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Temporal Synapse is a 2013 six-part permanent, reactive art installation created by Project One located inside Sidney and Lois Eskenazi Hospital, near
Temporal_Synapse
The ribbon synapse is a type of neuronal synapse characterized by the presence of an electron-dense structure, the synaptic ribbon, that holds vesicles
Ribbon_synapse
Type of synapse
of synapses, such as axo-dendritic synapses and axo-somatic synapses. The spatio-temporal properties of neurons get altered by the type of synapse formed
Axo-axonic_synapse
Process in neuroscience
neurons) and temporal (from a single neuron) summation of all inputs at that moment. It is traditionally thought that the closer a synapse is to the neuron's
Summation_(neurophysiology)
Persistent strengthening of synapses based on recent patterns of activity
neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity. These are patterns of synaptic activity
Long-term_potentiation
Biological process that adjusts the strength of connections between neurons in the brain
precise temporal relationship is critical for synaptic modification: when the presynaptic spike occurs just before the postsynaptic one, the synapse is potentiated;
Spike-timing-dependent plasticity
Spike-timing-dependent_plasticity
Part of an animal that coordinates actions and senses
neighbouring cells through electrical synapses or cause chemicals called neurotransmitters to be released at chemical synapses. A cell that receives a synaptic
Nervous_system
Type of synapse
An excitatory synapse is a synapse in which an action potential in a presynaptic neuron depolarizes the membrane of the postsynaptic cell, and thus increases
Excitatory_synapse
Center Waiting Room Acrylic on Canvas 158” x 49.5” Eskenazi Health Temporal Synapse Project One 2013 Sidney & Lois Eskenazi Hospital: Blue Elevator Bays
List of artworks in the Eskenazi Health Art Collection
List_of_artworks_in_the_Eskenazi_Health_Art_Collection
Association fiber tract of the brain
radiate to and synapse on neurons in the occipital lobe, or turn downward and forward around the putamen and then radiate to and synapse on neurons in
Superior longitudinal fasciculus
Superior_longitudinal_fasciculus
Art collection
Cruse-Griffin Sunday Morning Margo Sawyer Synchronicity of Color Project One Temporal Synapse Casey Roberts The Arrival India Cruse-Griffin Two Moons Artur Silva
Eskenazi Health Art Collection
Eskenazi_Health_Art_Collection
Nerve in the skull
the greater petrosal nerve to synapse in the ganglion. The greater petrosal nerve enters the petrous part of the temporal bone and travels anteromedially
Greater_petrosal_nerve
Electrical signal inhibiting a neuron from firing
inhibitory and excitatory synapses. The size of the neuron can also affect the inhibitory postsynaptic potential. Simple temporal summation of postsynaptic
Inhibitory postsynaptic potential
Inhibitory_postsynaptic_potential
Neuroscientific theory
role of Hebbian learning mechanisms at synapses in the marine gastropod Aplysia californica. Because synapses in the peripheral nervous system of marine
Hebbian_theory
Psychological condition wherein a person is compelled to write or draw
with temporal lobe changes in epilepsy and in Geschwind syndrome. Structures that may have an effect on hypergraphia when damaged due to temporal lobe
Hypergraphia
Nerve of the parotid gland
the otic ganglion (where they synapse). It passes out of the tympanic cavity through the petrous part of the temporal bone into the middle cranial fossa
Lesser_petrosal_nerve
Sound frequency changes responsible for perceptions of loudness, pitch and timbre
The coding of temporal information in the auditory nerve can be disrupted by two main mechanisms: reduced synchrony and loss of synapses and/or auditory
Temporal envelope and fine structure
Temporal_envelope_and_fine_structure
Type of artificial neural network
function analogous to neural synapses. Numerous applications for such physical neural networks are possible. For example, a temporal summation device can be
Physical_neural_network
Ability of a synapse to strengthen or weaken over time according to its activity
In neuroscience, synaptic plasticity is the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity
Synaptic_plasticity
1943 paper proposing artificial neural networks
summation, temporal summation, and facilitation. The definition above is spatial summation (which they pictured as having multiple synapses placed close
A Logical Calculus of the Ideas Immanent in Nervous Activity
A_Logical_Calculus_of_the_Ideas_Immanent_in_Nervous_Activity
Type of field-effect transistor
transistor. The transistor is designed to mimic the feature of the human synapse known as plasticity, or the variation of the speed and strength of the
NOMFET
Experimental drug
PMID 38916481. "Delving into the Latest Updates on Bexicaserin with Synapse". Synapse. 28 October 2024. Retrieved 29 October 2024. Petersen AV, Jensen CS
Bexicaserin
Phenomenon of neural activity
20–50 Hz. Thalamic cells synapse on apical dendrites of pyramidal cells in the cortex. These pyramidal cells reciprocally synapse back on thalamic neurons
Recurrent thalamo-cortical resonance
Recurrent_thalamo-cortical_resonance
Potential difference across the postsynaptic membrane
stimuli are coming from different synapses at the same time (spatial) or at different times from the same synapse (temporal). Summation has been referred
Synaptic_potential
Network or circuit of neurons
A neural circuit is a population of neurons interconnected by synapses to carry out a specific function when activated. Multiple neural circuits interconnect
Neural_circuit
Impulse transmission between neurons
terminal of the presynaptic neuron, mainly at GABAergic and glutamatergic synapses. Neurotransmission is regulated by several different factors: the availability
Neurotransmission
Processes which grow and shape an organism's nervous tissue over its lifetime(s)
and dendrites, which allow them to communicate with other neurons via synapses. Synaptic communication between neurons leads to the establishment of functional
Development of the nervous system
Development_of_the_nervous_system
Any process that modulates the potential difference across a post-synaptic membrane
change by the difference between them.[citation needed] Temporal summation: When a single synapse inputs that are close together in time, their potentials
Postsynaptic_potential
Biological theory of intelligence
Hierarchical temporal memory (HTM) is a biologically constrained machine intelligence technology developed by Numenta. Originally described in the 2004
Hierarchical_temporal_memory
Photoreceptor cells that can function in lower light better than cone cells
hyperpolarized, it does not release its transmitter at the bipolar-ganglion synapse and the synapse is not excited. Activation of photopigments by light sends a signal
Rod_cell
In neurophysiology, a reduction of neuronal synapse efficacy
depression (LTD) is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs
Long-term_depression
scientists try to use the Schaffer collateral synapse as a sample synapse, a typical excitatory glutamatergic synapse in the cortex that has very well been studied
Schaffer_collateral
are induced by activity at neighboring synapses or by modulatory inputs, rather than by activity at the synapse itself. Synaptic plasticity more broadly
Heterosynaptic_plasticity
Brain stimulation through physical and social surroundings
but also during adulthood to a lesser degree. With extra synapses there is also increased synapse activity, leading to an increased size and number of glial
Environmental_enrichment
Cranial nerve IX, for the tongue and pharynx
pass via the corticobulbar tract in the genu of the internal capsule to synapse bilaterally on the ambiguus nuclei in the medulla. Parasympathetic component
Glossopharyngeal_nerve
Division of the autonomic nervous system
usually arise from specific nuclei in the central nervous system (CNS) and synapse at one of four parasympathetic ganglia: ciliary, pterygopalatine, otic
Parasympathetic nervous system
Parasympathetic_nervous_system
Type of synaptic plasticity
plasticity. Homosynaptic plasticity is input-specific, meaning changes in synapse strength occur only at post-synaptic targets specifically stimulated by
Homosynaptic_plasticity
between Golgi cells. The main synapse made by these cells is a synapse onto the mossy fibre–granule cell excitatory synapse in a glomerulus. The glomerulus
Golgi_cell
Protein-coding gene in the species Homo sapiens
for synapse regulation and presynaptic differentiation in the brain. Expression of the gene has been linked to early formation of excitatory synapses through
SLITRK1
Protein-coding gene in the species Homo sapiens
Kreutz MR, Bockmann J, Seidenbecher C, et al. (October 1999). "Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins
SHANK2
Neural circuit in the hippocampus
DG via the perforant path (synapse 1), DG → CA3 via mossy fibres (synapse 2), CA3 → CA1 via schaffer collaterals (synapse 3) The circuit was initially
Trisynaptic_circuit
Increase in postsynaptic potential by impulses
localization. Ca2+ plays a significant role in transmitting signals at chemical synapses. Voltage-gated Ca2+ channels are located within the presynaptic terminal
Neural_facilitation
Form of homeostatic plasticity
the strength of each synapse by the same factor (multiplicative change), so that the relative synaptic weighting of each synapse is preserved. (Chemical)
Synaptic_scaling
Cranial nerve VII, for the face and tasting
nerve typically travels from the pons through the facial canal in the temporal bone and exits the skull at the stylomastoid foramen. It arises from the
Facial_nerve
Modifying synaptic strength via cell adhesion molecules
exhibit distinct spatial and temporal expression patterns. For example, N-cadherin is widely expressed at the developing synapse and later remains near the
Synaptic_stabilization
Chemical substance that enables neurotransmission
signaling molecule secreted by a neuron to affect another cell across a synapse. The cell receiving the signal, or target cell, may be another neuron,
Neurotransmitter
Large part of the brain containing the cerebral cortex
the frontal lobe, send their axons to the brainstem and spinal cord to synapse on the lower motor neurons, which innervate the muscles. Through this connection
Cerebrum
Chemical compound
AMPA, kainic acid and N-methyl-D-aspartic acid (NMDA) channels. In the synapse, these receptors serve very different purposes. AMPA can be used experimentally
AMPA
Protein-coding gene in humans
binding Cellular component integral component of membrane cell junction synapse plasma membrane membrane synaptic vesicle vesicle axon terminus presynapse
PRRT2
Primary cell of the nervous system
Neurons receive and conduct impulses. They communicate with other cells via synapses, which are specialized connections that commonly use minute amounts of
Neuron
Artificial neural network that mimics neurons
neuroscience is to determine whether neurons communicate by a rate or temporal code. Temporal coding implies that a single spiking neuron can replace hundreds
Spiking_neural_network
Pharmaceutical compound
1 March 2025. "Delving into the Latest Updates on ICI-170809 with Synapse". Synapse. 23 January 2025. Retrieved 1 March 2025. Frenken M, Kaumann AJ (August
ICI-170809
Protein-coding gene in humans
Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein that in humans is encoded by the
DLG3
American neuroscientist
order to predict the risk of cognitive decline long before it occurs. The Synapse Project supported the proposition that participating in mentally challenging
Denise_C._Park
Hypothetical reconstruction of information from the brain
termed synapses, and their interactions are subsequently learning. Synapse strengths modulate learning and are altered based on the temporal and spatial
Neural_decoding
Mammalian protein found in humans
excitatory glutamatergic terminals however it is not expressed in all synapses as was previously thought. There is a slightly stronger colocalisation
SV2A
Neuroplasticity that arise from use of cognitive functions
dendrites and axons are interfaced through a small connection called a synapse. This component of the neuron contains a variety of chemical messengers
Activity-dependent_plasticity
Category of memory stabilizing processes
Synaptic consolidation occurs rapidly on a small scale in the individual synapses within the first few hours of learning. Systems consolidation occurs on
Memory_consolidation
Synapse in the mammalian auditory central nervous system
The calyx of Held is a particularly large excitatory synapse in the mammalian auditory nervous system, so named after Hans Held who first described it
Calyx_of_Held
Mammalian protein found in Homo sapiens
kinases. PAK3 is preferentially expressed in neuronal cells and involved in synapse formation and plasticity and mental retardation. PAK3 was initially cloned
PAK3
Delimited medium where some stimuli can evoke neuronal responses
retina of the eye is composed of input from all of the photoreceptors which synapse with it, and a group of ganglion cells in turn forms the receptive field
Receptive_field
Small projection on a neuron that receives signals
transmitted onto dendrites by upstream neurons (usually via their axons) via synapses which are located at various points throughout the dendritic tree. Dendrites
Dendrite
Protein-coding gene in the species Homo sapiens
be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4
NLGN4X
Chemical compound
November 2025. Retrieved 12 March 2026. "Delving into the Latest Updates on Sultiame with Synapse". Synapse. 12 March 2026. Retrieved 12 March 2026.
Sultiame
Type of protein
(October 2011). "Downregulation of gephyrin in temporal lobe epilepsy neurons in humans and a rat model". Synapse. 65 (10): 1006–14. doi:10.1002/syn.20928.
Gephyrin
Projections from the cerebral cortex to the pontine nuclei
e. ventral part of cerebral peduncle) to reach the pontine nuclei and synapse with neurons that give rise to pontocerebellar fibers. As the corticopontine
Corticopontine_fibers
Protein-coding gene in the species Homo sapiens
junction synapse synaptic vesicle membrane membrane cytoplasmic vesicle integral component of synaptic vesicle membrane excitatory synapse Biological
Solute carrier family 17 (vesicular glutamate transporter), member 6
Solute_carrier_family_17_(vesicular_glutamate_transporter),_member_6
Biological processes that may contribute to autism
explain different autistic features. These hypotheses include defects in synapse structure and function, reduced synaptic plasticity, disrupted neural circuit
Mechanism_of_autism
Protein-coding gene in the species Homo sapiens
"Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy". Neurology. 51 (6): 1730–1. doi:10.1212/wnl.51.6.1730. PMID 9855534
LGI1
Collection of facial nerve neurons
gustatory (i.e. superior/rostral) part of the solitary nucleus where they synapse with second-order neurons. The geniculate ganglion is conical in shape
Geniculate_ganglion
Left and right cerebral hemispheres of the brain
made up of gray matter, composed of neuronal cell bodies, dendrites, and synapses; this outer layer constitutes the cerebral cortex (cortex is Latin for
Cerebral_hemisphere
Organ central to the nervous system
neurons in the cerebellum is 55–70 billion. Each neuron is connected by synapses to several thousand other neurons, typically communicating with one another
Brain
Neurological process
Memory allocation is a process that determines which specific synapses and neurons in a neural network will store a given memory. Although multiple neurons
Neuronal_memory_allocation
Protein-coding gene in the species Homo sapiens
postsynaptic density membrane plasma membrane synapse neuromuscular junction glutamatergic synapse cholinergic synapse postsynaptic specialization Biological
DLGAP3
Within molecular and cell biology, temporal feedback, also referred to as interlinked or interlocked feedback, is a biological regulatory motif in which
Temporal_feedback
Region of the brain that processes visual information
Goldshmit Y, Bourne JA (2010). "Retinal afferents synapse with relay cells targeting the middle temporal area in the pulvinar and lateral geniculate nuclei"
Visual_cortex
Type of brain cell
rodent brains, and make contact with more than ten times the number of synapses. Research since the mid-1990s has shown that astrocytes propagate intercellular
Astrocyte
Neuron communication by electric impulses
ends of an axon; these signals can then connect with other neurons at synapses, or to motor cells or glands. In other types of cells, their main function
Action_potential
Form of neuroplasticity
soma of an individual neuron, remote from the synapse. Synaptic plasticity is the ability of a synapse between two neurons to change in strength over
Nonsynaptic_plasticity
Vertebrate brain region
also result from oxygen starvation (hypoxia), encephalitis, or medial temporal lobe epilepsy. People with extensive, bilateral hippocampal damage may
Hippocampus
Areas of neuronal cell bodies in the brain
and unmyelinated axons), glial cells (astrocytes and oligodendrocytes), synapses, and capillaries. Grey matter is distinguished from white matter in that
Grey_matter
Exocrine gland, one for each eye, that secrete tears
pterygopalatine ganglion where the preganglionic parasympathetic axons synapse with the postganglionic parasympathetic neurons. The postganglionic neurons
Lacrimal_gland
Protein-coding gene in the species Homo sapiens
in synapse formation within the dorsal lateral geniculate nucleus (dLGN) of mice. LRRTM1 aids in the assembly of complex retinogeniculate synapses in
LRRTM1
Neural structure
bulb including periglomerular cells which synapse within and between glomeruli, and granule cells which synapse with mitral cells. The granule cell layer
Olfactory_bulb
Faculty of mind to store and retrieve data
receptors, and new synapse pathways that reinforce the communicative strength between neurons. The production of new proteins devoted to synapse reinforcement
Memory
Protein and coding gene in humans
membrane membrane postsynaptic density plasma membrane apical part of cell synapse axon cell junction Z discdkac neuron projection costamere postsynapse cytosol
HOMER1
Changes in membrane potential varying in size
but rather can be produced by neurotransmitters that are released at synapses which activate ligand-gated ion channels. They occur at the postsynaptic
Graded_potential
Type of dendrite found at the apex of cortical pyramidal cell pathways
areas to survive Temporal Lobe Epilepsy. Kainic acid, used to model TLE and related scleroses, affects primarily the mossy fiber synapses in CA3. It is thought
Apical_dendrite
Overview of and topical guide to the human nervous system
and to non-neuronal cells such as those in muscles or glands. Chemical synapse Gap junction Synaptic plasticity Long-term potentiation Neurotransmitter
Outline of the human nervous system
Outline_of_the_human_nervous_system
Innate escape mechanism by crustaceans
that the synapses they subsequently made with the MoG passed depolarizing currents in a direct and unidirectional manner. These electrical synapses account
Caridoid_escape_reaction
hypothesis, has been proposed to explain how neural signaling at a particular synapse creates a target for subsequent plasticity-related product (PRP) trafficking
Synaptic_tagging
Capacity of neurons to regulate their own excitability relative to network activity
and experiences strengthen synapses (long-term potentiation) and lack of action and experiences weaken or diminish synapses (long-term depression). However
Homeostatic_plasticity
Quantum interpretation of neuroscience
different from the more commonly known action potentials involving axons and synapses. These oscillations are waves and create wave interference patterns in
Holonomic_brain_theory
Ability to attribute mental states to oneself and others
shows that the medial prefrontal cortex (mPFC), the posterior superior temporal sulcus (pSTS), the precuneus, and the amygdala are associated with theory
Theory_of_mind
5-HT2C receptor agonist
30 October 2024. "Delving into the Latest Updates on BMB-101 with Synapse". Synapse. 29 October 2024. Retrieved 30 October 2024. Vasilkevich A, Duan J
BMB-101
Protein-coding gene in the species Homo sapiens
nucleus cytoplasm cytosol host cell postsynaptic density glutamatergic synapse Biological process regulation of DNA recombination intracellular transport
Importin_subunit_alpha-5
Signal processing computational method
ISBN 0-262-69315-1 Hérault, J.; Ans, B. (1984). "Réseau de neurones à synapses modifiables: Décodage de messages sensoriels composites par apprentissage
Independent component analysis
Independent_component_analysis
Type of imaging sensor
illumination. Event cameras typically report timestamps with a microsecond temporal resolution, 120 dB dynamic range, and less under/overexposure and motion
Event_camera
Mechanisms that form the human nervous system
generation of synapses between axons and their postsynaptic partners. The synaptic pruning that occurs in adolescence. The lifelong changes in synapses which
Development of the nervous system in humans
Development_of_the_nervous_system_in_humans
Release of neurotransmitters in a synapse
fuses at the presynaptic membrane, releasing neurotransmitters across the synapse through a fusion pore. The vesicle can then be quickly reused after fusion
Kiss-and-run_fusion
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