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SEC61 ALPHA-1

  • Sec61 alpha 1
  • Protein transport protein Sec61 subunit alpha isoform 1 is a protein encoded by the SEC61A1 gene in humans. The protein encoded by this gene belongs to

    Sec61 alpha 1

    Sec61 alpha 1

    Sec61_alpha_1

  • Sec61
  • Protein family

    Sec61, termed SecYEG in prokaryotes, is a membrane protein complex found in all domains of life. As the core component of the translocon, it transports

    Sec61

    Sec61

  • List of A1 genes, proteins or receptors
  • binding motif protein, Y-linked, family 1, member A1 Replication protein A1 S100 calcium binding protein A1 Sec61 alpha 1 Serum amyloid A1 Solute carrier family

    List of A1 genes, proteins or receptors

    List_of_A1_genes,_proteins_or_receptors

  • Translocon
  • Protein complex for polypeptide membrane transport

    is formed from Sec proteins (Sec: secretory), with the hetero-trimeric Sec61 being the channel. In prokaryotes, the homologous channel complex is known

    Translocon

    Translocon

  • SEC61B
  • Mammalian protein found in Homo sapiens

    Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene. The Sec61 complex is the central component of

    SEC61B

    SEC61B

    SEC61B

  • Mycolactone
  • Chemical compound

    Contranslational translocation is regulated by the Sec61 translocon. Thus, when mycolactone binds to the alpha subunit of Sec61, it inhibits the translocon and prevents

    Mycolactone

    Mycolactone

    Mycolactone

  • Target peptide
  • Type of peptide chain

    the Sec61 channel, which shares structural and sequence similarity with SecYEG, but is present in the endoplasmic reticulum. Both the SecYEG and Sec61 channels

    Target peptide

    Target_peptide

  • Oligosaccharyltransferase
  • Class of enzymes

    Oligosaccharyltransferase or OST (EC 2.4.1.119) is a membrane protein complex that transfers a 14-sugar oligosaccharide from dolichol to nascent protein

    Oligosaccharyltransferase

    Oligosaccharyltransferase

    Oligosaccharyltransferase

  • William J. Lennarz
  • American biochemist (1934–2021)

    conduct each experiment. It was found that OT binds the ribosome, and the Sec61 translocon complex binds the ribosome as well to form a complex to glycosylate

    William J. Lennarz

    William_J._Lennarz

  • Signal peptide
  • Short peptide present at N-terminal of newly synthesized proteins

    the Sec61 channel, which shares structural and sequence homology with SecYEG, but is present in the endoplasmic reticulum. Both the SecYEG and Sec61 channels

    Signal peptide

    Signal_peptide

  • DAD1
  • Type of enzyme

    mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits". Biochemistry. 44 (16): 5982–92.

    DAD1

    DAD1

    DAD1

  • SecY protein
  • Protein family

    serving as the missing link to alphaproteobacteria. SEC61A1; SEC61A2; Sec61 Translocon Protein targeting Bacterial secretion system Van den Berg B,

    SecY protein

    SecY protein

    SecY_protein

  • Protein targeting
  • Biological mechanism for routing proteins

    translocon, a membrane-bound protein conducting channel composed of the Sec61 translocation complex in eukaryotes, and the homologous SecYEG complex in

    Protein targeting

    Protein_targeting

  • Cholera toxin
  • Bacteria-produced protein complex and disease agent

    degradation (ERAD) pathway to translocate into the cytosol through the Sec61 translocon. Unlike typical ERAD substrates, CTA1 evades ubiquitination due

    Cholera toxin

    Cholera toxin

    Cholera_toxin

  • Structural biology
  • Study of molecular structures in biology

    Osborne AR, Rapoport TA, van den Berg B (2005). "Protein translocation by the Sec61/SecY channel". Annual Review of Cell and Developmental Biology. 21: 529–550

    Structural biology

    Structural biology

    Structural_biology

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