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Database of protein families
Pfam is a database of protein families that includes their annotations and multiple sequence alignments generated using hidden Markov models. The latest
Pfam
Malaysian League player
The PFAM Player of the Month (Malaysia Premier League) is an association football award that recognises the best Malaysian League player that played in
PFAM Player of the Month (Malaysia Premier League)
PFAM_Player_of_the_Month_(Malaysia_Premier_League)
The PFAM Player of the Month is an association football award that recognises the best Malaysian League player each month of the season. The player nominated
PFAM_Player_of_the_Month
characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992
Domain_of_unknown_function
(Malay: Persatuan Pemain-Pemain Bolasepak Profesional Malaysia, abbrev: PFAM) is a representative organisation for professional football players in Malaysia
Professional Footballers Association of Malaysia
Professional_Footballers_Association_of_Malaysia
Protein domain
incorporates text from the public domain Pfam and InterPro: IPR001764 This article incorporates text from the public domain Pfam and InterPro: IPR002772 Portal:
Glycoside_hydrolase_family_3
Family of globular proteins
Human serum albumin This article incorporates text from the public domain Pfam and InterPro: IPR014760 Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi
Albumin
Protein domain
incorporates text from the public domain Pfam and InterPro: IPR019815 This article incorporates text from the public domain Pfam and InterPro: IPR019814
Translation initiation factor IF-3
Translation_initiation_factor_IF-3
Class of enzymes
glycosyltransferase 48 family (GT48). Some members of the glycosyltransferase 2 family (Pfam PF13632), such as the curdlan synthase CrdS (Q9X2V0), also has a similar
1,3-Beta-glucan_synthase
File format for biological sequence alignments
Stockholm format is a multiple sequence alignment format used by Pfam, Rfam and Dfam, to disseminate protein, RNA and DNA sequence alignments. The alignment
Stockholm_format
Protein-coding gene in the species Homo sapiens
protein belonging to the MFS Pfam clan. It is an Atypical solute carrier. It belongs to the major facilitator superfamily MFS Pfam Clan. MFSD1 has been identified
MFSD1
Family of enzymes
(16): 3746–52. doi:10.1093/nar/26.16.3746. PMC 147763. PMID 9685491. This article incorporates text from the public domain Pfam and InterPro: IPR004843
Calcineurin-like phosphoesterase
Calcineurin-like_phosphoesterase
to determine the evolutionary relationships between proteins. Similar to Pfam, CATH, and SCOP, ECOD compiles domains instead of whole proteins. However
Evolutionary Classification of Protein Domains
Evolutionary_Classification_of_Protein_Domains
Football league season
Anugerah Pemain Terbaik Bulanan PFAM bulan Mei 2015". pfam.my. PFAM. June 2015. (in Malay)"ANUGERAH PEMAIN TERBAIK BULANAN PFAM-asiana.my EDISI JUN 2015".
2015_Malaysia_Super_League
Protein domain
incorporates text from the public domain Pfam and InterPro: IPR002350 This article incorporates text from the public domain Pfam and InterPro: IPR011497
Kazal_domain
Protein family
PMC 21213. PMID 9192620. This article incorporates text from the public domain Pfam and InterPro: IPR000635 Single-Stranded+DNA+Binding+Proteins at the U.S.
Single-strand DNA-binding protein
Single-strand_DNA-binding_protein
Family of ion channel proteins
The transmembrane cation channel superfamily was defined in InterPro and Pfam as the family of tetrameric ion channels. These include the sodium, potassium
Cation_channel_superfamily
Enzyme family
S2CID 21305517. Media related to Monooxygenases at Wikimedia Commons This article incorporates text from the public domain Pfam and InterPro: IPR002938
Monooxygenase
Eukaryotic organelle
mammals, amphibians, avians and slime mold. The Vault model used by the Pfam database identifies homologues in Paramecium tetraurelia, Kinetoplastida
Vault_(organelle)
Women's football club in Marrakech
Football Academy Marrakech (Arabic: أكاديمية فينيكس لكرة القدم مراكش), known as PFAM for short, is a professional women's football club based in Marrakech. Founded
Phoenix_Marrakesh
Protein family
filtered by species (Homo sapiens)". InterPro. "Family: Dmrt1 (PF12374)". Pfam. "Jpred results (MTECSGTSQPPPASVPTTAASEGRMVIQDIPAVTSRGHVENTPD)". www.compbio
DM_domain
Family of repressor proteins in bacteriophage lambda
Structure. 12 (4): 569–81. doi:10.1016/j.str.2004.02.024. PMID 15062080. This article incorporates text from the public domain Pfam and InterPro: IPR000655
Cro_repressor_family
Protein domain found in carbohydrate-active enzymes
incorporates text from the public domain Pfam and InterPro: IPR000254 This article incorporates text from the public domain Pfam and InterPro: IPR002883 This article
Carbohydrate-binding_module
superfamily domain containing 3 (MFSD3) is a protein belonging to the MFS Pfam clan. It is an Atypical solute carrier located to the neuronal plasma membrane
Mfsd3
alignments and phylogenetic trees covering many common protein domains. Pfam: database of protein domains Phylogeny Sequence alignment Whelan, Simon;
PANDIT_(database)
Protein family
Lett. 96 (2): 261–75. doi:10.1016/j.imlet.2004.09.011. PMID 15585332. This article incorporates text from the public domain Pfam and InterPro: IPR010582
Catalase-related immune-responsive domain
Catalase-related_immune-responsive_domain
Protein in wheat and other cereals
[Seed storage proteins] N-terminal helical domain Identifiers Symbol Gliadin Pfam PF13016 InterPro IPR016140 Available protein structures: PDB IPR016140
Gliadin
Protein family
Microbiology. 54: 881–941. doi:10.1146/annurev.micro.54.1.881. PMID 11018148. This article incorporates text from the public domain Pfam and InterPro: IPR002481
Ferric uptake regulator family
Ferric_uptake_regulator_family
Restriction enzyme
the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the public domain Pfam and InterPro: IPR004194
BamHI
Protein family
13 (4): 269–79. doi:10.1002/psc.846. PMID 17394123. S2CID 35117012. This article incorporates text from the public domain Pfam and InterPro: IPR022717
Tachystatin
Protein family
1128/JB.181.5.1555-1561.1999. PMC 93546. PMID 10049388. This article incorporates text from the public domain Pfam and InterPro: IPR002901 Portal: Biology
Glycoside_hydrolase_family_73
Protein family
2 (2): 123–135. doi:10.1016/S1567-1356(02)00083-1. ISSN 1567-1356. This article incorporates text from the public domain Pfam and InterPro: IPR019605
Misato segment II myosin-like domain
Misato_segment_II_myosin-like_domain
Protein family
incorporates text from the public domain Pfam and InterPro: IPR013096 This article incorporates text from the public domain Pfam and InterPro: IPR006045 This article
Cupin_superfamily
Class of enzymes
incorporates text from the public domain Pfam and InterPro: IPR000310 This article incorporates text from the public domain Pfam and InterPro: IPR005308 This article
Group III pyridoxal-dependent decarboxylases
Group_III_pyridoxal-dependent_decarboxylases
Protein domain
incorporates text from the public domain Pfam and InterPro: IPR018980 This article incorporates text from the public domain Pfam and InterPro: IPR019748 This article
FERM_domain
Secretoglobin protein
14: 14. doi:10.1186/s13223-018-0239-8. PMC 5891966. PMID 29643919. This article incorporates text from the public domain Pfam and InterPro: IPR015332
Fel_d_1
Gene found in fruit flies
to controversy. Both Indy proteins belong to the sodium sulfate symporter Pfam family. Its name originates from a well-known comic line in Monty Python
Indy_(gene)
Protein domain
incorporates text from the public domain Pfam and InterPro: IPR014742 This article incorporates text from the public domain Pfam and InterPro: IPR014741 This article
Cbl_TKB_domain
Protein family
Bibcode:2000PNAS...9713561N. doi:10.1073/pnas.240224997. PMC 17615. PMID 11095707. This article incorporates text from the public domain Pfam and InterPro: IPR000170
High potential iron–sulfur protein
High_potential_iron–sulfur_protein
Protein family
SemiSWEET PQ-loop Identifiers Symbol PQ-loop Pfam PF03083 Pfam clan PQ-loop InterPro IPR006603 SMART SM00679 TCDB 2.A.123 OPM superfamily 415 OPM protein
SWEET_transporters
Protein domain
incorporates text from the public domain Pfam and InterPro: IPR015888 This article incorporates text from the public domain Pfam and InterPro: IPR012889 This article
L-fucose_isomerase
Class of enzymes
30435–41. doi:10.1074/jbc.M104103200. PMID 11397813. Portal: Biology This article incorporates text from the public domain Pfam and InterPro: IPR015213 v t e
Cholesterol_oxidase
Protein family
(1): 3–8. doi:10.1093/glycob/cwx089. PMID 29040563. This article incorporates text from the public domain Pfam and InterPro: IPR004888 Portal: Biology
Glycoside_hydrolase_family_63
Proteins that regulate circadian rhythms
incorporates text from the public domain Pfam and InterPro: IPR011648 This article incorporates text from the public domain Pfam and InterPro: IPR011649 This article
Cyanobacterial_clock_proteins
Low-calorie sweetener and flavor modifier
Ribbon diagram of thaumatin I. From PDB: 1RQW. Identifiers Symbol Thaumatin Pfam PF00314 InterPro IPR001938 SMART SM00205 PROSITE PDOC00286 SCOP2 1thu / SCOPe
Thaumatin
Membrane proteins that adhere temporarily to membranes with which they are associated
org. Retrieved 2023-11-28. "Pfam entry: Annexin". Archived from the original on 2007-09-29. Retrieved 2007-01-25. "Pfam entry Synapsin N". Archived from
Peripheral_membrane_protein
Protein family
(FAT) domain, Pfam PF02259 kinase domain (KD; PI3_PI4_kinase), PIKK- regulatory domain (PRD), and C-terminus FAT-C-terminal (FATC) domain Pfam PF02260 Lempiäinen
Phosphatidylinositol 3-kinase-related kinase
Phosphatidylinositol_3-kinase-related_kinase
Plasma membrane found in gram-negative bacteria
incorporates text from the public domain Pfam and InterPro: IPR007485 This article incorporates text from the public domain Pfam and InterPro: IPR010664
Bacterial_outer_membrane
Protein family
Glycosyl hydrolases family 6 Identifiers Symbol Glyco_hydro_6 Pfam PF01341 InterPro IPR001524 SCOP2 1cb2 / SCOPe / SUPFAM CAZy GH6 Available protein structures:
Glycoside_hydrolase_family_6
Protein family
doi:10.1016/S0021-9258(17)46215-6. PMID 2398053. Portal: Biology This article incorporates text from the public domain Pfam and InterPro: IPR007269 v t e
Protein-S-isoprenylcysteine O-methyltransferase
Protein-S-isoprenylcysteine_O-methyltransferase
Proteins that transport oxygen throughout the bodies of some invertebrate animals
functional unit from the hemocyanin of an octopus Identifiers Symbol Hemocyanin_M Pfam PF00372 InterPro IPR000896 PROSITE PDOC00184 SCOP2 1lla / SCOPe / SUPFAM
Hemocyanin
InterPro Family
zostericola (sipunculid worm) IPR002063 – InterPro entry for hemerythrin This article incorporates text from the public domain Pfam and InterPro: IPR012312
Hemerythrin
Protein family
doi:10.1111/j.1742-4658.2005.04667.x. PMID 15885096. S2CID 31472776. This article incorporates text from the public domain Pfam and InterPro: IPR015360
XPC-binding
Rock band from New Orleans
Should Ever Fall on Hard Times (Yep Roc, 2008) Sin To Sin (PFAM Records, 2013) Juarez (PFAM Records, 2014) TV.com Chart Positions, Allmusic.com Variety
The_Iguanas_(Louisiana_band)
Protein family
incorporates text from the public domain Pfam and InterPro: IPR000172 This article incorporates text from the public domain Pfam and InterPro: IPR007867
Glucose-methanol-choline oxidoreductase family
Glucose-methanol-choline_oxidoreductase_family
Protein family
doi:10.1016/S0021-9258(18)93302-8. PMID 4872176. Portal: Biology This article incorporates text from the public domain Pfam and InterPro: IPR012131 v t e
Histidinol_dehydrogenase
Protein domain
2A, Containing the GAF A and GAF B Domains. Identifiers Symbol GAF Pfam PF01590 Pfam clan CL0161 InterPro IPR003018 SMART GAF SCOP2 1fl4 / SCOPe / SUPFAM
GAF_domain
Method of stimulus sensing and response in cells
incorporates text from the public domain Pfam and InterPro: IPR011712 This article incorporates text from the public domain Pfam and InterPro: IPR010559 This article
Two-component regulatory system
Two-component_regulatory_system
Protein domain
10117084C. doi:10.1073/pnas.0406134101. PMC 535365. PMID 15569936. This article incorporates text from the public domain Pfam and InterPro: IPR000160
GGDEF_domain
Protein domain
Bibcode:1995PNAS...92.2563H. doi:10.1073/pnas.92.7.2563. PMC 42258. PMID 7708685. This article incorporates text from the public domain Pfam and InterPro: IPR000569
HECT_domain
Protein family
Glycosyl hydrolase family 1 Identifiers Symbol Glyco_hydro_1 Pfam PF00232 Pfam clan CL0058 InterPro IPR001360 PROSITE PDOC00495 SCOP2 1cbg / SCOPe / SUPFAM
Glycoside_hydrolase_family_1
Biological database of proteins
"families", and are assumed to have a closer common ancestor. Similar to CATH and Pfam databases, SCOP provides a classification of individual structural domains
Structural Classification of Proteins database
Structural_Classification_of_Proteins_database
Protein family
PMC 545545. PMID 15644435. This article incorporates text from the public domain Pfam and InterPro: IPR000679 GATA family Archived 2013-12-07 at the Wayback Machine
GATA_zinc_finger
Large group of transport proteins
MAC/Perforin domain Identifiers Symbol MACPF Pfam PF01823 Pfam clan CDC InterPro IPR001862 SMART MACPF PROSITE PDOC00251 TCDB 1.C.39 OPM superfamily 168
MACPF
Protein family
unknown function) 6, and was one of the first DUF families to appear in Pfam. Maximum likelihood phylogenetic analysis indicates that this family contains
EamA
Mammalian protein found in humans
the structure information available in the PDB for Pig Colipase This article incorporates text from the public domain Pfam and InterPro: IPR001981 v t e
Colipase
Protein family
incorporates text from the public domain Pfam and InterPro: IPR022217 This article incorporates text from the public domain Pfam and InterPro: IPR019506 This article
Protease_inhibitor_(biology)
Enzyme that hydrolyses α bonds of large α-linked polysaccharides
incorporates text from the public domain Pfam and InterPro: IPR006047 This article incorporates text from the public domain Pfam and InterPro: IPR012850 This article
Α-Amylase
Protein family
doi:10.1002/prot.21550. PMID 17654545. S2CID 2845167. This article incorporates text from the public domain Pfam and InterPro: IPR002016 Portal: Biology
Haem_peroxidase
Type of enzyme
Subject Headings (MeSH) Proteopedia: Metalloproteases This article incorporates text from the public domain Pfam and InterPro: IPR008915 Portal: Biology
Metalloproteinase
Bacterial regulatory protein involved in envelope stress response
interact with downstream regulators. It is classified under the Pfam protein family Pfam PF07095. IgaA is essential for intracellular survival and growth
IgaA
Toxic lectin
Crystal structure of PHA-L (PDB 1fat) Identifiers Symbol Lectin_legB Pfam PF00139 Pfam clan CL0004 InterPro IPR001220 PROSITE PDOC00278 SCOP2 1lem / SCOPe
Phytohaemagglutinin
Protein family
22 (2): 205–15. doi:10.1093/emboj/cdg031. PMC 140106. PMID 12514126. This article incorporates text from the public domain Pfam and InterPro: IPR007138
ABM_domain
Protein domain
known structure of pancreatic lipase shows this domain binds to procolipase Pfam PF01114, which mediates membrane association. This domain forms a beta-sandwich
PLAT_domain
Protein family
.418C. doi:10.1007/s00239-022-10071-3. PMC 9643190. PMID 36181519. This article incorporates text from the public domain Pfam and InterPro: IPR000275
Coagulin
Cellular antigens specific for melanoma cells
members of the family". Cancer Res. 61 (14): 5544–5551. PMID 11454705. This article incorporates text from the public domain Pfam and InterPro: IPR002190
Melanoma-associated_antigen
Links clathrin to receptors in coated vesicles
TRG_LysEnd_APsAcLL_1 Eukaryotic Linear Motif resource motif class TRG_LysEnd_APsAcLL_3 This article incorporates text from the public domain Pfam and InterPro: IPR008968
Clathrin_adaptor_protein
Enzyme
8-dihydroneopterin aldolase in complex with guanine Identifiers Symbol FolB Pfam PF02152 Pfam clan CL0334 InterPro IPR006157 SCOP2 1b9l / SCOPe / SUPFAM Available
Dihydroneopterin_aldolase
Protein family
doi:10.1016/s0969-2126(01)00680-3. PMID 11738040. Bateman A (2004). "The Pfam protein families database". Nucleic Acids Research. 32 (90001): 138–141.
Universal_stress_protein
DNA-binding protein domain found in transcription factors
8 (6): 440–50. doi:10.1038/nrm2190. PMID 17522590. S2CID 31546098. This article incorporates text from the public domain Pfam and InterPro: IPR001766
Fork_head_domain
Protein domain
the extracellular matrix). Human tensin has actin-binding sites, an SH2 (Pfam PF00017) domain and a region similar to the tumour suppressor PTEN. The PTB
Phosphotyrosine-binding domain
Phosphotyrosine-binding_domain
Soluble protein complex in blood plasma and involved in clot formation
Identifiers Symbol Fibrinogen_C Pfam PF00147 Pfam clan CL0422 InterPro IPR002181 PROSITE PDOC00445 SCOP2 1fza / SCOPe / SUPFAM Available protein structures:
Fibrinogen
Protein family
Azurin Azurin tetramer, Pseudomonas aeruginosa Identifiers Symbol Copper-bind Pfam PF00127 SCOP2 5azu / SCOPe / SUPFAM CDD cd13922 Available protein structures:
Azurin
Genus of viruses
incorporates text from the public domain Pfam and InterPro: IPR000936 This article incorporates text from the public domain Pfam and InterPro: IPR002533 This article
Alphavirus
Protein families found in peroxisomes
Peroxin 11 Identifiers Symbol PEX-11 Pfam PF05648 InterPro IPR008733 Membranome 191 Available protein structures: PDB IPR008733 PF05648 (ECOD; PDBsum)
Peroxin
Family of plant proteins
Dehydrin Identifiers Symbol Dehydrin Pfam PF00257 InterPro IPR000167 PROSITE PS00315 Available protein structures: PDB IPR000167 PF00257 (ECOD; PDBsum)
Dehydrin
Protein family
PDB for UniProt: P16113 (Photoactive yellow protein) at the PDBe-KB. This article incorporates text from the public domain Pfam and InterPro: IPR012130
Photoactive_yellow_protein
Protein family
inhibitors. Federal University of São Paulo. Retrieved 2008-12-19. This article incorporates text from the public domain Pfam and InterPro: IPR002160
Kunitz_STI_protease_inhibitor
Family of integral membrane proteins
Transmembrane exosortase (Exosortase_EpsH) Identifiers Symbol Exosortase_EpsH Pfam PF09721 Available protein structures: PDB PF09721 (ECOD; PDBsum) AlphaFold
Exosortase
Protein family
43 (20): 10065–80. doi:10.1093/nar/gkv1053. PMC 4787788. PMID 26481363. "Pfam alignment: PF03377 metagenome (auto-generated match)". Retrieved 28 May 2019
TALE-likes
Family of proteins which produce bioluminescence
incorporates text from the public domain Pfam and InterPro: IPR018804 This article incorporates text from the public domain Pfam and InterPro: IPR007959 This article
Luciferase
Class of enzymes
metalloproteinase Gas gangrene This article incorporates text from the public domain Pfam and InterPro: IPR013510 Gerard J. Tortora, Berdell R. Funke, Cristine L.
Collagenase
Protein family
the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the public domain Pfam and InterPro: IPR008187
Vpu_protein
Structural protein which encapsidates viral RNA
Res. 3 (1): 35–40. doi:10.1016/0168-1702(85)90039-5. PMID 4024728. This article incorporates text from the public domain Pfam and InterPro: IPR002141
Influenza_virus_nucleoprotein
Proteins
incorporates text from the public domain Pfam and InterPro: IPR010472 This article incorporates text from the public domain Pfam and InterPro: IPR015425 This article
Formins
Superfamily of enzymes
Phosphoglucomutase-1 from rabbit (PDB: 1c4g) Identifiers Symbol PGM_I-III Pfam clan CL0754 ECOD 7528.1.1 InterPro IPR016055 CDD cd03084 Available protein
Alpha-D-phosphohexomutase superfamily
Alpha-D-phosphohexomutase_superfamily
Protein family
1093–106. doi:10.1016/j.cell.2005.09.044. PMID 16360038. S2CID 6158027. This article incorporates text from the public domain Pfam and InterPro: IPR014889
Transcription_factor_DP
Protein found in Drosophila melanogaster
Spätzle Identifiers Symbol Spaetzle Pfam PF16077 InterPro IPR032104 Available protein structures: PDB IPR032104 PF16077 (ECOD; PDBsum) AlphaFold IPR032104
Spätzle_(protein)
Class of enzymes
incorporates text from the public domain Pfam and InterPro: IPR001117 This article incorporates text from the public domain Pfam and InterPro: IPR011706 This article
Multicopper_oxidase
Class of enzymes
incorporates text from the public domain Pfam and InterPro: IPR000146 This article incorporates text from the public domain Pfam and InterPro: IPR009164 This article
Fructose_1,6-bisphosphatase
PFAM
PFAM
PFAM
PFAM
PFAM
PFAM
PFAM
PFAM
PFAM