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Protein that binds to single-stranded DNA in eukaryotic cells
binding protein (SSB). Single-stranded binding protein Replication protein A1 Replication protein A2 Replication protein A3 Wold MS (1997). "Replication protein
Replication_protein_A
Protein-coding gene in the species Homo sapiens
Replication protein A 14 kDa subunit is a protein that in humans is encoded by the RPA3 gene. RPA is a single-stranded DNA-binding protein that is conserved
Replication_protein_A3
Class of proteins
(HSV-1) SSB, ICP8, is a nuclear protein that, along other replication proteins is required for viral DNA replication during lytic infection. Six herpes
Single-stranded binding protein
Single-stranded_binding_protein
Protein-coding gene in the species Homo sapiens
RPA3, Replication protein A1, STAT3, TP53BP1 and Uracil-DNA glycosylase. Single-stranded binding protein Replication protein A Replication protein A1 Replication
Replication_protein_A2
Protein-coding gene in the species Homo sapiens
Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene. Replication protein A1 has been shown to interact
Replication_protein_A1
Nuclear protein inhibiting DNA replication
Geminin, DNA replication inhibitor, also known as GMNN, is a protein in humans encoded by the GMNN gene. A nuclear protein present in most eukaryotes
Geminin
Proteins assisting in protein folding
identified as being required for E. coli DNA replication. It has been noted that increased expression of Hsp70 proteins in the cell results in a decreased tendency
Chaperone_(protein)
Protein-coding gene in humans
with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein
CDC45-related_protein
Mammalian protein found in humans
necessary DNA replication factors. Within 72–96 hours of active pRb induction in A2-4 cells, the target DNA replication factor proteins—MCMs, RPA34, DBF4
Retinoblastoma_protein
Enzyme found in humans
phosphorylation in response to replication arrest. (In the absence of DNA damage or replication fork stalling, WRN protein remains localized to the nucleoli
Werner_syndrome_helicase
Protein
domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells". The EMBO
P21
Group of proteins
group of chromosomal proteins that are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA
High-mobility_group
HIV-infected individual who does not progress to immune deficiency
high quantities of a protein called APOBEC3G that disrupts viral replication in cells. APOBEC3G, or "A3" for short, is a protein that sabotages reverse
Long-term_nonprogressor
Protein-coding gene in humans
process of semi-conservative replication, similar to that of cis. In addition, according to Kaplan and Christopher, the protein is also involved in the biological
Telomeric repeat-binding factor 1
Telomeric_repeat-binding_factor_1
Protein-coding gene in the species Homo sapiens
Histone H4 is a protein that in humans is encoded by the HIST2H4A gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
HIST2H4A
Family of viruses
Caulimoviridae genomes do not encode an integrase protein. Thus their integration is not mandatory in their replication life cycle. The virion enter in the host
Caulimoviridae
Protein-coding gene in the species Homo sapiens
LAMP3 with the inhibition of the viral replication of Influenza A cells. LAMP3 is a Type I integral membrane protein consisting of about 416 amino acid residues
LAMP3
Protein found in lentiviruses
lentiviral Vif. Vif1 is a 23-kilodalton protein that is essential for viral replication. Vif1 inhibits the cellular protein APOBEC3G from entering the virion
Viral_infectivity_factor
Protein-coding gene in the species Homo sapiens
the replication and transmission of mitochondrial DNA. Mutagenic studies have further supported HSP60 regulatory involvement in the replication and transmission
GroEL
Protein found in humans
Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. ISG15 is induced by type I interferon
ISG15
Protein-coding gene in the species Homo sapiens
Purine-rich element binding protein G is a protein that in humans is encoded by the PURG gene. The exact function of this gene is not known, however, its
PURG
Protein-coding gene in humans
"Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway". Molecular
CHTF18
Hydrophobic scaffold protein
glucose sensing and DNA replication to limb patterning and circadian rhythms. The catalytic core of CRLs consists of a RING protein and a cullin family member
Cullin
Regulatory protein found in most eukaryotic tissues
critical host cell processes to support their own replication. The retinoic acid-inducible gene I (RIG-I) protein is a primary immune system sensor for viral
Ubiquitin
Proteins that regulate circadian rhythms
cyanobacterial clock proteins are the main circadian regulator in cyanobacteria. The cyanobacterial clock proteins comprise three proteins: KaiA, KaiB and
Cyanobacterial_clock_proteins
Protein-coding gene in the species Homo sapiens
Meteorin, glial cell differentiation regulator is a protein that in humans is encoded by the METRN gene. Meteorin regulates glial cell differentiation
METRN
Protein-coding gene in the species Homo sapiens
division control protein 45, which is required for initiation of chromosomal DNA replication, as well as co-expression with CDT1, a DNA replication licensing
TEDC2
Species of bacterium
UCYN-A3, and UCYN-A4 (see § Diversity below); studies have shown that these groups are adapted to different marine environments. UCYN-A1 and UCYN-A3 co-exist
Atelocyanobacterium_thalassa
Family of transcription factors
encode proteins involved in DNA replication (for example DNA polymerase, thymidine kinase, dihydrofolate reductase and cdc6), and chromosomal replication (replication
E2F
Protein-coding gene in the species Homo sapiens
initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform
ORC5
DNA-containing virus-like particles produced by bacteria and archaea
for DNA packaging. The phage genes specifying its regulation and DNA replication have typically been deleted, and expression of the cluster of structural
Gene_transfer_agent
Mammalian protein found in humans
Blagosklonny MV, Powell SN (December 2004). "The interaction of p53 with replication protein A mediates suppression of homologous recombination". Oncogene. 23
P53
Protein-coding gene in the species Homo sapiens
Histone H1.5 is a protein that in humans is encoded by the HIST1H1B gene. Histones are basic nuclear proteins responsible for nucleosome structure of
HIST1H1B
Protein-coding gene in humans
dC->dU-editing enzyme APOBEC-3C is a protein that in humans is encoded by the APOBEC3C gene. A3C belong to the A3 family of cytidine deaminases that act
APOBEC3C
Protein-coding gene in the species Homo sapiens
Factor (SRSF) protein kinase-1 SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene. This gene encodes a serine/arginine protein kinase specific
SRPK1
important roles in many processes such as cellular replication, protein-protein interactions, and DNA replication. If these zinc ejectors unintentionally bind
Zinc_finger_inhibitor
Protein-coding gene in the species Homo sapiens
immunoglobulin protein (BiPS) also known as 78 kDa glucose-regulated protein (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) is a protein that in humans
Binding immunoglobulin protein
Binding_immunoglobulin_protein
Protein-coding gene in the species Homo sapiens
Histone H1.1 is a protein that in humans is encoded by the HIST1H1A gene. Histones are basic nuclear proteins responsible for nucleosome structure of
HIST1H1A
Protein-coding gene in humans
polymerase δ, which is crucial for DNA replication. As a result, CRL4 complexes are able to control the onset of DNA replication, chromatin remodeling and progression
CUL4B
Group of signal transduction pathways involved in embryonic development
of proteins such as cyclin D1 and c-myc, which control the G1 to S phase transition in the cell cycle. Entry into the S phase causes DNA replication and
Wnt_signaling_pathway
Type of virus
engineering a deletion of Met-51 of the matrix protein ablates virtually all infection of normal tissues, while replication in tumour cells is unaffected. Recent
Oncolytic_virus
InterPro Family
replication and transcription. In this framework, NPM2 primarily contributes to histone storage and regulated release, rather than direct replication-coupled
Nucleoplasmin
Protein found in humans
was termed "nonsuppressible insulin-like activity" (NSILA). IGF1 is a protein that in humans is encoded by the IGF1 gene. IGF1 consists of 70 amino acids
Insulin-like_growth_factor_1
Chemical compound
immunosuppressive. All adenosine receptor subtypes (A1, A2A, A2B, and A3) are G-protein-coupled receptors. The four receptor subtypes are further classified
Adenosine
Protein-coding gene in the species Homo sapiens
1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16. This protein belongs to the DNAJ/Hsp40 protein family, which is
DNAJA3
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene. The protein encoded by this gene
MAPK1
Protein-coding gene in the species Homo sapiens
Phospholipase D3, also known as PLD3, is a protein that in humans is encoded by the PLD3 gene. PLD3 belongs to the phospholipase D superfamily because
PLD3
Protein-coding gene in the species Homo sapiens
Heat shock 70 kDa protein 8 also known as heat shock cognate 71 kDa protein or Hsc70 or Hsp73 is a heat shock protein that in humans is encoded by the
HSPA8
Protein found in humans
the synthesis of histone proteins (the major protein component of chromatin), and subsequently supports the DNA replication stage of the cell cycle. Finally
Cyclin-dependent_kinase_2
Protein-coding gene in the species Homo sapiens
Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene. Together with hSPT4, it composes DSIF in humans. SUPT5H
SUPT5H
Family of transcription factors involved in anatomical development
FOX (forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth
FOX_proteins
Protein-coding gene in the species Homo sapiens
Methyl methanesulfonate-sensitivity protein 22-like also known as MMS22-like, DNA repair protein is a protein that in humans is encoded by the MMS22L
MMS22L
Protein-coding gene in the species Homo sapiens
Myotonin-protein kinase (MT-PK) also known as myotonic dystrophy protein kinase (MDPK) or dystrophia myotonica protein kinase (DMPK) is an enzyme that
Myotonin-protein_kinase
Soluble protein
calregulin, CRP55, CaBP3, calsequestrin-like protein, and endoplasmic reticulum resident protein 60 (ERp60), is a protein that in humans is encoded by the CALR
Calreticulin
Protein found in humans
Protein Wnt-5a is a protein that in humans is encoded by the WNT5A gene. The WNT gene family consists of structurally related genes that encode secreted
Protein_Wnt-5a
Protein-coding gene in the species Homo sapiens
Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene. It is one of the two types of cyclin A: cyclin A1 is expressed during meiosis and
Cyclin_A2
Medical condition
proliferation through pathways involving phosphorylated retinoblastoma protein (pRB). TS can be diagnosed based on clinical observations, but is usually
Trichodysplasia_spinulosa
Protein
DNA repair protein XRCC1, also known as X-ray repair cross-complementing protein 1, is a protein that in humans is encoded by the XRCC1 gene. XRCC1 is
XRCC1
Protein-coding gene in the species Homo sapiens
neuropeptide S receptor (NPSR) is a member of the G-protein coupled receptor superfamily of integral membrane proteins which binds neuropeptide S (NPS). It was formerly
Neuropeptide_S_receptor
Protein found in humans
Neurogenic locus notch homolog protein 1 (Notch 1) is a protein encoded in humans by the NOTCH1 gene. Notch 1 is a single-pass transmembrane receptor.
Notch_1
RNA family
mitochondria, it plays a direct role in the initiation of mitochondrial DNA replication. In the nucleus, it is involved in precursor rRNA processing, where it
RNase_MRP
Protein-coding gene in the species Homo sapiens
Tyrosine-protein kinase receptor UFO is a protein that in human is encoded by the AXL gene. The gene was initially designated as UFO, in allusion to the
AXL_receptor_tyrosine_kinase
Protein-coding gene in the species Homo sapiens
Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene. Histones are basic nuclear proteins that are responsible for the nucleosome
HIST1H2BK
Human protein and coding gene
homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene. It is a member of the CCAAT/enhancer-binding protein (C/EBP)
DNA damage-inducible transcript 3
DNA_damage-inducible_transcript_3
Enzymes that catalyze acyl group transfer from acetyl-CoA to histones
(HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine
Histone_acetyltransferase
Protein-coding gene in the species Homo sapiens
Histone H3.1 is a protein that in humans is encoded by the HIST1H3F gene. Histones are basic nuclear proteins that are responsible for the nucleosome
HIST1H3F
Protein-coding gene in the species Homo sapiens
respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth
NRF1
Protein-coding gene in the species Homo sapiens
ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA
UBE2B
Peptide hormone
adipose tissue (about two-thirds of body cells) Increase of DNA replication and protein synthesis via control of amino acid uptake Modification of the
Insulin
Protein-coding gene in the species Homo sapiens
cellular transcription factors and as replication factors for adenovirus DNA replication. Diversity in this protein family is generated by multiple genes
NFIA
Genus of viruses
proteases into the structural capsid proteins and the nonstructural proteins, which are mainly involved in the replication of the virus. RNA recombination
Enterovirus
Protein-coding gene in the species Homo sapiens
DnaJ homolog subfamily C member 2 is a protein that in humans is encoded by the DNAJC2 gene. This gene is a member of the M-phase phosphoprotein (MPP)
ZRF1
Transcription factor
exert their modulatory effect in the vicinity of any sequence to which the protein domain binds. Besides the presence of additional domains that regulate
Zinc finger transcription factor
Zinc_finger_transcription_factor
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
stress granules are biomolecular condensates in the cytosol composed of proteins and RNA that assemble into 0.1–2 μm membraneless organelles when the cell
Stress_granule
Group of proteins
and are less abundant. HMGNs are nucleosome binding proteins that help in transcription, replication, recombination, and DNA repair. They can also alter
HMGN
Human protein-coding gene
Histone H3.1 is a protein that in humans is encoded by the HIST1H3J gene. Histones are basic nuclear proteins that are responsible for the nucleosome
HIST1H3J
Protein-coding gene in the species Homo sapiens
Histone H3.1 is a protein that in humans is encoded by the HIST1H3I gene. Histones are basic nuclear proteins that are responsible for the nucleosome
HIST1H3I
Protein-coding gene in the species Homo sapiens
working with other proteins in the DNA damage response. R loops may arise from replication stress, such as when transcription and replication occur at the same
SETX
Protein-coding gene in the species Homo sapiens
Replication initiator 1 is a protein that in humans is encoded by the REPIN1 gene. The protein helps enable RNA binding activity as a replication initiation-region
REPIN1
Protein-coding gene in the species Homo sapiens
Histone H1.2 is a protein that in humans is encoded by the HIST1H1C gene. Histones are basic nuclear proteins responsible for nucleosome structure of
HIST1H1C
Protein-coding gene in the species Homo sapiens
Histone H3.1 is a protein in humans that is encoded by the H3C1 gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
Histone_H3.1
Protein-coding gene in the species Homo sapiens
interaction with PCNA and UHRF1 has been implicated in localizing it to the replication fork. The direct co-operation between DNMT1 and G9a coordinates DNA and
DNMT1
Protein-coding gene in the species Homo sapiens
Autophagic Trafficking through Regulation of Host SNARE Proteins to Promote Virus Replication and Cell Exit". Cell Reports. 22 (12): 3304–3314. doi:10
SNAP29
Antibiotic resistance caused by a plasmid
possess mechanisms that ensure their independent replication as well as those that regulate their replication number and guarantee stable inheritance during
Plasmid-mediated_resistance
Protein-coding gene in the species Homo sapiens
Histone H2B type 2-E is a protein that in humans is encoded by the HIST2H2BE gene. Histones are basic nuclear proteins that are responsible for the nucleosome
HIST2H2BE
Protein-coding gene in the species Homo sapiens
Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BF gene. Histones are basic nuclear proteins that are responsible for the
HIST1H2BF
Protein-coding gene in the species Homo sapiens
X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. The XBP1 gene is located on chromosome 22 while
XBP1
Enzyme
"PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells". Mol. Cell. Biol. 20 (3):
PPP2R1A
Protein-coding gene in the species Homo sapiens
X-type is a protein that in humans is encoded by the NFIX gene. NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40
NFIX
Protein found in humans
known as CDH28 or its abbreviation CDHR3, is a protein that in humans is encoded by the CDHR3 gene. The protein is predominately expressed in respiratory epithelium
Cadherin related family member 3
Cadherin_related_family_member_3
Protein-coding gene in the species Homo sapiens
transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth
TGF_beta_1
Protein-coding gene in the species Homo sapiens
Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. The Prox1 gene is critical for the development of multiple tissues
PROX1
Protein-coding gene in the species Homo sapiens
ionizing radiation, chromatin-modifying interventions and inhibitors of DNA replication). The expression can be as well affected by some infectious agents such
MHC class I polypeptide–related sequence A
MHC_class_I_polypeptide–related_sequence_A
Protein-coding gene in the species Homo sapiens
ubiquitin-protein ligases, or E3S. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA
UBE2A
Protein-coding gene in humans
centrosome replication per cell cycle. NuSAP is a substrate of cyclin F that is involved in cell division. It is a microtubule-associated protein that is
CCNF
Histone H4 is a protein that in humans is encoded by the HIST4H4 gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure
HIST4H4
Protein-coding gene in the species Homo sapiens
Zinc finger MIZ domain-containing protein 1 is a protein that in humans is encoded by the ZMIZ1 gene. ZMIZ1 has been shown to interact with Androgen receptor
ZMIZ1
Protein-coding gene in the species Homo sapiens
locus protein (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3)
MECOM
Mammalian protein found in Homo sapiens
Anillin is a conserved protein implicated in cytoskeletal dynamics during cellularization and cytokinesis. The ANLN gene in humans and the scraps gene
ANLN
Class of drugs used to treat malignant tumors
cells, such as drugs that directly damage DNA structure or affect its replication or transcription functions (e.g., alkylating agents, antitumor antibiotics
Antineoplastic
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