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Enzyme that cleaves other proteins into smaller peptides
A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides
Protease
Topics referred to by the same term
Protease A may refer to one of two enzymes: Streptogrisin A Omptin This disambiguation page lists articles associated with the title Protease A. If an
Protease_A
Class of enzymes
Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins. Serine serves as the nucleophilic amino acid at the enzyme's
Serine_protease
Pathogenic type of misfolded protein
animals. The PrP found in infectious prions has a different structure and is resistant to proteases, the enzymes in the body that can normally break
Prion
Medical condition
Variably protease-sensitive prionopathy (VPSPr) (formerly known as Protease Sensitive Prionopathy) is a sporadic transmissible spongiform encephalopathy
Variably protease-sensitive prionopathy
Variably_protease-sensitive_prionopathy
Intramembrane cellular enzymes
Intramembrane proteases (IMPs), also known as intramembrane-cleaving proteases (I-CLiPs), are enzymes that have the property of cleaving transmembrane
Intramembrane_protease
Class of enzymes
Cysteine proteases, also known as thiol proteases, are hydrolase enzymes that degrade proteins. These proteases share a common catalytic mechanism that
Cysteine_protease
Class of enzymes
The 3C-like protease (3CLpro) or main protease (Mpro), formally known as C30 endopeptidase, is the main protease found in coronaviruses. It cleaves the
3C-like_protease
Topics referred to by the same term
Protease inhibitor can refer to: Protease inhibitor (pharmacology): a class of medication that inhibits viral protease Protease inhibitor (biology): molecules
Protease_inhibitor
Set of three coordinated amino acids
enzymes (e.g. proteases, amidases, esterases, acylases, lipases and β-lactamases). An acid-base-nucleophile triad is a common motif for generating a nucleophilic
Catalytic_triad
Group of proteolytic enzymes
Glutamic proteases are a group of proteolytic enzymes containing a glutamic acid residue within the active site. This type of protease was first described
Glutamic_protease
Highly specific protease
TEV protease (EC 3.4.22.44, Tobacco Etch Virus nuclear-inclusion-a endopeptidase) is a highly sequence-specific cysteine protease from Tobacco Etch Virus
TEV_protease
Protein family
Aspartic proteases (also "aspartyl proteases", "aspartic endopeptidases") are a catalytic type of protease enzymes that use an activated water molecule
Aspartic_protease
Class of antiviral drugs used to treat HIV/AIDS and hepatitis C
and COVID-19. These protease inhibitors prevent viral replication by selectively binding to viral proteases (e.g. HIV-1 protease) and blocking proteolytic
Protease inhibitor (pharmacology)
Protease_inhibitor_(pharmacology)
Class of enzymes
proteasome, large multicatalytic protease, proteasome organelle, alkaline protease, 26S protease, tricorn proteinase, tricorn protease) is an enzyme. This enzyme
Proteasome endopeptidase complex
Proteasome_endopeptidase_complex
Protein-coding gene in the species Homo sapiens
Serine protease 57 is a protein that in humans is encoded by the PRSS57 gene. This gene encodes an arginine-specific serine protease and member of the
Serine_protease_57
Class of enzymes
Threonine proteases are a family of proteolytic enzymes harbouring a threonine (Thr) residue within the active site. The prototype members of this class
Threonine_protease
Topics referred to by the same term
Protease VII may refer to: Omptin Caspase 1 This disambiguation page lists articles associated with the title Protease VII. If an internal link incorrectly
Protease_VII
Protein-coding gene in the species Homo sapiens
Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene. The HTRA1 protein is composed of four distinct protein domains. They are
Serine_protease_HTRA1
Enzyme encoded by hepatitis C virus
NS2-3 protease (of hepatitis C virus, HCV) is an enzyme responsible for proteolytic cleavage between NS2 and NS3, which are non-structural proteins that
NS2-3_protease
blood vessels. Numerous proteases including matrix metalloproteinases (MMPs), a disintegrin and metalloproteinase domain (ADAM), a disintegrin and metalloproteinase
Proteases_in_angiogenesis
Class of enzymes
Picornain 3C (EC 3.4.22.28) is a protease found in picornaviruses, which cleaves peptide bonds of non-terminal sequences. Picornain 3C’s endopeptidase
Picornain_3C
Protein family
dsDNA viruses). These proteases are generally part of a larger pol or gag polyprotein. Retroviral proteases are homologous to a single domain of the two-domain
Retroviral_aspartyl_protease
Protein-coding gene in the species Homo sapiens
Protease activated receptor 2 (PAR2) also known as coagulation factor II (thrombin) receptor-like 1 (F2RL1) or G-protein coupled receptor 11 (GPR11) is
Protease-activated_receptor_2
Protein family
The PA clan (Proteases of mixed nucleophile, superfamily A) is the largest group of proteases with common ancestry as identified by structural homology
PA_clan_of_proteases
History of molecular discovery
ligands, like protease inhibitors, that can modulate catalytic activities has an enormous therapeutic effect. Hence, inhibition of the HIV protease is one of
Discovery and development of HIV-protease inhibitors
Discovery_and_development_of_HIV-protease_inhibitors
Subfamily of related G protein-coupled receptors
Protease-activated receptors (PAR) are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular
Protease-activated_receptor
Protein family
In biology and biochemistry, protease inhibitors, or antiproteases, are molecules that inhibit the function of proteases (enzymes that aid the breakdown
Protease_inhibitor_(biology)
Chemical compound
In biochemistry, phenylmethylsulfonyl fluoride (PMSF) is a serine protease inhibitor (serine hydrolase inactivator) commonly used in the preparation of
PMSF
Proteolytic enzyme found in Bacillus subtilis
is a protease (a protein-digesting enzyme) initially obtained from Bacillus subtilis. Subtilisins belong to subtilases, a group of serine proteases that
Subtilisin
Family of enzymes
In molecular biology, the Lon protease family is a family of enzymes that break peptide bonds in proteins resulting in smaller peptides or amino acids
Lon_protease_family
Topics referred to by the same term
classes of acidic proteases: Aspartic proteases - that use a catalytic aspartic acid in their active site Glutamic proteases - that use a catalytic glutamic
Acidic_protease
Cysteine protease enzyme
Zingibain, zingipain, or ginger protease (EC 3.4.22.67) is a cysteine protease enzyme found in ginger (Zingiber officinale) rhizomes. It catalyses the
Zingibain
Index of enzymes associated with the same name
IgA protease may refer to: IgA specific serine endopeptidase, an enzyme IgA-specific metalloendopeptidase, an enzyme This set index page lists enzyme articles
IgA_protease
Mammalian protein found in Homo sapiens
Membrane-bound transcription factor site-1 protease, or site-1 protease (S1P) for short, also known as subtilisin/kexin-isozyme 1 (SKI-1), is an enzyme
Membrane-bound transcription factor site-1 protease
Membrane-bound_transcription_factor_site-1_protease
Enzyme involved with peptide bond hydrolysis in retroviruses
HIV-1 protease or PR is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential
HIV-1_protease
Protein family
The rhomboid proteases are a family of enzymes that exist in almost all species. They are proteases: they cut the polypeptide chain of other proteins.
Rhomboid_protease
Antiretroviral medication
therapy (HAART). Ritonavir is a protease inhibitor, though it now mainly serves to boost the potency of other protease inhibitors. It may also be used
Ritonavir
Class of enzymes in HIV
HIV-2 protease or retropepsin (EC 3.4.23.47) is an enzyme. This enzyme catalyses the following chemical reaction Endopeptidase for which the P1 residue
HIV-2_protease
Proteases (also sometimes referred to as proteolytic enzymes or peptidases) are in use, or have been proposed or tried, for a number of purposes related
Proteases (medical and related uses)
Proteases_(medical_and_related_uses)
Metalloprotease enzyme
(a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is a
ADAMTS13
Enzyme found in humans
enzyme (IDE) (also known as insulinase, insulin protease, or insulysin) is a large zinc-binding protease of the M16 metalloprotease family of enzymes. It
Insulin-degrading_enzyme
Human protein and coding gene
Lon protease homolog, mitochondrial is a protease, an enzyme that in humans is encoded by the LONP1 gene. The nuclear-gene encoded mitochondrial matrix
LONP1
Protease enzyme
picornavirus endopeptidase 2A, poliovirus protease 2A, rhinovirus protease 2A, 2A protease, 2A proteinase, protease 2A, proteinase 2Apro, picornaviral 2A
Picornain_2A
Pandemic caused by SARS-CoV-2
for Medicinal Products for Human Use (CHMP) approved the oral antiviral protease inhibitor, Paxlovid (nirmatrelvir plus the HIV antiviral ritonavir), to
COVID-19_pandemic
Class of enzymes
Membrane-bound transcription factor site-2 protease, also known as S2P endopeptidase or site-2 protease (S2P), is an enzyme (EC 3.4.24.85) encoded by the
Membrane-bound transcription factor site-2 protease
Membrane-bound_transcription_factor_site-2_protease
Broad-spectrum serine protease
21.64, protease K, endopeptidase K, Tritirachium alkaline proteinase, Tritirachium album serine proteinase, Tritirachium album proteinase K) is a broad-spectrum
Proteinase_K
(EC 3.4.21.32, Uca pugilator collagenolytic proteinase, crab protease I, crab protease II) is an enzyme. This enzyme catalyses the Hydrolysis of proteins
Brachyurin
Breakdown of proteins into smaller polypeptides or amino acids
years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Proteolysis in organisms
Proteolysis
Class of enzymes
mast cell protease 1, skeletal muscle protease, skin chymotryptic proteinase, mast cell serine proteinase, skeletal muscle protease) are a family of serine
Chymase
Class of enzymes
endopeptidase (EC 3.4.22.50, AcNPV protease, BmNPV protease, NPV protease, baculovirus cathepsin, nucleopolyhedrosis virus protease, viral cathepsin) is an enzyme
V-cath_endopeptidase
Integrated web resource focused on proteases
web resource focused on proteases. Its domain now links to a scam/spam browser extender. PMAP was designed to aid the protease researchers in reasoning
The_Proteolysis_Map
Enzyme found in humans
HTRA2 encodes a serine protease. The human gene has 8 exons and locates at chromosome band 2p12. Protein HtrA2, also known as Omi, is a mitochondrially-located
Serine protease HTRA2, mitochondrial
Serine_protease_HTRA2,_mitochondrial
Protein-coding gene in the species Homo sapiens
known as secretory leukocyte protease inhibitor (SLPI), is an enzyme that in humans is encoded by the SLPI gene. SLPI is a highly cationic single-chain
SLPI
Protein family of cysteine protease enzymes
Papain-like proteases (or papain-like (cysteine) peptidases; abbreviated PLP or PLCP) are a large family of cysteine protease enzymes that share structural
Papain-like_protease
putative protease, human endogenous retrovirus K retropepsin, HERV K10 endopeptidase, HERV K10 retropepsin, HERV-K PR, HERV-K protease, HERV-K113 protease, human
Human endogenous retrovirus K endopeptidase
Human_endogenous_retrovirus_K_endopeptidase
Degenerative neurological disorder
familial insomnia, kuru, and variably protease-sensitive prionopathy. Susceptibility and disease phenotype are influenced by a common polymorphism at codon 129
Creutzfeldt–Jakob_disease
Protein family
4.21.92, endopeptidase Ti, caseinolytic protease, protease Ti, ATP-dependent Clp protease, ClpP, Clp protease). This enzyme catalyses the following chemical
Endopeptidase_Clp
Class of enzymes
Nuclear-inclusion-a endopeptidase (EC 3.4.22.44, potyvirus NIa protease) is a protease enzyme found in potyviruses. This enzyme catalyses the following
Nuclear-inclusion-a endopeptidase
Nuclear-inclusion-a_endopeptidase
lectin-associated serine protease-2 (EC 3.4.21.104, MASP-2, MASP2, MBP-associated serine protease-2, mannose-binding lectin-associated serine protease-2, p100, mannan-binding
Mannan-binding lectin-associated serine protease-2
Mannan-binding_lectin-associated_serine_protease-2
Species of bacterium
directly activates SpeB (streptococcal pyrogenic exotoxin B), a cysteine protease that acts as a virulence factor. In the absence of this pathway, biofilm
Streptococcus_pyogenes
Protein family
Kunitz soybean trypsin inhibitor is a type of protein contained in legume seeds which functions as a protease inhibitor. Kunitz-type soybean trypsin inhibitors
Kunitz_STI_protease_inhibitor
Type of enzyme
coli serine proteinase La, gene lon protease, gene lon proteins, PIM1 protease, PIM1 proteinase, serine protease La) is an enzyme. This enzyme catalyses
Endopeptidase_La
Streptogrisin A (EC 3.4.21.80, Streptomyces griseus protease A, protease A, proteinase A, Streptomyces griseus proteinase A, Streptomyces griseus serine
Streptogrisin_A
4.21.107, DegP, DegP protease, HtrA, high temperature requirement protease A, HrtA heat shock protein, protease Do, Do protease) is an enzyme. This enzyme
Peptidase_Do
Enzyme produced by enterobacterium
(Serratia E-15 protease, also known as serralysin, serrapeptase, serratiapeptase, serratia peptidase, serratio peptidase, or serrapeptidase) is a proteolytic
Serratiopeptidase
Class of enzymes
22.14, actinidin, Actinidia anionic protease, proteinase A2 of Actinidia chinensis) is a type of cysteine protease enzyme found in fruits, including kiwifruit
Actinidain
Class of enzymes
Smt3-protein conjugate proteinase, Ubl-specific protease 1, Ulp1, Ulp1 endopeptidase, Ulp1 protease) is an enzyme. This enzyme catalyses the following
Ulp1_peptidase
Protein family
deubiquitinases, ubiquitin proteases, ubiquitin hydrolases, or ubiquitin isopeptidases, are a large group of proteases that cleave ubiquitin from proteins
Deubiquitinating_enzyme
Enzyme
Metridin (EC 3.4.21.3, Metridium proteinase A, sea anemone protease A, sea anemone proteinase A) is an enzyme. This enzyme catalyses the following chemical
Metridin
Papain-like protease protein domain
papain-like protease (PLPro or PLP) is a papain-like protease protein domain encoded in the genomes of nidoviruses. It is expressed as part of a large polyprotein
Nidoviral papain-like protease
Nidoviral_papain-like_protease
pancreatic necrosis virus protease, IPNV Vp4 protease, IPNV Vp4 peptidase, NS protease, NS-associated protease, Vp4 protease) is an enzyme. This enzyme
Infectious pancreatic necrosis birnavirus Vp4 peptidase
Infectious_pancreatic_necrosis_birnavirus_Vp4_peptidase
Class of enzymes
protein A, and insulin-like growth factor binding protein-4 protease is a protein encoded by the PAPPA gene in humans. PAPPA is a secreted protease whose
Pappalysin-1
Extracellular metalloprotease expressed by S. aureus
extracellular metalloprotease expressed by Staphylococcus aureus. This protease is a major contributor to the bacterium's virulence, or ability to cause
Aureolysin
(HIV protease inhibitor) Darunavir (HIV protease inhibitor) Delavirdine (non-nucleoside reverse transcriptase inhibitor) Fosamprenavir (HIV protease inhibitor)
List_of_sulfonamides
Group of brain diseases induced by prions
Gerstmann–Sträussler–Scheinker syndrome, fatal familial insomnia, kuru, and variably protease-sensitive prionopathy. Creutzfeldt–Jakob disease has been divided into
Transmissible spongiform encephalopathy
Transmissible_spongiform_encephalopathy
Widely used enzyme extracted from papayas
Papain, also known as papaya proteinase I, is a cysteine protease (EC 3.4.22.2) enzyme present in papaya (Carica papaya) and mountain papaya (Vasconcellea
Papain
Spectrum of conditions caused by HIV infection
inhibitors (NNRTIs), protease inhibitors (PIs), integrase strand transfer inhibitors (INSTIs), a fusion inhibitor, a CCR5 antagonist, a CD4 T lymphocyte (CD4)
HIV/AIDS
Bacterial protein
OmpT is an aspartyl protease found on the outer membrane of Escherichia coli. OmpT is a subtype of the family of omptin proteases, which are found on
OmpT
Mannose-binding protein-associated serine protease are serine proteases involved in the complement system. Types include: MASP1 MASP2 mannan-binding lectin
Mannose-binding protein-associated serine protease
Mannose-binding_protein-associated_serine_protease
Class of enzymes
ADAMTS-13, ADAMTS13, vWF-cleaving protease, VWF-CP, vWF-degrading protease, Upshaw factor, von Willebrand factor cleaving protease, ADAMTS13 peptidase) is an
ADAMTS13_endopeptidase
Protein-targeting ATP-dependent enzyme family
In molecular biology, the CLP protease family is a family of serine peptidases belong to the MEROPS peptidase family S14 (ClpP endopeptidase family, clan
Clp_protease_family
Chemical compound
with other protease inhibitors. When boosted with ritonavir it is equivalent in potency to lopinavir for use in salvage therapy in people with a degree of
Atazanavir
Independent evolution of similar features
proteases use different amino acid functional groups (alcohol or thiol) as a nucleophile. To activate that nucleophile, they orient an acidic and a basic
Convergent_evolution
Flavivirin (EC 3.4.21.91, Yellow fever virus (flavivirus) protease, NS2B-3 proteinase) is a protease, a type of enzyme. Chambers TJ, Hahn CS, Galler R, Rice
Flavivirin
Protein-coding gene in the species Homo sapiens
overlapping proteolytic activity with m-AAA protease 1. The OMA1 protease acts at the intersection of a mitochondrial quality control system and energy
OMA1
Prohormone-processing protease
Kexin (EC 3.4.21.61) is a prohormone-processing protease, specifically a yeast serine peptidase, found in the budding yeast (S. cerevisiae). It catalyzes
Kexin
Topics referred to by the same term
PLP may refer to: Papain-like protease, a family of cysteine protease enzymes Phantom limb pain, pain felt as from a missing limb Proteolipid protein
PLP
Human protein
Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. The human urokinase protein was
Urokinase
Class of enzymes
influenza A virus, thereby activating it and causing the symptoms of flu. Tryptase is also known by mast cell tryptase, mast cell protease II, skin tryptase
Tryptase
Mammalian protein found in humans
protease-activated receptor 1, coagulation factor II receptor and thrombin receptor is a protein that in humans is encoded by the F2R gene. PAR1 is a
Proteinase-activated receptor 1
Proteinase-activated_receptor_1
Sub-discipline of biology
substrates on a system-wide scale. This includes the analysis of the protease and protease-substrate repertoires, also called "protease degradomes". The
Degradomics
Protein family
protease VII, protease A, gene ompT proteins, ompT protease, protein a, Pla, OmpT) are a family of bacterial proteases. They are aspartate proteases,
Omptin
Protein family
RB (June 1999). "Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity". The Journal of Biological Chemistry
Matriptase
Enzymes from the stomachs of ruminants, used in cheese production
Rennet (/ˈrɛnɪt/) is a complex set of enzymes produced in the stomachs of ruminant mammals. Its key component is chymosin, a protease enzyme that curdles
Rennet
Protein domain
Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential
Caspase
Family of digestive enzymes
Trypsin is a type of serine protease enzyme from the PA clan superfamily found in the digestive system of many vertebrates, where it begins the digestion
Trypsin
Active region of an enzyme
development. HIV protease belongs to aspartic protease family and has a similar mechanism. Firstly the aspartate residue activates a water molecule and
Active_site
Superfamily of proteins with similar structures and diverse functions
Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms
Serpin
Enzyme
processing peptidase, calicivirus trypsin-like cysteine protease, calicivirus TCP, calicivirus 3C-like protease, calicivirus endopeptidase, rabbit hemorrhagic
Calicivirin
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