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Model of protein allosteric regulation
Morpheeins are proteins that can form two or more different homo-oligomers (morpheein forms), but must come apart and change shape to convert between
Morpheein
Regulation of enzyme activity
propagated to all subunits The morpheein model of allosteric regulation is a dissociative concerted model. A morpheein is a homo-oligomeric structure
Allosteric_regulation
Protein-coding gene in the species Homo sapiens
porphobilinogen as a common precursor. Porphobilinogen synthase is the prototype morpheein. It catalyzes the following reaction, the second step of the biosynthesis
Delta-aminolevulinic acid dehydratase
Delta-aminolevulinic_acid_dehydratase
Enzyme involved in fruit browning
other polyphenols. PPO is listed as a morpheein, a protein that can form two or more different homo-oligomers (morpheein forms), but must come apart and change
Polyphenol_oxidase
Enzyme family
isoleucine degradation, and butanoate metabolism. This protein may use the morpheein model of allosteric regulation. As of late 2007, 7 structures have been
3-oxoacid_CoA-transferase
Enzyme
condition adenylosuccinate lyase deficiency. This protein may use the morpheein model of allosteric regulation. Adenylosuccinate lyase (ASL) is an enzyme
Adenylosuccinate_lyase
Immune system messenger protein which induces inflammation
dimers and trimers in dynamic equilibrium suggests that TNF might be a morpheein. Small molecules that stabilize TNF dimers and prevent the assembly of
Tumor_necrosis_factor
Class of enzymes
participates in fructose and mannose metabolism. This protein may use the morpheein model of allosteric regulation. As of late 2007, 3 structures have been
GDP-mannose_6-dehydrogenase
Class of enzyme
bacteria, and higher plants. Some varieties of this protein may use the morpheein model of allosteric regulation. This enzyme belongs to the family of isomerases
Chorismate_mutase
Class of enzymes
enzyme participates in terpenoid biosynthesis. This protein may use the morpheein model of allosteric regulation. As of late 2007, two structures have been
Aristolochene_synthase
Class of enzymes
suspected to act as a mitogen for fibroblast lines. Tryptase may use the morpheein model of allosteric regulation. Mast cell tryptase-6 is involved in Trichinella
Tryptase
Class of enzymes
WikiPathways: "GlycolysisGluconeogenesis_WP534". This protein may use the morpheein model of allosteric regulation. Ethanol is dehydrogenated to acetaldehyde
Lactate_dehydrogenase
Enzyme
glycolysis or gluconeogenesis.[citation needed] This protein may use the morpheein model of allosteric regulation. Glycerol Kinase (alternative name, ATP:glycerol
Glycerol_kinase
Class of enzymes
phosphoribosyl pyrophosphate + uracil This protein is thought to use the morpheein model of allosteric regulation. Enzyme 2.4.2.9 at KEGG Pathway Database
Uracil phosphoribosyltransferase
Uracil_phosphoribosyltransferase
Mammalian protein found in Homo sapiens
crystal structure was also put forward in 2016. This protein may use the morpheein model of allosteric regulation. DBH is inhibited by disulfiram, tropolone
Dopamine_beta-hydroxylase
Class of enzymes
and geranylgeranyl pyrophosphate synthase. This protein may use the morpheein model of allosteric regulation. As of late 2007, two structures have been
Farnesyltranstransferase
Protein-coding gene in the species Homo sapiens
AdoHcyase binds one NAD+ cofactor per subunit. This protein may use the morpheein model of allosteric regulation. Overall hydrolysis begins with dehydrogenative
Adenosylhomocysteinase
Enzyme
explaining the need for the regulatory mechanism. This protein may use the morpheein model of allosteric regulation. NADP-malic enzyme, as all other C4 decarboxylases
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
Malate_dehydrogenase_(oxaloacetate-decarboxylating)_(NADP+)
Enzyme found in humans
ligase and hydrolase activity respectively. This protein may use the morpheein model of allosteric regulation. GRCh38: Ensembl release 89: ENSG00000062485
Citrate_synthase
Hexameric enzyme
hyperinsulinism-hyperammonemia syndrome. Allosteric regulation: This protein may use the morpheein model of allosteric regulation. Allosteric inhibitors: Guanosine triphosphate
Glutamate_dehydrogenase
Class of enzymes
Additionally, apk is a synonym for lysC. Aspartokinases may use the morpheein model of allosteric regulation. In Escherichia coli, aspartokinase is
Aspartate_kinase
Enzyme in glycolysis
mammalian monomers, possessing 2 similar domains). This protein may use the morpheein model of allosteric regulation. PFK is about 300 amino acids in length
Phosphofructokinase
Enzyme of the glycolysis metabolic pathway
thiol group of the enzyme's cysteine residue. This protein may use the morpheein model of allosteric regulation. As its name indicates, glyceraldehyde
Glyceraldehyde 3-phosphate dehydrogenase
Glyceraldehyde_3-phosphate_dehydrogenase
site, is involved in interacting with gyrase. This protein may use the morpheein model of allosteric regulation. Glutamate racemase has emerged as a potential
Glutamate_racemase
Class of enzymes
consequently p53R2 serves a major factor in dNTP supply. RNR may use the morpheein model of allosteric regulation. Ribonucleotide reductase (RNR) is a key
Ribonucleotide_reductase
Enzyme that regulates the metabolism of fatty acids
also inhibits AMPK directly.[citation needed] This protein may use the morpheein model of allosteric regulation. At the juncture of lipid synthesis and
Acetyl-CoA_carboxylase
Mammalian protein found in humans
than the binding of substrates to the enzyme. This protein may use the morpheein model of allosteric regulation. Human CBS performs a crucial step in the
Cystathionine_beta_synthase
Protein-coding gene in the species Homo sapiens
neurodegenerative and cardiac disease, Friedreich's ataxia. This protein may use the morpheein model of allosteric regulation. Lipoic acid GRCh38: Ensembl release 89:
Dihydrolipoamide dehydrogenase
Dihydrolipoamide_dehydrogenase
Mammalian protein found in Homo sapiens
dihydrobiopterin (qBH2), which is then reduced to BH4. PAH is proposed to use the morpheein model of allosteric regulation. Mammalian PAH exists in an equilibrium
Phenylalanine_hydroxylase
intermediate that is stabilized by nearby Lys41. This protein may use the morpheein model of allosteric regulation. Ribonuclease Raines RT (1998). "Ribonuclease
Bovine pancreatic ribonuclease
Bovine_pancreatic_ribonuclease
Class of enzymes
for the enzyme for use in cancer chemotherapy. PNP protein may use the morpheein model of allosteric regulation. Purine nucleoside phosphorylase, together
Purine nucleoside phosphorylase
Purine_nucleoside_phosphorylase
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