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TAFENOQUINE

  • Tafenoquine
  • Antimalarial drug

    Tafenoquine, sold under the brand name Krintafel among others, is a medication used to prevent and to treat malaria. With respect to acute malaria, it

    Tafenoquine

    Tafenoquine

    Tafenoquine

  • Plasmodium vivax
  • Species of single-celled organism

    trial was completed that studied a single-dose alternative drug named tafenoquine. It is an 8-aminoquinoline, of the same family as primaquine, developed

    Plasmodium vivax

    Plasmodium vivax

    Plasmodium_vivax

  • Quinine
  • Medication used to treat malaria and babesiosis

    chloroquine# ferroquine† hydroxychloroquine# (8-): primaquine# pamaquine‡ tafenoquine 4-Methanolquinolines mefloquine# quinine# quinidine Other lumefantrine

    Quinine

    Quinine

    Quinine

  • 8-Aminoquinoline
  • Antimalarial drug precursor

    structurally analogous to 8-hydroxyquinoline. The derivatives primaquine, tafenoquine and pamaquine have been tested for anti-malaria activity. Primaquine

    8-Aminoquinoline

    8-Aminoquinoline

    8-Aminoquinoline

  • Primaquine
  • Pharmaceutical drug

    hypothesized that primaquine (and perhaps also the newer, related drug tafenoquine) might kill a proportion of non-circulating merozoites as well as hypnozoites

    Primaquine

    Primaquine

    Primaquine

  • Atovaquone/proguanil
  • Chemical compound

    chloroquine# ferroquine† hydroxychloroquine# (8-): primaquine# pamaquine‡ tafenoquine 4-Methanolquinolines mefloquine# quinine# quinidine Other lumefantrine

    Atovaquone/proguanil

    Atovaquone/proguanil

  • Glucose-6-phosphate dehydrogenase deficiency
  • Medical condition

    acute hemolysis in people with G6PD deficiency include primaquine and tafenoquine. Dapsone, methylene blue, pegloticase, rasburicase, and toluidine should

    Glucose-6-phosphate dehydrogenase deficiency

    Glucose-6-phosphate dehydrogenase deficiency

    Glucose-6-phosphate_dehydrogenase_deficiency

  • Piperaquine
  • Chemical compound

    chloroquine# ferroquine† hydroxychloroquine# (8-): primaquine# pamaquine‡ tafenoquine 4-Methanolquinolines mefloquine# quinine# quinidine Other lumefantrine

    Piperaquine

    Piperaquine

    Piperaquine

  • Antimalarial medication
  • Agents used in the treatment of malaria

    doses (e.g., retinopathy with chloroquine, acute haemolytic anaemia with tafenoquine). Antimalarial drugs may be used to treat malaria in three categories

    Antimalarial medication

    Antimalarial medication

    Antimalarial_medication

  • Quinism
  • encephalopathy due to intoxication by chloroquine, quinacrine, mefloquine, and tafenoquine. It is associated with brain dysfunction and brainstem dysfunction. It

    Quinism

    Quinism

  • Hemolytic anemia
  • Reduced oxygen-carrying ability of the blood due to breakdown of red blood cells

    oxidative drugs like primaquine it can become symptomatic. Primaquine and tafenoquine can pass through the placenta, causing hemolytic anemia in utero if the

    Hemolytic anemia

    Hemolytic anemia

    Hemolytic_anemia

  • Pregnancy-associated malaria
  • Impact of malaria on human pregnancies

    in determining if certain antimalarial drugs such as Primaquine and Tafenoquine can be used since these antimalarial drugs are more likely to cause red

    Pregnancy-associated malaria

    Pregnancy-associated_malaria

  • ATC code P01
  • Pharmaceutical drug classification

    P01BA02 Hydroxychloroquine P01BA03 Primaquine P01BA06 Amodiaquine P01BA07 Tafenoquine P01BB01 Proguanil P01BB02 Cycloguanil embonate P01BB51 Proguanil and

    ATC code P01

    ATC_code_P01

  • Plasmodium ovale
  • Species of single-celled organism

    PMID 20665090. S2CID 1727294. Markus, MB (2021). "Safety and efficacy of tafenoquine for Plasmodium vivax malaria prophylaxis and radical cure: overview and

    Plasmodium ovale

    Plasmodium ovale

    Plasmodium_ovale

  • List of drugs granted breakthrough therapy designation
  • colorectal cancer Ribociclib Novartis Pharmaceuticals breast cancer Tafenoquine GlaxoSmithKline Plasmodium vivax malaria Iobenguane I 131 Progenics Pharmaceuticals

    List of drugs granted breakthrough therapy designation

    List_of_drugs_granted_breakthrough_therapy_designation

  • Lyda Osorio
  • Colombian physician, epidemiologist and infectious disease specialist

    postdoctoral fellow. During her year at GSK she worked on a trial evaluating tafenoquine against P. vivax malaria, and on clinical data from a trial studying

    Lyda Osorio

    Lyda_Osorio

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