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Presence of myoglobin in the urine
Myoglobinuria is the presence of myoglobin in the urine, which usually results from rhabdomyolysis or muscle injury. Myoglobin is present in muscle cells
Myoglobinuria
Condition in which damaged skeletal muscle breaks down rapidly
quantity of myoglobin exceeds the binding capacity of haptoglobin. Myoglobinuria, the presence of myoglobin in the urine, occurs when the level in plasma
Rhabdomyolysis
Enzyme of the respiratory chain encoded by the mitochondrial genome
deficiency, colorectal cancer, sensorineural deafness, and recurrent myoglobinuria. In humans, the MT-CO1 gene is located from nucleotide pairs 5904 to
Cytochrome c oxidase subunit I
Cytochrome_c_oxidase_subunit_I
Muscular diseases caused by defects in metabolic processes
or pseudohypertrophy) especially of the calves, Reddish-brown urine (myoglobinuria) and considerable breakdown of muscle tissue (rhabdomyolysis). The degree
Metabolic_myopathy
Enzyme of the respiratory chain encoded by the mitochondrial genome
optic neuropathy, mitochondrial complex IV deficiency, and recurrent myoglobinuria . The MT-CO3 gene produces a 30 kDa protein composed of 261 amino acids
Cytochrome c oxidase subunit III
Cytochrome_c_oxidase_subunit_III
Class of enzymes
Mutations of the M subunit have been linked to the rare disease exertional myoglobinuria (see OMIM article), and mutations of the H subunit have been described
Lactate_dehydrogenase
Human disease caused by deficiency of a muscle enzyme
previous episodes of myoglobinuria and 6.8% had normal CK (including those with fixed muscle weakness); so an absence of myoglobinuria and normal CK should
Glycogen storage disease type V
Glycogen_storage_disease_type_V
Medical condition
asymptomatic increases in serum creatine kinase and muscle cramps with myoglobinuria. Because dystrophin is located on the X chromosome, dystrophinopathy
Dystrophinopathy
Array of tests performed on urine
cells (hematuria), free hemoglobin (hemoglobinuria), or myoglobin (myoglobinuria). Red blood cells can sometimes be distinguished from free hemoglobin
Urinalysis
Extremely venomous snake native to Australia
myoglobin into the bloodstream; this pigment is excreted in the urine (myoglobinuria), which may appear reddish‑brown, and can severely damage renal tubules
Inland_taipan
Medical condition
males. CPT II deficiency is also the most frequent cause of hereditary myoglobinuria. The three main types of carnitine palmitoyltransferase II deficiency
Carnitine palmitoyltransferase II deficiency
Carnitine_palmitoyltransferase_II_deficiency
Presence of an excess of serum proteins in the urine
Interstitial nephritis Sickle cell disease Hemoglobinuria Multiple myeloma Myoglobinuria Organ rejection: Ebola virus disease Nail–patella syndrome Familial
Proteinuria
Cholesterol-lowering medication
rhabdomyolysis, and it may be very serious leading to acute kidney injury due to myoglobinuria. When rhabdomyolysis is suspected or diagnosed, atorvastatin therapy
Atorvastatin
Species of snake
Sea snake venom can cause damage to skeletal muscle with consequent myoglobinuria, neuromuscular paralysis or direct renal damage. The venoms of significant
Yellow-bellied_sea_snake
Higher than typical heart rate
R. (October 1964). "Hereditary metabolic myopathy with paroxysmal myoglobinuria due to abnormal glycolysis". Journal of Neurology, Neurosurgery, and
Sinus_tachycardia
Equine atypical myopathy, also known as atypical myoglobinuria, or EAM is a fatal disease of horses (equidae) characterized by acute rhabdomyolysis. It
Equine_atypical_myopathy
Inability to perform physical exercise at normal levels
with Exercise-induced Vissing, John (2016). "Exercise intolerance and myoglobinuria". In Lisak, Robert P.; Truong, Daniel D.; Carroll, William M.; Bhidayasiri
Exercise_intolerance
Myofibrillar lysis Myofibroblastic tumors Myoglobinuria dominant form Myoglobinuria recurrent Myoglobinuria Myokymia Myoneurogastrointestinal encephalopathy
List_of_diseases_(M)
Sudden fatigue during endurance sports
synthesis). Severe breakdown of muscle leads to rhabdomyolysis and myoglobinuria. Excessive use of the myokinase reaction and purine nucleotide cycle
Hitting_the_wall
Diagnostic tool used in urinalysis
provided that correspond to the reactions that occur with hemoglobinuria, myoglobinuria and hematuria (RBCs). In the presence of free hemoglobin/myoglobin,
Urine_test_strip
Burn caused by microwave radiation
affected tissue can even be charred. Muscle tissue destruction can lead to myoglobinuria, with renal failure following in severe cases; this is similar to burns
Microwave_burn
Muscular disease in which the muscle fibers do not function correctly
myositis (M61) Myositis ossificans (M62.89) Rhabdomyolysis and (R82.1) myoglobinurias The Food and Drug Administration is recommending that physicians restrict
Myopathy
Iron and oxygen-binding protein
assemblies. Cytoglobin Hemoglobin Hemoprotein Neuroglobin Phytoglobin Myoglobinuria - The presence of myoglobin in the urine Ischemia-reperfusion injury
Myoglobin
Medical condition
pseudoathletic appearance of hypertrophic calf muscles. Renal failure by myoglobinuria, second wind phenomenon, inappropriate rapid heart rate (sinus tachycardia)
Glycogen_storage_disease
World Health Organization (WHO) priority list of medical tests
diagnose intravascular haemolysis, kidney conditions, rhabdomyolysis (myoglobinuria) Dipstick Urine Pregnancy testing Human chorionic gonadotrophin (hCG)
WHO model list of essential in vitro diagnostics
WHO_model_list_of_essential_in_vitro_diagnostics
late adulthood in the form of progressive limb muscle weakness without myoglobinuria or cramps. 生命科学関連研究への支援 [Contributor Toward Life Science Research] (in
Seiichiro_Tarui
Class of drugs to lower cholesterol
Henderson R (20 January 2015). "Rhabdomyolysis and Other Causes of Myoglobinuria". Archived from the original on 7 May 2015. Retrieved 6 May 2015. Mendes
Statin
Medical condition
exercise-induced muscle cramps and weakness (sometimes rhabdomyolysis), myoglobinuria, as well as with haemolytic anaemia causing dark urine a few hours later
Phosphofructokinase deficiency
Phosphofructokinase_deficiency
Exercise phenomenon
synthesis). Severe breakdown of muscle leads to rhabdomyolysis and myoglobinuria. Excessive use of the myokinase reaction and purine nucleotide cycle
Second_wind
Presence of small amounts of blood in urine
Association guidelines for microhematuria were updated. Proteinuria Hematuria Myoglobinuria Hemoglobinuria "Sickle Cell trait and Hematuria: Information for healthcare
Microhematuria
Class of enzymes
muscle weakness (myopathy) and exercise induced cramping and spasms, myoglobinuria (presence of myoglobin in urine, indicating muscle destruction) and
Phosphofructokinase_1
Snake Attacks Causing Health Concern
responsible for causing generalized rhabdomyolysis, with muscle pain and myoglobinuria, the coagulant action results in blood being unable to coagulate, and
Snakebite_in_Latin_America
Protein-coding gene in the species Homo sapiens
G, et al. (October 2008). "Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood". American Journal of Human Genetics. 83 (4): 489–94. doi:10
LPIN1
Enzyme in glycolysis
disorder characterised by severe nausea, vomiting, muscle cramps and myoglobinuria in response to bursts of intense or vigorous exercise. Sufferers are
Phosphofructokinase
laboratory changes include evidence of rhabdomyolysis (elevated CK and AST, myoglobinuria) and low blood selenium levels. On necropsy, muscles are pale with areas
Nutritional muscular dystrophy
Nutritional_muscular_dystrophy
azoturia also known as black water disease, set fast, and/or paralytic myoglobinuria. Tying-up related is mild as compared to azoturia, which is the more
Equine exertional rhabdomyolysis
Equine_exertional_rhabdomyolysis
Chemical compound
Lesbos who also consumed quail suffered from the same poisoning, causing myoglobinuria and acute kidney injury. This condition is called coturnism. Though
Coniine
Muscle disorders caused by mitochondrial dysfunction
intolerance manifesting as exercise-induced myalgia, muscle stiffness, myoglobinuria and rhabdomyolysis. A few Limb–girdle muscular dystrophies are known
Mitochondrial_myopathy
Biochemical shuttle reaction
fasting and prolonged exercise, and treatment of complications, such as myoglobinuria, hypoglycemia, and hepatic dysfunction. Carnitine Fatty Acid Lipid Metabolism
Carnitine_shuttle
Syndrome of muscle weakness in children
of a high level of creatine kinase suggests the diagnosis of BACM. Myoglobinuria is rare and points to the possibility of the development of rhabdomyolysis
Benign acute childhood myositis
Benign_acute_childhood_myositis
Medical condition
hyperthermia may cause muscle cell destruction (rhabdomyolysis) and myoglobinuria resulting in kidney failure. Individuals with cocaine overdose should
Cocaine_intoxication
Medical condition
some rhabdomyolysis and myoglobinuria. Liver symptoms: Hepatomegaly RBC symptoms: Hemolytic anemia. Rhabdomyolysis/myoglobinuria may cause acute renal failure
Inborn errors of carbohydrate metabolism
Inborn_errors_of_carbohydrate_metabolism
Syndrome where the sinus heart rate is inexplicably faster than expected
R. (October 1964). "Hereditary metabolic myopathy with paroxysmal myoglobinuria due to abnormal glycolysis1". Journal of Neurology, Neurosurgery, and
Inappropriate sinus tachycardia
Inappropriate_sinus_tachycardia
Mitochondrial protein involved in iron–sulfur cluster biosynthesis
myopathy with deficiency of succinate dehydrogenase and aconitase; myoglobinuria due to abnormal glycolysis; myopathy with deficiency of ISCU; Larsson–Linderholm
ISCU
systemically throughout the body. This can cause muscle pain, weakness, and myoglobinuria (with the color of urine varying from a deep red to a muddy brown),
Myolysis
Abnormally increased hemoglobin in urine
microscopically despite a positive dipstick test suggests hemoglobinuria or myoglobinuria. The medical term for RBCs in the urine is hematuria. Laboratory tests
Hemoglobinuria
Chemical compound
cardiac arrest Renal glycosuria, proteinuria, hematuria, oliguria, myoglobinuria, acute renal failure Musculoskeletal weakness, muscle spasms, muscle
Oenanthotoxin
Protein-coding gene in the species Homo sapiens
are other clinical presentations that have been identified, namely: myoglobinuria, dicarboxylic aciduria, feeding difficulties in infancy, muscular hypotonia
Hydroxyacyl-Coenzyme A dehydrogenase
Hydroxyacyl-Coenzyme_A_dehydrogenase
Class of enzymes
strenuous efforts which may trigger myalgias, cramps, muscle necrosis and myoglobinuria. An unusual pathologic feature of PGAM deficiency is the association
Phosphoglycerate_mutase
however it is known that upon injection with the toxin, muscle damage and myoglobinuria will follow. Data has shown that the tiger snake is one of the major
Notexin
Medical condition
R. (October 1964). "Hereditary metabolic myopathy with paroxysmal myoglobinuria due to abnormal glycolysis1". Journal of Neurology, Neurosurgery, and
Mitochondrial complex II deficiency
Mitochondrial_complex_II_deficiency
False appearance of an athletic body due to disease or injury
R. (October 1964). "Hereditary metabolic myopathy with paroxysmal myoglobinuria due to abnormal glycolysis1". Journal of Neurology, Neurosurgery, and
Pseudoathletic_appearance
Test for Fallopian tube patency
hyperthermia, respiratory failure, rhabdomyolysis, metabolic acidosis, myoglobinuria, renal failure, coma, and death. While there have been recent studies
Chromopertubation
Protein
mitochondrial myopathy, Leber hereditary optic neuropathy, muscle weakness, myoglobinuria, blood acidosis, renal tubulopathy, and more. Complex III deficiency
UQCRB
Mammalian protein found in Homo sapiens
defects of muscle phosphofructokinase and AMP deaminase in a child with myoglobinuria". Neurology. 50 (1): 296–8. doi:10.1212/wnl.50.1.296. PMID 9443500.
AMP_deaminase
131440; PDGFRB Myoclonic epilepsy, severe, of infancy; 607208; GABRG2 Myoglobinuria, acute recurrent, autosomal recessive; 268200; LPIN1 Myokymia with neonatal
List_of_OMIM_disorder_codes
Protein-coding gene in the species Homo sapiens
kinase variant (PGK Shizuoka) associated with chronic hemolysis and myoglobinuria". Blood. 79 (6): 1582–5. doi:10.1182/blood.V79.6.1582.1582. PMID 1547346
PGK1
Type of enzyme
metastasis of malignancies. Mutations in LDHA have been linked to exertional myoglobinuria. Click on genes, proteins and metabolites below to link to respective
Lactate_dehydrogenase_A
Mammalian protein found in humans
in the carnitine palmitoyltransferase II gene in familial recurrent myoglobinuria patients". Nat. Genet. 4 (3): 314–320. doi:10.1038/ng0793-314. PMID 8358442
Carnitine palmitoyltransferase II
Carnitine_palmitoyltransferase_II
Protein-coding gene in the species Homo sapiens
presents as isolated skeletal muscle involvement, rhabdomyolysis, and myoglobinuria, which is triggered by exercise or fasting. The disease is typically
ACADVL
Mitochondrial protein-coding gene
mitochondrial myopathy, Leber hereditary optic neuropathy, muscle weakness, myoglobinuria, blood acidosis, renal tubulopathy, and more. Complex III deficiency
MT-CYB
Drugs for heart or blood vessels diseases
into rhabdomyolysis, a condition manifested by muscle necrosis and myoglobinuria due to heightened creatine kinase levels. Another consequence of taking
Cardiovascular_agents
651.701.600 – paralysis, hyperkalemic periodic MeSH C05.651.807.628 – myoglobinuria MeSH C05.651.869.870 – tenosynovitis MeSH C05.660.207.207 – cleidocranial
List_of_MeSH_codes_(C05)
MYOGLOBINURIA
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