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Pharmaceutical drug
Protamine sulfate is a medication that is used to reverse the effects of heparin. It is specifically used in heparin overdose, in low molecular weight
Protamine_sulfate
Protein family
heart rate. Protamine sulfate is an antidote for heparin overdose, but severe allergy may occur. A chain shortened version of protamine also acts as
Protamine
Chemical compound
range. It is still used as an alternative to protamine sulfate for patients who are sensitive to protamine, and at least one surgical center has gone back
Hexadimethrine_bromide
Anticoagulant
disease, and stroke), severe liver disease, or severe hypertension. Protamine sulfate has been given to counteract the anticoagulant effect of heparin (1 mg
Heparin
Technique that temporarily takes over the function of the heart and lungs during surgery
off of bypass support, the cross-clamp and cannulas are removed and protamine sulfate is administered to reverse the anticoagulative effects of heparin
Cardiopulmonary_bypass
Key enzyme of photosynthesis involved in carbon fixation
efficient method for precipitating out RuBisCO involves the usage of protamine sulfate solution. Other existing methods for depleting RuBisCO and studying
RuBisCO
Swiss biochemist (1843–1895)
discovered the alkaline substance protamine, the account of which he published in 1874. It later found use, as protamine sulfate, in the stabilization of insulin
Friedrich_Miescher
American serial killer (born 1950)
Santos's previous heparin poisoning, they quickly administered a dose of protamine sulfate (a drug used to reverse the effects of heparin). Santos responded
Genene_Jones
Formulary by the World Health Organization
Enoxaparin Heparin sodium Phytomenadione Protamine sulfate Tranexamic acid Warfarin Complementary: Heparin sodiumα Protamine sulfateα Warfarinα Deferasirox Hydroxyurea
WHO Model List of Essential Medicines
WHO_Model_List_of_Essential_Medicines
Substance that can counteract a form of poisoning
agents, some poison mushrooms Protamine sulfate Heparin poisoning Prussian blue Thallium poisoning Physostigmine sulfate Anticholinergic poisoning Pyridoxine
Antidote
Transfer process in genetics
have been used to improve transduction efficiency such as polybrene, protamine sulfate, retronectin, and DEAE Dextran. Gene therapy: Correcting genetic diseases
Transduction_(genetics)
Anticoagulant medication
Heparin anticoagulant effects are typically reversible with protamine sulfate, while protamine's effect on LMWH is limited. LMWH has less of an effect on
Low-molecular-weight_heparin
Anticoagulant medication (blood thinner)
case, anti-Xa units can be measured and dosing adjusted accordingly. Protamine sulfate is less effective at reversing enoxaparin compared to heparin, with
Enoxaparin_sodium
(Ixiaro) aluminium hydroxide, bovine serum albumin, formaldehyde, protamine sulfate, sodium metabisulphite Meningococcal vaccine (Menactra) Formaldehyde
List_of_vaccine_excipients
Anticoagulant
by prothrombin complex concentrate and/or vitamin K and heparin by protamine sulfate. Ximelagatran was generally well tolerated in the trial populations
Ximelagatran
Medical procedure for purifying blood
as it is generally well tolerated and can be quickly reversed with protamine sulfate. Low-molecular weight heparin (LMWH) is however, becoming increasingly
Hemodialysis
Pharmaceutical drug
levels can be measured, and are often used to monitor tinzaparin. Protamine sulfate will reverse tinzaparin by 85% per package insert. Cheer S.M. et al
Tinzaparin_sodium
Drugs for heart or blood vessels diseases
Mogielnicki, Andrzej (2016). "The toxicology of heparin reversal with protamine: Past, present and future". Expert Opinion on Drug Metabolism & Toxicology
Cardiovascular_agents
Pharmaceutical drug classification
V03AB08 Sodium nitrite V03AB09 Dimercaprol V03AB13 Obidoxime V03AB14 Protamine V03AB15 Naloxone V03AB16 Ethanol V03AB17 Methylthioninium chloride V03AB18
ATC_code_V03
Prion Progesterone Prolactin (PRL) Proline Propionic acid Prostaglandins Protamine Protease Proteasome Protein Proteinoid Purine Putrescine Pyrethrin Pyridoxine
List_of_biomolecules
Formulary
Desmopressin Emicizumab Enoxaparin Phytomenadione Complementary: Heparin sodiumα Protamine sulfateα Warfarin Deferasirox Complementary: Deferoxamineα Hydroxyurea
WHO Model List of Essential Medicines for Children
WHO_Model_List_of_Essential_Medicines_for_Children
Class of chemicals and interactions
biocompatible and biodegradable. Polyelectrolytes such as dextran sulfate (DSS), protamine (PRM) or poly-L-arginine all fulfill these requirements and may
Emulsion stabilization using polyelectrolytes
Emulsion_stabilization_using_polyelectrolytes
Peptide hormone
B1 BOVINE INSULIN 2omg: Structure of human insulin cocrystallized with protamine and urea 2omh: Structure of human insulin cocrystallized with ARG-12 peptide
Insulin
Polymeric drug carrier
amine groups and grafted with heparin to form microspheres that provide protamine-stimulated, targeted drug release for the delivery of therapeutics to
Dextran_drug_delivery_systems
150 – cyclic gmp-dependent protein kinases MeSH D12.644.360.200.575 – protamine kinase MeSH D12.644.360.250 – cyclin-dependent kinases MeSH D12.644.360
List_of_MeSH_codes_(D12.644)
gmp-dependent protein kinases MeSH D08.811.913.696.620.682.700.150.575 – protamine kinase MeSH D08.811.913.696.620.682.700.200 – cyclin-dependent kinases
List_of_MeSH_codes_(D08)
PROTAMINE SULFATE
PROTAMINE SULFATE
PROTAMINE SULFATE
PROTAMINE SULFATE
PROTAMINE SULFATE
PROTAMINE SULFATE
PROTAMINE SULFATE
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PROTAMINE SULFATE