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SYNAPSIN 2

  • Synapsin 2
  • Protein-coding gene in the species Homo sapiens

    Synapsin II is the collective name for synapsin IIa and synapsin IIb, two nearly identical phosphoproteins in the synapsin family that in humans are encoded

    Synapsin 2

    Synapsin 2

    Synapsin_2

  • Synapsin
  • Family of proteins

    The synapsins are a family of proteins that have long been implicated in the regulation of neurotransmitter release at chemical synapses. Specifically

    Synapsin

    Synapsin

    Synapsin

  • Synapsin I
  • Protein-coding gene in the species Homo sapiens

    Synapsin I, is the collective name for Synapsin Ia and Synapsin Ib, two nearly identical phosphoproteins that in humans are encoded by the SYN1 gene.

    Synapsin I

    Synapsin I

    Synapsin_I

  • SYN3
  • Protein-coding gene in the species Homo sapiens

    Synapsin-3 is a protein that in humans is encoded by the SYN3 gene. This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins

    SYN3

    SYN3

    SYN3

  • Post-tetanic potentiation
  • RIM1α-knockout mice. Synapsin II is an abundant phosphoprotein known for its involvement in vesicle release. Synapsin II, along with synapsins I and III, anchors

    Post-tetanic potentiation

    Post-tetanic_potentiation

  • Nitromemantine
  • Chemical compound

    Nitromemantine (developmental code names YQW-36 and EM-036), also known as NitroSynapsin, is a derivative of memantine developed in 2006 for the treatment of Alzheimer's

    Nitromemantine

    Nitromemantine

    Nitromemantine

  • Synaptic vesicle
  • Neurotransmitters that are released at the synapse

    Bähler, M. (1989). "Electrostatic and hydrophobic interactions of synapsin I and synapsin I fragments with phospholipid bilayers". The Journal of Cell Biology

    Synaptic vesicle

    Synaptic vesicle

    Synaptic_vesicle

  • Active zone
  • protein, synapsin, that mediates the clustering of the reserve pool vesicles and attachment to the cytoskeleton. Phosphorylation of synapsin mobilizes

    Active zone

    Active zone

    Active_zone

  • SNARE protein
  • Protein family

    residues, and it is flanked by leucine zippering. Layers '-1', '+1' and '+2' at the centre of the complex most closely follow ideal leucine-zipper geometry

    SNARE protein

    SNARE protein

    SNARE_protein

  • Athetosis
  • Condition of uncontrolled writhing movements

    is toxic as it prevents the phosphorylation of many proteins, including synapsin I which binds vesicles in the presynaptic terminal. Therefore, it directly

    Athetosis

    Athetosis

    Athetosis

  • Alev Erisir
  • Turkish-American neuroscientist

    "Terminals of the major thalamic input to visual cortex are devoid of synapsin proteins". Neuroscience. 243: 115–125. doi:10.1016/j.neuroscience.2013

    Alev Erisir

    Alev_Erisir

  • Amphiphysin
  • Protein-coding gene in the species Homo sapiens

    Greengard P, Benfenati F (September 2000). "Specificity of the binding of synapsin I to Src homology 3 domains". The Journal of Biological Chemistry. 275

    Amphiphysin

    Amphiphysin

    Amphiphysin

  • Reflex seizure
  • Medical condition

    watching television in a bright well-lit room at a distance of at least 2 meters, and avoiding television or video games when tired. LCD TV screens

    Reflex seizure

    Reflex_seizure

  • TIMP1
  • Protein-coding gene in the species Homo sapiens

    polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. In adrenocortical

    TIMP1

    TIMP1

    TIMP1

  • Fiber photometry
  • Calcium imaging technique

    promoters like Ca2+/calmodulin-dependent protein kinase II (CaMKII) and human synapsin (hSyn) that confer excitatory neuronal and pan-neuronal expression, respectively

    Fiber photometry

    Fiber_photometry

  • Alpha-synuclein
  • Protein found in humans

    Atias M, Tevet Y, Sun J, Stavsky A, Tal S, Kahn J, et al. (June 2019). "Synapsins regulate α-synuclein functions". Proceedings of the National Academy of

    Alpha-synuclein

    Alpha-synuclein

    Alpha-synuclein

  • NOS1AP
  • Protein-coding gene in the species Homo sapiens

    adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. NOS1AP polymorphisms has been associated with the QT interval length

    NOS1AP

    NOS1AP

    NOS1AP

  • Axoplasm
  • Cytoplasm found within the axon of a neuron

    "Fast Vesicle Transport Is Required for the Slow Axonal Transport of Synapsin". Neuroscience. 33 (39): 15362–15375. doi:10.1523/jneurosci.1148-13.2013

    Axoplasm

    Axoplasm

  • Actin-binding protein
  • Class of proteins

    S-adenosyl-L-homocysteine hydrolase, (SAHH) Sla2p Synaptopodin Scinderin (adseverin) Synapsins Scruin Spectrin Severin Spectraplakins SVSII Shot (Short stop) Spire Shroom

    Actin-binding protein

    Actin-binding_protein

  • List of MeSH codes (D12.776.641)
  • 575.281 – enkephalins MeSH D12.776.641.650.575.281.075 – enkephalin, ala(2)-mephe(4)-gly(5)- MeSH D12.776.641.650.575.281.231 – enkephalin, leucine MeSH D12

    List of MeSH codes (D12.776.641)

    List_of_MeSH_codes_(D12.776.641)

  • Peripheral membrane protein
  • Membrane proteins that adhere temporarily to membranes with which they are associated

    Archived from the original on 2007-09-29. Retrieved 2007-01-25. "Pfam entry Synapsin N". Archived from the original on 2007-09-26. Retrieved 2007-01-25. "Pfam

    Peripheral membrane protein

    Peripheral membrane protein

    Peripheral_membrane_protein

  • Vesicular monoamine transporter
  • Family of transport proteins

    and increase the number of DTBZ binding sites. It has also mobilized a synapsin-dependent reserve pool of dopamine-containing synaptic vesicles, which

    Vesicular monoamine transporter

    Vesicular_monoamine_transporter

  • Cyclin-dependent kinase 5
  • Protein found in humans

    RasGRF2, Pak1, WAVE1, neurabin-1, TrkB, 5-HT6R, talin, drebrin, synapsin I, synapsin III, CRMP1, GKAP, SPAR, PSD-95, and LRRK2. The mammalian circadian

    Cyclin-dependent kinase 5

    Cyclin-dependent kinase 5

    Cyclin-dependent_kinase_5

  • TRPC6
  • Protein and coding gene in humans

    overexpressing TRPC6 greatly increased dendritic spine density and the level of synapsin I and PSD-95 cluster, known as the pre- and postsynaptic markers. TRPC6

    TRPC6

    TRPC6

    TRPC6

  • Gluten immunochemistry
  • islet cells in the pancreas. Anti-gliadin antibodies have been found to synapsin I Omega-gliadin and the HMW Glutenin subunit antibodies have been found

    Gluten immunochemistry

    Gluten_immunochemistry

  • CAMK1
  • Protein-coding gene in humans

    phospho-switch controls the dynamic association of synapsins with synaptic vesicles". Neuron. 24 (2): 377–87. doi:10.1016/S0896-6273(00)80851-X. PMID 10571231

    CAMK1

    CAMK1

    CAMK1

  • Neuronal lineage marker
  • Endogenous tag expressed in different cells along neurogenesis and differentiated cells

    mitotically active neuronal precursors. Microtubule-associated protein 2 (MAP-2) is a cytoskeletal protein. Its expression is weak in neuronal precursors

    Neuronal lineage marker

    Neuronal lineage marker

    Neuronal_lineage_marker

  • UHMK1
  • Protein-coding gene in the species Homo sapiens

    UHMK1 also phosphorylates the CNS proteins myelin basic protein (MBP) and synapsin I so that genetic abnormalities in UHMK1 could contribute to the genetic

    UHMK1

    UHMK1

    UHMK1

  • TIMP4
  • Protein-coding gene in the species Homo sapiens

    and nested gene organization within the synapsin locus is conserved from Drosophila to human". Genomics. 57 (2): 293–296. doi:10.1006/geno.1999.5776. PMID 10198170

    TIMP4

    TIMP4

    TIMP4

  • CAMK2G
  • Protein-coding gene in humans

    and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I." Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7518–22. Bibcode:1987PNAS..

    CAMK2G

    CAMK2G

    CAMK2G

  • Neutrophil cytosolic factor 1
  • Protein-coding gene in the species Homo sapiens

    Camilli P, Greengard P, Benfenati F (2000). "Specificity of the binding of synapsin I to Src homology 3 domains". J. Biol. Chem. 275 (38): 29857–67. doi:10

    Neutrophil cytosolic factor 1

    Neutrophil cytosolic factor 1

    Neutrophil_cytosolic_factor_1

  • Short-term synaptic depression
  • Form of neural negative feedback

    PMID 19202060. Zhang, Minchuan; Augustine, George J. (2021-03-16). "Synapsins and the Synaptic Vesicle Reserve Pool: Floats or Anchors?". Cells. 10

    Short-term synaptic depression

    Short-term synaptic depression

    Short-term_synaptic_depression

  • SPTAN1
  • Protein-coding gene in the species Homo sapiens

    Hayes NV, Baines AJ (Jun 1991). "Site specificity in the interactions of synapsin 1 with tubulin". The Biochemical Journal. 276. 276 (Pt 3): 793–799. doi:10

    SPTAN1

    SPTAN1

    SPTAN1

  • List of MeSH codes (D12.776)
  • 220.525.212.750 – cofilin 2 MeSH D12.776.220.525.212.875 – destrin MeSH D12.776.220.525.246.500 – actin-related protein 2 MeSH D12.776.220.525.246.750

    List of MeSH codes (D12.776)

    List_of_MeSH_codes_(D12.776)

  • Nerve tissue protein
  • Calcium-Sensor Proteins Neuropeptides Olfactory Marker Protein S100 Proteins Synapsins Synaptophysin Synucleins Tubulin Nerve+tissue+proteins at the U.S. National

    Nerve tissue protein

    Nerve_tissue_protein

  • N-ethylmaleimide sensitive fusion protein
  • Protein-coding gene in Homo sapiens

    Takahashi H, Nawa H (Jun 2001). "A quantitative study on the expression of synapsin II and N-ethylmaleimide-sensitive fusion protein in schizophrenic patients"

    N-ethylmaleimide sensitive fusion protein

    N-ethylmaleimide sensitive fusion protein

    N-ethylmaleimide_sensitive_fusion_protein

  • Alcino J. Silva
  • American neuroscientist (born 1961)

    plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway". J Neurosci. 25 (42): 9721–34. doi:10.1523/jneurosci

    Alcino J. Silva

    Alcino J. Silva

    Alcino_J._Silva

  • Linda Hsieh-Wilson
  • American chemist

    Nature Chemical Biology. 2 (9): 467–473. doi:10.1038/nchembio810. PMID 16878128. S2CID 1229340. "Sweet Memories of Synapsins?". Science's STKE. 2006 (317)

    Linda Hsieh-Wilson

    Linda_Hsieh-Wilson

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