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Topics referred to by the same term
Negative selection may refer to: Negative selection (natural selection), the selective removal of rare alleles that are deleterious Negative selection
Negative_selection
Selective removal of alleles that are deleterious
In natural selection, negative selection or purifying selection is the selective removal of alleles that are deleterious. This can result in stabilising
Negative selection (natural selection)
Negative_selection_(natural_selection)
Aversion to the success of one's subordinates
Negative selection is a political process that occurs especially in rigid hierarchies, most notably dictatorships, but also to lesser degrees in such settings
Negative_selection_(politics)
Type of specialized cells
cortex to the medulla, where the process continues as a negative selection. Without negative selection thymocytes are unable to respond to TCR triggering by
Thymic_epithelial_cell
Premature form of T cells present in the thymus
thymocytes into mature T cells according to either negative or positive selection. This selection process is vitally important in shaping the population
Thymocyte
Mechanism of evolution by differential reproduction
balancing selection acts to maintain genetic variation in a population, even in the absence of de novo mutation, by negative frequency-dependent selection. One
Natural_selection
Type of white blood cell
double-negative one (DN1) cells. To become T cells, the thymocytes must undergo multiple DN stages as well as positive selection and negative selection. Double
T_cell
Endocrine gland
receptors of the body (called positive selection) and not against proteins of the body (called negative selection). The thymus is largest and most active
Thymus
Elimination of autoreactive lymphocytes by the immune system
In immunology, central tolerance (also known as negative selection) is the process of eliminating any developing T or B lymphocytes that are autoreactive
Central_tolerance
Breeding for desired characteristics
Selective breeding (also called artificial selection) is the process by which humans use animal breeding and plant breeding to selectively develop particular
Selective_breeding
Evolutionary process
frequency-dependent selection, the fitness of a phenotype or genotype increases as it becomes more common. In negative frequency-dependent selection, the fitness
Frequency-dependent_selection
technique has shown its efficacy, even though it remains limited. With negative selection, the antibody used is against surface antigen(s) which are known to
Magnetic-activated cell sorting
Magnetic-activated_cell_sorting
Allele equilibrium in a population when creation equals elimination by negative selection
counteracted by negative selection, which acts to purge deleterious mutations. Setting aside other factors (e.g., balancing selection, and genetic drift)
Mutation–selection_balance
Microbiological technique
especially useful for "negative selection". However, it is more correct to refer to "negative screening" instead of using the term 'selection'. For example, if
Replica_plating
Type of genetic selection favoring one extreme phenotype
Balancing selection Disruptive selection Frequency-dependent foraging by pollinators Negative selection (natural selection) Stabilizing selection Peppered
Directional_selection
Young adult novel by Kiera Cass
The Selection is a young adult novel by Kiera Cass first published on April 14, 2012, by HarperCollins. It is the first in a five-book series, followed
The_Selection
Type of selection in evolution where a trait stabilizes around the average value
Stabilizing selection (not to be confused with negative or purifying selection) is a type of natural selection in which the population mean stabilizes
Stabilizing_selection
Disorders of adaptive immune system
(positive selection). In contrast, variants in the TYK2 gene protect against autoimmune diseases but increase the risk of infection (negative selection). This
Autoimmune_disease
Class of rule-based machine learning systems
(on negative selection) and Kephart et al. published their first papers on AIS in 1994, and Dasgupta conducted extensive studies on Negative Selection Algorithms
Artificial_immune_system
Phenomenon inducing a loss of genetic diversity
Background selection describes the loss of genetic diversity at a locus due to negative selection against deleterious alleles with which it is in linkage
Background_selection
Genetic study of ancient Neanderthal DNA
selected out of the gene pool. Barring hybrid incompatibility or negative selection, most Neanderthal DNA may descend from the children of modern human
Neanderthal_genetics
Protein-coding gene in the species Homo sapiens
guides it to thymic medulla, where negative selection takes place. ccr7 knockout mice have leaky negative selection are prone autoimmune disorders. The
C-C_chemokine_receptor_type_7
are considered to result in positive selection, whereas high affinity interactions are typical for negative selection and interaction with mTECs. MHC II
Cortical thymic epithelial cells
Cortical_thymic_epithelial_cells
Molecule triggering an immune response
antigens. Antibodies usually do not react with self-antigens due to negative selection of T cells in the thymus and B cells in the bone marrow. The diseases
Antigen
Method for identifying the sequence-specific target site of a DNA-binding domain
clone. The two reporter genes, HIS3 and URA3, allow for positive and negative selections, respectively. At the end of the process, positive clones are sequenced
Bacterial_one-hybrid_system
Management concept by Laurence J. Peter
Founder's syndrome – Founder(s) maintaining disproportionate control Negative selection (politics) – Aversion to the success of one's subordinates Parkinson's
Peter_principle
Biological test for adaptive evolution
between species (i.e. Dn/Ds = Pn/Ps). When positive or negative selection (natural selection) influences nonsynonymous variation, the ratios will no
McDonald–Kreitman_test
Gene conferring a phenotype useful for artificial selection
antibiotic selection. Negative or counterselectable markers are selectable markers that eliminate or inhibit growth of the host organism upon selection. An example
Selectable_marker
Human hybridization during the Paleolithic
influenced the biology of modern humans through both positive and negative selection. Adaptive introgression provided genetic variants that proved beneficial
Interbreeding between archaic and modern humans
Interbreeding_between_archaic_and_modern_humans
called negative selection. If the maturing B cells strongly interact with these self antigens, they undergo death by apoptosis. Negative selection is important
Receptor_editing
involved in selection as they do not impact an organism’s fitness. These findings began to show that the positive or negative selection in Darwinian
The Neutral Theory of Molecular Evolution
The_Neutral_Theory_of_Molecular_Evolution
Aspect of T-cell interactions
involves two distinct developmental stages: positive selection and negative selection. Positive selection ensures that any T-cells with a high enough affinity
MHC_restriction
Gene variant
experienced negative selection pressure as a result of pathogens that became more widespread during Roman expansion. The idea that negative selection played
CCR5-Δ32
Aversion to the success of one's peers
Anti-intellectualism Crab mentality Discrimination of excellence Leveling mechanism Negative selection (politics) Overachievement Schadenfreude Taking the piss The Moral
Tall_poppy_syndrome
Group of bacteria that do not retain the Gram stain used in bacterial differentiation
Gram-negative bacteria are bacteria that, unlike gram-positive bacteria, do not retain the crystal violet stain used in the Gram staining method of bacterial
Gram-negative_bacteria
Removal of autoreactive B and T cells before they become immunocompetent
recognition and destruction of the self host cells, making it a type of negative selection. Ultimately, clonal deletion plays a role in central tolerance. Clonal
Clonal_deletion
Bias in a statistical analysis due to non-random selection
Selection bias is the bias introduced by the selection of individuals, groups, or data for analysis in such a way that the association between exposure
Selection_bias
in these autoreactive T cells (negative selection) or they deviate them to become T regulatory cells (Treg selection), which suppress self-reactive T
Promiscuous_gene_expression
Book
proposes Putt's Law and Putt's Corollary which are principles of negative selection similar to the Dilbert principle proposed by Scott Adams in 1995.
Putt's Law and the Successful Technocrat
Putt's_Law_and_the_Successful_Technocrat
Extinct species of human
that negative selection was likely acting on archaic variants, and provides an appropriate set of null models for evaluating positive selection on introgressed
Neanderthal
Technique for producing oligonucleotides that specifically bind to a target
specificity of aptamers selected by a given SELEX procedure, a negative selection, or counter selection, step can be added prior to or immediately following target
Systematic evolution of ligands by exponential enrichment
Systematic_evolution_of_ligands_by_exponential_enrichment
cells must generate a functional B cell receptor (BCR) and overcome negative selection induced by reactivity with autoantigens. Transitional cells can be
Transitional_B_cell
Removal of autoreactive T and B cells outside of the primary lymphoid organs
lymphocytes in the periphery. Dendritic cells (DCs) participate in the negative selection of autoreactive T cells in the thymus, but they also mediate peripheral
Peripheral_tolerance
Mating with individuals with dissimilar phenotypes
Disassortative mating (also known as negative assortative mating or heterogamy) is a mating pattern in which individuals with dissimilar phenotypes mate
Disassortative_mating
thymocytes determines whether the thymocytes undergo positive or negative selection. Thymic nurse cells (TNCs) are a sub-population of cortical thymic
Thymic_nurse_cell
Formal constraint in quantum mechanics
chemistry, a selection rule, or transition rule, formally constrains the possible transitions of a system from one quantum state to another. Selection rules
Selection_rule
Selective trading based on possession of hidden information
suggested that, the utilization of collateral could reduce the negative effect of adverse selection. In practice, through the promotion of information sharing
Adverse_selection
Type of white blood cell
B cells do not receive the proper signals and cease to develop. Negative selection occurs through the binding of self-antigen with the BCR; if the BCR
B_cell
Proposed cause of autoimmunity
positive selection, but bind strongly to self-antigens are negatively selected also by active induction of apoptosis. This negative selection is known
Molecular_mimicry
Ecological theory concerning the selection of life history traits
The r/K selection theory is an evolutionary hypothesis examining the selection of traits in an organism that trade off between quantity and quality of
R/K_selection_theory
Klein L, Kyewski B, Allen PM, Hogquist KA (June 2014). "Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)". Nature
Medullary thymic epithelial cells
Medullary_thymic_epithelial_cells
Doubt about God's existence
considered the question of God's existence but has not reached a positive or negative conclusion. In this sense, someone who does not comprehend the question
Agnosticism
Hypothesis about ADHD
positive selection. Furthermore, a 2020 study found that ADHD allele frequency has been decreasing for up to 35,000 years, indicating negative selection. These
Hunter versus farmer hypothesis
Hunter_versus_farmer_hypothesis
Satirical observation by Scott Adams
do not manage and those who manage what they do not understand."). Negative selection (politics) – Aversion to the success of one's subordinates "Funny
Dilbert_principle
Photographic image produced directly from film
in the selection of images for further enlargement, and for cataloging and identification purposes. For 120 roll film (once a common negative size for
Contact_print
Cell from a primary tumor carried by blood circulation
epithelial cancer cells in breast cancer patients by negative selection. The principle of negative selection is based on the retrieval of all blood cells by
Circulating_tumor_cell
Highest-ranking officer of an organization
senior executives are governed by the board of directors. The proper selection and evaluation of the CEO and the executive team is critical to the company’s
Chief_executive_officer
1871 book by Charles Darwin
choices for their wellbeing. For each tendency of society to produce negative selections, Darwin also saw the possibility of society to itself check these
The Descent of Man, and Selection in Relation to Sex
The_Descent_of_Man,_and_Selection_in_Relation_to_Sex
complex (MHC) are known as dominant epitopes. These are stimulants of negative selection mechanisms to remove potentially self destructing autoreactive T cells
Cryptic_self_epitopes
Freedom from interference by other people
Negative liberty, or negative freedom, is freedom from interference by other people. Negative liberty is primarily concerned with freedom from external
Negative_liberty
2026 United States Supreme Court case
including both Learning Resources, Inc. v. Trump and Trump v. V.O.S. Selections, Inc., challenging the president's authority to issue tariffs under IEEPA
Learning Resources, Inc. v. Trump
Learning_Resources,_Inc._v._Trump
English naturalist and biologist (1809–1882)
process he called natural selection, in which the struggle for existence has a similar effect to the artificial selection involved in selective breeding
Charles_Darwin
American musician (1962–2010)
bassist, and composer of the gothic metal band Type O Negative. Before forming Type O Negative, Steele had formed the heavy metal band Fallout and the
Peter_Steele
(complexity). Both of these tendencies can be overcome by selection, including stabilizing or negative selection, with the result that diversity or complexity often
Zero-Force_Evolutionary_Law
Cellular process
epithelial cells, and cross present "self" peptides on MHC class I as a negative selection check on cytotoxic T cells that have a high affinity for self peptides
Cross-presentation
Indirect selection process in breeding
antibiotic selection. Negative selectable markers are selectable markers that eliminate or inhibit growth of the host organism upon selection. An example
Marker-assisted_selection
Genetic technique to create random mutants
example of a negative selection method. Saenz HL, Dehio C (October 2005). "Signature-tagged mutagenesis: technical advances in a negative selection method for
Signature-tagged_mutagenesis
Cancer selection can be viewed through the lens of natural selection. The animal host's body is the environment which applies the selective pressures
Cancer_selection
Artificial selection of the sex of offspring
Sex selection is the attempt to control the sex of the offspring to achieve a desired sex. It can be accomplished in several ways, both pre- and post-implantation
Sex_selection
Hard negative mining, also referred to as hard negative sampling, is a family of techniques in machine learning for selecting or constructing negative samples
Hard_negative_mining
2020 film by Kyle Rankin
North America on their platform on January 14, 2021. It received generally negative reviews from critics. High school student Zoe Hull struggles with the death
Run_Hide_Fight
Natural selection for extreme trait values over intermediate ones
Disruptive selection. Character displacement Balancing selection Directional selection Negative selection (natural selection) Stabilizing selection Sympatric
Disruptive_selection
Immune system protein
proteins are eliminated through cell death (apoptosis). Thus AIRE drives negative selection of self-recognizing T cells. When AIRE is defective, T cells that
Autoimmune_regulator
Men's association football team
2026, after the match against Spain. Positive record Neutral record Negative record March 2007 October 2007 – June 2008 July 2015 – October 2015 April
Argentina national football team
Argentina_national_football_team
Mode of natural selection
Fecundity selection, also known as fertility selection, is the fitness advantage resulting from selection on traits that increases the number of offspring
Fecundity_selection
State of unresponsiveness of the immune system
the same antigen, autoreactivity is held in check. This process of negative selection ensures that T and B cells that could initiate a potent immune response
Immune_tolerance
Species of fly
Sepsis thoracica shows positive directional selection in body size that corresponds with negative selection of melanism. In addition, body size and coloration
Sepsis_thoracica
but his cinematic portrayals, particularly in the 2021 film, have been negatively received. Michael Kennedy of Screen Rant commented in 2021, "While the
Characters of the Mortal Kombat series
Characters_of_the_Mortal_Kombat_series
Social media platform owned by Meta
for its success and influence, Instagram has also been criticized for negatively affecting teens' mental health, its policy and interface changes, its
method with flexible and balanced control of false negatives and false positives for hit selection in RNA interference high-throughput screening assays"
Hit_selection
In genetics, a stretch of DNA sequences located between genes
regions will evolve slowly because their sequence is maintained by negative selection. In species with very large genomes, a large percentage of intergenic
Intergenic_region
Use of knowledge for practical goals
to economic development and improves human prosperity, it can also have negative impacts such as pollution and resource depletion, and can cause social
Technology
Process in evolutionary theory
Apostatic selection is a form of negative frequency-dependent selection. It describes the survival of individual prey animals that are different (through
Apostatic_selection
from medullary thymic epithelial cells (mTECs) and also function in negative selection of self-reactive T cells. Some subsets of these cells were observed
Thymic_mimetic_cells
Obligation on a party in a dispute to provide sufficient warrant for their position
to prove negative claims. Philosophers Steven D. Hale and Stephen Law state that the phrase "you cannot prove a negative" is itself a negative claim that
Burden_of_proof_(philosophy)
Business practice
Negative option billing is a business practice in which customers are given goods or services that were not previously ordered, and must either continue
Negative_option_billing
Hostility, prejudice, or discrimination against Jews
Antisemitic tendencies may be motivated primarily by negative sentiment towards Jews as a people or negative sentiment towards Jews with regard to Judaism.
Antisemitism
Men's association football team
after the match against Norway. Positive Record Neutral Record Negative Record AFA and CBF differ from the total match count. Here, it shows only
Brazil_national_football_team
selection gradient indicates disruptive selection. When, β= 0 and γ is significantly negative, the selection gradient indicates stabilizing selection
Selection_gradient
American evolutionary biologist and sociobiologist (1943–2026)
proposing how natural selection could evolve ways to detect cheaters. His next major work, "Parental investment and sexual selection", was published the
Robert_Trivers
International governing body of association football
UEFA Player Eligibility Rules: Major Changes in European Football and the Negative Effect on Minors" (PDF). Emory International Law Review. Archived from
FIFA
2010 book by Christopher Ryan and Cacilda Jethá
a non-monogamous, non-polygynous history. The authors argue that mate selection among pre-agricultural humans was not the subject of intragroup competition
Sex_at_Dawn
Protein-coding gene in the species Homo sapiens
et al. (August 1995). "Essential role for ZAP-70 in both positive and negative selection of thymocytes". Nature. 376 (6539): 435–438. Bibcode:1995Natur.376
ZAP70
Warm-blooded animals with wings and feathers
breeding situations. Many types of avian sexual selection have been identified; intersexual selection, also known as female choice; and intrasexual competition
Bird
Study of the role of genetic factors in determining health and disease
presence of evolutionary pressures that induce negative selection during molecular evolution. This negative selection can be determined by tracking the skewness
Genetic_epidemiology
Personal tendency towards negative emotions and poor self-concept
In psychology, negative affectivity (NA), or negative affect, is a personality variable that involves the experience of negative emotions and poor self-concept
Negative_affectivity
American filmmaker (born 1952)
(2007), and Don't Worry, He Won't Get Far on Foot (2018) while receiving negative receptions for his films Even Cowgirls Get the Blues (1993), Psycho (1998)
Gus_Van_Sant
Type of immune cell involved in germinal center formation and maintenance
antigen is re-encountered. TFH cells are also thought to facilitate negative selection of potentially autoimmune-causing mutated B cells in the germinal
Follicular_B_helper_T_cells
Supreme being in theistic belief systems
medieval philosophers approach to knowledge of God through negative attributes, called Negative theology. For example, one should not say that God is wise
God
1932 dystopian novel by Aldous Huxley
frightening vision of the future. Huxley referred to Brave New World as a "negative utopia", somewhat influenced by Wells's own The Sleeper Awakes (dealing
Brave_New_World
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