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Podosomes are conical, actin-rich structures formed on the ventral plasma membrane of animal cells. Their size ranges from approximately 0.5 μm to 2.0 μm
Podosome
Medical condition
known for its role in the formation of cellular projections known as podosomes, which allow cells to migrate. A mouse model that lacks the Tks4 gene
Frank–Ter_Haar_syndrome
Biological membrane that separates the interior of a cell from its outside environment
"supramembrane" structures such as caveolae, postsynaptic densities, podosomes, invadopodia, focal adhesions, and different types of cell junction. These
Cell_membrane
Protein-coding gene in the species Homo sapiens
cytoplasm cell cortex brush border extracellular exosome cytoskeleton podosome cell junction cell projection plasma membrane protein-containing complex
SCIN
Mixture of peptides and proteins derived from animals
whole cells, for the study of cellular protrusions called invadopodia and podosomes, which are protrusive structures in cancer cells and play an important
Gelatin
Protein-coding gene in the species Homo sapiens
filament binding Cellular component extracellular region myelin sheath podosome cell junction cell projection extracellular exosome cytoskeleton actin
WDR1
Skin cancer originating in melanocytes
Molecular basis for melanoma cell motility: actin-rich podosomes (yellow), along with cell nuclei (blue), actin (red), and an actin regulator (green)
Melanoma
extracellular matrix in cancer invasiveness and metastasis. Very similar to podosomes, invadopodia are found in invasive cancer cells and are important for
Invadopodia
Formation of muscular tissue, particularly during embryonic development
at the plasma membrane. This accumulation facilitates the formation of podosome-like protrusions, where the fusogen Myomaker is localized, playing a crucial
Myogenesis
Enclosing or separating membrane in organisms acting as selective semi-permeable barrier
of "supramembrane" structures such as caveolae, postsynaptic density, podosome, invadopodium, desmosome, hemidesmosome, focal adhesion, and cell junctions
Biological_membrane
Filament in the cytoplasm of eukaryotic cells
intracellular vesicles, and motile processes in endocytosis, exocytosis, podosome formation, and phagocytosis. Actoclampins also propel such intracellular
Actin_filament
Chemical compound
production of phosphatidylinositol 5-phosphate fuels the formation of podosome-like protrusions regulating myoblast fusion". Proc. Natl. Acad. Sci. U
Phosphatidylinositol 4,5-bisphosphate
Phosphatidylinositol_4,5-bisphosphate
Protein-coding gene in the species Homo sapiens
NADPH oxidase complex Golgi apparatus rough endoplasmic reticulum soma podosome plasma membrane Biological process protein targeting to membrane superoxide
Neutrophil_cytosolic_factor_1
Protein-coding gene in the species Homo sapiens
production of phosphatidylinositol 5-phosphate fuels the formation of podosome-like protrusions regulating myoblast fusion". Proc. Natl. Acad. Sci. U
Myotubularin_1
Protein-coding gene in the species Homo sapiens
phosphatase activity protein tyrosine phosphatase activity Cellular component podosome cell junction cell projection focal adhesion cytoplasm cytosol nucleoplasm
PTPN12
Mammalian protein found in humans
myeloid and lymphoid immune cells. Many of these, such as phagocytosis and podosome formation, related to its role in regulating the polymerization of actin
Wiskott–Aldrich syndrome protein
Wiskott–Aldrich_syndrome_protein
Network of filamentous proteins that forms the internal framework of cells
form specialized structures, such as flagella, cilia, lamellipodia and podosomes. The structure, function and dynamic behavior of the cytoskeleton can
Cytoskeleton
Protein-coding gene in the species Homo sapiens
binding protein binding Cellular component cytoplasm microtubule minus-end podosome cell junction plasma membrane cell projection midbody cleavage furrow costamere
SVIL
Chemical compound
(hu SRC Y530F) has on the actin cytoskeleton, namely the formation of podosome rosettes, otherwise known as invadopodia. SU6656 was initially published
SU6656
Protein found in humans
(February 2002). "Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts"
Cortactin
Immune system messenger protein which induces inflammation
transcription factor activity cellular response to nicotine positive regulation of podosome assembly regulation of reactive oxygen species metabolic process positive
Tumor_necrosis_factor
Protein-coding gene in the species Homo sapiens
membrane axon cell junction Z discdkac actin filament actin cytoskeleton podosome cytoskeleton nucleus lamellipodium cytoplasm cytosol Biological process
Palladin
Protein-coding gene in the species Homo sapiens
filament capping extracellular matrix disassembly positive regulation of podosome assembly actin filament capping protein-containing complex assembly Sources:Amigo
Macrophage-capping_protein
Protein-coding gene in the species Homo sapiens
protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells". J. Biol. Chem. 278 (19): 16844–51. doi:10.1074/jbc
SH3PXD2A
Inorganic chemist and researcher
Owen, Dylan M.; Thrasher, Adrian J. (2015). "Platelet actin nodules are podosome-like structures dependent on Wiskott–Aldrich syndrome protein and ARP2/3
Zoe_Pikramenou
Protein-coding gene in the species Homo sapiens
microvillus cell junction microspike cell projection membrane actin cytoskeleton podosome extracellular exosome cytoskeleton growth cone lamellipodium filamentous
FSCN1
Protein-coding gene in the species Homo sapiens
vesicle membrane extracellular exosome cytoskeleton cytoplasmic vesicle podosome lamellipodium cytoplasm ruffle cell cortex cytosol extracellular region
Drebrin-like
Protein-coding gene in the species Homo sapiens
function protein binding phospholipid binding Cellular component cytoplasm podosome cell junction plasma membrane cell projection cell cortex phagocytic cup
Bridging_integrator_2
Mammalian protein found in Homo sapiens
density lamellipodium azurophil granule lumen ficolin-1-rich granule lumen podosome core Biological process cytosolic transport Fc-gamma receptor signaling
ACTR2
Mammalian protein found in humans
membrane actin filament postsynaptic density mitochondrial inner membrane podosome nucleoplasm glutamatergic synapse postsynaptic specialization, intracellular
Proto-oncogene tyrosine-protein kinase Src
Proto-oncogene_tyrosine-protein_kinase_Src
Protein found in humans
apical junction complex cytosol cytoplasm apical part of cell cell junction podosome cell projection nucleus cell-cell junction adherens junction intercalated
Tight_junction_protein_ZO-1
Protein-coding gene in humans
protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells". The Journal of Biological Chemistry. 278 (19):
ADAM19
Protein-coding gene in the species Homo sapiens
ruffle membrane actin filament actin cytoskeleton actin filament bundle podosome phagocytic cup extracellular exosome cytoskeleton extracellular space cell
LCP1
Mammalian protein found in Homo sapiens
energy input. As an important actin regulator, gelsolin plays a role in podosome formation (along with Arp3, cortactin, and Rho GTPases). Gelsolin also
Gelsolin
Actin projections on the leading edge of lamellipodia of migrating cells
pseudopods, thin filopodia, thick filopodia, gliopodia, myopodia, invadopodia, podosomes, telopodes, tunneling nanotubes and dendrites. Filopodia are also used
Filopodia
Protein and coding gene in humans
lipopolysaccharide cellular response to cytokine stimulus positive regulation of podosome assembly negative regulation of oxidative phosphorylation positive regulation
Transforming_protein_RhoA
Protein-coding gene in the species Homo sapiens
cell types, TRPV2 mediates cytokine release, phagocytosis, endocytosis, podosome assembly, and inflammation. The influx of calcium seems to play an important
TRPV2
Protein-coding gene in the species Homo sapiens
testosterone stimulus regulation of lymphocyte migration positive regulation of podosome assembly gland morphogenesis positive regulation of gene expression establishment
Moesin
Cell that removes bone tissue
zones are bounded by belts of specialized adhesion structures called podosomes. Attachment to the bone matrix is facilitated by integrin receptors, such
Osteoclast
Mammalian protein found in humans
membrane raft fascia adherens costamere cytoskeleton extracellular exosome podosome secretory granule lumen specific granule lumen ficolin-1-rich granule lumen
Vinculin
Mammalian protein found in humans
(Feb 2002). "Essential role of neural Wiskott–Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts"
Actin nucleation-promoting factor WASL
Actin_nucleation-promoting_factor_WASL
Protein-coding gene in the species Homo sapiens
specialised adhesion structures of hematopoietic cells they are also present in podosome's F actin surrounding ring structure. Isoform 2 may act as a repressor of
FERMT3
Protein-coding gene in the species Homo sapiens
component cytoplasm cell projection plasma membrane nucleoplasm cell junction podosome nucleus cell periphery cytosol Biological process intracellular signal
ARHGEF5
Human protein and coding gene
nucleus catalytic step 2 spliceosome cell projection extracellular exosome podosome spliceosomal complex cell junction extracellular matrix nucleoplasm cytoplasmic
HNRNPK
Mammalian protein found in Homo sapiens
regulation of cell population proliferation MAPK cascade positive regulation of podosome assembly negative regulation of extrinsic apoptotic signaling pathway in
Granulocyte-macrophage colony-stimulating factor
Granulocyte-macrophage_colony-stimulating_factor
Protein-coding gene in the species Homo sapiens
binding phosphatase binding GTPase binding Cellular component cytoplasm podosome cell junction endosome cell projection early endosome membrane membrane
SH3GL1
Type of cytokine
regulation of DNA-binding transcription factor activity positive regulation of podosome assembly MAPK cascade positive regulation of transcription, DNA-templated
Interleukin_5
Protein-coding gene in the species Homo sapiens
outgrowth was reduced. The study found that the protein localizes to podosomes, a surface in animals that is essential for cell migration and matrix
Galectin-7
accumulates at the plasma membrane thereby facilitating the formation of podosome-like protrusions, playing a crucial role in the spatiotemporal regulation
Phosphatidylinositol 5-phosphate
Phosphatidylinositol_5-phosphate
Mammalian protein found in Homo sapiens
membrane cell junction soma microtubule cytoskeleton cytoplasmic vesicle podosome postsynaptic density protein-containing complex glutamatergic synapse postsynaptic
ARHGEF2
transformation are rounding of the cell and the formation of actin rich podosomes on the basal surface of the cell. These structures are correlated with
V-Src
Protein-coding gene in the species Homo sapiens
et al. (June 2006). "The kinesin KIF1C and microtubule plus ends regulate podosome dynamics in macrophages". Molecular Biology of the Cell. 17 (6): 2811–23
KIF1C
Protein-coding gene in the species Homo sapiens
remodeling actin cytoskeleton reorganization regulation of integrin activation podosome assembly cell adhesion Rac protein signal transduction regulation of Rho
FARP2
Protein in humans
Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the
ANKMY1
Protein-coding gene in the species Homo sapiens
and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes". Mol Biol Cell. 22 (2): 202–15. doi:10.1091/mbc.E10-05-0394. PMC 3020916
FLOT2
Protein-coding gene in the species Homo sapiens
of cell microvillus cell surface early endosome endoplasmic reticulum podosome sarcolemma extracellular exosome external side of plasma membrane extracellular
VCAM-1
Motor protein found in humans
cytoskeleton vesicle podosome cytoplasm kinesin complex microtubule Biological process extracellular matrix disassembly regulation of podosome assembly organelle
KIF9
Human protein-coding gene
protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells". J. Biol. Chem. 278 (19): 16844–51. doi:10.1074/jbc
ADAM12
Index of articles on biophysics
transporter Plasmolysis Platelet-derived growth factor receptor Pleuroperitoneal Podosome Polar membrane Porosome Potassium channel Prenylation Preprohormone Pressure-volume
Index_of_biophysics_articles
Protein-coding gene in the species Homo sapiens
binding Cellular component cytoplasm cytosol dendritic spine membrane podosome cell projection membrane plasma membrane Biological process cilium assembly
DDEF1
Protein-coding gene in humans
protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells". J. Biol. Chem. 278 (19): 16844–51. doi:10.1074/jbc
ADAM15
Protein-coding gene in the species Homo sapiens
ion binding Cellular component cytoplasm perinuclear region of cytoplasm podosome cell junction plasma membrane cell projection nucleus focal adhesion membrane
LPXN
Protein-coding gene in humans
plasma membrane cell surface specific granule dense core granule membrane podosome phagolysosome alpha9-beta1 integrin-ADAM8 complex plasma membrane specific
ADAM8
Enzyme found in humans
positive regulation of apoptotic signaling pathway positive regulation of podosome assembly Fc-epsilon receptor signaling pathway protein phosphorylation
Mitogen-activated protein kinase 9
Mitogen-activated_protein_kinase_9
Protein-coding gene in humans
regulation of inflammatory response regulation of cell shape regulation of podosome assembly peptidyl-tyrosine autophosphorylation phagocytosis integrin-mediated
HCK
Academic journal
machinery Establishing polarity Exploring the nucleus Imaging Invadopodia and podosomes Mechanotransduction Microtubule dynamics Mitochondria Stem cells Tools
Journal_of_Cell_Science
Protein-coding gene in the species Homo sapiens
actin filament binding Cellular component cytoplasm filamentous actin podosome cytosol muscle thin filament tropomyosin cortical cytoskeleton extracellular
TPM4
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