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Protein
Zinc finger protein SNAI2 (also called SLUG) is a transcription factor that in humans is encoded by the SNAI2 gene. It promotes epithelial to mesenchymal
SNAI2
Genetic condition involving hearing loss and depigmentation
have been two known patients identified with mutations in both copies of SNAI2 (classified as type 2D); these individuals presented with Waardenburg syndrome
Waardenburg_syndrome
Genetic pigmentation disorder of the skin and hair
both.[citation needed] Piebaldism may be associated with the genes KIT or SNAI2. Usually diagnosed at birth with the appearance of patches of white skin
Piebaldism
Medical condition
syndrome, is a rare congenital disorder caused by a mutation in the SLUG (SNAI2) gene. It is characterized by the lack of pigmentation in the skin, hair
Waardenburg_syndrome_type_2D
Topics referred to by the same term
open-source autopilot system oriented toward inexpensive autonomous aircraft SNAI2, a transcription factor in humans Slug, another name for Chinese handball
Slug_(disambiguation)
Human chromosome
phosphate transporter 2 SLURP1: secreted LY6/PLAUR domain containing 1 SNAI2: snail homolog 2 (Drosophila) SNHG6: encoding protein Small nucleolar RNA
Chromosome_8
disease VWF dominant 1:10,000 Waardenburg syndrome PAX3, MITF, WS2B, WS2C, SNAI2, EDNRB, EDN3, SOX10 dominant 1:42,000 Warkany syndrome 2 8 trisomy
List_of_genetic_disorders
Human protein-coding gene
84% of lobular breast carcinomas. Several proteins such as SNAI1, ZEB2, SNAI2, TWIST1 and ZEB1 have been found to downregulate E-cadherin expression.
Cadherin-1
ENSG00000124216 C2H2 ZF Known motif – High-throughput in vitro [832] VCACCTGY SNAI2 ENSG00000019549 C2H2 ZF Known motif – High-throughput in vitro [833] RRCAGGTGYR
List of human transcription factors
List_of_human_transcription_factors
Pluripotent embryonic cell group giving rise to diverse cell lineages
that induces the expression of EMT promoting transcription factors such as SNAI2 and FOXD3. Although all neural crest cells undergo EMT, the timing of delamination
Neural_crest
G protein
for the subsequent induction of the pro-invasive transcription factors Snai2 (Slug), Sox9 or Twist. Further reading: Rho family of GTPases Aronheim A
Chp_(GTPase)
Mammalian protein found in Homo sapiens
epithelial mesenchymal transition by decreasing repression of SNAI1 and SNAI2, resulting in tumor growth and metastasis. Like breast cancer, downregulation
TOX3
Protein-coding gene in the species Homo sapiens
PMID 24096486. Mistry DS, Chen Y, Wang Y, Zhang K, Sen GL (December 2014). "SNAI2 controls the undifferentiated state of human epidermal progenitor cells"
KLF4
Q8IYR2 15411 SMYD5 HGNC:16258; Q6GMV2 15412 SNAI1 HGNC:11128; O95863 15413 SNAI2 HGNC:11094; O43623 15414 SNAI3 HGNC:18411; Q3KNW1 15415 SNAP23 HGNC:11131;
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
Biological process in animal connective tissue
indirectly can be considered as EMT-TF (EMT inducing TFs). SNAI1/Snail 1, SNAI2/Snail 2 (also known as Slug), ZEB1, ZEB2, TCF3 and KLF8 (Kruppel-like factor
Epithelial–mesenchymal transition
Epithelial–mesenchymal_transition
Cancer cells with features of normal cells
target genes, such as the E-cadherin gene repressor SLUG (also known as SNAI2). Mechanical properties of the tumor microenvironment, such as hypoxia,
Cancer_stem_cell
Developmental and Stem Cell Biologist
showed that up regulation of the zinc-finger transcriptional repressor SNAI2 could bypass the need for BMP inhibition. In subsequent work she demonstrated
Carole_LaBonne
Mammalian protein found in Homo sapiens
non-translated exon 0 and next to the first protein-coding exon 1). SLUG (SNAI2), a transcription factor, upregulates the expression of L1CAM. L1CAM has
Neural cell adhesion molecule L1
Neural_cell_adhesion_molecule_L1
Pick disease; 172700; MAPT Pick disease; 172700; PSEN1 Piebaldism; 172800; SNAI2 Pierson syndrome; 609049; LAMB2 Pigmented adrenocortical disease, primary
List_of_OMIM_disorder_codes
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