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Protein-coding gene in the species Homo sapiens
domain family member 1 is a protein that in humans is encoded by the TBC1D1 gene. TBC1D1 is the founding member of a family of proteins sharing a 180- to
TBC1D1
Transport protein
GLUT4 translocation differ but ultimately converge on TBC1D1/4. Phosphorylation of TBC1D1/4 inactivates it, allowing Rab proteins to load GTP and directly
GLUT4
Protein-coding gene in the species Homo sapiens
Sakamoto K, Holman GD (July 2008). "Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic". American Journal of Physiology. Endocrinology
TBC1D4
Class of enzymes
uptake in skeletal muscle by phosphorylating Rab-GTPase-activating protein TBC1D1, which ultimately induces fusion of GLUT4 vesicles with the plasma membrane
AMP-activated_protein_kinase
Relation between obesity and genetic factors
against obesity. Other candidate anti-obesity-related genes include ALK, TBC1D1, and SRA1. The term "non-syndromic obesity" is sometimes used to exclude
Genetics_of_obesity
Protein domain
domains. In addition, all proteins in the TBC family contain this domain: TBC1D1 (Bub2) TBC1D2 TBC1D2B TBC1D3 TBC1D3B TBC1D3C TBC1D3D TBC1D3E TBC1D3F TBC1D3G
TBC_domain
Research institution
G. Joost, H. Al-Hasani: Deletion of both Rab-GTPase–activating proteins TBC1D1 and TBC1D4 in mice eliminates insulin- and AICAR-stimulated glucose transport
German_Diabetes_Center
Q86VP1 16344 TAX1BP3 HGNC:30684; O14907 16345 TBATA HGNC:23511; Q96M53 16346 TBC1D1 HGNC:11578; Q86TI0 16347 TBC1D2 HGNC:18026; Q9BYX2 16348 TBC1D2B HGNC:29183;
List of human protein-coding genes 8
List_of_human_protein-coding_genes_8
Cell and developmental biologist
Diabetologia 02-2017 DOI: 10.1007/s00125-16-4151-9 Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via
Carol_MacKintosh
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