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Drug biological activity
Off-target activity is biological activity of a drug that is different from and not directed at that of its intended biological target. It most commonly
Off-target_activity
Type of unintended effects of genetic modification techniques
Off-target genome editing refers to nonspecific and unintended genetic modifications that can arise through the use of engineered nuclease technologies
Off-target_genome_editing
Concept in pharmacology
has offered a variety of strategies to identify off-targets on a proteome wide scale. Off-target activity Klabunde, T.; Evers, A. (2005). "GPCR antitarget
Antitarget
Gene editing method
engineered variants of the Cas9 nuclease that significantly reduce off-target activity have been developed. CRISPR-Cas9 genome editing techniques have many
CRISPR_gene_editing
Class of drugs
also reduce the activity of related proteins such as GDF11, activins, and bone morphogenetic proteins. While this off target activity can increase their
Myostatin_inhibitor
Molecule used to overcome antibiotic resistance in bacteria
In addition to its β-lactamase inhibition, clavulanic acid shows off-target activity in the nervous system by upregulating the glutamate transporter 1
Clavulanic_acid
Medication drug
other important hormonal activity. Because of its antimineralocorticoid activity and lack of undesirable off-target activity, drospirenone is said to
Drospirenone
American biotechnology company
requirements, advantageous off-target activity, and allele-specific editing capabilities, which could broaden the range of targetable diseases in the genome
Mammoth_Biosciences
Drug class
and TB-21007. Certain drugs show weak GABAA receptor NAM activity as an off-target activity that is responsible for undesirable side effects like anxiety
GABAA receptor negative allosteric modulator
GABAA_receptor_negative_allosteric_modulator
Medication class with multiple uses
antagonistic beta blocker in 1962. But pronethalol suffered from off-target activity and associated side effects and toxicity. As such, it did not enter
Beta_blocker
Pharmaceutical drug
unclear and several competing hypotheses exist. Mefloquine has known off-target activities. This includes affinity for the serotonin 5-HT2A receptor and to
Mefloquine
Techniques used to study protein–small molecule interactions
high-affinity interactions with therapeutic targets, but they may also lead to undesirable off-target activity, and they may also be substrates of metabolic
Chemoproteomics
Information technology paradigm at certain aerodromes
involves the establishment of a target start approval time (TSAT), target off block time (TOBT) and target take off time (TTOT) for each flight. Airport
Airport Collaborative Decision Making
Airport_Collaborative_Decision_Making
Subdiscipline of medicine employing interaction of drugs with light for drug delivery
selective activation of the biomolecules helps prevent or minimize off-target activity and systemic side effects. Moreover, light being the regulatory element
Photopharmacology
American supernatural horror franchise
the demon when the daughter, Leila, is targeted as she was born on the same date as Hunter from Paranormal Activity 2. Along with normal recorders, the family
Paranormal Activity (franchise)
Paranormal_Activity_(franchise)
Science of drugs and medications and their effects
epigenetic reprogramming. Therefore, drugs should be screened for off-target activity by gene expression profiling, in addition to conventional ligand
Pharmacology
Artificial enzymes
theoretically yield less off-target activity. A comparison of a pair of 3-finger ZFNs and a pair of 4-finger ZFNs detected off-target cleavage in human cells
Zinc-finger_nuclease
Form of advertising
advertising currently uses second-order proxies for targets, such as tracking online or mobile web activities of consumers, associating historical web page
Targeted_advertising
Chemical compound
reaction with glutathione. B-elimination reaction follows, resulting in off-target activity and a loss of efficacy of the drugs. No general method exist for
Maleimide
Dhekelia, and the West Bank. Additional alleged activity was reported in Azerbaijan, while maritime targets included vessels of the United States Navy and
List of attacks during the 2026 Iran war
List_of_attacks_during_the_2026_Iran_war
genome in what constitutes dramatic off-target activity. It is therefore necessary for fusion constructs and targeting mechanisms to be optimized for reliable
Epigenome_editing
Entactogen drug
B (2024). "Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA". Front Neurosci. 18 1353131. doi:10.3389/fnins.2024.1353131
Methylone
Potent human TAAR1 antagonist
stability, and a favorable preliminary profile of off-target activity (≥1–10 μM at 42 other targets). It is far more potent (893-fold) as an antagonist
RTI-7470-44
Small molecule (PROTAC)
PROTACs need only to bind their targets with high selectivity (rather than inhibit the target protein's enzymatic activity), efforts are underway to retool
Proteolysis_targeting_chimera
Enzymes that cleave DNA in specific ways
range like CRISPR based genome editing[clarification needed]. The off-target activity of an active nuclease may lead to unwanted double-strand breaks and
Transcription activator-like effector nuclease
Transcription_activator-like_effector_nuclease
Releases: Hot Off the Press & Archives". Target Corporate. Archived from the original on 2015-04-30. Retrieved 2015-06-20. "Sources: Target Investigating
History_of_Target_Corporation
Dopamine agonist medication
occasionally prescribed off-label for depression. Its effectiveness as an antidepressant may be a product of its strong partial agonistic activity on and preferential
Pramipexole
Type of genetic engineering
construction and testing of the proteins created for targeting each DNA sequence. Because off-target activity of an active nuclease would have potentially dangerous
Genome_editing
RNA molecule that specifies a target sequence
Gang (June 2014). "CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences". Nucleic Acids
Guide_RNA
Chemical compound
9.08,11]dodecane-3-ol with sigma (s) receptor ligands modulates off-target activity and subtype selectivity". Bioorg. Med. Chem. Lett. 21 (12): 3622–3626
NE-100
American microbiologist
Nelson, D. C. Bensen, and K. J. Shaw. 2013. Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular
Karen_Joy_Shaw
2014 film by Christopher Landon
Paranormal Activity: The Marked Ones is a 2014 American found footage supernatural horror film written and directed by Christopher Landon. It is a spin-off and
Paranormal Activity: The Marked Ones
Paranormal_Activity:_The_Marked_Ones
Chemical compound
progesterone receptor, the biological target of progestogens like progesterone. It has no other important hormonal activity. The medication is a prodrug of
Allylestrenol
and phage-induced directed evolution of Cas9 to engineer reduced off-target activity". PLOS ONE. 15 (4) e0231716. Bibcode:2020PLoSO..1531716C. doi:10
Mutagenesis (molecular biology technique)
Mutagenesis_(molecular_biology_technique)
Technique in molecular biology
and phage-induced directed evolution of Cas9 to engineer reduced off-target activity". PLOS ONE. 15 (4) e0231716. Bibcode:2020PLoSO..1531716C. doi:10
Site-directed_mutagenesis
Sexual stimulation of one's own genitals
psychological benefits have been attributed to a healthy attitude toward sexual activity in general and to masturbation in particular. Masturbation is considered
Masturbation
Pharmaceutical compound
model of multiple sclerosis. Originally believed to be selective, off-target activities of WOBE437 have subsequently been identified and described. WOBE437
WOBE437
Stage of drug discovery
synthesize lead compounds, new analogs with improved potency, reduced off-target activities, and physiochemical/metabolic properties suggestive of reasonable
Hit_to_lead
Combination drug
progestogens in breast cancer may be more related to their off-target activity than their progestogenic activity. In accordance, a study found that the effectiveness
Estradiol valerate/gestonorone caproate
Estradiol_valerate/gestonorone_caproate
protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases". Nucleic Acids Res. 39 (1): 381–92. doi:10
Recombinant AAV mediated genome engineering
Recombinant_AAV_mediated_genome_engineering
Research tool in genomics
the possible PAM sites are identified and selected for. On- and off-target activity should be analysed, as should GC content, and homopolymer stretches
Genome-wide CRISPR-Cas9 knockout screens
Genome-wide_CRISPR-Cas9_knockout_screens
Laws criminalising certain sexual acts
enforced to target against sexual activities between individuals of the opposite sex, and have mostly been used to target against sexual activities between
Sodomy_law
Using a bow to shoot arrows
combat. In modern times, it is mainly a competitive sport and recreational activity. A person who practices archery is typically called an archer, bowman,
Archery
Comic strip character from The Beano
activities and attitudes. From his first appearance in 1953, Walter became the target of Dennis' pranks and misbehaviour, but he would brush it off.
Walter_the_Softy
Television show filmed in Vancouver
Human Target is an American spy action television series that was broadcast by Fox in the United States. Based loosely on the Human Target comic book character
Human_Target_(2010_TV_series)
Pharmaceutical compound
Compound 22 was also screened for off-target activity at 47 targets at a concentration of 10 μM. The screened targets included monoamine receptors, monoamine
Compound 22 (TAAR1 antagonist)
Compound_22_(TAAR1_antagonist)
Military doctrinal concept
collection methods. This includes warning (to include ballistic missile activity), targeting analysis, threat capability assessment, situational awareness, battle
Intelligence, surveillance, target acquisition, and reconnaissance
Intelligence,_surveillance,_target_acquisition,_and_reconnaissance
Pharmaceutical compound
sustained efficacy in a rat model of Parkinson's disease and limited off-target activity". British Journal of Pharmacology bph.70351. doi:10.1111/bph.70351
Matsupexole
Medication producing effects similar to progesterone
progestogenic activity but rather due to off-target activities (e.g., androgenic activity, glucocorticoid activity, antimineralocorticoid activity). At high
Progestogen_(medication)
Group of people toward which an organization has decided to aim its marketing efforts
as the focus of its activities, in which case, it would normally identify a primary target and a secondary target. Primary target markets are those market
Target_market
Automotive vehicle capable of driving across difficult terrain beyond sealed roads
and other low-traction terrains. Off-road vehicles are widely used in various contexts, from recreational activities to practical applications like agriculture
Off-road_vehicle
South Korean biochemist (born 1964)
Jungjoon; Kim, Jin-Soo (30 June 2015). "Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9". Molecules and
Kim_Jin-soo_(biologist)
Philippine Navy tanker
Philippine and U.S. forces hit the target ship during the activity. It sank around 10:49 a.m. at about 15 kilometers off Laoag City, Ilocos Norte Province
BRP_Lake_Caliraya
Baseball stadium in Minneapolis, Minnesota
scored. Target Field doesn't come off as being primarily a pitcher's park anymore. In particular, the low left-field wall is an attractive target for right-handed
Target_Field
2025 protests against Donald Trump
nationwide 'Hands Off!' rallies". www.wctv.tv. Archived from the original on April 7, 2025. Retrieved April 6, 2025. "Hands Off! protests target Trump, Musk
Hands_Off_protests
Pharmaceutical compound
simultaneously at multiple targets, with the aim being to find compounds which would show both SSRI and α2A agonist activity, but off-target screening subsequently
Z8779877149
Connected or disconnected state for equipment and services
refer to either computing activities performed while disconnected from the Internet, or alternatives to Internet activities (such as shopping in brick-and-mortar
Online_and_offline
Identification of a military target entity
artillery, rockets, missiles and identifying other High Pay-off Targets (HPTs) and High Value Targets (HVTs). HPTs, which if successfully engaged and neutralized
Target_acquisition
U.S. intelligence and covert action agency
while attacking civilian targets inside Cuba: 'our covert activities would now be directed toward the destruction of targets important to the [Cuban]
Central_Intelligence_Agency
Chemical compound
glucocorticoid, or antimineralocorticoid activities, and hence is a pure progestogen with no off-target activity. Clinical studies have found that, on the
Algestone_acetophenide
American criminal (born 1971)
November 12, 1971) is an American criminal known for his modus operandi activity of breaking and entering into McDonald's locations by drilling through
Jeffrey_Manchester
Sports involving firearms used to hit targets
made getting smaller shot groups on the target more attainable as the possibility of the firearm moving off the aiming point after the shooter pressed
Shooting_sports
validate molecular targets. While early definitions for chemical probes, including criteria for potency, selectivity, and cellular activity, focused on reversible
Chemical_probe
Attacking player position in football
long history in the game, but the terminology to describe their playing activity has varied over the years. Originally, such players were termed inside
Forward (association football)
Forward_(association_football)
Use of AI by the Israel Defense Forces in the Gaza war
the IDF said "more than 12,000" targets in Gaza had been identified by its target administration division. The activities of the division, formed in 2019
AI-assisted targeting in the Gaza Strip
AI-assisted_targeting_in_the_Gaza_Strip
Species of small, biologically immortal jellyfish
commonly seen in most jellyfish. Jellyfish, also known as medusae, then bud off these polyps and continue their life in a free-swimming form, eventually
Turritopsis_dohrnii
Cast of American crime drama TV series
Moltisanti for stolen credit card numbers, were involved in terrorist activity. Tony provides their names and a cell phone number to Agent Harris, who
List of The Sopranos characters
List_of_The_Sopranos_characters
Class of pharmaceutical drugs
possess off-target actions including progestogenic, antimineralocorticoid, and/or glucocorticoid activity in addition to their antiandrogen activity, and
Antiandrogen
Temporary housing company
activity is in North Dakota, as a result of the North Dakota oil boom from the Bakken Formation. In addition to its North Dakota properties, Target Hospitality
Target_Hospitality
Attraction between people of the same sex or gender
attraction or sexual activity include men who have sex with men or MSM (used in the medical community when specifically discussing sexual activity) and homoerotic
Homosexuality
Portrayal of sexual subject matter
Pornography usage is considered a widespread recreational activity in-line with other digital activities such as social media or video games. People who regard
Pornography
Extrajudicial assassination by governments
Executive Order 12036 Executive Order 12333 High-value target International counter-terrorism activities of the CIA Justifiable homicide Kill authorizations
Targeted_killing
Brevity code for NATO communications
elevation information on a potential target.** [A/A] [A/S] [AIR-MAR] CEASE [activity] Discontinue stated activity (e.g., CEASE BUZZER, LASER, SPARKLE,
Multi-service tactical brevity code
Multi-service_tactical_brevity_code
United States government units targeted by the Department of Government Efficiency
focused on the Public Building Service (PBS) as they target offices to RIF. 600 employees were laid off on March 3 and on March 5, in one of PBS regions,
US federal agencies targeted by DOGE
US_federal_agencies_targeted_by_DOGE
Ascended master teachings religious movement
The I AM Activity, also referred to as the I AM Temple, is a neo-Theosophical religious movement founded in the early 1930s by Guy Ballard (1878–1939)
"I_AM"_Activity
Transfer of the meaning of something in one language into another
communication of the meaning of a source-language text by means of an equivalent target-language text. The English language draws a terminological distinction (which
Translation
Abandoned drug for bipolar depression
activity, and reversed stress-induced reinstatement of cocaine-seeking behavior. However, PF-04455242 also showed a variety of other weak off-target activities
PF-04455242
Biomolecule
siRNA and target mRNA near the cleaving site. Other times, the Argonaute proteins of the RISC lack endonuclease activity even when the target mRNA and
Small_interfering_RNA
Covert and paramilitary unit of the CIA
The Special Activities Center (SAC) is the center of the United States Central Intelligence Agency (CIA) responsible for covert operations. The clandestine
Special_Activities_Center
Marvel Comics fictional character
predominantly Black neighborhood, where they engaged in "vigilante-style activity." Alfonso III, Fernando (February 26, 2017). "Chief removes Punisher emblem
Punisher
Pharmaceutical compound
prevention but as having serious side effects due to undesirable off-target activities. Whereas methysergide is functionally an agonist of the serotonin
XC-101
Fear and dislike of that which is perceived to be foreign or strange
suspicion of one group's activities by members of the other group, a desire to eliminate the presence of the group that is the target of suspicion, and fear
Xenophobia
2025 United States District Court case
E.K. v. Department of Defense Education Activity is a case pending in the U.S District Court for the Eastern District of Virginia brought by the American
E.K. v. Department of Defense Education Activity
E.K._v._Department_of_Defense_Education_Activity
Analytical technique to study proteins
der Wel, Tom; Soethoudt, Marjolein (2017-06-09). "Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474". Science
Activity-based_proteomics
Crop planted to manage erosion and soil quality
can increase microbial activity in the soil, which has a positive effect on nitrogen availability, nitrogen uptake in target crops, and crop yields.
Cover_crop
American actor and comedian (1951–2014)
inflated and immediately released. I watched in awe as he virtually caromed off the walls of the classrooms and hallways. To say that he was 'on' would be
Robin_Williams
Practice of leading the work of a team to achieve goals and criteria at a specified time
Project – improve the direct output of an activity (quantity, quality, time) within a business process with a targeted completion time up to 3 months. Level
Project_management
the Trump administration took a series of actions using the government to target his political opponents and civil society. News outlets described his actions
Targeting of political opponents and civil society under the second Trump administration
Targeting_of_political_opponents_and_civil_society_under_the_second_Trump_administration
Advanced persistent threat operated by the Chinese government
to a target, they put a strong emphasis on stealth, almost exclusively relying on living-off-the-land techniques and hands-on-keyboard activity. Volt
Volt_Typhoon
Violent tactic resulting in the attacker's intentional death
been intended to set off the load. The explosion itself did not seem to form part of a suicide attack on a specific planned target other than possibly
Suicide_attack
American naval base in Bahrain
Naval Support Activity Bahrain (or NSA Bahrain) is a United States Navy base situated in the Kingdom of Bahrain and is home to U.S. Naval Forces Central
Naval Support Activity Bahrain
Naval_Support_Activity_Bahrain
United States Navy component of JSOC
its Army and Air Force counterparts, Delta Force, Intelligence Support Activity, the 75th Ranger Regiment's Regimental Reconnaissance Company and 24th
SEAL_Team_Six
long message he received while in Alaska, apparently detailing illegal activities by his own cabinet that were allegedly unknown to him. At the end of July
List of United States presidential assassination attempts and plots
List_of_United_States_presidential_assassination_attempts_and_plots
American pastor and activist (1929–2014)
homosexual activity. This resulted in much negative attention for the family. When the Phelpses called on local churches to speak against the activity in Gage
Fred_Phelps
Attack on a human by a shark
sensing the electric fields that are generated by all animals due to the activity of their nerves and muscles. Most of the oceanic whitetip shark's attacks
Shark_attack
Series of covert and illegal projects by the FBI
intolerable in a democratic society even if all of the targets had been involved in violent activity, but COINTELPRO went far beyond that ... the Bureau
COINTELPRO
Many states also include close-in-age exemptions, which legalize sexual activity involving those under the age of consent, when both partners are close-in-age
Age of consent in the United States
Age_of_consent_in_the_United_States
Irish sports promoter and suspected crime boss (born 1977)
mainland Europe, and "has associations that facilitate international criminal activity in Europe, Asia, the Middle East, and South America." The Kinahan Cartel
Daniel_Kinahan
Physical activity that improves health
Exercise or working out is physical activity that enhances or maintains fitness and overall health. It is performed for various reasons, including weight
Exercise
Brand of binary explosive targets
an exploding target for lawful sporting activity, as solely intended by the commercial manufacturer." Under Vermont law, exploding targets were found to
Tannerite
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