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Protein transport protein Sec61 subunit alpha isoform 1 is a protein encoded by the SEC61A1 gene in humans. The protein encoded by this gene belongs to
Sec61_alpha_1
Protein family
Sec61, termed SecYEG in prokaryotes, is a membrane protein complex found in all domains of life. As the core component of the translocon, it transports
Sec61
binding motif protein, Y-linked, family 1, member A1 Replication protein A1 S100 calcium binding protein A1 Sec61 alpha 1 Serum amyloid A1 Solute carrier family
List of A1 genes, proteins or receptors
List_of_A1_genes,_proteins_or_receptors
Protein complex for polypeptide membrane transport
is formed from Sec proteins (Sec: secretory), with the hetero-trimeric Sec61 being the channel. In prokaryotes, the homologous channel complex is known
Translocon
Mammalian protein found in Homo sapiens
Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene. The Sec61 complex is the central component of
SEC61B
Chemical compound
Contranslational translocation is regulated by the Sec61 translocon. Thus, when mycolactone binds to the alpha subunit of Sec61, it inhibits the translocon and prevents
Mycolactone
Type of peptide chain
the Sec61 channel, which shares structural and sequence similarity with SecYEG, but is present in the endoplasmic reticulum. Both the SecYEG and Sec61 channels
Target_peptide
Class of enzymes
Oligosaccharyltransferase or OST (EC 2.4.1.119) is a membrane protein complex that transfers a 14-sugar oligosaccharide from dolichol to nascent protein
Oligosaccharyltransferase
American biochemist (1934–2021)
conduct each experiment. It was found that OT binds the ribosome, and the Sec61 translocon complex binds the ribosome as well to form a complex to glycosylate
William_J._Lennarz
Short peptide present at N-terminal of newly synthesized proteins
the Sec61 channel, which shares structural and sequence homology with SecYEG, but is present in the endoplasmic reticulum. Both the SecYEG and Sec61 channels
Signal_peptide
Type of enzyme
mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits". Biochemistry. 44 (16): 5982–92.
DAD1
Protein family
serving as the missing link to alphaproteobacteria. SEC61A1; SEC61A2; Sec61 Translocon Protein targeting Bacterial secretion system Van den Berg B,
SecY_protein
Biological mechanism for routing proteins
translocon, a membrane-bound protein conducting channel composed of the Sec61 translocation complex in eukaryotes, and the homologous SecYEG complex in
Protein_targeting
Bacteria-produced protein complex and disease agent
degradation (ERAD) pathway to translocate into the cytosol through the Sec61 translocon. Unlike typical ERAD substrates, CTA1 evades ubiquitination due
Cholera_toxin
Study of molecular structures in biology
Osborne AR, Rapoport TA, van den Berg B (2005). "Protein translocation by the Sec61/SecY channel". Annual Review of Cell and Developmental Biology. 21: 529–550
Structural_biology
SEC61 ALPHA-1
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SEC61 ALPHA-1
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SEC61 ALPHA-1
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SEC61 ALPHA-1