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Human protein
Prostatic acid phosphatase (PAP), also prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. It may be found in increased
Prostatic_acid_phosphatase
Gland of the male reproductive system
the prostatic urethra, which joins with the two ejaculatory ducts. The prostate is covered in a surface called the prostatic capsule or prostatic fascia
Prostate
Glands located on the anterior wall of the vagina
prostate act similarly by secreting prostate-specific antigen (PSA), which is an ejaculate protein produced in males, and prostatic acid phosphatase,
Skene's_gland
Class of enzymes
various acid phosphatase isoenzymes:[citation needed] ACP1 ACP2 ACPP (ACP3), prostatic acid phosphatase ACP5, tartrate-resistant acid phosphatase ACP6 ACPT
Acid_phosphatase
Expulsion of fluid during orgasm
urine, measuring substances such as urea, creatinine, prostatic acid phosphatase (PAP), prostate-specific antigen (PSA), glucose and fructose levels. Early
Female_ejaculation
Mammalian protein found in humans
usually uses PSA in combination with other antibodies, such as prostatic acid phosphatase and CD57. The physiological function of KLK3 is the dissolution
Prostate-specific_antigen
Biotechnology company
epitopes. In the case of Provenge, this disease related protein is prostatic acid phosphatase and the signalling component is GM-CSF. Dendreon believes its
Dendreon
Topics referred to by the same term
protein phosphatase), an enzyme encoded by the human ACP1 gene ACP2 (lysosomal acid phosphatase), an enzyme encoded by the human ACP2 gene ACP3 (Prostatic acid
ACP
Homodimeric protein enzyme
The enzyme alkaline phosphatase (ALP, alkaline phenyl phosphatase, also abbreviated PhoA) is a phosphatase with the physiological role of dephosphorylating
Alkaline_phosphatase
American Food and Drug Administration is for prostatic acid phosphatase, a commonly over-expressed prostate cancer antigen. O'Neill, David W. (November
Antigen-presenting cell vaccine
Antigen-presenting_cell_vaccine
Male reproductive organ cancer
issues other than prostate cancer, such as benign prostatic hyperplasia (non-cancerous enlargement of the prostate). Advanced prostate tumors can metastasize
Prostate_cancer
Topics referred to by the same term
ventilation used in the treatment of sleep apnea Prostatic acid phosphatase, an enzyme produced by the prostate Pulmonary alveolar proteinosis, a rare lung
PAP
with prostatic acid phosphatase pulsed antigen-presenting cells (provenge) plus bevacizumab in patients with serologic progression of prostate cancer
Dendritic cell-based cancer vaccine
Dendritic_cell-based_cancer_vaccine
Protein-coding gene in the species Homo sapiens
Tartrate-resistant acid phosphatase (TRAP or TRAPase), also called acid phosphatase 5, tartrate resistant (ACP5) or TRAP5b, is a glycosylated monomeric
Tartrate-resistant acid phosphatase
Tartrate-resistant_acid_phosphatase
Medical condition
CD30 hPG80 Prostate cancer Prostate-specific antigen Prostatic acid phosphatase Glutamate carboxypeptidase II erbB-3 receptor Early prostate cancer antigen-2
Germinoma
Tumor suppressor gene
PTEN (phosphatase and tensin homolog) is a gene found in humans which encodes for the protein PTEN, also known as phosphatidylinositol-3,4,5-trisphosphate
PTEN_(gene)
Protein-coding gene in the species Homo sapiens
Lysophosphatidic acid phosphatase type 6 is an acid phosphatase enzyme that is encoded in humans by the ACP6 gene. It acts as a phosphomonoesterase at
Lysophosphatidic acid phosphatase type 6
Lysophosphatidic_acid_phosphatase_type_6
Protein-coding gene in the species Homo sapiens
Lipid phosphate phosphohydrolase 1 also known as phosphatidic acid phosphatase 2a is an enzyme that in humans is encoded by the PPAP2A gene. Lipid phosphate
PPAP2A
Insoluble protein aggregate with a fibrillar morphology
serine/threonine-protein kinase 1/3 (RIP1/RIP3) Fragments of prostatic acid phosphatase and semenogelins Functional amyloid in other organisms: Curli
Amyloid
Reproductive biofluid of male or hermaphroditic animals
(sometimes clear), thin fluid containing proteolytic enzymes, citric acid, acid phosphatase and lipids. The bulbourethral glands secrete a clear lubricant into
Semen
Topics referred to by the same term
associated with Gaucher disease Public-safety answering point Prostatic-specific acid phosphatase Personal sound amplification products Presentation Service
PSAP
Medication
(PA2024) consisting of two parts: The antigen prostatic acid phosphatase (PAP), which is present in 95% of prostate cancer cells and An immune signaling factor
Sipuleucel-T
Medical intervention
vaccine-like strategy for prostate cancer in which dendritic cells from the patient are loaded with prostatic acid phosphatase peptides to induce a specific
Cancer_treatment
Class of enzymes
the superfamily that also contains the phosphatase portion of phosphofructokinase 2 and prostatic acid phosphatase. The catalyzed mutase reaction involves
Phosphoglycerate_mutase
Artificial stimulation of the immune system to treat cancer
with the fusion protein PA2024 made from GM-CSF and prostate-specific prostatic acid phosphatase (PAP) and reinfused. This process is repeated three times
Cancer_immunotherapy
Protein-coding gene in the species Homo sapiens
Réhault S, Juliano L, et al. (2002). "Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates"
SEMG2
Pharmaceutical compound
Earlier studies with bicalutamide instead assessed changes in prostatic acid phosphatase (PAP) levels; proportions of patients with decreases of PAP of
Pharmacology_of_bicalutamide
Human prostate cancer cell line
have low testosterone-5-alpha reductase and acidic phosphatase activity, and do not express PSA (prostate-specific antigen). Karyotypic analysis: near-triploid
PC3
Condition in which a male has abnormally low semen volume
7.2–7.8. An acidic seminal pH (pH < 7.2) suggests damage to the seminal vesicles and an alkaline seminal pH (pH > 8) suggests prostatic involvement.
Hypospermia
monoclonal antibody – prostate-specific antigen – prostate-specific antigen test – prostatectomy – prostatic acid phosphatase – prostatic intraepithelial neoplasia
Index_of_oncology_articles
and carcinoid-like tumors, as well as prostatic adenocarcinoma exhibiting focal neuroendocrine phenotype. Prostatic neuroendocrine cells, also known as
Neuroendocrine differentiation
Neuroendocrine_differentiation
Protein-coding gene in humans
phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein
ACP1
Chemical compound
of advanced prostatic cancer. Efficacy and cardiovascular complications: a 2-year follow-up report of a national, prospective prostatic cancer study
Polyestradiol_phosphate
Mammalian protein found in Homo sapiens
single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase". Biochemistry. 40 (50): 15341–8. doi:10.1021/bi015775e. PMID 11735417
KLK4
Cell line
alpha-dihydrotestosterone modulation of cell growth and acid phosphatase production. LNCaP cells also express Prostate Specific Antigen (PSA). In vivo, Male mice develop
LNCaP
Biological signaling pathway h
inactive, the SH2 domains interact with the catalytic domain, and so the phosphatase is unable to function. When SHP-1 is activated however, the SH2 domains
JAK-STAT_signaling_pathway
Chemical compound
of estradiol with phosphoric acid, and acts as a prodrug of estradiol in the body. It is rapidly cleaved by phosphatase enzymes into estradiol upon administration
Estradiol_phosphate
Chemical compound
treatment of prostate cancer has been researched. Flutamide has been studied in the treatment of benign prostatic hyperplasia (BPH; enlarged prostate) in men
Flutamide
Protein-coding gene in the species Homo sapiens
Réhault S, Juliano L, et al. (2002). "Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates"
Semenogelin_I
to be part of the complex, the same as RNA chaperone Hfq, PAP (prostatic acid phosphatase), other kinds of chaperones and ribosomal proteins. These have
Degradosome
Hypothesized anatomical detail
Skene's gland and male prostate acting similarly in terms of prostate-specific antigen and prostate-specific acid phosphatase studies, which led to a
G-spot
Protein-coding gene in humans
Taylor-Blake B, Twomey MA, Herrala A, Voikar V, et al. (October 2008). "Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine"
CHRNA6
Ester of an estrogen
estradiol phosphate. It is slowly cleaved into estradiol and phosphoric acid by phosphatases. Compared to conventional estradiol esters, polyestradiol phosphate
Estrogen_ester
Study of body fluids in a crime scene
semen is called the acid phosphatase (AP) test. The AP test detects the enzyme acid phosphatase that is secreted from the prostate gland. However, this
Forensic_serology
Procedure to gather facts about a suspected rape
In addition, acid phosphatase levels in high concentrations is a good indicator of recent coitus. Acid phosphatase is found in prostatic secretions and
Rape_investigation
Chemical compound
Andersson M, Müntzing J (1971). "Effects of oestrogen on phosphatase activity in the ventral prostate of intact, castrated, and androgen-treated castrated
Polyestriol_phosphate
Chemical compound
2013). "Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT
PP2_(kinase_inhibitor)
Protein-coding gene in the species Homo sapiens
mechanism has yet to be discovered. Furthermore, the serine/threonine phosphatase PP2 has been shown to degrade Pim-1. PIM1 has been shown to interact
PIM1
Protein-coding gene in the species Homo sapiens
single transmembrane region, a 158 amino acid long juxtamembrane domain and two tandem tyrosine phosphatase domains (referred to as D1 and D2) in its
PTPRM
Class of enzymes
the phosphatase domain is located on the C-terminal. It resembles the family of proteins that include phosphoglycerate mutases and acid phosphatases. The
Phosphofructokinase_2
American physician
A.L., Hopkins, J.A., Sproul, E.E., Stout, A.P. (1954) Prostatic cancer. XI. Early prostatic cancer diagnosed by arbitrary open perineal biopsy among
Edith_E._Sproul
Class of enzymes
isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important regulators of
PHLPP
Protein-coding gene in the species Homo sapiens
Acidic leucine-rich nuclear phosphoprotein 32 family member A is a protein that in humans is encoded by the ANP32A gene. It is one of the targets of an
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Acidic_leucine-rich_nuclear_phosphoprotein_32_family_member_A
Mammalian protein found in Homo sapiens
colonic and prostatic epithelial cells, by immunohistochemistry and immunofluorescence studies. Membrane immunostaining in the colon and prostate was lower
Arylsulfatase_B
Class of protein kinase enzymes
reduce cell proliferation.[citation needed] Protein serine/threonine phosphatase, enzyme for reverse process. Pseudokinase, a protein without enzyme activity
Serine/threonine-specific protein kinase
Serine/threonine-specific_protein_kinase
Protein
Protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32), is a protein that
PPP1R1B
Protein-coding gene in the species Homo sapiens
exchange factor (GEF) for RAP1. PTP-PEST, a soluble protein tyrosine phosphatase that is ubiquitously expressed in mice both during embryonic development
Embryonal fyn-associated substrate
Embryonal_fyn-associated_substrate
the specific PI and PIP kinases and PIP phosphatases present in the organelle. These kinases and phosphatases conduct phosphorylation and dephosphorylation
Phosphatidylinositol 3,4-bisphosphate
Phosphatidylinositol_3,4-bisphosphate
injury Alk phos alkaline phosphatase (sometimes abbreviated as ALP) ALL acute lymphoblastic leukemia allergies ALP alkaline phosphatase (sometimes abbreviated
List of medical abbreviations: A
List_of_medical_abbreviations:_A
Chemical compound
vitro against gastric, colon, prostate, and breast cancer lines. It has the capability to inhibit protein tyrosine phosphatase 1B, a key metabolite involved
Psoralidin
Protein-coding gene in the species Homo sapiens
phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res
WD repeat-containing protein 77
WD_repeat-containing_protein_77
rectus abdominis myocutaneous flap (TRAM flap) TRAP tartrate-resistant acid phosphatase T2RF type 2 respiratory failure TRF transfer (pronounced "turf") TRF'd
List of medical abbreviations: T
List_of_medical_abbreviations:_T
Illness from ingesting arsenic
tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase". The EMBO Journal. 15 (22): 6269–79. Bibcode:1996EMBO...15.6269C. doi:10
Arsenic_poisoning
Distortion of the sense of taste
rely on calcium receptors. Zinc "is an important cofactor for alkaline phosphatase, the most abundant enzyme in taste bud membranes; it is also a component
Dysgeusia
Protein found in humans
Protein phosphatase 1 regulatory subunit 14A also known as CPI-17 (C-kinase potentiated Protein phosphatase-1 Inhibitor Mr = 17 kDa) is a protein that
PPP1R14A
Organic compound with a –C≡N functional group
"Calyculins and Related Marine Natural Products as Serine-Threonine Protein Phosphatase PP1 and PP2A Inhibitors and Total Syntheses of Calyculin A, B, and C"
Nitrile
Ronquist G (1985). "Prostate specific acid phosphatase versus five other possible tumor markers: a comparative study in men with prostatic carcinoma". Scandinavian
Thymidine kinase in clinical chemistry
Thymidine_kinase_in_clinical_chemistry
Protein-coding gene in the species Homo sapiens
Protein tyrosine phosphatase type IVA 2 is an enzyme that in humans is encoded by the PTP4A2 gene. The protein encoded by this gene belongs to a small
PTP4A2
Protein-coding gene in the species Homo sapiens
protein involved in the inhibition of the serine-threonine phosphatase activity of Protein phosphatase 2A (PP2A). PP2A is a trimeric enzyme composed of a catalytic
CIP2A
Protein found in humans
in humans is encoded by the IRS1 gene. It is a 180 kDa protein with amino acid sequence of 1242 residues. It contains a single pleckstrin homology (PH)
Insulin_receptor_substrate_1
Protein-coding gene in the species Homo sapiens
constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative
PPP2R1B
South Wales, Sydney, Australia, researching the role of kinases and phosphatases in cholesterol transport and steroidogenesis. Papadopoulos has published
Vassilios_Papadopoulos
Protein-coding gene in the species Homo sapiens
ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway". J. Biol. Chem
MAPK3
Class of chemical compounds
An N-acylethanolamine (NAE) is a type of fatty acid amide where one of several types of acyl groups is linked to the nitrogen atom of ethanolamine, and
N-Acylethanolamine
Epigenetic modification to the DNA packaging protein Histone H3
signals and environmental conditions. Kinases phosphorylate proteins and phosphatases dephosphorylate proteins. Many enzymes and receptors are switched "on"
H3T11P
Protein found in humans
shape that allows it to interact with multiple protein types including phosphatases, ion channels, and kinases. This conformational change is associated
Calmodulin_1
Drug for erectile dysfunction and hypertension
prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this
Sildenafil
(1): 62–63. Harkness, R. A.; Nicol, A. D. (December 1969). "Plasma Uric Acid Levels in Children". Archives of Disease in Childhood. 44 (238): 773–778
List of human blood components
List_of_human_blood_components
Protein-coding gene in humans
in Saccharomyces cerevisiae) P21waf-1 (another CDK inhibitor) Hyaluronic acid synthase Hyaluronidase GRCh38: Ensembl release 89: ENSG00000111276 – Ensembl
CDKN1B
Chemical compound
osteoclast-specific markers (calcitonin receptor, tartarate-resistant acid phosphatase, cathepsin K, dendritic cell-specific transmembrane protein, V-ATPase
Nirogacestat
Compounds that inhibit histone deacetylases
innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1". J Leukoc Biol. 95 (4): 651–9. doi:10.1189/jlb.1013565. PMID 24374966
Histone_deacetylase_inhibitor
Enzyme
treatments. Most tyrosine kinases have an associated protein tyrosine phosphatase, which removes the phosphate group. Protein kinases are a group of enzymes
Tyrosine_kinase
Package to gather physical evidence of a rape
specific enzymes that are unique to seminal fluid (enzymes prostatic acid phosphates or acid phosphatase) can be used to prove sexual contact. Serial rape is
Rape_kit
Chemical compound
on prostatic cancer. I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate". CA
Diethylstilbestrol
Protein
promoter for glucose 6-phosphatase and increases its rate of transcription. FOXO1, through increasing transcription of glucose-6-phosphatase, indirectly increases
Forkhead_box_protein_O1
Chemical compound
ISSN 0172-777X. Scott WW, Menon M, Walsh PC (April 1980). "Hormonal Therapy of Prostatic Cancer". Cancer. 45 (Suppl 7): 1929–1936. doi:10.1002/cncr.1980.45.s7
Estriol_succinate
American molecular biologist (born 1947)
(1997). "PTEN a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer". Science. 275 (5308): 1943–1947. doi:10
Michael_Wigler
deficiency induced adverse effects in the treatment of prostate cancer". Prostate Cancer Prostatic Dis. 12 (4): 333–8. doi:10.1038/pcan.2009.35. PMID 19901933
Side_effects_of_bicalutamide
Abnormal formation of clumps of inflammatory cells (granulomata)
reflect a cholestatic pattern and include raised levels of alkaline phosphatase (which is the most common liver function test anomaly seen in those with
Sarcoidosis
Protein family
Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acids. They are found primarily on the surface of
Siglec
Protein-coding gene in the species Homo sapiens
fibrinolysis. A molecular complex containing receptor-type tyrosine phosphatase zeta (PTPζ), low density lipoprotein receptor-related protein (LRP1)
Midkine
American biochemist and academic
Sensing and Mitochondrial Coenzyme Q Biosynthesis: Are They Connected by a Phosphatase?" The FASEB Journal, vol. 31, no. S1, 1 Apr. 2017. ResearchGate Barber
Tracy_L._Johnson
Situation where tumor cells have been deprived of oxygen
thought that the low pH of hypoxic tumors in result of high levels of lactic acid can promote tumor cell invasion by destruction of adjacent non-cancerous
Tumor_hypoxia
Protein-coding gene in the species Homo sapiens
Free fatty acid receptor 1 (FFAR1), also known as G-protein coupled receptor 40 (GPR40), is a rhodopsin-like G-protein coupled receptor that is coded (i
Free_fatty_acid_receptor_1
Enzyme found in humans
Proline-serine-threonine phosphatase-interacting protein 2 is an enzyme that in humans is encoded by the PSTPIP2 gene. This protein, also known as macrophage
PSTPIP2
Chemical compound
estramustine), also known as prostatin or prostatic secretion protein (PSP), which has been detected in prostate cancer, glioma, melanoma, and breast cancer
Estramustine_phosphate
Chemical compound
for GTx-758, C-terminal telopeptide (CTX) and bone specific alkaline phosphatase (BSAP) levels (markers of bone turnover) increased in the leuprorelin
GTx-758
Protein-coding gene in the species Homo sapiens
regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase". The Biochemical Journal. 391 (Pt 3): 699–710
SYTL1
Human chromosome
OLFM1: olfactomedin 1 PHF2: PHD finger protein 2 PHPT1: phosphohistidine phosphatase 1 PIP5K1B: phosphatidylinositol-4-phosphate 5-kinase type-1 beta PLAA:
Chromosome_9
Rare disease of the bones
pumping is inhibited and bone resorption by osteoclasts is defective, as an acidic environment is needed to dissociate calcium hydroxyapatite from the bone
Osteopetrosis
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