cell that can become specialized
Mathieu; Schroeder, Timm; Xie, Stephanie Z.; Dick, John E. (August 2021). "TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate"
Stem_cell
ENSG00000068323 bHLH Known motif – High-throughput in vitro [946] RKCACGTGNB TFEB ENSG00000112561 bHLH Known motif – High-throughput in vitro [947] RNCACGTGAY
List of human transcription factors
List_of_human_transcription_factors
Rare autosomal dominant cancer syndrome
tumorigenesis in BHD have been shown to be driven by the constitutive activation of TFEB. BHD can be suggested by clinical findings but is definitively diagnosed
Birt–Hogg–Dubé_syndrome
Form of kidney cancer
disease-associated renal cell carcinoma Renal cell carcinoma with t(6;11) translocation (TFEB) Hybrid oncocytoma/chromophobe renal cell carcinoma Hereditary leiomyomatosis
Renal_cell_carcinoma
Chemical compound
research was published showing that trehalose induces autophagy by activating TFEB, a protein that acts as a master regulator of the autophagy-lysosome pathway
Trehalose
Mammalian protein found in Homo sapiens
localization of the autophagy-related transcription factors FOXO3/FOXO3A and TFEB, suggesting that DIRAS1, along with DIRAS2, may behave as a surrogates in
DIRAS1
German molecular biologist
Dieterich, Christoph; Antebi, Adam (2016-03-22). "Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals".
Adam_Antebi
Protein-coding gene in the species Homo sapiens
Tessarollo L, Reid SW, et al. (1999). "The bHLH-Zip transcription factor Tfeb is essential for placental vascularization". Development. 125 (23): 4607–16
TFEC
Retrieved 1 November 2025. "Международная банковская карта "SYÝAHAT"". tfeb.gov.tm. Retrieved 1 November 2025. "Turkmenistan production in 2019, by FAO"
Economy_of_Turkmenistan
Protein-coding gene in humans
Lu J, Kim D, Wang J (April 2020). Kao A (ed.). "C9orf72/ALFA-1 controls TFEB/HLH-30-dependent metabolism through dynamic regulation of Rag GTPases". PLoS
C9orf72
Protein-coding gene in the species Homo sapiens
Reid SW, Jenkins NA, Copeland NG (1999). "The bHLH-Zip transcription factor Tfeb is essential for placental vascularization". Development. 125 (23): 4607–16
TFE3
Non-coding RNA in the species Homo sapiens
Bridge J, et al. (July 2003). "Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution"
MALAT1
Medical condition
chromatin remodeling (SETD2, BAP1, or PBRM) may lead to higher rate of TFE3/TFEB fusion. Additionally, CIMP papillary renal cell carcinoma tumors exhibited
Papillary renal cell carcinoma
Papillary_renal_cell_carcinoma
Q14188 16598 TFDP3 HGNC:24603; Q5H9I0 16599 TFE3 HGNC:11752; P19532 16600 TFEB HGNC:11753; P19484 16601 TFEC HGNC:11754; O14948 16602 TFF1 HGNC:11755; P04155
List of human protein-coding genes 8
List_of_human_protein-coding_genes_8
Protein-coding gene in humans
progranulin and lysosomal marker LAMP-1. Progranulin expression is regulated by TFEB, a transcription factor that mediates proteins involved in lysosomal biosynthesis
Granulin
American geneticist
IRGM and mammalian Atg8s regulate lysosomal biogenesis and control mTOR and TFEB. A recent review proposed membrane "atg8ylation" as a general stress/remodeling
Vojo_Deretic
Indian biologist
increase in intracellular calcium levels and modulation of PPP3/calcineurin-TFEB (transcription factor EB) axis. Autophagy. 2018. doi: 10.1080/15548627.2018
Ashwani_Kumar_(scientist)
Immunologist and associate professor
Evangelos; Razani, Babak; Rovina, Nikoletta; Xanthou, Georgina (July 2022). "TFEB signaling attenuates NLRP3-driven inflammatory responses in severe asthma"
Georgina_Xanthou
Chemical compound
bacterial infection, however, NAADP induction of lysosomal Ca2+ efflux and TFEB activation leads to enhanced expression of inflammatory cytokines. Since
Nicotinic acid adenine dinucleotide phosphate
Nicotinic_acid_adenine_dinucleotide_phosphate
TFEB
TFEB
TFEB
TFEB
Male
Norse
Old Norse name derived from the word steinn, STEINN means "stone."
Female
Greek
(ΧÏÏσηίς) Greek name derived from the word khrysos, KHRYSEIS means "golden." In mythology, this is the name of a Trojan girl mentioned briefly in Homer's Iliad.
Male
Greek
(ΠαÏαμονιμος) Ancient Greek name possibly derived from the word paramone, PARAMONIMOS means "constant, enduring," or composed of para "beside, beyond" and the name Monimos "to be favorable, pleasing." In ancient Greece there was a slave contract known as the paramone; though of limited duration, it was the most restrictive type of slavery, giving the master absolute rights.
Boy/Male
Hindu, Indian
Protector of the Conch
Girl/Female
Indian
A narrator of Hadith
Male
Spanish
Spanish form of Hebrew Zekaryah, ZACARÃAS means "whom Jehovah remembered."
Biblical
father of the wine-press,a Persian chamberlain, God-given; one of the seven eunuchs in the Persian court of Ahasuerus in charge of the wine
Boy/Male
Sikh
Swaggerific
Boy/Male
Hindu
Saviour of boars and monkeys
Girl/Female
Hindu
Lovable, Passionate, A musical Raag
TFEB
TFEB
TFEB
TFEB
TFEB