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Type of ion separator used in mass spectrometry
In mass spectrometry, Orbitrap is an ion trap mass analyzer consisting of an outer barrel-like electrode and a coaxial inner spindle-like electrode that
Orbitrap
Device for trapping charged particles
(Fourier-transform ion cyclotron resonance), Paul trap or the Kingdon trap. The Orbitrap, introduced in 2005, is based on the Kingdon trap. Other types of mass
Ion_trap
Analytical technique based on determining mass to charge ratio of ions
that is highly delocalized in time is also highly localized in frequency. Orbitrap analyzers are similar to FTMS analyzers. Ions are electrostatically trapped
Mass_spectrometry
Set of proteins that can be expressed by a genome, cell, tissue, or organism
to study the proteome. Some important mass spectrometry methods include Orbitrap Mass Spectrometry, MALDI (Matrix Assisted Laser Desorption/Ionization)
Proteome
American biotechnology company
promote the integration of Seer’s Proteograph system with Thermo Fisher’s Orbitrap mass spectrometers. In June 2025, Seer announced a collaboration with Korea
Seer,_Inc.
Russian physicist (born 1966)
born 1966) is a Russian physicist who led the team that developed the Orbitrap, a type of mass spectrometer, and received the 2008 American Society for
Aleksandr_Makarov_(physicist)
Pharmaceutical compound
and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro". Journal
TB-500
Type of molecular mass
cross lapping of the m/z peaks. If a high-resolution instrument like an orbitrap or an ion cyclotron resonance is used, these two molecules can be distinguished
Monoisotopic_mass
transform ion cyclotron resonance or Orbitrap mass spectrometer is marketed by Thermo Scientific as the LTQ FT and LTQ Orbitrap, respectively. Glish, G.; McLuckey
Hybrid_mass_spectrometer
effective—and therefore most common—on quadrupole mass spectrometers, Orbitrap, and Fourier transform ion cyclotron resonance mass spectrometers. Selected
Selected_ion_monitoring
Species of flowering plant
; Skaltsounis, A.-L. (2013). "From olive drupes to olive Oil. An HPLC-orbitrap-based qualitative and quantitative exploration of olive key metabolites"
Olive
Instrument in mass spectrometry
transform ion cyclotron resonance Acronym FTICR Classification Mass spectrometry Other techniques Related Ion trap Quadrupole ion trap Penning trap Orbitrap
Fourier-transform ion cyclotron resonance
Fourier-transform_ion_cyclotron_resonance
Peptide hormone and neuropeptide
(January 2019). "Oxytocin analysis from human serum, urine, and saliva by orbitrap liquid chromatography-mass spectrometry". Drug Testing and Analysis. 11
Oxytocin
Technique used in mass spectroscopy
SESI-MS SUPER SESI coupled with Thermo Fisher Scientific-Orbitrap
Electrospray_ionization
analyses. Molecules introduced into the Orbitrap are fragmented, accelerated, and analyzed. Because the Orbitrap characterizes molecular masses by measuring
Position-specific isotope analysis
Position-specific_isotope_analysis
Ambient ionization technique
of grape volatile composition using secondary electrospray ionization orbitrap mass spectrometry: A preliminary study of grape ripening". Food Control
Secondary electrospray ionization
Secondary_electrospray_ionization
Unit relating to the field of mass spectrometry
York: Wiley. ISBN 978-0-471-96696-8. The Orbitrap: a novel high-performance electrostatic trap (ASMS) Orbitrap Instrumentation: The First Decade and Beyond
Thomson_(unit)
Species of plant
extraction coupled with ultra-performance liquid chromatography/Tandem orbitrap mass spectrometry". Rapid Communications in Mass Spectrometry. 32 (20):
Nicotiana_tabacum
Type of mass spectrometry
higher-energy collisional dissociation (HCD). HCD is a CID technique specific to orbitrap mass spectrometers in which fragmentation takes place external to the ion
Tandem_mass_spectrometry
Substituted cathinone designer drug
pubic hair samples by liquid chromatography-high resolution/high accuracy Orbitrap mass spectrometry". Forensic Science International. 265: 131–7. doi:10
3-Methylmethcathinone
Species of flowering plant in the poppy family
PJ (2021). "Benzylisoquinoline alkaloid analysis using high-resolution Orbitrap LC-MSn". J Mass Spectrom. 56 (2) e4683. doi:10.1002/jms.4683. PMID 33410198
Papaver_somniferum
Biological molecules constituting nucleic acids
Monitoring, MRM) and high-resolution mass spectrometry (HRMS)—including Orbitrap or Time-of-Flight (TOF) analyzers—allow for the simultaneous quantification
Nucleotide
Species of tree
Anti-Diabetic Properties and Identification of Active Compounds Using UHPLC-ESI-Orbitrap-MS/MS in Mangifera odorata L. Peel and Seed Kernel". Molecules. 24 (2):
Mangifera_odorata
American chemist
2018. "Award Abstract #0747990 CAREER: A Dual Reaction Cell, ETD-enabled Orbitrap Mass Spectrometer for Top-down Proteomics". National Science Foundation
Joshua_Coon
Chemical compound
ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer". Xenobiotica; the Fate of Foreign Compounds in Biological
Geniposide
racehorse saddle and others Aleksandr Makarov (born 1966), Russia/Germany – Orbitrap mass spectrometer Stepan Makarov (1849–1904), Russia – Icebreaker Yermak
List_of_inventors
linear quadrupole trap to store ions formed by ESI for injection into an orbitrap mass analyzer. Ions passed through an orifice and skimmer, a quadrupole
Linear_ion_trap
Study of the separation, identification, and quantification of matter
chemistry. The handling of large datasets ("big data") from instruments like Orbitrap mass spectrometers has made advanced data analysis, including machine learning
Analytical_chemistry
Ambient ionization technique
implemented in 2013, and is coupled to a high resolving power hybrid Quadrupole-Orbitrap mass spectrometer. The computer controlled motorized stage and a charge-coupled
Matrix-assisted laser desorption electrospray ionization
Matrix-assisted_laser_desorption_electrospray_ionization
were awarded with Nobel Prize in Physics for this discovery in 2010. 2005 Orbitrap by Aleksandr Makarov 2006 PEARL (PEtawatt pARametric Laser) First petawatt
Timeline of Russian innovation
Timeline_of_Russian_innovation
Chemical compound
hypertensive rats using liquid chromatography coupled with quadrupole-Orbitrap mass spectrometry". Journal of Chromatography. B, Analytical Technologies
S-1-Propenyl-L-cysteine
Scientific study of chemical processes involving metabolites
limitation.[citation needed] Most recently, ion trap techniques such as orbitrap mass spectrometry are also applied to metabolomics research. Nuclear magnetic
Metabolomics
Ionization technique
"Biological Applications of AP MALDI with Thermo Scientific Exactive Orbitrap MS" (PDF). 443-539-1710. Thermo Scientific. Retrieved 17 June 2011.[dead
Matrix-assisted laser desorption/ionization
Matrix-assisted_laser_desorption/ionization
Mass spectrometry software
such as TOF, Orbitrap and FT-ICR usually provide data with high mass accuracy, as do coupled devices such as Q-TOF, IT-TOF or IT-Orbitrap. Spectra measured
SIRIUS_(software)
Measure of statistical effect size
to outliers. high-throughput screening SSMD Z-score or Standard score "Orbitrap LC-MS - US". thermofisher.com. Zhang, JH; Chung, TDY; Oldenburg, KR (1999)
Z-factor
reflecting telescope and night vision telescope Alexander Makarov, inventor of orbitrap Dmitry Maksutov, inventor of the Maksutov telescope Boris Mamyrin, inventor
List_of_Russian_people
of light-emitting diode and crystadine Alexander Makarov, inventor of orbitrap Boris Mamyrin, inventor of reflectron Leonid Mandelshtam, co-discoverer
List_of_Russian_physicists
development of the ion trap technique". 1999 Alexander Makarov presents the Orbitrap mass spectrometer. 2002 John Bennett Fenn and Koichi Tanaka are awarded
History_of_mass_spectrometry
Quantification of biomolecules via mass spectrometry without using chemical labels
time-of-flight (ToF), fourier transform ion cyclotron resonance (FTICR), or Orbitrap mass analyzers. The high-resolution power facilitates the extraction of
Label-free_quantification
Chemical compound
Protomers Using Structures for Lossless Ion Manipulations Ion Mobility-Orbitrap Mass Spectrometry". Journal of the American Society for Mass Spectrometry
Secbutonitazene
Mass spectrometry technique to induce fragmentation of selected ions in the gas phase
Higher-energy collisional dissociation (HCD) is a CID technique specific to the orbitrap mass spectrometer in which fragmentation takes place external to the trap
Collision-induced dissociation
Collision-induced_dissociation
The introduction of high-performance mass spectrometry (for example, Orbitrap) in 2000 has revolutionised the field, since the entire preserved sequences
Ancient_protein
transform ion cyclotron resonance or Penning trap and newly developed orbitrap. However, Paul trap receives a great focus from researchers for a MMS because
Miniature_mass_spectrometer
Ambient ionization technique
analysis sampling. Lipids can be detected through a coupling procedure with orbitrap mass spectroscopy. DAPPI has also been known to couple with liquid chromotography
Desorption atmospheric pressure photoionization
Desorption_atmospheric_pressure_photoionization
Hu Q, Noll RJ, Li H, Makarov A, Hardman M, Graham Cooks R (2005). "The Orbitrap: a new mass spectrometer". Journal of Mass Spectrometry. 40 (4): 430–443
List_of_Russian_inventors
of light-emitting diode and crystadine Alexander Makarov, inventor of orbitrap Boris Mamyrin, inventor of reflectron Leonid Mandelshtam, co-discoverer
List_of_Russian_scientists
Dutch chemist
were later commercialized by the company ThermoFisher Scientific as the Orbitrap EMR and UHMR. In proteomics, Heck is most renowned for his work on quantitative
Albert_J._R._Heck
Application of mass spectrometry to aerosol particles
or ultra-high resolution mass spectrometer, such as an FTICR-MS or an Orbitrap, as very high resolution is needed to differentiate between the high number
Aerosol_mass_spectrometry
Tool in chemical analysis
electronics the intensity is typically measured in volts. In FTICR and Orbitraps the frequency domain signal (the y-axis) is related to the power (~amplitude
Mass_spectrum
Analytical methods used to monitor environmental hazards
are required. Combinations of quadrupole, time-of-flight, ion trap, and orbitrap mass spectrometry analyzers have emerged, along with high-performance liquid
Screening_(environmental)
Medical diagnostic technique
proteome depth and resolution. Mass spectrometry innovations Thermo Fisher's Orbitrap Astral enables the measurement of thousands of proteins from minimal samples
Proteomic_profiling
chromatograph. Inlet ionization techniques can be used with an Orbitrap mass analyzer, Orbitrap fourier transform mass spectrometer, linear trap quadrupole
Matrix-assisted_ionization
Chemical compound
was performed by reverse-phase HPLC. The MS detection used a quadrupole-orbitrap high-resolution detector after heated electrospray in negative ionization
Atractyloside
Signal-processing operation
post-ringing that the latter introduces. During oscillation within an Orbitrap, a transient signal may not be stable until the ions settle into their
Apodization
Post-translational carbohydrate modification of proteins
Glycoproteomics (IsoTaG) analysis of sialylated N- and O-glycopeptides on an Orbitrap Fusion Tribrid using azido and alkynyl sugars". Analytical and Bioanalytical
O-GlcNAc
Edible substance extracted from leaves
has been developed that uses an ultra-high-resolution hybrid ion trap orbitrap mass spectrometer with electrospray ionization coupled to an ultra-high
Leaf_protein_concentrate
heteroatoms. The data can also be represented with a Van Krevelen diagram. Orbitrap Marshall, Alan G.; Rodgers, Ryan P. (2004). "Petroleomics: The Next Grand
Petroleomics
Chemical compound
of Xin-Su-Ning capsules acting on arrhythmia by integrating UHPLC-LTQ-Orbitrap, ADME prediction and network target analysis". Phytomedicine. 44: 117–128
Palmatine
Gant, Julia Chamot-Rooke, Article 105296 "Bottom-up Proteomics". PlanetOrbitrap. Thermo Fisher Scientific. Retrieved 20 November 2017. Washburn MP, Wolters
Bottom-up_proteomics
Species of flowering plant
Cakilcioglu, Ugur; Sinan, Kouadio Ibrahime; Zengin, Gokhan (2023-06-08). "Orbitrap Mass Spectrometry-Based Profiling of Secondary Metabolites in Two Unexplored
Eminium_intortum
Mass spectrometry method for fragmenting complex macromolecules
of the instrument interfered with the high-resolution analyzer in LQT-Orbitrap and quadrupole time-of-flight (QTOF), so alternate ionization methods for
Electron-transfer dissociation
Electron-transfer_dissociation
American chemist
(Allium cepa), ramsons (Allium ursinum) and human garlic breath using SESI-Orbitrap MS". Food Chemistry. 397: e54501. doi:10.1016/j.foodchem.2022.133804. PMID 35932686
Eric_Block
Techniques used to study protein–small molecule interactions
vast majority of proteomic studies are analyzed using high-resolution orbitrap mass spectrometers and samples are processed using a generalizable workflow
Chemoproteomics
Chemical compound found in some lichens
fumarprotocetraric acid lactones identified and characterized by UHPLC-PDA/ESI/ORBITRAP/MS/MS from the Antarctic lichen Cladonia metacorallifera". Separations
Connorstictic_acid
Analytical chemistry technique
(August 2020). "A robust sheath-flow CE–MS interface for hyphenation with Orbitrap MS". Electrophoresis. 41 (15): 1280–1286. doi:10.1002/elps.202000044. PMID 32358866
Capillary electrophoresis–mass spectrometry
Capillary_electrophoresis–mass_spectrometry
Chemical compound
liquid chromatography/electrospray ionization linear ion trap quadrupole Orbitrap mass spectrometry and liquid hromatography/electrospray ionization tandem
Prunin
American professor and geologist
designed novel instrumentation for high-precision isotope analysis, including Orbitrap mass spectrometers capable of resolving molecular isotopic structures.
John_Eiler
ionization and analysed using a variety of mass analysers, including Orbitraps, Ion Cyclotrons and Time-Of-Flight. Effective fractionation is critical
Top-down_proteomics
Scientist and physician (b. 1975)
Nano-flow Chromatography and Accumulated Ion Monitoring on Quadrupole-Orbitrap-Linear Ion Trap Mass Spectrometer". Molecular & Cellular Proteomics. 16
Alex_Kentsis
Swiss manufacturer of mass spectrometry equipment
"Mass Spec Firm Spectroswiss Develops Tech to Enable Super Resolution on Orbitrap Instruments". GenomeWeb. 3 March 2023. Nagornov, K. O.; Kozhinov, A. N
Spectroswiss
British biological mass spectrometrist
of Parameters for Confident Phosphorylation Site Localization Using an Orbitrap Fusion Tribrid Mass Spectrometer". Journal of Proteome Research. 16 (9):
Claire_E._Eyers
Australian scientist
molecules, such as intact lipids and metalloporphyrins, are analysed by Orbitrap liquid chromatography-mass spectrometry (LC-MS). Grice collaborated with
Kliti_Grice
Study of complete lipid profile in organisms
in total lipid extracts: a study by quadrupole TOF and linear ion trap-orbitrap mass spectrometry". J Mass Spectrom. 41 (3): 372–89. Bibcode:2006JMSp.
Lipidomics
ions with a mass resolution of 100,000 when coupled with a quadrupole orbitrap mass spectrometer. The advantages of using LSI includes a solvent-free
Laser_spray_ionization
Ohmic contact Onset of deconfinement Optode Optoelectric nuclear battery Orbitrap Outer space Particle-in-cell Particle accelerator Paschen's law Peek's
List of plasma physics articles
List_of_plasma_physics_articles
Chemical compound
plasma by ultra-high-performance liquid chromatography-quadrupole exactive Orbitrap mass spectrometry and its application to pharmacokinetic studies". Biomedical
Evernic_acid
Ionization Method
mass spectrometers such as time-of-flight mass spectrometers (TOF-MS) or Orbitrap-MS for non-target analysis, where the entire substance spectrum of a sample
Soft Ionization by Chemical Reaction in Transfer
Soft_Ionization_by_Chemical_Reaction_in_Transfer
Ionization technique
multiple manufacturers, such as triple quadrupole, time-of-flight, and orbitrap mass spectrometers. On the downside, since no chromatographic separation
Laser diode thermal desorption
Laser_diode_thermal_desorption
Alpha FT-IR spectrometer. 2006: Gold - Thermo Electron Corp - Finnigan LTQ Orbitrap hybrid mass spectrometer; Silver - Chata Biosystems Inc - Chem+Mix; Bronze
Pittcon_Editors'_Awards
American chemist
British Mass Spectrometry Society Desorption electrospray ionization MIKES Orbitrap "Chemistry - Research Analytics". Archived from the original on December
R._Graham_Cooks
Investigation of microscopic remains on archaeological artefacts
chemical (CI) ionisation) and types of analysers (e.g. Quadrupole and Orbitrap). For hydrophobic lipids, they are extracted from biological or archaeological
Organic_residue_analysis
Orbital period Orbital plane (astronomy) Orbital state vectors Orbiting body Orbitrap Ordal Demokan Order and disorder (physics) Order operator Ordered exponential
Index_of_physics_articles_(O)
using matrix-assisted laser desorption ionization (MALDI) paired with an orbitrap high-resolution mass spectrometer. Another suggested approach has been
Polyelectrolyte theory of the gene
Polyelectrolyte_theory_of_the_gene
Chemical compound
Fumarprotocetraric Acid Lactones Identified and Characterized by UHPLC-PDA/ESI/ORBITRAP/MS/MS from the Antarctic Lichen Cladonia metacorallifera". Separations
Succinprotocetraric_acid
Dutch mass spectrometry researcher
A. (2017). "Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids". Chemical Communications
Ron_Heeren
Chemist
Combined Precursor Isotopic Labeling and Isobaric Tagging Performance on Orbitraps To Study the Peripheral Proteome of Alzheimer's Disease". Analytical Chemistry
Renã_A._S._Robinson
ORBITRAP
ORBITRAP
ORBITRAP
ORBITRAP
Boy/Male
Hindu, Indian, Sanskrit
King of the Risen Sun
Girl/Female
Hindu, Indian
Lakshmi
Boy/Male
Tamil
Devachandra | தேவசஂதà¯à®°à®¾
Moon among the gods
Boy/Male
Hindu, Indian
The Sun
Surname or Lastname
English
English : variant of Treece.
Boy/Male
Sikh
Firm in battle, A widow
Surname or Lastname
English (chiefly Norfolk)
English (chiefly Norfolk) : occupational name for the master of a ship, Middle English skipper (from Middle Low German, Middle Dutch schipper).English (chiefly Norfolk) : from an agent derivative of Middle English skip(en) ‘to jump or spring’ (apparently of Scandinavian origin), hence an occupational name for an acrobat or professional tumbler, or nickname for a high-spirited person.English (chiefly Norfolk) : occupational name for a basket-maker, from an agent derivative of Middle English skipp(e), skepp(e) ‘basket’, ‘hamper’ (Old Norse skeppa).
Girl/Female
Arabic, Indian, Muslim, Punjabi, Sikh
Blessed; God Gifted
Boy/Male
Hindu, Indian, Marathi
The One who is Deeply Religious
Boy/Male
African, Arabic, Christian, French, German, Gujarati, Hindu, Indian, Muslim, Pashtun, Sindhi
A Prophet's Name; The Biblical Elijah is the English Language Equivalent
ORBITRAP
ORBITRAP
ORBITRAP
ORBITRAP
ORBITRAP